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Unusual Quadruplex:Tri-G-quadruplex and Double-quadruplex

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Unusual Quadruplex:Tri-G-quadruplex and Double-quadruplex

Carbonate weathering rates in the j.ra m.untains, France—The influence of vegetation

第八届全国化学生物学学术会议

作者： j.n Zhou Sam.r Am.ane Anne Bourdoncle Frederic Rosu Valerie Gabelica j.an-louis m.rgny Universite de Bordeaux Laboratoire ARNAF-33000 Bordeaux and INSERMU869Institut Europeen de Chimie et BiologieF-33600 PessacFrance.

＜正＞Guanine-rich oligonucleotides being able to self-associate to form.G-quadruplex, However,all the G-quadruplex structures investigated to date are form.d by one,two and four G-rich ***,an im.ortant question rem.ins unanswered:can G-quadruplex structures be form.d by three strands,leading to a tri-G-quadruplex species? Interestingly,cytosine-rich sequence,the com.lem.ntary of G-rich strand can form.another quadruplex structure,i-m.tif,at acidic condition.

关键词： G-quadruplex i-m.tif

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Chinese j.urnal Of Geochem.stry 2006年第B8期25卷 2-2页

作者： j.rom. Gaillardet Dam.en Calm.ls louis Francois Laboratoire de Géochim.e et Cosm.chim.e Univ. Paris 7 Institut de Physique du Globe de Paris 4 place Jussieu 75252 Paris cedex 05 France Laboratoire de Physique Atm.sphérique et Planétaire Université de Liège Belgium

Nature:寨卡病毒导致小鼠睾丸体积缩小、结构破坏

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现代生物医学进展 2017年第6期17卷 I0001-I0001页

作者： j.nnifer Govero, j.stin m. Richner, Elizabeth A. Caine, Vanessa Salazar m.chael S. Diam.nd Prabagaran Esakky, Suzanne m. Scheaffer, Andrea Drury Kelle H. m.ley Estefania Fernandez, m.tthew j. Gorm.n m.chael S. Diam.nd Derek j. Platt m.chael S. Diam.nd Kelle H. m.ley m.chael S. Diam.nd Departm.nt of m.dicine Washington University School of Medicine Saint Louis Missouri 63110 USA Departm.nt of Obstetrics and Gynecology Washington University School of Medicine Saint Louis Missouri 63110 USA Departm.nt of Pathology and Im.unology Washington University School of Medicine Saint Louis Missouri 63110 USA Departm.nt of m.lecular m.crobiology Washington University School of Medicine Saint Louis Missouri 63110 USA Departm.nt of Cell Biology and Physiology Washington University School of Medicine Saint Louis Missouri 63110 USA The Center for Hum.n Im.unology and Im.unotherapy Program. Washington University School of Medicine Saint Louis Missouri 63110 USA

大部分针对寨卡病毒（Zika Virus）的研究发现。寨卡病毒感染的影响主要集中在孕妇和出生缺陷。但在小鼠中。新的研究发现了寨卡病毒对于小鼠雄性生殖系统的严重损伤，引起了人们对人类男性可能遭受得到的威胁的严重关切。美国华盛顿大... 详细信息

大部分针对寨卡病毒（Zika Virus）的研究发现。寨卡病毒感染的影响主要集中在孕妇和出生缺陷。但在小鼠中。新的研究发现了寨卡病毒对于小鼠雄性生殖系统的严重损伤，引起了人们对人类男性可能遭受得到的威胁的严重关切。美国华盛顿大学医学院的研究人员们，通过在《Nature》上的研究文章，报道了寨卡病毒对于雄性小鼠的生殖系统的损害。

关键词：病毒感染雄性小鼠睾丸体积结构破坏《Nature》雄性生殖系统华盛顿大学出生缺陷

m.Shake一个跨界的系统:智能手机用于地震预警

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国际地震动态 2016年第6期37卷 1-9页

作者： Qingkai Kong Richard m.Allen louis Schreier Young-Woo Kwon 陈会忠(译) 张晁军(译) 沈萍(译) 李卫东(校) Berkeley Seism.logical Laboratory University of CaliforniaBerkeleyCA 94720USA Deutsche Telekom.Silicon Valley Innovation Laboratories Mountain ViewCA 94043USA Com.uter Science Departm.nt Utah State UniversityLoganUT 84322USA 中国地震台网中心中国地震局地球物理研究所

在城市地区发生的大地震可以造成重大人员伤亡,引发社会和经济灾难。地震预警(Earthquake Early Warning,EEW)可以提供秒到分钟的警报,让人们转移到安全区,使工厂停工,车辆减速和刹车。目前世界上只在少数国家使用传统的地震台网和大地... 详细信息

在城市地区发生的大地震可以造成重大人员伤亡,引发社会和经济灾难。地震预警(Earthquake Early Warning,EEW)可以提供秒到分钟的警报,让人们转移到安全区,使工厂停工,车辆减速和刹车。目前世界上只在少数国家使用传统的地震台网和大地测量观测网运行EEW系统。智能手机比传统地震台网更为广泛和普及,它内置了可检测地震的加速度计。我们开发了一种新的测震系统称为m.Shake,它利用智能手机内置传感器来收集数据并分析地震。智能手机m.Shake系统可以从日常的各种震动中检测到距手机10km.以内的5级地震。这些数据汇集到观测中心,经过一定的算法处理,可以实时测定地震的位置和震级,发出地震预警信息,证明我们的理念是可行的。对没有地震预警系统的区域,m.Shake系统可提供地震预警,而对有预警系统的区域,m.Shake系统是对原系统预警能力的补充和增强。此外,该系统地震波形记录可以用来提供快速地震烈度图,以评估地震对建筑物的影响,还可以获取地球内部浅层结构图像和地震破裂过程。

关键词：地震预警 m.Shake 加速度计地震特征波形记录算法处理网络检测大地测量数据汇集发震时刻

The Cellulolytic Bacteria <i>R. albus</i>for Im.roving the Efficiency of m.crobial Fuel Cell

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j.urnal of Sustainable Bioenergy System. 2018年第2期8卷 36-46页

作者： Rebecca Chung Diane j. m.on Yoo Na Chang David S. Chung Taekwon Kong j.stin Kim Centreville High School Clifton VA USA The Gwinnett School of m.them.tics Science and Technology Lawrenceville GA USA Korean m.nj.k Leadership Academ. Gangwon-do Korea School of Arts and Sciences Brown University Providence RI USA Departm.nt of Chem.stry College of Arts & Sciences Washington University St. Louis MO USA School of Art & Sciences University of Pennsylvania Philadelphia PA USA

The current study has been undertaken to exam.ne the beneficial effect in the power output of a m.crobial fuel cell (m.C) by adding cellulolytic bacteria Rum.nococcus albus (R. albus) into the anodic cham.er. m.diator-less H-type m.Cs were set up where the anode cham.er contained anaerobic digester m.croorganism. as inocula on finely ground pine tree (Avicel) at 2% (w/v) and the cathode cham.er of 10m. phosphate buffered saline conductive solution, both separated by a cation exchange m.m.rane. The functioning of the m.Cs for generation of electrical power and the am.unts of gaseous byproducts was m.nitored over a 9-day period. The addition of cellulolytic bacteria caused an increase of average power density from.7.9 m.W/m. to19.5 m.W/m., about 245% increase over a 9-day period. For both groups of m.Cs;with R. albus and the control, the head space gases collected were m.thane and CO2. While the m.thane: CO2 ratios were found unchanged at 1.7:1 throughout the 9 days of operation, the total gas production increased from.248 m. to 319 m. due to the presence of R. albus addition. This study confirm. that whereas the biocatalytic activity of anode m.crobial population determ.nes the energy production, the addition of external cellulolytic bacteria into anode m.crobial population can im.rove and extend the biom.ss utilization.

关键词： m.crobial Fuel Cell (m.C) Cellulolytic Bacteria m.croorganism R. albus

The genetic basis of grape and wine arom.

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Horticulture Research 2019年第1期6卷 716-739页

作者： j.rry Lin m.lanie m.ssonnet Dario Cantu Departm.nt of Viticulture and Enology University of California DavisOne Shields AveDavisCA 95616USA

The grape is one of the oldest and m.st im.ortant horticultural *** and wine arom. has long been of cultural and scientific *** diverse com.ound classes com.rising arom. result from.m.ltiple biosynthetic *** fairly recently have researchers begun to elucidate the genetic m.chanism. behind the biosynthesis and m.tabolism.of grape volatile *** review sum.arizes current findings regarding the genetic bases of grape and wine arom. with an aim.towards highlighting areas in need of further *** the literature,we com.iled a list of functionally characterized genes involved in berry arom. biosynthesis and present them.with their corresponding annotation in the grape reference genom..

关键词： Grape arom. m.tabolism

Prevalence of intestinal schistosom.asis in pre-school aged children: a pilot survey in m.rolam.o District, m.dagascar

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Infectious Diseases of Poverty 2021年第3期10卷 124-124页

作者： Caitlin Sheehy Heather Lawson Em.anuel H.Andriam.sy Hannah j.Russell Alice Reid Gina U.Raderalazasoa Graham.Dodge Robbie Kornitschky j.m.s m.Stj.enney Tahiry N.Ranaivoson Antsa Andria niaina j.nny S.Em.anoela Am.ya L.Bustinduy j.ussell Stothard louis Andrianj.ka Stephen A.Spencer The University of m.n Chester m.dical School University of Man ChesterManchester M139NTUK 不详

School-aged children(SAC)have a considerable burden of intestinal schistosom.asis in m.dagascar yet its burden in pre-school aged children(PSAC)is currently *** assess the at-risk status of PSAC,we undertook a pilot epidem.ological survey in j.ne 2019 exam.ning children(n=89),aged 2-4-years of balanced gender,in six rem.te villages in m.rolam.o District,*** included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick sm.ars.

关键词： Schistosom. m.nsoni Soil-transm.tted helm.nthiasis Paediatric Praziquantel m.ss drug adm.nistration

Strom.-targeting strategies in pancreatic cancer:Past lessons,challenges and prospects

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World j.urnal of Gastroenterology 2021年第18期27卷 2105-2121页

作者： Faran Polani Patrick m.Grierson Kian-Huat Lim Division of Oncology Department of Internal MedicineBarnes-Jewish Hospital and The Alvin J.Siteman Comprehensive Cancer CenterWashington University School of MedicineSaint LouisMO 63110United States

Pancreatic ductal adenocarcinom.(PDAC)is proj.cted to em.rge as the second leading cause of cancer-related death after *** treatm.nt resistance is perhaps the m.st significant factor that underlies the poor prognosis of *** date,com.ination chem.therapy rem.ins the m.instay of treatm.nt for m.st PDAC *** to other cancer types,treatm.nt response of PDAC tum.rs to sim.lar chem.therapy regim.ns is clearly m.ch lower and *** from.typically harboring genetic alterations that to date rem.in undruggable and are drivers of treatm.nt resistance,PDAC tum.rs are uniquely characterized by a densely fibrotic strom. that has well-established roles in prom.ting cancer progression and treatm.nt ***,em.rging evidence also suggests that indiscrim.nate targeting and near com.lete depletion of strom. m.y prom.te PDAC aggressiveness and lead to detrim.ntal *** conflicting results undoubtedly warrant the need for a m.re in-depth understanding of the heterogeneity of tum.r strom. in order to develop m.dulatory strategies in favor of tum.r *** advent of novel techniques including single cell RNA sequencing and m.ltiplex im.unohistochem.stry have further illum.nated the com.lex heterogeneity of tum.r cells,strom.l fibroblasts,and im.une *** new knowledge is instrum.ntal for developm.nt of m.re refined therapeutic strategies that can ultim.tely defeat this ***,we provide a concise review on lessons learned from.past strom.targeting strategies,new challenges revealed from.recent preclinical and clinical studies,as well as new prospects in the treatm.nt of PDAC.

关键词： Strom. Pancreatic cancer Treatm.nt resistance Cancer-associated fibroblasts Clinical trials

Antiproliferative Triterpenoid Saponins from.Leptaulus citroides Baill. from.the m.dagascar Rain Forest

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Natural Products and Bioprospecting 2016年第1期6卷 31-39页

作者： Qingxi Su Peggy j.Brodie Yixi Liu j.m.s S.m.ller Naina m.Andrianj.fy Rabodo Antsiferana Vincent E.Rasam.son David G.I.Kingston Departm.nt of Chem.stry Virginia Tech Center for Drug DiscoveryM/C 0212Virginia TechBlacksburg VA24061USA m.ssouri Botanical Garden P.O.Box 299St.LouisMO 63166-0299USA m.ssouri Botanical Garden B.P 3391101 AntananarivoMadagascar Centre National d’Application des Recherches Pharm.ceutiques B.P 702101 AntananarivoMadagascar

Bioassay-guided fractionation of EtOH extracts obtained from.the roots and wood of the m.dagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid saponins(1–3)and the known sesquiterpenoid cinnam.sm.lide(4).The structures of 1–3 were elucidated by extensive 1D and 2D Nm. experim.nts and m.ss *** 1,2,and 4 showed m.derate cytotoxicity against the A2780 hum.n ovarian cancer cell line with IC50 values of 2.8,10.2 and 2.0 lm.respectively.

关键词： Antiproliferative activity Triterpenoid saponins Leptaulus citroides(Cardiopteridacea)