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Financial Innovation 2022年第1期8卷 2045-2078页

作者： Laura Grassi Nicolas Figini lorenzo Fedeli School of Management Politecnico di Milanovia Lambruschini 4bMilanItaly

The coupling of data and digital innovation opens the way for new business in the financial services sector,where customers are placed at the centre of decisions and data can help to develop customer *** carry out our research,we adopted a multi-case study approach to explore how a data strategy is developed in the retail banking industry,together with its relationship with customer value,paying particular attention to the heterogeneity between traditional banks and financial technology companies(FinTechs).Two main points emerged from the ***,there are three possible approaches to Open Finance,which are mainly defined by their different corporate cultures,organisational configurations,technological architecture and data ***,it is not enough to be a FinTech to be best placed to exploit the market,as some traditional banks share the FinTechs’approach to Open *** new tailored products,customising their prices and offering them over the right channels through targeted communication are all data-driven initiatives that stem from cross-or up-selling potential,core to the retail banking industry for turning a customer into a cash flow,thus enabling value to be created for *** findings additionally revealed that there is a form of external information asymmetry between the customer and the bank,and that there is also an internal asymmetry between bank departments,as their visibility on information about the same customer may differ.

关键词： FinTech Open finance Customer orientation Customer centric Data valorisation Open banking

Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy

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World Journal of Gastroenterology 2019年第35期25卷 5257-5265页

作者： Silvia Nardelli Stefania Gioia Jessica Faccioli Oliviero Riggio lorenzo Ridola Department of Translational and Precision Medicine "Sapienza" University of Rome

Minimal hepatic encephalopathy (MHE) represents the mildest type of hepatic encephalopathy (HE). MHE is considered as a preclinical stage of HE and is part of a wide spectrum of typical neurocognitive alterations characteristic of patients with liver cirrhosis, particularly involving the areas of attention, alertness, response inhibition, and executive functions. MHE can be detected by testing the patients’ psychometric performance, attention, working memory, psychomotor speed, and visuospatial ability, as well as by means of electrophysiological and other functional brain measures. MHE is very frequent, affecting from 20% up to 80% of patients tested, depending of the diagnostic tools used. Although subclinical, MHE is considered to be clinically relevant. In fact, MHE has been related to the patients’ falls, fitness to drive, and working ability. As a consequence, MHE affects the patients and caregivers lives by altering their quality of life and even their socioeconomic status. Recently sarcopenia, a very common condition in patients with advanced liver disease, has been shown to be strictly related to both minimal and overt HE. Aim of this review is to summarize the most recently published evidences about the emerging relationship between sarcopenia and cognitive impairment in cirrhotic patients and provide suggestions for future research.

关键词： Minimal hepatic encephalopathy Cognitive impairment Sarcopenia Muscle alterations Cirrhosis

Thermal and catalytic pyrolysis of a synthetic mixture representative of packaging plastics residue

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Frontiers of Chemical Science and Engineering 2020年第2期14卷 288-303页

作者： Simona Colantonio lorenzo Cafiero Doina De Angelis Nicolo MIppolito Riccardo Tuffi Stefano Vecchio Ciprioti Department for Sustainability ENEA—Casaccia Research CenterRome 00123Italy Department of Chemical Materials and Environmental EngineeringSapienza University of RomeRome 00184Italy Department of SBAI Sapienza University of RomeRome 00161Italy

A synthetic mixture of real waste packaging plastics representative of the residue from a material recovery facility(plasmix)was submitted to thermal and catalytic *** thermogravimetry experiments coupled with Fourier transform infrared spectroscopy were performed to evaluate the effects of the catalysts on the polymers’degradation temperatures and to determine the main compounds produced during *** thermal and catalytic experiments were conducted at 370℃,450℃ and 650℃ using a bench scale *** oil,gas,and char yields were analyzed and the compositions of the reaction products were *** primary aim of this study was to understand the effects of zeolitic hydrogen ultra stable zeolite Y(HUSY)and hydrogen zeolite socony mobil-5(HZSM5)catalysts with high silica content on the pyrolysis process and the products’*** showed that HUSY significantly reduces the degradation temperature of all the polymers—particularly the ***5 had a significant effect on the degradation of polyethylene due to its smaller pore *** balance showed that oil is always the main product of pyrolysis,regardless of the process ***,all pyrolysis runs performed at 370℃ were *** use of either zeolites resulted in a decrease in the heavy oil fraction and the prevention of wax *** has the best performance in terms of the total monoaromatic yield(29 wt-%at 450℃),while HZSM5 promoted the production of gases(41 wt-%at 650℃).Plasmix is a potential input material for pyrolysis that is positively affected by the presence of the two tested zeolites.A more effective separation of polyethylene terephthalate during the selection process could lead to higher quality pyrolysis products.

关键词： packaging plastics waste plasmix pyrolysis zeolite catalyst degradation temperature

A Review of Basic Mechanical Behavior of Laminated Bamboo Lumber

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Journal of Renewable Materials 2022年第2期10卷 273-300页

作者： Assima Dauletbek Haitao Li Rodolfo lorenzo Ileana Corbi Ottavia Corbi Mahmud Ashraf College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Joint International Research Laboratory for Bio-Composite Building Materials and Structures Nanjing Forestry UniversityNanjing210037China University College London LondonWC1E 6BTUK University of Naples Federico II Naples80133Italy Deakin University GeelongVIC 3216Australia

Over the past decade,the physical and mechanical performances of laminated bamboo lumber(LBL)–a bamboo-based structural material,have been extensively studied using experimental,analytical,and numerical *** paper presents a review of existing knowledge in the literature about the mechanical properties of *** paper involved the review of the response of LBL to different types of loading such as tension,bending,compres-sion,and *** on results of the literature reviewed,the strength of LBL parallel to grain was 90–124 MPa with MOE of 10700 MPa in tension,29.55–72.60 MPa,and MOE of 8396–11022 MPa in compression,63.87–128.4 MPa,and MOE of 8320–10912 MPa in bending,and 7.15–17.5 MPa in *** average strength of LBL was similar and in some cases exceeded the average values of bamboo-or wood-based materials,while the variability of its mechanical parameters was *** variability in strength values of LBL was affected by bamboo species,density and thickness of bamboo strips,growth portion,type of treatment,strips arrange-ments,and type of adhesive which in turn calls for classification of LBL by strength grades,degree of hardness,the capability of impregnation and penetration,as well as by areas of application in *** study pro-vided and discussed concluding observations,the current research gap,and future research directions on the mechanical properties of LBL.

关键词： Laminated bamboo lumber mechanical properties composites

Thiopurines are an independent risk factor for active tuberculosis in inflammatory bowel disease patients

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World Journal of Gastroenterology 2023年第9期29卷 1536-1538页

作者： Flora Maria lorenzo Fortes Raquel Rocha Genoile Oliveira Santana Ciências da Vida Universidade do Estado da BahiaSalvador 41150000Brazil Programa de Pós-Graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110060Brazil Ciência da Nutrição Universidade Federal da BahiaSalvador 40110160Brazil

The use of thiopurines is an independent risk factor for active tuberculosis in patients with inflammatory bowel disease.

关键词： Tuberculosis Inflammatory bowel disease Thiopurines Therapy Risk

Versatile multiplexed super-resolution imaging of nanostructures by Quencher-Exchange-PAINT

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Nano Research 2018年第12期11卷 6141-6154页

作者： Tobias Lutz Alexander H.Clowsley Ruisheng Lin Stefano Pagliara lorenzo Di Michele Christian Soeller Living Systems Institute & Biomedical Physics University of ExeterExeter EX44QDUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK

The optical super-resolution technique DNA-PAINT (Point Accumulation Imaging in Nanoscale Topography) provides a flexible way to achieve imaging of nanoscale structures at ∼10-nanometer resolution. In DNA-PAINT, fluorescently labeled DNA “imager” strands bind transiently and with high specificity to complementary target “docking” strands anchored to the structure of interest. The localization of single binding events enables the assembly of a super-resolution image, and this approach effectively circumvents photobleaching. The solution exchange of imager strands is the basis of Exchange-PAINT, which enables multiplexed imaging that avoids chromatic aberrations. Fluid exchange during imaging typically requires specialized chambers or washes, which can disturb the sample. Additionally, diffusional washout of imager strands is slow in thick samples such as biological tissue slices. Here, we introduce Quencher-Exchange-PAINT—a new approach to Exchange-PAINT in regular open-top imaging chambers—which overcomes the comparatively slow imager strand switching via diffusional imager washout. Quencher-Exchange-PAINT uses “quencher” strands, i.e., oligonucleotides that prevent the imager from binding to the targets, to rapidly reduce unwanted single-stranded imager concentrations to negligible levels, decoupled from the absolute imager concentration. The quencher strands contain an effective dye quencher that reduces the fluorescence of quenched imager strands to negligible levels. We characterized Quencher-Exchange-PAINT when applied to synthetic, cellular, and thick tissue samples. Quencher-Exchange-PAINT opens the way for efficient multiplexed imaging of complex nanostructures, e.g., in thick tissues, without the need for washing steps.

关键词： super-resolution microscopy fluorescence imaging DNA nanotechnology DNA-PAINT fluorescence quencher

Over-the-scope clip closure of two chronic fistulas after gastric band penetration

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World Journal of Gastroenterology 2010年第13期16卷 1665-1669页

作者： Federico Iacopini Nicola Di lorenzo Fabrizio Altorio Marc-Oliver Schurr Agostino Scozzarro Gastroenterology and Endoscopy Unit Ospedale San Giuseppe Albano Laziale Department of Surgical Science Policlinico Università di Tor Vergata Steinbeis University Berlin IHCI-Institute

Gastrointestinal perforations are conservatively managed at endoscopy by through-the-scope endoclips and covered self expandable stents, according to the size and tissue features of the perforation. This is believed to be the first report of successful closure of two gastrocutaneous fistulas with over-the-scope clips (OTSCs). After laparoscopic gastric banding, a 45-year old woman presented with band erosion and penetration. Despite surgical band removal and gastric wall suturing, external drainage of enteric material persisted for 2 wk, and esophagogastroduodenoscopy demonstrated two adjacent 10-mm and 15-mm fistulous orifices at the esophagogastric junction. After cauterization of the margins, the 10-mm fistulous tract was grasped by the OTSC anchor, invaginated into the applicator cap, and closed by a traumatic OTSC. The other 15-mm fistula was too large to be firmly grasped, and a fully-covered metal stent was temporarily placed. No leak occurred during the following 6 wk. At stent removal: the OTSC was completely embedded in hyperplastic overgrowth; the 15-mm fistula significantly reduced in diameter, and it was closed by another traumatic OTSC. After the procedure, no external fistula recurred and both OTSCs were lost spontaneously after 4 wk. The use of the anchor and the OTSC seem highly effective for successful closure of small chronic perforations.

关键词： Gastrointestinal endoscopy Fistula Stent Esophagogastric junction

Peripheral clonal selection shapes the human γδ T-cell repertoire

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Cellular & Molecular Immunology 2017年第9期14卷 733-735页

作者： Biagio Di lorenzo Julie Déchanet-Merville Bruno Silva-Santos Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de Lisboa1649-028 LisbonPortugal Instituto Superior Tecnico Universidade de Lisboa1649-028 LisbonPortugal ImmunoConcept CNRS UMR 5164Equipe Labelisée Ligue Contre le CancerUniversity of BordeauxF-33000 BordeauxFrance

γδT cells are often placed at the interface between innate and adaptive *** cells share T-cell receptor(TCR)rearrangements and memory functions1 in common with theirαβT-cell counterparts but differ in terms of the... 详细信息

关键词： Figure kinetics selection

The effect of chemical structure of carboxylate molecules on hydroxyapatite nanoparticles.A structural and morphological study

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Bioactive Materials 2021年第8期6卷 2360-2371页

作者： lorenzo Degli Esposti Alessio Adamiano Dritan Siliqi Cinzia Giannini Michele Iafisco Institute of Science and Technology for Ceramics(ISTEC) National Research Council(CNR)Via Granarolo 6448018FaenzaItaly Institute of Crystallography(IC) National Research Council(CNR)Via Amendola 122/O70126BariItaly

Being the most abundant non-macromolecular organic component of bone,the role of citrate(Cit)in hydroxyapatite(HA)crystallization is of high *** this work we have investigated the influence of hydroxycitrate(CitOH)and glutarate(Glr)on HA crystallization in terms of particle growth,composition,and morphology in comparison to *** and Glr have been selected for this work because they share the same backbone structure of Cit but bear different functional groups in the central *** data has revealed that CitOH strongly inhibits HA crystallization more efficiently than ***-HA nanoparticles are composed of platy,elongated particles similar to those of Cit-HA but they are *** smaller and have a lower crystal *** the other hand,Glr does not inhibit HA crystallization as Cit,but leads to the formation of OCP platelets that convert with maturation time to HA nanorods with larger aspect ratio than *** comparison to Cit-HA samples,Glr-HA nanoparticles have bigger dimensions,and higher structural ***,our data reveal that the central carboxyl group of Cit is involved in the selective binding with HA crystal surface and in regulating HA crystal *** results of this work highlight new possibilities to control the formation of HA for designing advanced bioactive materials and give new insights on the role of the structure of Cit in regulating the HA morphology.

关键词： Hydroxyapatite Nanoparticles Biomineralization Citrate Carboxylates Hydroxycitrate Glutarate

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

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World Journal of Gastroenterology 2017年第10期23卷 1747-1757页

作者： Eleonora Poggiogalle lorenzo Maria Donini Andrea Lenzi Claudio Chiesa Lucia Pacifico Department of Experimental Medicine-Medical Pathophysiology Food Science and Endocrinology SectionSapienza University of Rome Institute of Translational Pharmacology National Research Council Policlinico Umberto I Hospital Sapienza University of Rome

The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle.

关键词： Non-alcoholic fatty liver disease Bone Skeletal muscle Osteoporosis Sarcopenia