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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 40-41页

作者： Gustot T Lemmers A louis E 赵天智 Division of Gastroenterol ogy Erasme University Hospital Free University of Brussels 808 Lennik St 107 0 Brussels Belgium.Dr

Introduction: Soluble cytokine receptors (sCRs) modulate the in vivo activity of cytokines. Deficient sCR production could participate in the pathogenesis and course of Crohn’s disease(CD). The aim of the study was to examine the pro- file of sCRs in CD patients and their modulation by infliximab and corticoster ***: We prospectively examined active CD patients(aCD) treated with eit her infliximab (n=21) or corticosteroids(n=9), CD patients in clinical remission (rCD, n=20), ulcerative colitis patients (UC, n=24), and healthy subjects (HS, n=15). Cultures of colonic biopsies were also examined from CD inflamed (n=8), C D non-inflamed (n=7), and healthy mucosa(n=8). Levels of tumour necrosis factor α(TNF-α), soluble TNF receptor I (sTNFRI), soluble TNF receptor II (sTNFRII) ,interleukin 1 β(IL-1 β), soluble IL-1 receptor I (sIL-1 RI),soluble IL-1 receptor II (sIL-1 RII), IL-6, soluble IL-6 receptor(sIL-6R), and sgp 130 we re measured using ELISA. Results:Higher levels of sTNFRI (P< 0.05, P< 0.01), sTN FRII (P< 0.01,P< 0.01), sIL-1 RI (P< 0.05, NS), IL-6 (P< 0.01, P< 0.01), and s IL-6R (P< 0.05, NS) were observed in aCD compared with rCD and HS. Interestingl y, sIL-1 RII (P< 0.05, P< 0.01) and sgp 130 (P< 0.01, P< 0.01) were profoundly decreased in aCD compared with rCD and HS, and were negatively correlated with C RP. Deficient production of sIL-1 RII was specific to CD (not observed in ulcer ative colitis), and was further con-firmed at the mucosal level. Infliximab dec reased sTNFRII at one and four weeks (P< 0.05) and enhanced sIL-6R levels at on e week (P< 0.05). Corticosteroids increased sIL-1 RII levels at one week (P< 0. 05). Conclusion: CD is associated with dysregulated production of sCRs. Deficien cy in sIL-1 RII and sgp 130 may be essential to CD pathogenesis. Their replacem ent through the use of fusion proteins could represent future alternative therap eutic strategies for CD.

关键词：克罗恩病溃疡性结肠炎临床缓解期皮质激素治疗单抗治疗活检标本细胞因子活体内肿瘤坏死因子α 白细胞介素

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Evaluation of Google Glass^(■) with Camera Adaptor and GoPro^(■) as Teaching Tools for Endotracheal Intubation in the Austere Medical Environment

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Open Journal of Anesthesiology 2018年第8期8卷 229-239页

作者： Michael Son David Zimmer Ross McCauley Donald Zimmer Joseph Dynako Richard Skupski Bhavesh Patel Nuha Zackariya Faadil Shariff Lovely Nathalie Colas Gerson Pyram Marc Edson Augustin Carmeline Mathurin Stanley louis Patricia Saint louis Stanley Loriston Dan Herbstman Lucio Cervantes Shane Kappler Michael TMcCurdy Jecko Thachil Sarah Greve Mark Walsh University of Notre Dame Notre DameINUSA Memorial Hospital South BendINUSA Indiana University School of Medicine South BendINUSA Mayo Clinic PhoenixAZUSA Indiana University Bloomington BloomingtonINUSA Hospital Saint Luc Port-Au-PrinceHaiti Department of Anesthesiology Hopital Universitaire JustinienCap HaitienHaiti Third Eye Health ChicagoILUSA Adisat Colonia:Condessa Mexico CityMexico 1 University of Maryland School of Medicine BaltimoreMDUSA 1 Department of Haematology Manchester Royal InfirmaryManchesterUK 1 St Joseph Regional Medical Center MishawakaINUSA

Objective: Endotracheal intubation (ETI) is a life-saving emergency procedure, but it is a complex skill that is difficult to teach. Recent studies have shown that video laryngoscopy is effective in teaching ETI to learners at various levels of medical expertise;however, it has proven to be costly and provides images of inconsistent quality. In this educational proof of concept feasibility convenience sample pilot study, we aim to explore and compare the effectiveness of using modified Google Glass? (GG) and GoPro? (GP) technologies to visualize and teach ETI to critical care physicians in the austere medical environment of a low-income country. We propose, based on our findings, that this inexpensive technology could teach lifesaving ETI to pre-hospital providers in the austere medical environment, medical students, rural emergency physicians, critical care physicians in low-income countries, far forward military medical providers, and other learners. Methods: A case series of twenty-five patients, five in the United States (US) at Memorial Hospital in South Bend, IN and twenty at Saint Luc’s Hospital in Port Au Prince, Haiti, is presented. These patients were collected from November 1st 2015 through February 1st of 2016. The anesthesiologist and the emergency physicians in the United States utilized GG to intubate five patients in the US prior to the twenty patients intubated during two separate trips to Haiti. On the two separate trips to Haiti, the GG was trialed and modified to obtain better exposure. These adaptations resulted in the final collection of twenty patients studied with the adapted GG system and GP. Physicians graded airway visualization based on LEMON and Cormack-Lehane scores. Previously published parameters for the assessment of failed intubation risk and passage of the cords were used as data points for analysis using a Likert-Scale analysis for each parameter. The data were analyzed by averages of Likert-Scale scoring with their respective sta

关键词： Endotracheal Intubation Google Glass^(■) GoPro^(■) Cord Visualization Military Medicine Austere Medical Environment Low Income Country Rural Prehospital

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Isolation and Authentication of Local Rhizobia Nodulating Common Bean (Phaseolus vulgaris L.) in Different Agro-Ecological Zones of Côte d’Ivoire

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Advances in Microbiology 2023年第9期13卷 435-447页

作者： Marie-Paule Aboueuh Atsé Mako François De Paul N’Gbesso Ibrahim Konaté Noupé Diakaria Coulibaly Kouadio Amani Katiénapariga Tayourou Yéo louis Butare Department of Biochemistry-Microbiology Jean Lorougnon Guédé University (UJLoG) Daloa Côte d’Ivoire Research Station on Food Crops National Center for Agronomic Research (CNRA) Bouaké Côte d’Ivoire Crop Research Institute (CRI) Alliance of Biodiversity International and CIAT. C/O CSIR Kumasi Ghana

Legumes such as common bean (Phaseolus vulgaris L.) have been introduced into cropping systems for sustainable soil management. Consequently, the loss of fertility of the latter remains a major constraint to bean production because this legume is rarely fertilized, yet it is considered to be a poor nitrogen fixer in the absence of inoculation. To overcome this, this study was undertaken with the objective of seeking efficient local rhizobia in order to propose a bean inoculum formulation. To do this, soil samples taken from twelve localities in the Centre, North and West areas of C?te d’Ivoire were used to trap bean nodulating rhizobia. The ROBA1 bean accession used was sown in pots containing the sampled soils. Seedlings were uprooted at the start of flowering and nodulation was assessed. The isolates obtained were purified and then characterized phenotypically. The infectivity and symbiotic efficacy of these isolates were determined in vitro by the authentication test in which the purified isolates were reinoculated to their original host plant. A total of 24 rhizobium isolates were obtained from the soils of six localities. During morphological characterization, the isolates showed typical characteristics of Rhizobium. With the exception of RPC501, RPC505 and RPC522, all isolates were authenticated and able to nodulate the host plant in controlled culture. Isolates RPC502, RPC507, and RPC508 were effective and significantly increased (P < 0.05) nodule number and weight, height, and plant biomass. This study has, therefore, revealed the presence of effective local rhizobia in Ivorian soils and capable of nodulating common beans. A genetic characterization of efficient rhizobia identified after experimentation in different environmental conditions should be considered before being recommended as bean rhizobia inoculant.

关键词： Trapping Native Rhizobia Nodulation Common Bean Côte d’Ivoire

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Management of Subtalar Fractures-Dislocations at Ségou Hospital in Mali: A 7 Cases Series

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Surgical Science 2020年第4期11卷 51-60页

作者： Mahamadou Diallo Abdoul Kadri Moussa Layes Toure louis Traoré Cheick Oumar Sanogo Terna Traore Seydina Alioune Beye Abdrahamane Toure Making Mounkoro Mahamadou Kane Tiéman Coulibaly Orthopedic-Trauma Service Nianankoro Fomba Hospital Ségou Mali Orthopedic-Trauma Service Gabriel Touré Hospital Bamako Mali Orthopedic-Trauma Service Sikasso Hospital Sikasso Mali Orthopedic-Trauma Service Kati Hospital Kati Mali Anesthesia-Resuscitation Service Nianankoro Fomba Hospital Ségou Mali

Introduction: Subtalar or peritalian dislocation is rare;it represents 15% of peritalian injuries. The aim of this study was to describe the radioclinical and therapeutic characteristics and to assess the functional result. Patients and Methods: This study is about a continuous descriptive and prospective study over a period of 5 years. It has been conducted from March 2013 to February 2018 at the Ségou Hospital, a second referral hospital in Mali. The functional results were evaluated by the score of the American Orthopedic Foot and Ankle Society (AOFAS). Results: Seven cases of subtalar dislocation fractures were diagnosed in six male patients with an average age of 38 years (36 to 47 years old). In five cases the etiology of the trauma was a motorcycle accident and a fall from height. The lesion was bilateral in one case. The average time to care was 3 hours (1 to 9 hours). There was one case of open dislocation fracture with talus enucleation. The dislocation was medial in 6 cases and lateral in one case. It was pure in three cases. The treatment was orthopedic in 2 cases and surgical in 5 cases. The post-operative complications were complicated by an infection of the operative site in one case. The average length of hospital stay was 4 days. The functional result was excellent in 2 cases;good in 2 cases, fair in 2 cases and poor for 1 case. Conclusion: Subtalar dislocation is a rare and serious lesion of the posterior tarsus. The long-term prognosis depends on the earliness of treatment and the severity of the associated injuries.

关键词： Fracture Dislocation Subtalar Prognosis Treatment

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Total Thrombosis of Bifurcated Endoprosthesis: A Rare Complication of Endovascular Treatment of Abdominal Aortic Aneurysm

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Surgical Science 2019年第9期10卷 338-345页

作者： Birama Togola Bréhima Bengaly Madiassa Konaté Laurent Muller Olivier Szymoniak Mahamadou Coulibaly Drissa Traoré Bréhima Coulibaly Skaiste Vaitkevicienne Michel Peret Nouhoum Ongoiba Jean louis Debrux Department of Surgery “B” CHU Point “G” Bamako Mali Department of General Surgery Hospital Gabriel Touré Bamako Mali Department of Vascular and Thoracic Surgery of CH Cholet France Department of Vascular Surgery in Park Polyclinic of Cholet Cholet France Department of Thoracic and Cardiovascular Surgery Angers CHU Angers France

Background: Aortic stents are a therapeutic alternative to open surgery of abdominal aortic aneurysms. We report a case of treatment of an abdominal aortic aneurysm with a bifurcated stent, complicated by total thrombosis. aim: The purpose of this presentation was to understand the causes, mechanisms, incidents and accidents that contributed to this complication. Case Presentation: A 48-year-old man patient with a history of high blood pressure, ischemic heart disease, chronic obstructive pulmonary disease, who was found during a surveillance check-up, an infra-renal abdominal aorta aneurysm measured at 56 mm in diameter, asymptomatic but progressive. The indication of an endovascular treatment by the placement of a bifurcated prosthesis was posed and accepted. Thrombosis of the two limbs was intra-operative, upper-end migration without endoleak at 4 months postoperative, total thrombosis of the stent at 13 months postoperatively. Explantation of the stent followed by aortobi-iliac bypass was finally performed in the 15th month. Conclusion: The cardiopulmonary antecedents, the anatomical and evolutionary characteristics of the aneurysm could have played a role in the occurrence of the complications observed in this patient.

关键词： Aneurysm Abdominal Aorta Endovascular Complications Stent Thrombosis

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Epidemiological and Diagnostic Features of Non-Traumatic Gonalgia in Adults in Bouake (Ivory Coast): About 140 Patients

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Open Journal of Rheumatology and Autoimmune Diseases 2023年第4期13卷 78-87页

作者： Kouakou Ehaulier Soh Christian louis Sougué Charles Yao Konan Joe Clauvis Traore Aissata Koffi Joseph Kan Enock Goua Jean Jacques Same Bebey Francine Goupille Phillipe Daboiko Jean Claude Felix Rheumatology Department University Hospital Center Bouaké Bouaké C&#244te d’Ivoire Internal Medicine Department University Hospital Center Sour&#244 Sanou Bobo Dioulasso Burkina Faso Rheumatology Department Laquintinie Hospital Douala Cameroon Rheumatology Department University Hospital Center Tours France

Background: Non traumatic gonalgia is the second most common reason for rheumatology consultations and accounted for 15.6% of rheumatological disorders in Abidjan. Objective: The aim of this work was to study the epidemiological and diagnostic features of non-traumatic gonalgia (NTG) in a black adult population from sub-Saharan Africa. Patients and Methods: This was a five-year retrospective descriptive study (January 2014 to December 2018) of black sub-Saharan African adult patients with non traumatic gonalgia seen in the rheumatology department of the Bouake University Hospital in Côte d’Ivoire. Results: Of 2198 patients seen for rheumatological conditions, 140 had non traumatic gonalgia (6.4%). The mean age of patients was 56.13 ± 13.3 years (extremes 20 and 87 years), and the sex ratio was 0.43 (42 men and 98 women). Gonalgia without swelling was observed in 33.6% of cases. Symptoms were predominantly progressive (97.1%), chronic (82.1%) and bilateral (50%). The causes of TNM were gonarthrosis (85%), septic arthritis (7.1%), reactive arthritis (2.9%), gout (2.9%), rheumatoid arthritis (1.4%) and chondrocalcinosis (0.7%). Gonarthrosis (119/140) was bilateral in 65 patients, bi- or tri-compartmental in 83, radiographic stage (Kellgren and Lawrence) III in 80 and IV in 15. A germ was isolated in two cases of septic arthritis (methicillin-sensitive Staphylococcus aureus and Streptococcus pneumoniae). Conclusion: GNT is common in rheumatology practice in Bouake, and mainly affects women in their fifties. It is most often a chronic bilateral gonalgia, with gonarthrosis as the main etiology.

关键词： Non-Traumatic Gonalgia Gonarthrosis Bouake

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Yield, Growth and Vegetative Development Parameters Response of Dry Beans to Organic and Inorganic Fertilizers and Biofertilizer

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Agricultural Sciences 2023年第12期14卷 1688-1701页

作者： Noupé Diakaria Coulibaly André Gabazé Gadji Serge Hervé Kimou Christian Landry Ossey Lassina Fondio Mako François De Paul N’Gbesso Aya Félicité N’Gaza louis Butare CNRA (Centre National de Recherche Agronomique) Bouaké C&#244te d’Ivoire UFR Sciences et Technologies Université Alassane Ouattara Bouaké C&#244te d’Ivoire Alliance of Bioversity International and CIAT C/O IITA-Benin Station Cotonou Benin

As part of the promotion of common bean cultivation, fertilization methods will have to be proposed to growers. The aim of this study is therefore to develop a technical itinerary for dry bean fertilization. To this end, different types of chemical and organic fertilizers were evaluated on three dry bean varieties (HARI25/GHA19, HARI35/GHA19 and HARI36/GUI21). Seven (7) doses of chemical and organic fertilizers were used, including two controls (D0 with no fertilizer and D1, the reference dose using NPK base and cover fertilizers in the form of urea). The fertilization trial was set up as a Split-Plot design, with variety as the primary factor and dose as the secondary factor. The experiment was repeated three (3) times. The results showed that vegetative development parameters and fruit set rate varied according to the variety studied. For yield and its components, the treatments had a significant effect. Indeed, the response of varieties to fertilizers was specific. For each variety used, the optimum yield was obtained with a different treatment, thus highlighting the genotype effect of the dry bean varieties studied. Among the treatments tested, D4 (5 t organic fertilizer/ha) performed best in all three varieties, generating yield increases of 20%, 46% and 91% respectively.

关键词： Dry Bean Variety Chemical Fertilizer Organic Matter Biofertilizer

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Suicidal Ideation among Depressed People Living with HIV/AIDS in Nigeria, West Africa

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Open Journal of Medical Psychology 2014年第3期3卷 262-270页

作者： Rasaki O. Shittu Moradeyo K. Alabi louis O. Odeigah Musa A. Sanni Baba A. Issa Abdulganiyu T. Olanrewaju Abdullateef G. Sule Sunday A. Aderibigbe Department of Behavioural Sciences University of Ilorin Teaching Hospital Ilorin Nigeria Department of Epidemiology and Community Health University of Ilorin Teaching Hospital Ilorin Nigeria Department of Family Medicine Ahmadu Bello University Teaching Hospital Zaria Nigeria Department of Family Medicine Kwara State Specialist Hospital Ilorin Nigeria Department of Family Medicine University of Ilorin Teaching Hospital Ilorin Nigeria Department of Haematology Kwara State Specialist Hospital Ilorin Nigeria

Objective: Transient suicide thoughts are common to some people throughout the course of HIV disease and often do not indicate significant risk of suicide. However, persistent suicidal thoughts with associated feelings of hopelessness and intent to die are very serious and must be assessed promptly and carefully. The aim of this study, therefore, was to examine the relationship between depression, hopelessness, psychosocial stressors and suicidal ideation in PLWHAs. Methods: This was a hospital based, cross sectional, descriptive study, of one hundred and seventy depressed adult HIV/AIDS patients of Kwara State Specialist Hospital, Ilorin. Depression and suicidal assessment were evaluated using the PHQ-9 scale. A score of >9 or any affirmative response to question 9 of the PHQ-9 scale necessitated suicidal risk assessment. The social determinant questionnaire was used to evaluate social cohesion and negative life events. Results: The prevalence of depression among the HIV/AID patient was 56.7%. Twenty nine (17.1%) were hopeless, twenty eight (16.5%) had at one time or the other thought of taking their lives, six (3.5%) had plan to take their lives. There was strong statistical association between depression, hopelessness (p-value = 0.000) thought of taking life (p-value = 0.000) and plan to take their lives (p-value = 0.030). Conclusion: The significant correlations between hopelessness, depression and suicidal ideation are important markers that should alert clinicians to underlying suicide risk in HIV-positive patients. In addition, low social cohesion and stressful life events were found to be risk factors for depression and suicide. Clinicians should routinely enquire about suicidality in PLWHAs to assist early diagnosis and intervention.

关键词： Suicidal Ideation Depression HIV/AIDS Nigeria West Africa

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Profile of SARS-CoV-2 Infected Patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-louis, Senegal during the First Two Waves

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Advances in Infectious Diseases 2024年第2期14卷 322-337页

作者： Alassane Dièye Papa Latyr Junior Diouf Bourama Diémé Moustapha Diedhiou Diatou Dia-Gueye Amadou Diop Dia Samba Niang Ibrahima louis Martin Dieng Ameth Dieng Seynabou Lô Ndéye Méry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Emergency Department of Regional Hospital Center Saint-Louis Senegal Department of Infectious and Tropical Diseases of Fann Dakar Senegal

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. Objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-louis (Senegal) during the first two waves. Patients and Methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-louis (Senegal) with SARS-CoV-2 infection from March 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). Overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [OR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [OR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [OR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], SpO2 (ambient air) 95% [OR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [OR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [OR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [OR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [OR = 0.485;95% CI: 0.370 - 0.636;p = 0.0

关键词： SARS-CoV-2 Saint-louis Senegal

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COVID-19/Tuberculosis Co-Infection at the Epidemic Treatment Center (ETC) of Saint-louis (Senegal): About 9 Cases

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Advances in Infectious Diseases 2024年第1期14卷 56-66页

作者： Alassane Dièye Moustapha Diedhiou Papa Latyr Junior Diouf Mba Bambo Diakhaby Demba Makalou Samba Niang Diatou Dia-Gueye Amadou Diop Dia Ibrahima louis Martin Dieng Seynabou Lô Ndéye Méry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Department of Medicine Saint-Louis Regional Hospital Saint-Louis Senegal Infectious and Tropical Diseases Clinic of Fann Dakar Senegal

Introduction: COVID-19 is a global public health emergency that can cause acute respiratory distress syndrome. In countries where tuberculosis (TB) is endemic, coinfection of COVID-19 and TB is often encountered, which increases the risk of developing severe forms of COVID-19. Objectives: The aim of this study was to determine the prevalence of COVID-19/TB coinfection at the Epidemic treatment center (ETC) in Saint-louis (Senegal) and to describe the epidemiological, clinical, paraclinical, and outcome profile of co-infected patients. Patients and Methods: This is a retrospective, cross-sectional, descriptive cohort study based on the records of COVID-19/ TB co-infected patients who were hospitalized at the ETC in Saint-louis (Senegal) over an 18-month period from March 2020 to September 2021. Results: Out of a total of 454 hospitalizations, we collected records of 9 patients co-infected with COVID-19/TB, resulting in a prevalence of 2%. The study included patients with a median age of 34 years (range: 10-86 years), with a male predominance (7 cases) and a sex ratio of 3.5. The majority of patients (88.9%) had severe forms of COVID-19. Dyspnea and cough were reported in all patients (100%). Pulmonary TB was the most frequent localization, with 9 cases. The diagnosis of COVID-19 was confirmed by nasopharyngeal PCR in all patients (100%). Bacilloscopy was positive in 3 out of 5 cases. One patient tested positive for GeneXpert? MTB/RIF without rifampicin resistance. All patients were prescribed the hydroxychloroquine-azithromycin combination and anti-tuberculosis treatment. Out of the nine patients, four recovered (44.4%) and five died (55.5%). Conclusion: COVID-19/TB coinfection had a low prevalence in our cohort, but was associated with a high mortality due to the frequent occurrence of severe forms of the disease.

关键词： COVID-19 Tuberculosis Saint-louis Senegal

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