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The use of 5-alpha reductase inhibitors in the treatment of benign prostatic hyperplasia

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Asian Journal of Urology 2018年第1期5卷 28-32页

作者： Eric H.Kim john A.Brockman Gerald L.Andriole Division of Urologic Surgery Washington University School of MedicineSt.LouisMOUSA

Benign prostatic hyperplasia(BPH)is characterized by an enlarged prostate,lower urinary tract symptoms(LUTS),and a decreased urinary flow *** in older men,BPH is a progressive disease that can eventually lead to complications including acute urinary retention(AUR)and the need for BPH-related *** normal and abnormal prostate growth is driven by the androgen dihydrotestosterone(DHT),which is formed from testosterone under the influence of 5-alpha ***,5-alpha reductase inhibitors(5-ARIs)effectively reduce the serum and intraprostatic concentration of DHT,causing an involution of prostate *** 5-ARIs are currently available for the treatment of BPHdfinasteride and *** have been demonstrated to decrease prostate volume,improve LUTS and urinary flow rates,which ultimately reduces the risk of AUR and BPH-related ***,either alone or in combination with other BPH medications,5-ARIs are a mainstay of BPH management.

关键词： Benign prostatic hyperplasia 5-alpha reductase inhibitors Lower urinary tract symptoms

HIV Compartmentalization in Male Genital Tract:Relevance for Viral Eradication

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Infectious Diseases & Immunity 2021年第2期1卷 86-92页

作者： Xiaorong Peng Stéphane Isnard john Lin Brandon Fombuena Lena Royston Jean-Pierre Routy Infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontréalQCCanada Chronic Viral Illness Service McGill University Health CentreMontréalQCCanada State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310006China CIHR Canadian HIV Trials Network VancouverBCCanada Division of Hematology McGill University Health CentreMontréalQCCanada

Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical *** HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral *** compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)*** precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these *** on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular *** reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected *** distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.

关键词： HIV Compartmentalization Male genital tract Reservoir Testes

Handbook of Stem Cells

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HBV RNAseH activity is attractive target for antiviral drug screening

丛书名： v. 1

2004年

作者： Robert Lanza john Gearhart Brigid Hogan Douglas Melton Roger Pedersen James Thomson Michael West

ISBN: (数字)9780080533735

ISBN: (纸本)9780124366435

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, john Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger Pedersen, E. Donnall Thomas, James Thomson, Catherine Verfaillie, irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike.

关键词： Stem cells.

来源：畅想之星图书光盘版（南... 评论

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HBV RNAseH activity is attractive target for antiviral drug ...

Measurement of Arsenic Species in Infant Rice Cereals by Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry

2012全国临床微生物与感染免疫学术研讨会

作者： Tavis john Department of Molecular Microbiology and Immunology Saint Louis University School of MedicineSaint LouisMO63104USA

Objective To establish the suitable biochemical and cell-based RNAseH assays for antiviral drug screening. Methods We expressed HBV genotype D and H RNAseH in *** and enriched the enzymes by nickel-affinity *** RNAseH activity in the enriched lysates was characterized in preparation for drug screening. Twenty-one candidate HBV RNAseH inhibitors were identified using chemical structure-activity analyses based on inhibitors of the HIV RNAseH and *** also evaluated these inhibitors against HBV replication in tissue culture. Results Twelve anti-RNAseH and anti-integrase compounds inhibited the HBV RNAseH at 10 |xmol/L,the best compounds had low micromolar IC50 values against the RNAseH,and one compound inhibited HBV replication in tissue culture at 10μmol/*** HBV genotype D RNAseH was more sensitive to inhibition than genotype H. Conclusions This pilot study demonstrates that that recombinant HBV RNAseH suitable for low-throughput antiviral drug screening has been *** high percentage of compounds developed against the HIV RNAseH and integrase that were active against the HBV RNAseH indicates that the extensive drug design efforts against these HIV enzymes can guide anti-HBV RNAseH drug ***,differential inhibition of HBV genotype D and H RNAseHs indicates that viral genetic variability will be a factor during drug development.

关键词： HBV RNAseH Antiviral drug

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American Journal of Analytical Chemistry 2012年第10期3卷 693-697页

作者： john D. Brockman john W. N. Brown IV University of Missouri-Columbia Research Reactor St. Louis USA

Infant rice cereals were analyzed for total arsenic, inorganic arsenic (i-As) and the organic arsenic species monomethylarsonoic acid (MMA) and dimethylarsinic acid (DMA) using liquid chromatography inductively coupled plasma mass spectrometry (LC-ICP-MS). Total arsenic concentrations in the samples ranged from 110 ng/gup to 420 ng/g. The i-As in the rice cereals accounted for 33% to 77% of the total arsenic. The observed variability between infant rice cereals makes a dietary survey approach to accessing arsenic exposures difficult.

关键词： Arsenic Speciation Epidemiology Infant Rice Cereal Liquid Chromatography Inductively Coupled Plas-ma Mass Spectrometry

新版国际植物命名法规(维也纳法规)中的主要变化

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植物分类学报 2007年第2期45卷 251-255页

作者：张丽兵杨亲二 Nicholas J.TURLAND john MCNEILL Missouri Botanical Garden 中国科学院植物研究所系统与进化植物学国家重点实验室 Missouri Botanical Garden Saint LouisMissouri 63166U.S.A Royal Ontario Museum Torontoand Royal Botanic Garden Edinburgh20A Inverleith RowEdinburghEH3 5LRScotlandU.K.

出版于2006年9月的最新版的《国际植物命名法规》,即维也纳法规(Vienna Code),取代了圣路易斯法规(Saint louis Code)而成为管理植物学(包括藻类学和真菌学)科学命名的唯一有效法规。本文报道了维也纳法规和圣路易斯法规之间的主要区别... 详细信息

出版于2006年9月的最新版的《国际植物命名法规》,即维也纳法规(Vienna Code),取代了圣路易斯法规(Saint louis Code)而成为管理植物学(包括藻类学和真菌学)科学命名的唯一有效法规。本文报道了维也纳法规和圣路易斯法规之间的主要区别。这些区别包括两版法规在起始日期、有效发表、合格发表、化石植物、多型真菌、拼写和附录诸方面的不同。

关键词：命名法维也纳法规主要变化

高血压伴代谢综合征患者的抑郁症状与不良生活方式相关

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 51-52页

作者： Bonnet F. irving K. Terra J.-L. 孟欣 Department of Diabetology-Endocrinology Cardiovascular Hospital Louis Pradel 69394 Lyon France Dr.

Objective: Metabolic syndrome results from a complex interaction between lifestyle and genetic factors. Among this population, adhesion to healthy recommendations is a cornerstone of cardiovascular disease prevention. We examined the association between depression and multiple unhealthy behaviours in hypertensive patients with the metabolic syndrome. Research design and methods: Eight hundred and forty consecutive hypertensive subjects with the metabolic syndrome were studied in our secondary-care centre. Separated scores reflecting unhealthy behaviours(physical inactivity, smoking and unhealthy diet) were combined to produce a global unhealthy lifestyle score. The Hospital Anxiety and Depression scale was used to assess and quantify depression. We performed a separate analysis for each sex. Results: The prevalence of depression(13.0 versus 7.3%, P< 0.001) was greater in women than in men. Presence of depression was significantly associated in both men and women with unhealthy diet(in particular, excessive cholesterol and total caloric intake) but also with decreased physical activity in men and with smoking habits in women. In both sexes, the global unhealthy lifestyle score, reflecting a cluster of unhealthy behaviours, was positively correlated with the depression score. In multivariate analysis, the depression score appeared in both sexes as an independent determinant of unhealthy lifestyle. Conclusions: Among hypertensive subjects with the metabolic syndrome, depressive symptoms along a continuum of severity are independently associated with multiple unhealthy lifestyles. This suggests that even minor forms of depression may impact on adhesion to health behaviours beyond major depressive symptoms and/or psychiatric condition.

关键词：代谢综合征不健康生活方式郁症心血管疾病二级护理饮食习惯不健康行为遗传因素精神疾病体力活动

Lattice of Finite Group Actions on Prism Manifolds

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Advances in Pure Mathematics 2012年第3期2卷 149-168页

作者： john E. Kalliongis Ryo Ohashi Department of Mathematics and Computer Science Saint Louis University St. Louis USA Department of Mathematics King’s College Wilkes-Barre USA

The set of finite group actions (up to equivalence) which operate on a prism manifold M, preserve a Heegaard Klein bottle and have a fixed orbifold quotient type, form a partially ordered set. We describe the partial ordering of these actions by relating them to certain sets of ordered pairs of integers. There are seven possible orbifold quotient types, and for any fixed quotient type we show that the partially ordered set is isomorphic to a union of distributive lattices of a certain type. We give necessary and sufficent conditions, for these partially ordered sets to be isomorphic and to be a union of Boolean algebras.

关键词： Finite Group Action Prism 3-Manifold Equivalence of Actions Orbifold Partially Ordered Set Distributive Lattice

Additive Manufacturing:Incremental Improvements to a Disruptive Technology

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Accounts of Materials Research 2021年第8期2卷 574-576页

作者： john E.Barnes Kevin Slattery The Barnes Global Advisors PittsburghPennsylvaniaUnited States The Barnes Global Advisors St.LouisMissouriUnited States

Additive Manufacturing(AM)is disruptive and complex not only in its nature but also in what it can *** have always had difficulty absorbing complexity and disruption due to our skeptical nature and need to *** being a 3-dimensional solution is simply an example of how AM is disruptive because people are adept at thinking in two *** a technology as transformative as AM to progress,some assumptions have to be made and certain approximations have to be asserted and held to be true until they can be revisited *** we weigh the societal benefit that AM can and will bring,efficiency comes to the *** could be efficiency of energy use,efficiency of materials utilization,or efficiency in designs that are lighter and then use less *** matter what form efficiency takes,it impacts *** achieve a greater impact,AM must become more pervasive,and for it to become more pervasive,it must become more *** additional source of complexity in AM is the sheer number of process variables,such as feedstock,energy source,part geometry,and postprocessing,with more than 100 identified,1 not including the interrelationships between these *** similar numbers are present in other manufacturing processes,such as forging and casting,civilization has had between 200 and 5000 years to understand the variables in these processes,which is longer than society wants to wait in the case of AM.

关键词： casting Additive absorbing