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Perspective on novel proteins encoded by circular RNAs in glioblastoma

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Cancer Biology & Medicine 2022年第3期19卷 278-283页

作者： Xixi Li Xinya Gao nu Zhang Department of Neurosurgery Sun Yat-sen UniversityThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Circular RNAs(circRNAs)are generated by the non-canonical back-splicing of pre-mRNA and have been shown to be present in a wide variety of tissues at lower expression levels than their associated linear *** advent of high-throughput sequencing technologies has enabled the identification of circRNAs with biological functions in diseases,particularly *** their stable circular structures resist digestion by RNase R,circRNAs accumulate in the brain with aging in a conservative form wherein neurons seldom undergo mitosis;some of these RNAs have been reported to serve as prognostic biomarkers for central nervous system(CNS)disease2.

关键词： circular diseases conservative

effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine: An in silico pharmacological model

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Asian Pacific Journal of Tropical Medicine 2020年第8期13卷 366-374页

作者： Mila nu nu Htay Ian M Hastings eva Maria Hodel Katherine Kay Liverpool School of Tropical Medicine Liverpool L35QAUnited Kingdom Department of Community Medicine Melaka-Manipal Medical CollegeManipal Academy of Higher Education(MAHE)MelakaMalaysia Malawi-Liverpool-Wellcome Trust Clinical Research Programme BlantyreMalawi University of Liverpool Liverpool L693GFUnited Kingdom Metrum Research Group TariffvilleConnecticut06081United States of America

Objective:To explore the efficacy of intermittent preventive treatment in pregnancy(IPTp)with sulfadoxine and pyrimethamine(SP)against sensitive ***:A pharmacological model was used to investigate the effectiveness of the previous recommended at least two-dose regimen,currently recommended three-dose regimen and 4,6,8-weekly regimens with specific focus on the impact of various nonadherence patterns in multiple transmission ***:The effectiveness of the recommended three-dose regimen is high in all the transmission intensities,i.e.>99%,98%and 92%in low,moderate and high transmission intensities *** simulated 4 and 6 weekly IPTp-SP regimens were able to prevent new infections with sensitive parasites in almost all women(>99%)regardless of transmission ***,8 weekly interval dose schedules were found to have 71%and 86%protective efficacies in high and moderate transmission areas,*** highlights that patients are particularly vulnerable to acquiring new infections if IPTp-SP doses are ***:The pharmacological model predicts that full adherence to the currently recommended three-dose regimen should provide almost complete protection from malaria infection in moderate and high transmission ***,it also highlights that patients are particularly vulnerable to acquiring new infections if IPTp doses are spaced too widely or if doses are *** to the recommended IPTp-SP schedules is recommended.

关键词： Intermittent preventive treatment in pregnancy Sulfadoxine-pyrimethamine Malaria infection in pregnancy Three-dose regimen In silico pharmacological model

Degradation and fate of 2,4-dinitroanisole(DNAN)and its intermediates treated with Mg/Cu bimetal:Surface examination with XAS,DFT,and LDI-MS

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Journal of environmental Sciences 2023年第7期129卷 161-173页

作者： Andrew Mai emese Hadnagy Qiantao Shi lotanna e.e.nu Jason P.Robbins Simon G.Podkolzin Agamemnon Koutsospyros Christos Christodoulatos Center for environmental Systems Stevens Institute of TechnologyHobokenNJ 07030USA School of engineering and Technology University of Washington TacomaTacomaWA 98402USA

A novel Mg-based bimetal reagent(Mg/Cu)was used as an enhanced reductive system to degrade insensitivemunition 2,4-dinitroanisole(DNAN),a contaminant found in *** ofDNANwas significantly impacted by dissolved oxygen and studied in anoxic and oxic bimetal systems(i.e.,purging with N2,air,or O_(2) gas).Degradation occurred through sequential nitroreduction:first one nitro group was reduced(ortho or para)to form short-lived intermediates 2-amino-4-nitroanisole or 4-amino-2-nitroanisole(2-ANAN or 4-ANAN),and then subsequent reduction of the other nitro group formed 2,4-diaminoanisole(DAAN).The nitro-amino intermediates demonstrated regioselective reduction in the ortho position to 2-ANAN;Regioselectivity was also impacted by the anoxic/oxic *** O_(2)-purging DNAN degradation rate was slightly enhanced,but most notably O_(2) significantly accelerated DAAN *** also further degraded only in the oxygenated Mg/Cu *** of DNAN byproducts to the reagent occurred regardless of anoxic/oxic condition,resulting in a partition of carbon mass between the adsorbed phase(27%-35%)and dissolved phase(59%-72%).Additional surface techniqueswere applied to investigate contaminant interaction with *** functional theory(DFT)calculations identified preferential adsorption structures for DNAN on Cu with binding through two O atoms of one or both nitro groups.X-ray absorption spectroscopy(XAS)measurements determined the oxidation state of catalyticmetal Cu and formation of a Cu-O-N bond during *** desorption ionization mass spectrometry(LDI-MS)measurements also identified intermediate 2-ANAN adsorbed to the bimetal surface.

关键词： Insensitive munition Magnesium bimetal Reductive degradation Adsorption Surface analysis DFT DNAN Oxic

A pharmacologist's journey in medical education:a personal history

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Acta Pharmacologica Sinica 2004年第9期25卷 102-106页

作者： e e DANIeL AB T6G 2H7 Canada Department of Pharmacology Room 9-10 edmonton MSB University of Alberta

My journey as an educator in Pharmacology began in 1949, when, after finishing my MA in Biology at Johns Hopkins, Ⅰ decided that Ⅰ wanted to be involved in science with more relevance to humans. Ⅰhad been chasing f... 详细信息

关键词： ACe A pharmacologist’s journey in medical education

Validation of CFD-DeM model for iron ore reduction at particle level and parametric study

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Particuology 2020年第4期18卷 163-172页

作者： Dianyu e International Research Institute for Minerals Metallurgy and MaterialsJiangxi University of Science and TechnologyNanchang 330013China Department of Chemical engineering Monash UniversityClaytonVIC 3800Australia

Iron ore reduction is a primary unit operation in current metallurgy processes and dominates the energy consumption and greenhouse gas(GHG)emissions of the iron-making process,Therefore,even a slight improvement of the energy efficiency or GHG emissions of iron ore reduction would yield considerable benefits to the cost of pig iron and,more importantly,to mitigation of the associated carbon *** current study presents a discrete model that describes the iron ore reduction process for a single *** transient reaction progress can be predicted and is validated against experimental measurements under various operating conditions,including different reducing gases and *** effects of pressure,isothermality,gas composition,and flow rate on reduction are *** reduction rate increases significantly with increasing pressure until 5 atm,and the entire reduction process occurs more slowly under non-isothermal conditions than under isothermal *** work provides a solid foundation for the development of a comprehensive particulate system model that considers both heat and mass transfer.

关键词： Iron ore reduction Chemical reaction Blast furnace Discrete element method Computational fluid dynamics

Circular RNAs and human glioma

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Cancer Biology & Medicine 2019年第1期16卷 11-23页

作者： Jinglei Liu Kun Zhao nunu Huang nu Zhang Department of Neurosurgery The First Affiliated Hospital of Sun Yat-sen University Guangdong Provincial Key Laboratory of Brain Function and Disease

As a newly discovered type of RNA, circular RNAs(circRNAs) are widespread throughout the eukaryotic genome. The expression of circRNAs is regulated by both cis-elements and trans-factors, and the expression pattern of circRNAs is cell type-and diseasespecific. Similar to other types of non-coding RNAs, functions of circRNAs are also versatile. CircRNAs have been reported previously to function as microRNA(miRNA) sponges, protein sponges, coding RNAs or scaffolds for protein ***, several circRNAs have been reported to play important roles in human malignancies, including glioma. Here, we reviewed several reports related to circRNAs and glioma, as well as the potential diagnostic and therapeutic applications of circRNAs in brain cancer. In general, some circRNAs, such as circSMARCA5 and circCFH, are found to be expressed in a gliomaspecific pattern, these circRNAs may be used as tumor biomarkers. In addition, some circRNAs have been found to play oncogenic roles in glioma(e.g., circNFIX and circNT5e), whereas others have been reported to function as tumor suppressors(e.g.,circFBXW7 and circSHPRH). Furthermore, circRNA is a good tool for protein expression because of its higher stability compared to linear RNAs. Thus, circRNAs may also be an ideal choice for gene/protein delivery in future brain cancer therapies. There are some challenges in circRNA research in glioma and other diseases. Research related to circRNAs in glioma is comparatively new and many mysteries remain to be solved.

关键词： Circular RNA glioma miRNA sponge translation protein scaffold miRNA target

Thermal conductivity of systems with a gap in the phonon spectrum

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Chinese Physics B 2018年第7期27卷 424-430页

作者： e Salamatov Udmurt Federal Research Center Ural Branch of the Russian Academy of Sciences

An original theoretical model for describing the low-temperature thermal conductivity in systems with a region of forbidden values （a gap） in the phonon spectrum is proposed. The model is based on new experimental results on the temperature dependence of the phonon diffusion coefficient in nanoceramics and dielectric glasses which showed a similar anomalous behavior of the diffusion coefficient in these systems that may be described under the assumption of a gap in the phonon spectrum. In this paper, the role of the gap in low-temperature behavior of the thermal conductivity, ~＇（T）, is analyzed. The plateau in the temperature dependence of the thermal conductivity is shown to correlate with the position and the width of the gap. The temperature dependence of thermal conductivity of such systems when changing the scat- tering parameters related to various mechanisms is studied. It is found that the umklapp process （U-processes） involving low-frequency short-wavelength phonons below the gap forms the behavior of the temperature dependence of thermal con- ductivity in the plateau region. A comparison of the calculated and experimental results shows considerable possibilities of the model in describing the low-temperature thermal conductivity in glass-like systems.

关键词： phononic band gap phonon diffusion coefficient thermal conductivity glassy crystals

Long term survival of patients with raised pulmonary arterial systolic pressure utilizing echocardiography—a five-year prospective study

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Journal of Geriatric Cardiology 2012年第4期9卷 328-335页

作者： Maw Pin Tan Sushil K Bansal nu nu Wynn Murad Umerov Angela Gillham Alison Henderson Anthony Hildreth Shahid Junejo Department of Medicine Faculty of Medicine University of Malaya 50603 Kuala Lumpur Malaysia Department of Care of the elderly Sunderland Royal Hospital Kayll Road SR47TP United Kingdom Department of Cardiology Sunderland Royal Hospital Kayll Road SR4 7TP United Kingdom Centre for Collaborative Gerontology Northumbria University Ellison Place Newcastle upon Tyne NE1 8ST United Kingdom

Ba ckground Pulmonary arterial systolic pressure (PASP) can be estimated with transthoracic echocardiography. However, the significance of raised PASP on routine echocardiography is uncertain. In this study, we evaluated the mortality and hospitalization rates of subjects with raised PASP in a cohort of patients referred directly by their general practitioners for routine outpatient (open access) echocardiography for further analysis of suspected heart failure. Results A total of 485 subjects were referred for open access echocardiography at our hospital in 2002. A cohort of 209/485 (43%) consecutive subjects with measurable tricuspid regurgitation were followed for a minimum of five years investigating hospitalization rates and survival. Some 62 of 209 (30%) subjects had pulmonary hypertension (PH). Subjects with PH were significantly more likely to have four or more hospital admissions (22% vs. 8%; P 30 days of cumulative hospital stay over five years (29% vs. 13%; P ed with mortality (P = 0.003), while moderate to severe PHwas an independent predictor of mortality (hazard ratio: 4.31; 95% confidence interval (95% CI): 1.51–12.30). Records from the Office of National Statistics revealed that subjects with PH were more likely to have chronic lung diseases recorded as immediate or contributory causes of death (50% vs. 14%; P e echocardiography is associated with recurrent hospital admissions, prolonged hospitalizations and increased cause of mortality. Therefore, the diagnosis of PHon echocardiography deserves further clinical evaluation, with future studies designed at defining a suitable diagnostic strategy.

关键词： Chronic lung disease Dyspnoea Heart failure Pulmonary hypertension Transthoracic echocardiography

Magnetophotothermal interaction in a rotating solid cylinder of semiconductor silicone material with time dependent heat flow

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Applied Mathematics and Mechanics(english edition) 2021年第1期42卷 39-52页

作者： A.e.ABOUeLReGAL Department of Mathematics College of Science and ArtsJouf UniversityAl-Qurayyat 77423Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura 35516Egypt

A mathematical model linking thermoelasticity to photothermal experiments is proposed with the consideration of the photothermal *** system equations for coupled plasma,heat conduction with phase-lags(PLs),and motion equations are introduced and solved by using the Laplace transform *** photothermal,thermal,and elastic waves in a rotating solid cylinder of semiconductor material are analyzed with the proposed *** cylinder surface is constrained and subjected to a time-dependent pulse heat *** sensitivity of the physical fields for the angular velocity,PLs,and thermal vibration parameters is *** addition,the effects of the effective parameters on the physical quantities are graphically illustrated and discussed in detail.

关键词： photothermal phase-lag(PL) solid cylinder rotation semiconductor carrier concentration