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Lipoflavonoid Benefits in Patients with Tinnitus

International Journal of Otolaryngology and Head & Neck Surgery 2021年第3期10卷 147-157页

作者： lori E. Lonczak lori Lonczak Consulting LLC Fair Haven USA

Background: Otolaryngologists are regularly presented with patients experiencing tinnitus who are seeking treatment to help with resuming active and productive lives. Lemon bioflavonoid complexes are known to be safe nutritional supplements;however, data on patient satisfaction are limited. Objectives: The primary objectives were to better understand symptom severity reduction, symptom improvement, and patient satisfaction when lemon bioflavonoid complexes are taken at the recommended dose and duration of treatment. Methods: The SILENT experience study was conducted from January 2017 to January 2018, with 504 otolaryngologists from six states, identified from a purchased list. Each physician provided a free, 500-caplet sample of Lipo-Flavonoid®, a lemon bioflavonoid complex, to three patients who experienced tinnitus and completed a survey detailing patient demographics and symptoms. In total, 719 patients received the sample;51 patients followed through and completed a baseline symptom assessment and five surveys over 10 weeks. IRB approval was deemed unnecessary and the study was overseen by a practicing otolaryngologist. Statistical analysis was conducted on the reduction of symptom severity and symptom improvement over 10-weeks. Results: Bothersomeness of ringing or other noises in the ear(s) was reduced by 32% and patients reported a 55% improvement of all symptoms, which correlated with product satisfaction. Patient satisfaction scores were strong: 33% extremely satisfied, 49% somewhat satisfied, and 18% not satisfied. Compliance was high, with 86% of participants taking the product as directed for 60 days. The top reasons for physician recommendations (selected by >30%) were positive clinical experience (71%), good safety profile (66%), supported by data for over 50 years (37%), and efficacy (35%). Implications for Practice: These data support the use of this lemon

关键词： Lipoflavonoid Bioflavonoid Tinnitus Ringing

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Male Tibetan macaques' (Macaca thibetana) choice of infant bridging partners

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Zoological Research 2014年第3期35卷 222-230页

作者： Briana BAUER lori K. SHEERAN Megan D. MATHESON Jin-Hua LI R. Steven WAGNER Primate Behavior and Ecology Program Central Washington University Department of Anthropology Central Washington University Department of Psychology Central Washington University School of Resources and Environment Anhui University School of Life Sciences Anhui Normal University Department of Biological Sciences Central Washington University

Adult male Tibetan(Macaca thibetana), Barbary(M. sylvanus), and stump-tailed macaques(M. arctoides) engage in bridging, a ritualized infant-handling behavior. Previous researchers found a bias toward the use of male infants for this behavior, but its function is debated. Explanations include three hypotheses: paternal care, mating effort, and agonistic buffering. We studied a group of habituated, provisioned Tibetan macaques to test whether adult males' affiliative relationships with females predicted their use of an infant for bridging. We also examined biases for sex, age, and individual in males' choice of bridging infant. We collected data via all occurrences, focal animal, and scan methods, from August to September 2011 at the Valley of the Wild Monkeys, China. We found that male infants were significantly preferred over females for bridging, but of three male infants in the group, only one was used by all males, while one male infant was used less often than expected. Adult males had females they were significantly more likely to be proximate to and/or to groom, but these corresponded to the mother of the bridging infant for only one male. Our results are most consistent with the agonistic buffering hypothesis: lower-ranked males used the alpha male's preferred bridging infant in an attempt to regulate their interactions with the alpha.

关键词： Agonistic buffering Affiliated infant Paternal care

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FAIR Data and Metadata:GNSS Precise Positioning User Perspective

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Data Intelligence 2023年第1期5卷 43-74页

作者： Ivana Ivánová Ryan Keenan Christopher Marshall lori Mancell Eldar Rubinov Ryan Ruddick Nicholas Brown Graeme Kernich Spatial Sciences School of Earth and Planetary ScienceCurtin UniversityPerthWestern Australia6102Australia Positioning Insights Carlton NorthVictoria3054Australia FrontierSI Cnr Village St and Fishplate LnDocklandsVictoria3008Australia Geoscience Australia Cnr Jerrabomberra Ave and Hindmarsh DriveSymonstonAustralian Capital Territory2609Australia

The FAIR principles of Wilkinson et al.[1]are finding their way from research into application domains,one of which is the precise positioning with global satellite navigation systems(GNSS).Current GNSS users demand that data and services are findable online,accessible via open protocols(by both,machines and humans),interoperable with their legacy systems and reusable in various *** metadata are essential in seamless communication between GNSS data and service providers and their users,and,for decades,geodetic and geospatial standards are efficiently implemented to support ***,GNSS user community is transforming from precise positioning by highly specialised use by geodetic professionals to every-day precise positioning by autonomous vehicles or wellness obsessed ***,rapid technological developments allow alternative ways of offering data and services to their *** transforming circumstances warrant a review whether metadata defined in generic geospatial and geodetic standards in use still support FAIR use of modern GNSS data and services across its novel user *** paper reports the results of current GNSS users'requirements in various application sectors on the way data,metadata and services are *** engaged with GNSS stakeholders to validate our findings and to gain understanding on their perception of the FAIR *** results confirm that offering FAIR GNSS data and services is fundamental,but for a confident use of these,there is a need to review the way metadata are offered to the *** standard compliant GNSS community metadata profile and providing relevant metadata with data on-demand,the approach outlined in this paper,is a way to manage current GNSS users'expectations and the way to improve FAIR GNSS data and service delivery for both humans and the machines.

关键词： FAIR Metadata Standards Profile Precise positioning GNSS users Spatial data infrastructure

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CD4^+ T cell-mediated presentation of non-infectious HIV-1 virion antigens to HIV-specific CD8^+ T cells

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Chinese Medical Journal 2006年第19期119卷 1629-1638页

作者： XU Jian-qing Franco lori Julianna Lisziewicz State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Research Institute for Genetic and Human Therapy Washington DC 20007 USA

Background The mechanism of chronic immune activation and impairment of HIV-specific immune responses during chronic infection is not fully understood. However, it is known that high immune activation leads to more rapid progression to AIDS. We hypothesize that CD4^＋ T cell-mediated viral antigen presentation contributes to this pathologic immune activation in HIV-infected individuals. Methods HIV-specific T cells, responding to noninfectious HIV-1 virions as antigen, were measured by flow cytometric assays. These experimental conditions reflect the in vivo condition where noninfectious HIV-1 represents more than 99% of the antigens. Results CD4^＋ T cells purified from HIV-infected individuals were capable of cross presenting exogenous noninfectious HIV-1 virions to HIV-1-specific CD8^＋ T cells. Cross presentation required the entry of HIV-1 to CD4^＋ T cells and antigen translocation from endoplasmic reticulum to the Golgi complex. Blocking CD4^＋ mediated activation of HIV-specific CD8^＋ T cells and redirecting the viral antigens to antigen presenting cells improved HIV-specific T cell responses. Contusions One possible cause of chronic immune activation and impairment of HIV-1 specific T cell responses is represented by HIV-1 harboring CD4^＋ T cells cross presenting HIV-1 antigen to activate CD8^＋ T cells. This new mechanism provides the first evidence that cross presentation of noninfectious HIV-1 virions play a role in the immunopathogenesis of HIV-1 infection.

关键词： HIV antigen presenting CD4^+ T cell CD8+ T cell immune pathogenesis

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Cotton stomatal closure under varying temperature and vapor pressure deficit,correlation with the hydraulic conductance trait

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Journal of Cotton Research 2022年第3期5卷 217-227页

作者： WEDEGAERTNER Kurt SHEKOOFA Avat PURDOM Sam WALTERS Kellie DUNCAN lori RAPER Tyson B Department of Plant Sciences University of Tennessee2505 E.J.Chapman Dr.KnoxvilleTN 37996USA Department of Biosystems Engineering and Soil Science University of Tennessee2506 EJ Chapman DriveKnoxvilleTN 37996USA.

Background:Cotton(Gossypium hirsutum L.)is often grown in locations characterized by high atmospheric evaporative *** has been hypothesized that plants which resist hydraulic flow under this condition will limit water use and conserve soil ***,in a series of controlled environment experiments ten cotton cultivars were exposed to two different temperature and vapor pressure deficit(VPD)conditions(i.e.,38℃,>3 kPa and 32℃,1∼1.5 kPa)as well as a progressive soil ***,individual differences in shoot hydraulic conductance(K_(shoot))was measured using a hydraulic conductance flow meter(HCFM).Physiological parameters were reported included leaf area,dry leaf weight,stomatal conductance(g_(s)),and water use efficiency coefficient(WUE_(k)).Results:Differences were observed in K_(shoot) among cultivars under the 38℃,>3 kPa but not the 32℃,1∼1.5 kPa *** the 38℃,>3 kPa environment,correlations were found between K_(shoot),stomatal conductance(gs),VPD breakpoint,WUEk,total leaf area,dry leaf weight,fraction transpirable soil water(FTSW)threshold,and slope of TR decline after FTSW ***:Results show that the ability of some cotton cultivars to restrict water loss under high evaporative demand through early stomatal closure is associated with the cultivars’K_(shoot).The K_(shoot) is influential in the limitation of TR trait under high temperature and VPD.

关键词： Cotton FTSW threshold Shoot hydraulic conductance Temperature Transpiration rate VPD

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The Story of Holiday Told by an American Girl

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英语沙龙（高中） 2004年第12期 26-28页

作者： lori Ann Risser

与中国相似,西方世界同样节日纷多。本期"他乡物语"特邀美国女孩 lori Ann Risser(图中左三穿白衣者)为你讲述万圣节和感恩节的故事。lori 现就读于美国 Central College(史奥瓦州佩拉)的传播专业。她曾在中国学习过汉语,热爱越野和田... 详细信息

与中国相似,西方世界同样节日纷多。本期"他乡物语"特邀美国女孩 lori Ann Risser(图中左三穿白衣者)为你讲述万圣节和感恩节的故事。lori 现就读于美国 Central College(史奥瓦州佩拉)的传播专业。她曾在中国学习过汉语,热爱越野和田径运动。lori 将在以后为读者朋友带来更多的故事。

关键词：故事田径运动中国西方世界清教徒美国感恩节物语壁炉地面汉语

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The Story of Study Told by an American Girl

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英语沙龙（高中） 2005年第2期 53-55页

作者： lori Ann Risser

美国女孩lori 坐在电视机前嚼着巧克力,想起了过去这个学期一幕幕生动的场景……

关键词：巧克力电视机场景地质学学期广口瓶过去戏剧掩盖电影

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Goble, Andrew Edmund, Confluences of Medicine in Medieval Japan： Buddhist Healing, Chinese Knowledge, Islamic Formulas, and Wounds of War

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Frontiers of History in China 2013年第4期8卷 624-629页

作者： lori R. Meeks University of Southern California

Professor Goble＇s new book explores the medical writings of Buddhist priest and physician Kajiwara Shōzen （1265-1337）. Goble convincingly argues that Shōzen＇s massive medical compendia--Ton＇ishō （1304） and ...

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Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

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World Journal of Gastroenterology 2017年第40期23卷 7265-7273页

作者： Daniel Lew Soon Man Yoon Xiaofei Yan lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical Center F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute Cedars-Sinai Medical Center Department of Gastroenterology Cedars-Sinai Medical Center

AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic *** This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population *** Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an

关键词： Genetic associations Inflammatory bowel disease Anti-tumor necrosis factor Adverse events

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Clinical and historical features of emergency department patients with pericardial effusions

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世界急诊医学杂志(英文) 2017年第1期8卷 29-33页

作者： lori Stolz Josephine Valenzuela Elaine Situ-LaCasse Uwe Stolz Nicolas Hawbaker Matthew Thompson Srikar Adhikari Department of Emergency Medicine University of Arizona Department of Emergency Medicine University of California

BACKGROUND: Diagnosing pericardial effusion is critical for optimal patient care. Typically, clinicians use physical examination ? ndings and historical features suggesting pericardial effusion to determine which patients require echocardiography. The diagnostic characteristics of these tools are not well described. The objective of this study is to determine the prevalence of historical features and sensitivity of clinical signs to inform clinicians when to proceed with ***: A retrospective review of point-of-care echocardiograms performed over a two and a half year period in two emergency departments were reviewed for the presence of a pericardial effusion. Patient charts were reviewed and abstracted for presenting symptoms, historical features and clinical findings. The prevalence of presenting symptoms and historical features and the sensitivity of classic physical examination ? ndings associated with pericardial effusion and tamponade were ***: One hundred and fifty-three patients with pericardial effusion were identified. Of these patients, the most common presenting complaint was chest pain and shortness of breath. Patients had no historical features that would suggest pericardial effusion in 37.5% of cases. None of the patients with pericardial effusion or pericardial tamponade had all of the elements of Beck's triad. The sensitivity of Beck's triad was found to be 0(0%–19.4%). The sensitivity for one ? nding of Beck's triad to diagnose pericardial tamponade was 50%(28.0%–72.0%).CONCLUSION: History and physical examination findings perform poorly as tests for the diagnosis of pericardial effusion or pericardial tamponade. Clinicians must liberally evaluate patients suspected of having a pericardial effusion with echocardiography.

关键词： Pericardial effusion Ultrasound Echocardiography Cardiac tamponade Physical examination

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