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Use of oral vancomycin in children with autoimmune liver disease:A single centre experience

World Journal of Hepatology 2021年第12期13卷 2113-2127页

作者： Angelo Di Giorgio Anna Tulone Emanuele Nicastro lorenzo Norsa Aurelio Sonzogni lorenzo D'Antiga Pediatric Hepatology Gastroenterology and TransplantationHospital Papa Giovanni XXIIIBergamo 24127Italy Liver Pathology Hospital Papa Giovanni XXIIIBergamo 24127Italy

BACKGROUND Previous reports showed some beneficial effect of oral vancomycin treatment(OVT)in children with primary sclerosing cholangitis;conversely,the experience in patients with other autoimmune liver diseases(AILD),including autoimmune hepatitis(AIH)and autoimmune sclerosing cholangitis(ASC),is *** To assess the response to immunosuppressive treatment(IS)and to OVT in children diagnosed with *** Retrospective study of children diagnosed with AIH(normal biliary tree at cholangiography)and ASC(abnormal biliary tree at cholangiography)in the last 10 *** underwent standard immunosuppressive therapy(IS),but nonresponders received also *** remission[normal aspartate aminotransferase(AST)]and immunological remission(normal IgG and negative autoantibodies)rates and Sclerosing Cholangitis Outcomes in Pediatrics(SCOPE)index were assessed and compared during the follow *** 75 children were included[69%female,median age 10.5 years(5.6-13.4 years),AIH=54,ASC=21].Sixty-three patients(84%,AIH=52,ASC=11)were treated with standard IS and 61 achieved biochemical remission,whereas 12 not responding to IS[16%,F=75%,median age 13.5 years,(12.2-15.7),10 with ASC]required OVT and 8 achieved biochemical *** OVT increased the biochemical remission rate of the whole group of AILD patients from 81%(61/75)to 92%(69/75).Median values of AST,alanine aminotransferase(ALT)and gamma-glutamyl transferase(GGT)decreased significantly after OVT start(P<0.05).Complete normalization of livers enzymes(AST,ALT and GGT)was observed in 6/12 patients(50%).Decrease in SCOPE index score was reported in 5/12 patients(42%).At last follow up(median of 4.4 years,range 0.6-13.8 years)all 75 patients are alive,6(8%,1 with ASC)successfully discontinued medications,1(with ASC)required liver *** Children with AIH and ASC respond well to IS *** may represent a valuable treatment option to achieve biochemical remission in patients

关键词： Autoimmune hepatitis Autoimmune sclerosing cholangitis Autoimmune liver disease Vancomycin Children Liver transplantation

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Imaging resolution of biocatalytic activity using nanoscale scanning electrochemical microscopy

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Nano Research 2018年第8期11卷 4232-4244页

作者： Jase M .Abad Alvaro Y. Tesio EmUiano Martinez-Perinan Felix Pariente Encamacion lorenzo Departamento de Qufmica Analftica y Andlisis Instrumental Universidad Aut6noma de Madrid Cantoblanco 28049 Madrid Spain Centro de Investigaci6n y Desarrollo en Materiales Avanzados y Almacenamiento de Energfa de Jujuy-CIDMEJu (CONICET-UniversidadNacional de Jujuy) Centro de Desarrollo Tecnol6gico General Savio Av. Martijena s/n 4612-Palpald Jujuy Argentina Instituto Madrileno de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia) Campus UAM Cantoblanco 28049 Madrid Spain

Scanning electrochemical microscopy represents a powerful tool for electro（chemical） characterization of surfaces, but its applicability has been limited in most cases at microscale spatial resolution, and the greatest challenge has been the scaling down to the nanoscale for fabrication and the use of nanometer-sized tips. Here, Pt nanoelectrodes with nanometer electroactive area were fabricated and employed for imaging a distribution of gold nanoparticles （AuNPs） and bioelectrocatalytic activity of a redox-active enzyme immobilized on gold surfaces.

关键词： scanning electrochemicalmicroscopy gold nanoparticle redox enzyme nanoelectrode lactate oxidase

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Formation building and collision avoidance for a fleet of NAOs based on optical sensor with local positions and minimum communication

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Science China(Information Sciences) 2019年第5期62卷 214-236页

作者： Xiaomin WANG lorenzo BENOZZI Benoit ZERR Zexiao XIE Hélène THOMAS Benoit CLEMENT Engineering college Ocean University of China

Multi-robot system has become a research hotspot because of low demand on the sensors’ accuracy, high reliability, and high efficiency. To put all the robots together, formation control is a crucial problem. In this paper, we propose a local position-based method to plan trajectories and build a pyramid pattern for a fleet of NAOs in the obstacle-free environment by refering to the position-based method and giving an O(n log n) collision avoidance strategy inspired from one graph theory, where the local positions are estimated from optical sensors. To get the local positions, an integrated image processing method is developped. Firstly a mask-base is generated to store the features of NAOs, and a cross-correlation method is introduced to recognize the NAO. Subsequently, the distance and angle models are proposed to get the local information from a single image. Then, a visual compass is introduced to obtain the orientation of one NAO. After the local information exchange by the WiFi communication, a neighbor-check method is put foward to distinguish the homogeneous NAOs(all the NAOs look like the same). Further, a common frame is constructed as an artificial global frame, and straight non-intercrossing trajectories are planned according to the O(n log n) collision avoidance strategy. At last, the performance of our proposed local position-based method is verified by the simulations with up to 15 robots and the indoor experiments with 3 NAOs in a real environment. The convergence of the method has been demonstrated in both obstacle-free and static obstacle environments.

关键词： formation building a fleet of NAOs optical sensor visual compass local positions

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Review on Bond Properties between Wood and Fiber Reinforced Polymer

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Journal of Renewable Materials 2020年第8期8卷 993-1018页

作者： Zhen Wang Haitao Li Rodolfo lorenzo Ileana Corbi Ottavia Corbi Changhua Fang College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Department of Biomaterials International Centre for Bamboo and RattanBeijing100102China University College London LondonWC1E 6BTUK University of Naples Federico II Naples80133Italy

Retrofitting of existing ancient and modern timber structures has been an important project *** it triggers a need of excellent strengthening methods,so does the strengthening of newly built *** strengthening methods have shortcomings such as high costing and destroying the aesthetic of the structure,many of which can be overcome by means of using fiber reinforced polymer(FRP)***,the behavior of FRP-towood systems has yet to be thoroughly researched compared with their FRP-toconcrete or FRP-to-steel *** FRP retrofitting and strengthening timber structures has a promising future,better understanding of their failure modes will enable more precise designs balancing safety and *** of the most common FRP-to-wood systems in the literature are discussed in this paper,namely,the externally bonded reinforcement(EBR),the near-surface mounted(NSM)and the glued-in rods(GiR)*** of the FRP from the substrate is one of the most common failure modes,which exhibits the significance of the interface bond between FRP laminates and ***,bond properties and behavior of FRP-to-wood composite systems are described,parameters influencing the composite action are summarized in this paper,previous works on the bond interface of FRP and timber element are reviewed and future topics are also *** work can provide a reference for future research and engineering applications.

关键词： FRP wood bond strength strengthening retrofitting

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A Review of Experimental Research on the Mode I Fracture Behavior of Bamboo

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Journal of Renewable Materials 2023年第6期11卷 2787-2808页

作者： Yue Chen Haitao Li Lei Gao Wei Xu Rodolfo lorenzo Milan Gaff College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Joint International Research Laboratory for Bio-Composite Building Materials and Structures Nanjing Forestry UniversityNanjing210037China Department of Civil and Airport Engineering Nanjing University of Aeronautics and AstronauticsNanjing211106China University College London LondonWC1E 6BTUK Department of Furniture Design and Habitat BrnoMendel University in BrnoBrno61300Czech Republic Faculty of Civil Engineering Experimental CentreCzech Technical University in PragueThakurova 7Prague16629Czech Republic

Bamboo is an eco-friendly material with light weight,high strength,short growth cycle and high sustainability,which is widely used in building *** bamboo has further promoted the development of modern bamboo structures due to its unrestricted size and ***,as a fiber-reinforced material,fracture damage,especially Mode I fracture damage,becomes the most likely damage mode of its structure,so Mode I fracture characteristics are an important subject in the research of mechanical properties of *** paper summarizes the current status of experimental research on the Mode I fracture properties of bamboo based on the three-point bending(TPB)method,the single-edge notched beam(SENB)method,the compact tension(CT)method and the double cantilever beam(DCB)method,compares the fracture toughness of different species of bamboo,analyzes the toughening mechanisms and fracture damage modes,discusses the applicability of different theoretical calculation methods,and makes suggestions for future research priorities,aiming to provide a reference for future research and engineering applications in related fields.

关键词： Mode I fracture properties test method toughening mechanism fracture damage modes

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Foreign exchange trading and management with the stochastic dual dynamic programming method

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Financial Innovation 2023年第1期9卷 583-620页

作者： lorenzo Reus Guillermo Alexander Sepulveda‑Hurtado Escuela de Negocios Universidad Adolfo IbanezDiagonal Las Torres2640 SantiagoChile

We present a novel tool for generating speculative and hedging foreign exchange(FX)trading *** solution provides a schedule that determines trades in each rebalancing period based on future currency prices,net foreign account positions,and incoming(outgoing)flows from business *** obtain such policies,we construct a multistage stochastic programming(MSP)model and solve it using the stochastic dual dynamic programming(SDDP)numerical method,which specializes in solving high-dimensional MSP *** construct our methodology within an open-source SDDP package,avoiding implementing the method from *** measure the performance of our policies,we model FX prices as a mean-reverting stochastic process with random events that incorporate stochastic *** calibrate this price model on seven currency pairs,demonstrating that our trading policies not only outperform the benchmarks for each currency,but may also be close to ex-post optimal *** also show how the tool can be used to generate more or less conservative strategies by adjusting the risk tolerance,and how it can be used in a vari-ety of contexts and time scales,ranging from intraday speculative trading to monthly hedging for business ***,we examine the impact of increasing trade policy uncertainty(TPU)levels on our *** findings show that the volatility of currencies from emerging economies rises in comparison to currencies from devel-oped *** discover that an increase in the TPU level has no effect on the aver-age profit obtained by our ***,the risk exposure of the policies increases(decreases)for the group of currencies from emerging(developed)markets.

关键词： FX trading FX risk SDDP Multistage stochastic programming Julia Trade policy uncertainty

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Improved Peptidyl Linkers for Self-Assembly of Semiconductor Quantum Dot Bioconjugates

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Nano Research 2009年第2期2卷 121-129页

作者： lorenzo Berti Paola Serena D'Agostino Kelly Boeneman Igor L.Medintz CNR-INFM National Research Center on nanoStructures and bioSystems at Surfaces(S3)Via Campi213/A 41100 ModenaItaly University of California Davis Medical Center SacramentoCA 95817USA Center for Bio/Molecular Science and Engineering Code 6900 U.S.Naval Research LaboratoryWashingtonDC 20375USA

We demonstrate improved peptide linkers which allow both conjugation to biomolecules such as DNA and self-assembly with luminescent semiconductor quantum dots.A hexahistidine peptidyl sequence was generated by standard solid phase peptide synthesis and modified with the succinimidyl ester of iodoacetamide to yield a thiol-reactive iodoacetyl polyhistidine *** reactive peptide was conjugated to dye-labeled thiolated DNA which was utilized as a model target *** gel electrophoresis and fluorescence resonance energy transfer analysis confirmed that the linker allowed the DNA to self-assemble with quantum dots via metal-affinity driven *** contrast to previous peptidyl linkers that were based on disulfide exchange and were thus labile to reduction,the reactive haloacetyl chemistry demonstrated here results in a more stable thioether bond linking the DNA to the peptide which can withstand strongly reducing environments such as the intracellular *** thiol groups occur naturally in proteins,can be engineered into cloned proteins,inserted into nascent peptides or added to DNA during synthesis,the chemistry demonstrated here can provide a simple method for self-assembling a variety of stable quantum dot bioconjugates.

关键词： Semiconductor quantum dot peptide DNA nanocrystal bioconjugation iodoacetyl sulfhydryl polyhistidine metal-affinity fluorescence fluorescence resonance energy transfer(FRET)

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Neurological and psychiatric effects of hepatitis C virus infection

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World Journal of Gastroenterology 2021年第29期27卷 4846-4861页

作者： Jessica Faccioli Silvia Nardelli Stefania Gioia Oliviero Riggio lorenzo Ridola Department of Translational and Precision Medicine “Sapienza”University of RomeRome 00185Italy

Hepatitis C virus(HCV)infection is widespread and affects 71 million people *** hepatic manifestations are the most frequent,ranging from chronic hepatitis to cirrhosis and hepatocellular carcinoma,it is also associated with several extrahepatic *** patients may present nonspecific neurological symptoms,regardless of the presence of liver *** pathogenetic mechanisms underlying neurological symptoms have been hypothesized:neuroinvasion,immune-mediated damage,neurotransmitter alterations and *** of the central nervous system include cerebral vasculopathy,acute or subacute encephalopathy and inflammatory *** infection may be responsible for neuropathies,of which the most frequent form is symmetrical axonal sensory or sensory-motor polyneuropathy which causes loss of leg sensitivity and *** to 50%of patients with HCV infection may experience cognitive decline and psychological disorders,such as depression and *** associated neurocognitive disorder is independent of the presence of liver cirrhosis and affects different domains than in patients with hepatic *** can be studied using specific tests that mainly explore executive functions,verbal learning and verbal *** disorders significantly reduce the quality of *** new antiviral therapies improve the extrahepatic symptoms of HCV infection and their success depends on the achievement of sustained virological ***,the effect of therapy may differ depending on the type of organ involved;neurological symptoms can be irreversible if there is organic liver *** aim of this review is to provide a critical overview of physiopathological mechanisms,diagnostic and therapeutic strategies of the neurological and psychiatric effects of HCV infection.

关键词： Hepatitis C virus Neurological disorders Psychiatric disorders Antiviral therapy Quality of life Hepatic encephalopathy

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Adalimumab in ulcerative colitis: Two cases of mucosal healing and clinical response at two years

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World Journal of Gastroenterology 2009年第30期15卷 3814-3816页

作者： Manuel Barreiro-de Acosta Aurelio lorenzo Juan Enrique Dominguez-Muoz Department of Gastroenterology University Hospital of Santiago de CompostelaC/Choupanas/nE-15706-Santiago de CompostelaSpain

Infliximab (IFX) is currently the only biologic therapy used in the treatment of moderate-to-severe ulcerative colitis (UC). In the years to come, more biologic therapies will have a role in the management of moderate-to-severe UC. We report on two patients with steroid-dependent UC who, due to adverse reactions to IFX, have been under therapy with adalimumab for two years. Both patients received concomitant immunosuppressive treatment. Long term clinical remission and mucosal healing are described.

关键词： Adalimumab Ulcerative colitis Mucosalhealing Maintenance treatment

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Antiglutamatergic agents for obsessive-compulsive disorder:Where are we now and what are possible future prospects?

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World Journal of Psychiatry 2021年第9期11卷 568-580页

作者： Annalisa Maraone lorenzo Tarsitani Irene Pinucci Massimo Pasquini Department of Human Neurosciences Sapienza University of RomeRome 00185LazioItaly

Recent data suggest that obsessive-compulsive disorder(OCD)is driven by an imbalance among the habit learning system and the goal-directed *** frontostriatal loop termed cortico-striatal-thalamo-cortical(CSTC)circuitry loop is involved in habits and their dysfunction plays an important role in *** neurotransmission is the principal neurotransmitter implicated in the CSTC model of *** in the CSTC loop implies a high level of glutamate in the cortical-striatal pathways as well as a dysregulation of GABA ergic transmission,and could represent the pathophysiology of ***,the dysregulation of glutamate levels can lead to neurotoxicity,acting as a neuronal *** hypothesis of a role of neurotoxicity in the pathophysiology of OCD clinically correlates to the importance of an early intervention for ***,some studies have shown that a reduction of duration of untreated illness is related to an earlier onset of *** robust data supporting a progression of such brain changes are not available so far,an early intervention could help interrupt damage from ***,agents targeting glutamate neurotransmission may represent promising therapeutical option in OCD patients.

关键词： Obsessive-compulsive disorder Antiglutamatergic agents Glutammate Early intervention Neurophysiopathology Duration of untreated illness

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