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Assessment of the efficacy of an advanced tertiary sewage treatment plant to remove biologically active chemicals using endocrine and genotoxicity bioassays

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Emerging Contaminants 2021年第1期7卷 124-131页

作者： Lisa A.Hamilton Fujio Shiraishi Daisuke Nakajima Michael Boake Richard P.Lim Olivier Champeau louis a.tremblay School of Life Sciences Faculty of ScienceUniversity of TechnologySydney(UTS)PO Box 123BroadwayNSW2007Australia National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki305-8506Japan Veolia Water Australia Level 4Bay Centre65 Pirrama RoadPyrmontNSW2009Australia Cawthron Institute Private Bag 2Nelson7042New Zealand School of Biological Sciences University of AucklandPrivate Bag 92019Auckland1142New Zealand

There has been much effort to assess the efficacy of sewage treatment plants to remove chemicals with estrogenic activity,but other modes of toxicity have received less *** study assessed the efficacy of advanced tertiary technologies to remove estrogen receptor(ER),aryl hydrocarbon receptor(AhR),retinoic receptor(RAR)agonists and genotoxicity using recombinant gene *** sewage contained ER,AhR and RAR agonists and was *** sludge treatment removed over 69%of the ER,AhR and RAR aqueous phase *** and biologically activated carbon processes removed genotoxicity and most receptor agonists to below detection *** activity was associated with the semi-polar fraction of the aqueous phase and non-polar phase of the influent(maximum 30%).AhR and RAR activities were found in both the aqueous and particulate phases of *** RAR activity was frequently found in the polar fraction of aqueous and particulate phases of the process *** the influent,the greatest RAR activity was found in the polar fraction of the aqueous phase(>65%).Genotoxic activity was detected in all influent fractions but rapidly *** results showed that ER,AhR and RAR agonists were greatly reduced by the advanced tertiary treatment processes.

关键词： Yeast two-hybrid Analytical chemistry Estrogens Aryl hydrocarbon receptor Retinoic receptor umu genotoxicity bioassay Australia

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The role of emerging organic contaminants in the development of antimicrobial resistance

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Emerging Contaminants 2021年第1期7卷 160-171页

作者： Izzie Alderton Barry R.Palmer Jack A.Heinemann Isabelle Pattis louise Weaver Maria J.Gutierrez-Gines Jacqui Horswell louis a.tremblay Institute of Environmental Science&Research(ESR) New Zealand School of Health Sciences Massey UniversityWellingtonNew Zealand School of Biological Sciences University of CanterburyChristchurchNew Zealand Cawthron Institute NelsonNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

Antimicrobial resistance(AMR)threatens human and ecological health *** major changes occur across the human,animal and environmental sectors,the problem will continue to *** important component of AMR that deserves greater attention is the influence of emerging organic contaminants(EOCs)e ubiquitous compounds found,amongst others,in pharmaceuticals,personal care products,food,industrial and agricultural products,plastics and building *** are widely used and can accumulate in the environment from varied sources,predominantly via waste *** can interact with microbial communities potentially leading to the emergence and spread of *** and pharmaceuticals have been demonstrated to promote AMR *** resistance is a multi-faceted problem that requires input from all sectors,with robust strategies and policies needed to make headway with solving the issues of this important threat.

关键词： Resistance transfer Mechanisms of resistance Antimicrobial pollutants Antibiotics Personal care products Pharmaceuticals

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