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Short-and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma:does left or right side matter?

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 154-162,I0001,I0002页

作者： lotte c.franken Pim B.Olthof Joris I.Erdmann Otto M.van Delden Joanne Verheij Marc G.Besselink Olivier R.Busch Thomas M.van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of Surgery Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Department of Pathology Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background:The only potentially curative option for patients with perihilar cholangiocarcinoma(PHc)is resection,typically an extrahepatic bile duct resection in combination with(extended)liver *** such as bile leakage and liver failure have been suggested to be more common after right-sided resections compared to left-sided resections,whilst superior oncological outcomes have been reported after right-sided ***,data on outcomes after right-sided or left-sided liver resections in PHc are ***,we aimed to investigate short-and long-term outcomes after left and right hemihepatectomy in patients with ***:In this retrospective study,patients undergoing major liver resection for suspected PHc in a tertiary center between 2000-2018 were *** who had undergone left-sided resections were compared to patients with right-sided resections in terms of complications(90-day mortality,overall and severe morbidity and specific complications).For long-term outcomes,only patients with pathologically proven PHc were included in the survival ***:A total of 178 patients undergoing hemihepatectomy for suspected PHc were analysed,including 76 left-sided and 102 right-sided *** 90-day mortality was 14%(24 out of 178),with no significant difference after left-sided resection(11%;8 out of 76)versus right-sided resection(16%;16 out of 102)(P=0.319).Severe morbidity(clavein Dindo≥3)was also comparable in both groups:54%versus 61%(P=0.361).No differences in specific complications including bile leakage were observed,although liver failure appeared to occur more frequently after right hemihepatectomy(22%versus 11%,P=0.052).Five-year overall survival for pathologically proven PHc,excluding in-hospital mortality,did not differ;43.7%after left-sided resection *** 38.2%after right-sided resection(P=0.553).conclusions:Both short-and long-term outcomes between patients undergoing left and right hemihepate

关键词： Perihilar cholangiocarcinoma(PHc) hepatectomy outcomes mortality survival

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Occurrence of seeding metastases in resectable perihilar cholangiocarcinoma and the role of low-dose radiotherapy to prevent this

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World Journal of Hepatology 2020年第11期12卷 1089-1097页

作者： lotte c franken Eva Roos Job Saris Jeanin E van Hooft Otto M van Delden Joanne Verheij Joris I Erdmann Marc G Besselink Olivier R Busch Geertjan van Tienhoven Thomas M van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Pathology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Gastroenterology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Interventional Radiology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiation Oncology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands

BAcKGROUND Preoperative biliary drainage in patients with presumed resectable perihilar cholangiocarcinoma(PHc)is hypothesized to promote the occurrence of seeding *** metastases can occur at the surgical scars or at the site of postoperative drains,and in case of percutaneous biliary drainage,at the catheter *** prevent seeding metastases after resection,we routinely treated PHc patients with preoperative radiotherapy(RT)for over 25 years until January *** To investigate the incidence of seeding metastases following resection of *** All patients who underwent resection for pathology proven PHc between January 2000 and March 2019 were included in this retrospective *** 2000-January 2018,patients received preoperative RT(3×3.5 Gray).RT was omitted in patients treated after January *** A total of 171 patients underwent resection for PHc between January 2000 and March *** 171 patients undergoing resection,111 patients(65%)were treated with preoperative *** bile cytology showed no difference in the presence of viable tumor cells in bile of patients undergoing preoperative RT or ***,two patients(1.2%)with seeding metastases were identified,both in the laparotomy scar and both after preoperative RT(one patient with endoscopic and the other with percutaneous and endoscopic biliary drainage).cONcLUSION The incidence of seeding metastases in patients with resected PHc in our series was low(1.2%).This low incidence and the inability of providing evidence that preoperative low-dose RT prevents seeding metastases,has led us to discontinue preoperative RT in patients with resectable PHc in our center.

关键词： Perihilar cholangiocarcinoma Seeding metastases Preventive radiotherapy

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ScALABLE AND QUANTITATIVE DEcISION SUPPORT FOR THE INITIAL BUILDING DESIGN STAGES OF REFURBISHMENT

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Journal of Green Building 2019年第4期14卷 35-56页

作者： Sarah c.Andersen Kathrine L.Moller Simon W.Jorgensen lotte B.Jensen Morten Birkved Technical University of Denmark Department of Civil EngineeringBrovej2800Kgs.LyngbyDenmark Technical University of Denmark Department of Management EngineeringProduktionstorvet2800Kgs.LyngbyDenmark Danish Technological Institute Gregersensvej2630 TaastrupDenmark A4 arkitekter og ingeniører Gladsaxevej 1042860 SoborgDenmark Hovedstadens Beredskab Bag Radhuset 31550 Copenhagen VDenmark University of Southern Denmark Department of Chemical EngineeringBiotechnology and Environmental TechnologyCampusvej 555230 Odense-MDenmark

Decision-making within the building industry often involves various criteria of very different *** are qualitative,others quantitative,some are objective,others subjective,but ultimately,they should all be aggregated and handled holistically in order to support *** process can also be referred to as multi-criteria decision-making(McDM).Some aspects of McDM are often conducted unconsciously and *** implementing mathematical methods that have been proved applicable for McDM,multi-criteria decision-making processes can be handled more consciously and transparently and thus be made *** calculation method presented allows quantitative sustainability and qualitative indicator values to be accounted for with the level of importance *** McDM method used is Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS).As the model has already been described well in the scientific literature and is used frequently,the aim is to illustrate how TOPSIS can be applied for transparent decision-making within the building industry in the context of urban renewal and refurbishment schemes through case studies of various scales and *** case studies focused on in this paper incorporate a variety of specific pre-chosen criteria,including environmental performance,functional parameters and technical *** case studies cover different parameters of refurbishment in a major hospital compound in Denmark due to be taken out of *** central design decision is whether to refurbish or demolish the old hospital *** results reveal that decision support is first of all dependent on how the decision-making tool is applied and what choices are made in relation to the actual ***,by implementing a mathematically based McDM method like that being assessed in the case studies presented,the decisions and their argu-ments become transparent and are easily communicated withi

关键词： Multi-criteria Decision Making(McDM) mathematical decision support building design transparent decision making refurbishment urban renewal

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Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： Sofie Ingdam Halkjaer Bobby Lo Frederik cold Alice Hojer christensen Savanne Holster Julia Konig Robert Jan Brummer Olga c Aroniadis Perttu Lahtinen Tom Holvoet Lise lotte Gluud Andreas Munk Petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark copenhagen IBD center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions Research centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BAcKGROUND Irritable bowel syndrome(IBS)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched cochrane central,MEDLINE,EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials(RcTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBS symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(RR)and corresponding 95%cI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%cI for continuous *** cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight RcTs(484 participants)were included in the *** resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo(RR 1.19,95%cI:0.68-2.10).Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group(RR 1.17,95%cI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(RR 0.42,95%cI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBS patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%cI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis Systematic review

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Brazilian contribution to a better understanding of geriatric cardiology

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Journal of Geriatric cardiology 2012年第2期9卷 77-77页

作者： Jose c. Nicolau clatudia F. Gravina Roberto A. franken Aureliano coutinho 355-14 Andar S6o Paulo 01224-020 Brazil

Brazil is a South America country with a population of approximately 20 million people. It is the 5th biggest country in the world in territory extension, and its economy ranges between the 6th and 7th globally, according to different rankings （www. ***; access on May 19, 2012）. It is a very friendly country with a huge cultural, ethnic, regional and economic heterogeneity, and is a proud member of the BRIcS Group, along with Russia, India, china and South Africa.

关键词：心血管病巴西老年经济发展多样性俄罗斯

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抗氧化剂一、二级预防随机试验中的死亡率系统回顾及汇总分析

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美国医学会杂志（中文版） 2007年第5期26卷 278-291页

作者： Goran Bjelakovic Dimitrinka Nikolova Lise lotte Gluud Rose G. Simonetti christian Gluud 顾佳（译） The cochrane Hepato-Biliary Group Copenhagen Trial Unit Center for ClinicalIntervention Research Copenhagen University Hospital Rigshospitalet Copenhagen Denmark Department of Internal Medicine Gastroenterology and Hepatology University of Nis Nis Serbia Department of Internal Medicine and Divisione di Medicina Ospedale V. Cervello Palermo Italy

背景：抗氧化剂正用于多种疾病的预防。目的：评估补充抗氧化剂对一、二级预防随机临床试验参试者死亡率的影响。数据来源及试验选择：检索2005年10月前的电子数据库以及发表的文献目录。所有于成人中进行的、比较单独或联合使用β胡萝... 详细信息

背景：抗氧化剂正用于多种疾病的预防。目的：评估补充抗氧化剂对一、二级预防随机临床试验参试者死亡率的影响。数据来源及试验选择：检索2005年10月前的电子数据库以及发表的文献目录。所有于成人中进行的、比较单独或联合使用β胡萝卜素、维生素A、维生素c（抗坏血酸）、维生素E及硒剂的安慰剂或空白治疗对照随机试验均纳入分析。使用随机、盲法及随访作为评估入选试验偏倚的指标。采用随机效应分析法分析抗氧化剂对全因死亡率的影响，结果以相对危险度（relative risk，RR）及其95％可信区间（confidence interval，cI）表示。采用汇总回归评估试验协变量的影响。数据提取：共入选68项随即试验，包括232606例参试者（385篇文章）。数据整合：将所有低和高偏倚风险抗氧化剂试验汇总后发现，抗氧化剂对死亡率无显著影响（RR，1．02；95％cI，0．98～1．06）。多变量汇总回归分析表明，低偏倚风险试验（RR，1．16；95％cI，1．05～1．29）和硒剂（RR，0．998；95％cI，0．997～0．9995）与死亡率显著相关。在包括180938例参试者在内的47项低偏倚试验中，补充抗氧化剂显著增加死亡率（RR，1．05；95％cI，1．02～1．08）。排除硒剂试验后，在低偏倚风险试验中，β胡萝卜素（RR，1．07；95％cI，1．02～1，11）、维生素A（RR，1．16；95％cI，1．10～1．24）以及维生素E（RR，1．04；95％cI，1．01～1．07）单独或联合使用均显著增加死亡率。维生素c及硒剂对死亡率无显著影响。结论：β胡萝卜素、维生素A及维生素E治疗可能增加死亡率。维生素c和硒剂对死亡率的影响需要进一步研究。

关键词：全因死亡率随机试验抗氧化剂二级预防汇总分析系统回顾 β胡萝卜素维生素A

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Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.chapman Jonas A.Sellberg carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.c.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS cR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User cryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

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