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Development of otology specific outcome measure:Ear Outcome Survey-16 (EOS-16)

Journal of Otology 2021年第3期16卷 150-157页

作者： Juha T.Laakso Juha Silvola Timo Hirvonen Samuli Suutarla Ilkka Kivekas Riitta Saarinen lotta haavisto Jaakko Laitakari Antti A.Aarnisalo Aarno Dietz Jussi Jero Maija Hytonen Saku T.Sink Department of Otorhinolaryngology-Head and Neck Surgery Head and Neck CenterHelsinki University Hospital and University of HelsinkiHelsinkiFinland Department of Ear Noseand Throat-Division of SurgeryAkershus University HospitalLørenskogNorway Department of Otorhinolaryngology Kymenlaakso Central HospitalKotkaFinland Department of Otorhinolaryngology-Head and Neck Surgery Tampere University Hospital and Tampere UniversityTampereFinland Department of Otorhinolaryngology-Head and Neck Surgery Turku University Hospital and University of TurkuTurkuFinland Department of Otorhinolaryngology-Head and Neck Surgery Oulu University Hospital and PEDEGO Research UnitUniversity of Oulu and Medical Research Center OuluFinland Department of Otorhinolaryngology-Head and Neck Surgery Kuopio University Hospital and University of KuopioKuopioFinland

Purpose An important outcome measure of patient care is the impact on the patient’s health-related quality of life(HRQoL).Current ear-specific HRQoL instruments are designed for one diagnosis and emphasize different subdivisions such as symptoms,hearing problems,psychosocial impact,and the need for care.The optimal length of the recall period has not been studied.For these reasons,a new survey is needed that would cover most chronic ear diseases.Methods A preliminary 24-item survey(EOS-24)was created.Untreated adult patients(included n=186)with one of seven different chronic otologic conditions from all university hospitals in Finland were recruited to respond to EOS-24 and the 15D general HRQoL instrument.The recruiting otologists evaluated the severity of the disease and the disability caused by it.A control group was recruited.Based on the patients’responses in different diagnosis groups,the items were reduced according to pre-defined criteria.The resulting survey was validated using a thorough statistical analysis.Results The relevance and necessity of the original 24 items were thoroughly investigated,leading to the exclusion of 8 items and the modification of 1.The remaining 16 items were well-balanced between subdivisions and were useful in all seven diagnosis groups,thus constituting the final instrument,EOS-16.The most suitable recall period was three months.Conclusions EOS-16 has been created according to the HRQoL survey guidelines with a versatile nationwide patient population.The survey has been validated and can be used for a wide range of chronic ear diseases as a HRQoL instrument.

关键词： Otology Chronic ear diseases HRQoL Health-related quality of life PROM

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银行的净息差和利率期限结构变化

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新金融 2024年第6期 27-33+55页

作者： Christoph Memmel lotta Heckmann-Draisbach 德意志银行

编者按：了解利率变化对银行净息差和各利益相关方的影响至关重要。人们通常主要关注利率水平的变化，然而，利率期限结构的变化也是一大驱动因素，会对银行的利息业务产生重大影响。本文模拟了利率变化对银行净息差的影响，基于利率水... 详细信息

编者按：了解利率变化对银行净息差和各利益相关方的影响至关重要。人们通常主要关注利率水平的变化，然而，利率期限结构的变化也是一大驱动因素，会对银行的利息业务产生重大影响。本文模拟了利率变化对银行净息差的影响，基于利率水平变化和期限结构变化，研究的简化模型可以复制不同银行业务模式的典型特征，简化模型得出的结果与德国中小型银行的定量调查结果基本一致。该模型可以较好地描述银行的利息业务，解释银行净息差的动态变化。本刊摘编此篇德意志银行的工作论文，以飨读者。

关键词：银行净息差利率期限结构利率水平变化债券组合模型

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芬兰驻新德里大使馆翻新印度新德里

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世界建筑导报 2024年第2期39卷 96-99页

作者： Juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Simo Nuojua Harri Ahokas Anders Jönsson lotta Kindberg Mirja Sillanpää Sari Vesanen Tuomas Uusheimo(摄影) ALA建筑师事务所不详

皮耶蒂莱夫妇(Reima and Raili Pietilä)赢得了1963年的芬兰大使馆设计竞赛,该大使馆位于新德里查卡雅布里的外交飞地,参赛作品美而有力,名为“雪在山上说”。经过长时间的拖延,该项目于1980年被正式委托,并在原有概念的基础上重新进行... 详细信息

皮耶蒂莱夫妇(Reima and Raili Pietilä)赢得了1963年的芬兰大使馆设计竞赛,该大使馆位于新德里查卡雅布里的外交飞地,参赛作品美而有力,名为“雪在山上说”。经过长时间的拖延,该项目于1980年被正式委托,并在原有概念的基础上重新进行了设计。大使馆最终于1986年开放,1960年设计的巨大单体屋顶被分成六个独立建筑,围绕在一个中心花园周围。雕塑般的屋顶,这是大使馆最显著的建筑特征,类似于芬兰北部库萨莫附近的雪湖Kitkajärvi。

关键词：中心花园设计竞赛印度新德里芬兰

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库奥皮奥城市剧院芬兰库奥皮奥

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世界建筑导报 2024年第2期39卷 110-113页

作者： Juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Heikki Riitahuhta Toni Laurila Pekka Sivula Jyri Tartia Auvo Lindroos Harri Ahokas Petra Grisova Vladimir Ilic lotta Kindberg Santtu Hyvärinen Gerard Gutierrez Tuomas Uusheimo(摄影) ALA建筑师事务所不详

现在的库奥皮奥城市剧院是建筑师赫尔默•斯丹露丝和Risto-Veikko Luukkonen在20世纪60年代的现代主义建筑。扩建包括一个新的200座演播舞台,具有灵活的座位和舞台机械。新的空间还提供装载和物流、服装生产和存储,以及新舞台的支持功能... 详细信息

现在的库奥皮奥城市剧院是建筑师赫尔默•斯丹露丝和Risto-Veikko Luukkonen在20世纪60年代的现代主义建筑。扩建包括一个新的200座演播舞台,具有灵活的座位和舞台机械。新的空间还提供装载和物流、服装生产和存储,以及新舞台的支持功能。从市中心接近剧院时,唯一可见的变化是4米高的剧院塔楼。主舞台的舞台技术将全面更新,因此必须增加当前塔楼的高度。附加组件可形成一个发光的玻璃灯箱,使旧塔的独特形状易于辨认。

关键词：现代主义建筑主舞台舞台机械服装生产塔楼剧院

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High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids

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World Journal of Gastroenterology 2012年第9期18卷 923-929页

作者： lotta K Stenman Reetta Holma Riitta Korpela Institute of Biomedicine PharmacologyUniversity of Helsinki

AIM:To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism.METHODS:Male C57Bl/6J mice were fed on a high-fat (n=26) or low-fat diet (n=24) for 15 wk.Intestinal permeability was measured from duodenum,jejunum,ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator.Fecal bile acids were analyzed with gas chromatography.Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor (FXR) and tumor necrosis factor (TNF).RESULTS:Intestinal permeability was significantly increased by high-fat feeding in jejunum (median 0.334 for control vs 0.393 for high-fat,P=0.03) and colon (0.335 for control vs 0.433 for high-fat,P=0.01),but not in duodenum or ileum.The concentration of nearly all identified bile acids was significantly increased by high-fat feeding (P<0.001).The proportion of ursodeoxycholic acid (UDCA) in all bile acids was decreased (1.4%±0.1% in high-fat vs 2.8%±0.3% in controls,P<0.01) and correlated inversely with intestinal permeability (r=-0.72,P=0.01).High-fat feeding also increased jejunal FXR expression,as well as TNF expression along the intestine,especially in the colon.CONCLUSION:High-fat-feeding increased intestinal permeability,perhaps by a mechanism related to bile acid metabolism,namely a decreased proportion of fecal UDCA and increased FXR expression.

关键词：通透性高脂肪胆汁酸功能障碍肠道粪便 Altera 气相色谱分析

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Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification

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World Journal of Gastroenterology 2009年第47期15卷 5936-5945页

作者： Anna Lyra Teemu Rinttil Janne Nikkil lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva Department of Basic Veterinary Sciences Faculty of Veterinary Medicine University of HelsinkiHelsinki 00014Finland Alimetrics Ltd. EspooEspoo 02920Finland Valio Ltd. Research CentreHelsinki 00370 Finland Institute of Biomedicine Faculty of Medicine University of HelsinkiHelsinki 00014Finland VTT Biotechnology VTTEspoo 02044Finland The Finnish Red Cross Blood ServiceHelsinki 00310Finland Institute of Clinical Medicine University of HelsinkiHelsinki 00014Finland

AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-

关键词： rRNA基因肠道微生物主成分分析细菌种类核糖体RNA 基因序列分析综合征 IBS

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Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome

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World Journal of Gastroenterology 2010年第36期16卷 4532-4540页

作者： Erja Malinen lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright Department of Veterinary Biosciences Faculty of Veterinary MedicineUniversity of Helsinki00014 HelsinkiFinland Danisco Sweeteners Health and Nutrition02460 KantvikFinland Department of Clinical Nutrition Institute of Public Health and Clinical NutritionFaculty of Health SciencesUniversity of Eastern Finland70211 KuopioFinland Alimetrics Ltd. Koskelontie 19 B02920 EspooFinland Kuopio Harjula Hospital 70101 KuopioFinland Department of Biosciences University of Eastern Finland70211 KuopioFinland

AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition.

关键词： Irritable bowel syndrome Self-reported symptoms Gastrointestinal microbiota Quantitative realtime polymerase chain reaction

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Schottky barrier-based silicon nanowire pH sensor with live sensitivity control

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Nano Research 2014年第2期7卷 263-271页

作者： Felix M. Zorgiebel Sebastian Pregl lotta Romhildtt Jorg Opitz W. Weber T. Mikolajick Larysa Baraban Gianaurelio Cuniberti Institute for Materials Science and Max Bergmann Center ofBiomaterials TU Dresden 01062 Dresden Germany NaMLab GmbH 01187 Dresden Germany Fraunhofer Institute IZFP Dresden 01109 Dresden Germany Institute for Semiconductors and Microsystems Technology TU Dresden 01187 Dresden Germany Dresden Germany Center forAdvancing Electronics Dresden TU Dresden 01062 Dresden Germany

We demonstrate a pH sensor based on ultrasensitive nanosize Schottky junctions formed within bottom-up grown dopant-free arrays of assembled silicon nanowires. A new measurement concept relying on a continuous gate sweep is presented, which allows the straightforward determination of the point of maximum sensitivity of the device and allows sensing experiments to be performed in the optimum regime. Integration of devices into a portable fluidic system and an electrode isolation strategy affords a stable environment and enables long time robust FET sensing measurements in a liquid environment to be carried out. Investigations of the physical and chemical sensitivity of our devices at different pH values and a comparison with theoretical limits are also discussed. We believe that such a combination of nanofabrication and engineering advances make this Schottky barrier-powered silicon nanowire lab-on-a-chip platform suitable for efficient biodetection and even for more complex biochemical analysis.

关键词：硅纳米线阵列 pH传感器肖特基势垒基础感光度一体化设备控制生物检测

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Optoelectronic switching of nanowire-based hybrid organic/oxide/semiconductor field-effect transistors

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Nano Research 2015年第4期8卷 1229-1240页

作者： Eunhye Baek Sebastian Pregl Mehrdad Shaygan lotta Romhildt Walter M. Weber Thomas Mikolajick DmitryA. Ryndyk Larysa Baraban Gianaurelio Cuniberti Institute for Materials Science and Max Bergmann Center of Biomaterials TU Dresden 01062 Dresden Germany Center for Advancing Electronics Dresden TU Dresden 01062 Dresden Germany Division of IT Convergence Engineering Pohang University of Science and Technology Pohang Korea NaMLab GmbH Nothnitzer Strasse 64 01187 Dresden Germany Dresden Center for Computational Materials Science TU Dresden 01062 Dresden Germany

由组成的新奇感光性的混合地效果晶体管联邦货物税一器官的卟啉电影 / 氧化物 / 硅 nanowires 多重壳被介绍。由于在 nanowires 附近的氧化物壳，在混合 nanodevices 的水流的 photoswitching 被电场效果指导，在器官的电影以内由费用... 详细信息

由组成的新奇感光性的混合地效果晶体管联邦货物税一器官的卟啉电影 / 氧化物 / 硅 nanowires 多重壳被介绍。由于在 nanowires 附近的氧化物壳，在混合 nanodevices 的水流的 photoswitching 被电场效果指导，在器官的电影以内由费用再分配导致了。这个原则是 photoinduced 电子注射的一种选择，为依靠在器官的分子和金属或半导体之间的直接连接的设备有效。在紫轻照明之上的混合 nanodevices 的切换的动力学被调查，包 nanowires 的卟啉电影的厚度上的强壮的依赖被发现。而且，器官的电影的厚度被发现为 nanowire 联邦货物税的切换的效率也是一个关键参数，开在轻照明下面由电流的比率代表了在上并且处于黑暗条件。我们建议卟啉电影收费解释 nanowire 联邦货物税的 optoelectronic 行为由器官的电影 / 氧化物 / 半导体连接调停了的一个简单模型。

关键词：半导体场效应晶体管硅纳米线光电开关氧化物有机薄膜杂化纳米器件 FET

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Use of Multivariate Statistics in Order to Understand the Flow of Acid Rock Drainage from an Abandoned Mining Site

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Journal of Environmental Protection 2016年第3期7卷 358-371页

作者： Mattias Bäckström lotta Sartz Man-Technology-Environment Research Centre Orebro University Orebro Sweden Bergskraft Bergslagen AB Kumla Sweden

Pathways for acid rock drainage from an abandoned mining site (sulphidic ore) were investigated by analysing ground, seepage and surface waters. It was found that in affected ground and seepage waters pH was lower (average pH 5.0);sulphate higher (average 350 mg/L) and trace element concentrations were significantly increased (4330 μg/L copper and 7700 μg/L zinc) compared to surrounding waters. Multivariate statistics (principal component analysis) were used on the data set. Obtained loading plot showed a clear negative correlation between pH and parameters found at high concentrations, indicating that these parameters are found at the source term (acid rock drainage). Lead was also found in close proximity to iron and turbidity indicating that lead might be associated with particles. The score plot presented almost all samples from high concentrations to low concentrations along the first principal component (explaining 63% of the variation in the data set) indicating that dilution was an important mechanism for the decrease in concentrations as opposed to immobilisation on surfaces along the flowpath. Decrease in fluoride and sulphate along one of the suspected flowpath coincided with an increase in calcium. Through geochemical calculations it was concluded that calcite (CaCO3) dissolved along the flowpath and thus induced precipitation of gypsum (CaSO4) and fluorite (CaF2). Through a combination of PCA and geochemical calculations the most likely flowpaths for contaminated water from the abandoned mining site were presented, making it possible to prevent further negative effects on the surface water.

关键词： PCA PHREEQC Metals ARD Flowpath

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