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The Use of the ICTs in the Value Chain Proce,;ses and Their Impact on Organizational Performance

Chinese Business Review 2016年第9期15卷 437-446页

作者： Zulema Cordova Ruiz Sosima Carrillo loreto maria bravo zanoguera Jessica Lizbeth Cisneros Martinez Autonomus University of Baja California Mexicali Mexico

Companies are currently immersed in a process of competitiveness, which is increasingly more complicated to achieve differentiation that can guarantee you the preference of customers and consequently the success of the organization. It becomes partly crucial for the organization to be in the dynamics of the sector and market where it operates and wants its consolidation, because value systems become strategic elemente that play a role as key factors of success in organizations seeking priority intend to increase their organizational performance. Given the above, this research seeks to get to identify strategic uses of information and communication technologies in the processes of the value chain in small commercial businesses in Mexicali, aiming to contribute to the improvement of the competitiveness of the same. It is in this sense that the technologies of information and communication have become a powerful tool that will allow them to be innovative, cost-effective and this will have an impact on the performance of the organization that will allow you to improve your service, interact with customers and suppliers, and above all more efficiently meet their own needs and organizational expectations. This research was exploratory and within the relevant findings, coming to the conclusion that it is necessary to focus more emphatically on the client; organizations have deficiencies in relation to the strategic use of ICTs to streamline their billing, manufacturing, distribution, and storage of your products, activities highlighting this if they don＇t have a reconsideration in this aspect, at the risk of offset in terms of its competitors which would mean ceasing to be option on the market, stressing that this not only will be a trigger factor in mature companies, but those who need to improve their service and that they will serve as input for the conduction of processes along the value chain. The research is exploratory in nature, as evidenced in the use of the ICTs

关键词： information technologies and communication organizational performance value chain competitive small businesses improvement

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T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

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Cellular & Molecular Immunology 2017年第6期14卷 497-510页

作者： Jose-Ignacio Rodriguez-Barbosa Carlos Fernandez-Renedo Ana maria bravo Moral Leo Biihler maria-Luisa del Rio Transplantation Immunobiology Section Institute of Biomedicine University of Leon and Castilla and Leon Regional Transplantation Coordination Leon University Hospital Leon Spain Department of Veterinary Clinical Sciences University of Santiago de Compostela Veterinary Faculty Lugo Spain Visceral and Transplantation Surgery Department of Surgery University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland

The molecular pathways contributing to humoral-mediated allograft rejection are poorly defined. In this study, we assessed the role of the herpesvirus entry mediator/B- and T-lymphocyte attenuator （HVEM/BTLA） signalling pathway in the context of antibody-mediated allograft rejection. An experimental setting was designed to elucidate whether the blockade of HVEM/BTLA interactions could modulate de novo induction of host antidonor-specific antibodies during the course of graft rejection. To test this hypothesis, fully allogeneic major histocompatibility complex-mismatched skin grafts were transplanted onto the right flank of recipient mice that were treated with isotype control, anti-CD40L or modulatory antibodies of the HVEM/BTLA signalling pathway. The frequencies of CD4 T follicular helper （Tfh） cells （B220-, CD4＋ CXCR5＋ PD-lhigh）, extrafollicular helper cells （B220-, CD4＋ CXCR5- PD-1＋ and PD-1-） and germinal centre （GC） B cells （B220＋Fas＋ GL7＋） were analysed by flow cytometry in draining and non-draining lymph nodes at day 10 post transplantation during the acute phase of graft rejection. The host antidonor isotype-specific humoral immune response was also assessed. Whereas blockade of the CD40/CD40L pathway was highly effective in preventing the allogeneic humoral immune response, antibody-mediated blockade of the HVEM/BTLA-interacting pathway affected neither the expansion of Tfh cells nor the expansion of GC B cells. Consequently, the course of the host antidonor antibody-mediated response proceeded normally, without detectable evidence of impaired development. In summary, these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies in transplantation.

关键词： BTLA (CD272) humoral immunity HVEM (TNFRSF14, CD270) T follicular helper cells transplantation

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Pain assessment and management in the newborn:A systematized review

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World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： maria Teresa Garcia-Rodriguez Sergio Bujan-bravo Rocio Seijo-Bestilleiro Cristina Gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

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COVID-19 pandemic and nurse teaching:Our experience

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World Journal of Clinical Cases 2022年第8期10卷 2657-2659页

作者： Juan Carlos Molina Ruiz Jose Luis Guerrero Orriach maria Luisa bravo Arcas Angela Montilla Sans RocioEscano Gonzalez Department of Anesthesia Hu Virgen De La VictoriaMalaga 29006Spain

In this letter to the editor,we would like to show in our hospital how our nurse team manage formation during coronavirus disease 2019 pandemic.

关键词： COVID-19 Anesthesia Critical care Nurses First wave Training

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Robot-assisted oncologic pelvic surgery with Hugo™robot-assisted surgery system:A single-center experience

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Asian Journal of Urology 2023年第4期10卷 461-466页

作者： Angelo Territo Alessandro Uleri Andrea Gallioli Josep maria Gaya Paolo Verri Giuseppe Basile Alba Farré Alejandra bravo Alessandro Tedde Óscar Rodríguez Faba Joan Palou Alberto Breda Department of Urology FundacióPuigvertAutonomous University of BarcelonaBarcelonaSpain

Objective To report the outcomes of intra-and extra-peritoneal robot-assisted radical prostatectomy(RARP)and robot-assisted radical cystectomy(RARC)with Hugo™robot-assisted surgery(RAS)system(Medtronic,Minneapolis,MN,USA).Methods Data of twenty patients who underwent RARP and one RARC at our institution between February 2022 and January 2023 were *** primary endpoint of the study was to report the surgical setting of Hugo™RAS system to perform RARP and *** secondary endpoint was to assess the feasibility of RARP and RARC with this novel robotic platform and report the *** Seventeen patients underwent RARP with a transperitoneal approach,and three with an extraperitoneal approach;and one patient underwent RARC with intracorporeal ileal *** intraoperative complications *** docking and console time were 12(interquartile range[IQR]7-16)min and 185(IQR 177-192)min for transperitoneal RARP,15(IQR 12-17)min and 170(IQR 162-185)min for extraperitoneal *** intraoperative complications *** patient submitted to extraperitoneal RARP had a urinary tract infection in the postoperative period that required an antibiotic treatment(Clavien-Dindo Grade 2).In case of transperitoneal RARP,two minor complications occurred(one pelvic hematoma and one urinary tract infection;both Clavien-Dindo Grade 2).Conclusion Hugo™RAS system is a novel promising robotic platform that allows to perform major oncological pelvic *** showed the feasibility of RARP both intra-and extra-peritoneally and RARC with intracorporeal ileal conduit with this novel platform.

关键词： Bladder cancer Prostate cancer Radical cystectomy Radical prostatectomy Robotic surgery

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Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

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World Journal of Gastroenterology 2009年第28期15卷 3565-3568页

作者： Fabiana Pirani Carneiro maria de Nazareth Machado Sobreira Lívia bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes Department of Pathology University Hospital of Brasília Department of Radiology University Hospital of Brasília Department of Hematology University Hospital of Brasília Department of Surgery University Hospital of Brasília

We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss. On computed tomography （CT） a wall thickening of the fourth part of the duodenum was observed. Multiple biopsies obtained from the lesion showed infiltration of plasma cells and lymphocytes, but they were not conclusive. The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse infiltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria. An extensive deposition of amyloid was also observed. Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ： light chain positive. These cells also were positive for CD138 and CD56 but negative for CD20 and CD79. The findings were consistent with extramedullary plasmocytoma associated with a massive deposit of amyloid in duodenum. A subsequent workup for multiple myeloma was completely negative. The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up. Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.

关键词： Extramedullary plasmocytoma Amyloidosis Duodenum Plasma cell neoplasms Immunohistochemistry

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Characterization Of Peripherical Blood And Tumor Infiltrating Lymphocytes In Cervical Carcinoma Patients By Flow Cytometry

Characterization Of Peripherical Blood And Tumor Infiltratin...

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24th International Papillomavirus Conference and Clinical Workshop

作者： maria Angelica Cespedes Ardila maria Mercedes bravo Hernandez Susana Fiorentino Alba Lucia Combita Rojas Instituto Nacional de Cancerologia Instituto Nacional de Cancerologia Pontificia Universidad Javeriana Instituto Nacional de Cancerologia

＜正＞Decreases of host immune function,alterations in frequencies of lymphocyte subsets and increase of regulatory T cells（T reg ）have been observed in patients with different types of *** cervical cancer,the changes of immune responses in tumor milieu,especially the composition of TILs,may have important implications in terms of the progression of *** characterize the tumor infiltrating lymphocytes and peripheral blood lymphocytes in patients with cervical cancer,we analyzed 39 peripheral

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Efficacy of the adjuvanted subunit protein COVID-19 vaccine,SCB-2019:a phase 2 and 3 multicentre,double-blind,randomised,placebo-controlled trial

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四川生理科学杂志 2021年第11期43卷 1999-1999页

作者： Lulu bravo University of the Philippines Manila Ermita Manila Philippines Clover Biopharmaceuticals Cambridge MA USA Duke University Clinical Research Institute Duke University Medical Center Durham NC USA Oxford Vaccine Group University of Oxford Oxford UK Manila Doctors Hospital Manila Philippines Asian Hospital and Medical Center Alabang Muntinlupa Philippines Global Research in Infectious Diseases Singapore Centro de Estudios en Infectología Pediátrica Universidad Del Valle Clínica Imbanaco Cali Colombia Clinica De La Costa Barranquilla Atlantico Colombia Hospital Universidad del Norte Barranquilla Colombia Center of Attention in Medical Research Bogotá Colombia Faculty of Health Sciences at the University of Caldas Manizales Colombia Policlínico Social del Norte Bogotá Colombia Hospital de Clinicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil D'Or Institute for Research and Education Rio de Janeiro Brazil Federal University of Rio Grande do Norte Natal Brazil Infectious Diseases Division Universidade Federal de Santa Maria Rio Grande do Sul Brazil Atena Institute of Clinical Research Rio Grande do Norte Natal Brazil University of the East Ramon Magsaysay Memorial Medical Center Quezon City Philippines Far Eastern University Hospital - Nicanor Reyes Medical Foundation Quezon City Philippines Las Pinas Doctors Hospital Las Pinas City Philippines De La Salle Medical and Health Sciences Institute Cavite City Philippines Tropical Disease Foundation Cavite City Philippines Infection Control Service St Luke's Medical Center Taguig Philippines Anima Research Center Alken Belgium Clinic of Infectious Diseases CUB-Hôpital Erasme Bruxelles Belgium Pulmonology Department CHU Universite Catholique de Louvain Namur Site Sainte-Elisabeth Namur Belgium Soweto Clinical Trials Centre Johannesburg South Africa Wits Clinical Research Soweto Johannesburg South Africa DJW Research Noordheuwel Krugersdorp Gauteng South Africa Dr JM Enge

Background:A range of safe and effective vaccines against SARS CoV 2 are needed to address the COVID 19 *** aimed to assess the safety and efficacy of the COVID-19 vaccine ***:This ongoing phase 2 and 3 double-blind,placebo-controlled trial was done in adults aged 18 years and older who were in good health or with a stable chronic health condition,at 31 sites in five countries(Belgium,Brazil,Colombia,Philippines.

关键词： placebo centre double

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Real World Evidence (RWE, Real World Data), of the Effectiveness of Amoxicillin-Clavulanate in the Treatment of Children with Upper Respiratory Tract Infections (Tonsillitis, Otitis, Sinusitis)

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Open Journal of Respiratory Diseases 2024年第3期14卷 77-89页

作者： maria Gonzalez Yibirin Juan Chirinos David Alberto Rincón Matute Trinidad Coll Miriam Rosales Yuliana Guevara Kuanlin Doried Guitens Pérez Mauribel Figueroa Rosalía Romero Jurgensen Andrea Rojas Gabriel Jesús Arismendi González Milagros Salcedo Marife Martina Marin Marcano Carolina Mendoza Marycarmen Anuel maria Morao Raymond Aguilera Diego Ríos Maryenis Rodríguez Loren Sánchez Jennyfer Fernández Rafael González Zaidith Zerpa Nelson Rodríguez Mirluis Rojas Sixtaime Quijada mariangel Moya Diego Orsini Chris Gómez Hector Gamero José Rodríguez Laboratorios LETI S.A.V. Guarenas Venezuela Ambulatorio Rural tipo II CPT3 Pampatar Venezuela Ambulatorio Los Robles CPT Dr. Luis Rosas bravo Los Robles Venezuela Clnica Prevaler Pampatar Venezuela Hospital tipo 1 Dr. David Espinoza Rojas en Salamanca Salamanca Venezuela Centro Mdico Rotary El Valle Venezuela Ambulatorio Rural Tipo II CPT3 Dr. Enrique Albornoz Lares La Asuncin Venezuela

Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting from routine healthcare delivery. This study evaluates the clinical efficacy of amoxicillin + clavulanic acid in children with pharyngitis, acute otitis, or acute rhinosinusitis with suspected bacterial origin under normal office and home conditions. Methods: This was a real-life, prospective, observational, pharmacovigilance study. It included children of both sexes between 2 and 12 years old, with a diagnosis of Rhinopharyngitis (tonsillitis), Acute Otitis Media and Rhinosinusitis. The main effectiveness variable evaluated was reduction and time to resolution of symptoms. All patients received Amoxicillin/Clavulanic Acid suspension 600 mg/42.9 mg/5 mL at a dose of 90 mg/Kg/day in two doses, every 12 hours for 7 days. The evaluations were carried out at the beginning, at 72 hours (3rd day) and at 7 days. All patients underwent culture and antibiogram. Results: The majority of cultures were negative for pathogenic germs, suspecting unidentifiable germs, or viral etiology despite the rigorous selection of subjects following validated scores. The most frequently isolated germ was Staphylococcus aureus;growth of gram-negative bacteria was reported in 33.33% of the cultures. There was a significant improvement in symptoms in children with tonsillitis and rhinosinusitis from the first 72 hours of treatment, persisting until the 7 days. In the otitis media group, returning to normal by the tenth day. During the conduction of this investigation, no adverse effects associated with the prescribed therapy were reported.

关键词： Amoxicillin Clavulanic Acid Tonsillitis Otitis Sinusitis

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Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 389-395页

作者： Carlos Robles-Medranda maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys bravo Carlos Robles-Jara Hannah Pitanga Lukashok Gastroenterology and Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasUniversity Hospital OMNIGuayaquil 090505Ecuador

To evaluate the clinical impact of confocal laser endomicroscopy (CLE) in the diagnosis and management of patients with an uncertain diagnosis. METHODSA retrospective chart review was performed. Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included. Baseline characteristics, indications, previous diagnostic studies, findings at the time of CLE, clinical management and histological results were analyzed. Interventions based on CLE findings were also analyzed. We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens. RESULTSA total of 144 patients were included. Of these, 51% (74/144) were female. The mean age was 51 years old. In all, 41/144 (28.4%) lesions were neoplastic (13 bile duct, 10 gastric, 8 esophageal, 6 colonic, 1 duodenal, 1 rectal, 1 ampulloma and 1 pancreatic). The sensitivity, specificity, positive predictive value, negative predictive value, and observed agreement when CLE was used to detect N-lesions were 85.37%, 87.38%, 72.92%, 93.75% and 86.81%, respectively. Cohen’s Kappa was 69.20%, thus indicating good agreement. Changes in management were observed in 54% of the cases. CONCLUSIONCLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis.

关键词： Confocal laser endomicroscopy In vivo microscopy Barret esophagus Gastrointestinal cancer Pancreatic cyst Biliary strictures

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