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Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study

Journal of Cancer Therapy 2014年第14期5卷 1438-1449页

作者： lorenzo Bruno Lucia Barni Gaia Masini Sabrina Pacciani Edvige Lucarelli Antonella Masserelli Daniela Tomcykova Filippo Melli Luca Boni Giancarlo Freschi paolo Bechi Surgery and Translational Medicine University of Florence Florence Italy Diagnostic Imaging 4 Azienda Ospedaliero-Universitaria Careggi Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

The aim of this study was to evaluate the accuracy of multiple detector computed tomography (MDCT) in the preoperative staging of gastric cancer, prospectively comparing CT findings with pathological findings at surgery, in a single-center study. A total of 19 consecutive patients with primary cancer recruited between March and July 2014 were submitted to preoperative MDCT staging according to a standard protocol. All diagnostic procedures were performed by dedicated radiologists who were unaware of the final pathological results. Subsequently, 16 patients underwent surgical treatment and 15 were finally included in the study. The primary tumor was detected at CT in all 15 cases. CT results for T staging were in agreement with pathological findings in 12 of 15 cases, with overall accuracy of 80%. Stage-specific sensibility was high for advanced stages (sensibility for T1, T3, and T4 resulted 60%, 85.7%, and 100%, respectively), while earlier stages showed higher specificity (specificity for T1, T3, and T4 resulted 100%, 75%, and 91.7%, respectively). Overall N staging accuracy was 86.7%, with 13 of 15 patients correctly staged. Stage-specific sensibility was 75% for N0 and 100% for N3, while specificity was 100% for N0 and lower for advanced stages. Accuracy for peritoneal involvement was 100%. Our findings show a good performance of the diagnostic protocol performed with MDCT tested in this study.

关键词： Gastric Cancer MDCT Staging Oncologic Imaging

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Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas

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World Journal of Clinical Oncology 2013年第2期4卷 47-51页

作者： Francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di lorenzo Francesco Longo paolo Muto Concetta Schiavone Fabio Sandomenico Francesco Caponigro Head and Neck Medical Oncology Unit National Tumor Institute of Naples80131 NaplesItaly Medical Oncology Unit Hospital of Salerno84090 SalernoItaly Medical Oncology Unit University Federico II of Naples80131 NaplesItaly Otolaryngology Unit National Tumor Institute of Naples80131 NaplesItaly Fabio Sandomenico Radiotherapy UnitNational Tumor Institute of Naples80131 NaplesItaly

AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March *** underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without *** was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days *** retrospective analysis was approved by the review boards of the participating *** gave their consent to treatment and to anonymous analysis of clinical ***:Thirty-three patients were males and 7 were *** follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,*** response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 *** 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 *** toxicity was manageable and it did not cause any significant treatment *** the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 ***:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced *** role of adjuvant chemotherapy remains

关键词： Nasopharyngeal carcinoma Induction chemotherapy Concurrent chemoradiotherapy Adjuvant chemotherapy Locally advanced disease

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Unusual Presentation of COVID-19: Encephalitis and Syndrome of Inappropriate Anti-Diuretic Hormone Secretion

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International Journal of Clinical Medicine 2020年第10期11卷 559-564页

作者： Maresca Andrea Mongiardi Christian Montalbetti lorenzo Dentali Francesco Ageno Walter Mauri Marco Baj Andreina Grandi Anna Maria Grossi paolo Dalla Gasperina Daniela Zerba Francesco Sessa Aurelio Guasti Luigina University of Insubria Varese Italy ASST-Settelaghi Varese Italy

COVID-19 is a new challenge in clinical medicine. Although typical presentations include fever and pneumonia, we describe a case of COVID-19 presenting with neurological symptoms of encephalitis and infectious-related syndrome of inappropriate anti-diuretic hormone secretion. Because of the epidemic health problems, it is crucial to identify these patients as early as possible to follow the isolation procedures. We suggest that unclear neurological clinical presentations of patients should be considered for COVID-19.

关键词： COVID-19 SARS-Cov-2 Encephalitis Syndrome of Inappropriate Anti-Diuretic Hormone Isolation Procedures

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Predictors of survival in patients with established cirrhosis and hepatocellular carcinoma treated with sorafenib

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World Journal of Gastroenterology 2014年第3期20卷 786-794页

作者： Andrea L Inghilesi Donatella Gallori lorenzo Antonuzzo paolo Forte Daniela Tomcikova Umberto Arena Stefano Colagrande Silvia Pradella Bernardo Fani Elena Gianni Luca Boni Giacomo Laffi Francesco Di Costanzo Fabio Marra Dipartimento di Medicina Sperimentale e Clinica Università degli Studi di Firenze Oncologia Medica Azienda Ospedaliero-Universitaria Careggi Gastroenterologia 2 Azienda Ospedaliero-Universitaria Careggi Centro per il Coordinamento delle Sperimentazioni Cliniche Istituto Toscano Tumoriand Azienda Ospedaliero-Universitaria Careggi Dipartimento di Scienze Biomediche Sperimentali e ClinicheUniversità degli Studi di Firenze

AIM:To investigate in greater detail the efficacy and safety of sorafenib for the treatment of hepatocellular carcinoma(HCC)in patients with established ***:From October 2009 to July 2012 patients with an established diagnosis of cirrhosis and HCC treated with sorafenib were consecutively *** to the Barcelona Clinic Liver Cancer(BCLC)classification,patients were in the advanced stage(BCLC-C)or in the intermediate stage(BCLC-B)but unfit or unresponsive to other therapeutic *** was evaluated performing a 4-phase computed tomography or magnetic resonance imaging scan every 2-3 mo,and analyzed according to the modified Response Evaluation Criteria in Solid *** was administered at 800 mg/d,until radiological progression or occurrence of unacceptable adverse events(AEs).Univariate and multivariate analyses identified predictors of 16-wk clinical benefit and overall ***:Forty-four patients were enrolled,15 had intermediate HCC and 14 a Child-Pugh score of *** caused treatment interruption in 19 patients(43%),and median treatment duration was shorter in this subset(5 wk vs 19 wk,P<0.001)and in the BCLC-C subgroup(13 wk vs 40 wk,P=0.015).No significant differences in the reason for treatment interruption or in treatment duration were found comparing patients in Child-Pugh class A vs B or in patients older or younger than 70 *** 16 wk of treatment,18 patients(41%)had stable disease or partial *** with viral infection or BCLC-C were at higher risk of disease ***,extrahepatic spread,macrovascular invasion,alpha-fetoprotein or alkaline phosphatase levels at admission were independent predictors of overall ***:In patients with cirrhosis and HCC treated with sorafenib,AEs are a common cause of early treatment *** invasion and extrahepatic spread condition early response to treatment and *** biochemical parameters may be helpful

关键词： Hepatocellular carcinoma Sorafenib Cirrhosis Adver

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BESPOKE ROMANCE展厅

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现代装饰 2020年第10期 174-177页

作者： paolo Cesaretti Marianna Cristofaro Francesca Maioli lorenzo Pennati(摄) Luca Rotondo(摄) 舒禹(编译) Claudia Astarita pc-l<paolo cesaretti Arch

本案是陶瓷材料品牌Kale Group的临时展厅,设计的灵感来自于"无限的象征",方案的主题由三个最重要的关键词"精通""设计"’‘独特"组成,进而转为实体的几何形状。代表"完美"和"耐用性"的两个合并圆圈共同形成了展厅的外观,展厅内的混合... 详细信息

本案是陶瓷材料品牌Kale Group的临时展厅,设计的灵感来自于"无限的象征",方案的主题由三个最重要的关键词"精通""设计"’‘独特"组成,进而转为实体的几何形状。代表"完美"和"耐用性"的两个合并圆圈共同形成了展厅的外观,展厅内的混合会议空间也是一大特色,它同时兼具休息室和集体工作空间的功能。

关键词：几何形状陶瓷材料展厅耐用性关键词

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Big Data Analytics for Earth Sciences:the EarthServer approach

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International Journal of Digital Earth 2016年第1期9卷 3-29页

作者： Peter Baumann paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati lorenzo Bigagli Enrico Boldrini Riccardo Bruno Antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu Antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek Marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner Large-Scale Scientific Information Systems Jacobs UniversityBremenGermany Rasdaman GmbH BremenGermany CNR-IIA National Research Council of ItalyInstitute of Atmospheric Pollution ResearchFlorenceItaly EOX IT Services GmbH ViennaAustria Consorzio COMETA CataniaItaly Division of Catania Italian National Institute for Nuclear PhysicsCataniaItaly Department of Physics and Astronomy University of CataniaCataniaItaly MEEO S.r.l. FerraraItaly Plymouth Marine Laboratory PlymouthUK Fraunhofer IGD DarmstadtGermany Athena Research and Innovation Center in Information Communication&Knowledge Technologies AthensGreece British Geological Survey EdinburghUK Software Engineering Italia S.r.l. CataniaItaly British Geological Survey KeyworthUK NASA Ames Research Center Moffett FieldCAUSA

Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced *** and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and ***,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of ***,Big Earth Data Analytics requires specifically tailored techniques and *** EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and *** result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains.

关键词： big data Big Data Analytics array databases Earth Sciences interoperability standards

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免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗

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萨勒诺海运码头

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建筑创作 2016年第6期 200-225页

作者： Vincenzo Barilari Andrea Parenti Anja Simons Giovanna Sylos Labini Cedric Libert Filippo Innocenti paolo Zilli lorenzo Grifantini Electra Mikelides Eric Tong Zaha Hadid Architects(ZHA)

关键词：萨勒 Access 船码头海运水路运输入口 Hall

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意大利地中海隼(Falco biarmicus feldeggii)繁殖种群的景观尺度空间分布

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AMBIO－人类环境杂志 2008年第6期37卷 422-426页

作者： Alessandro Andreotti Giovanni Leonardi Maurizio Sarà Massimo Brunelli lorenzo De Lisio Augusto De Sanctis Mauro Magrini Riccardo Nardi paolo Perna Antonio Sigismondi 梁虹意大利野生动物研究所(INFS) 锡耶纳大学巴勒莫大学 Romana鸟类观察与保护站(S.R.O.P.U.) 意大利卡美日诺大学阿普利亚区公园办公室

地中海隼(Falco biarmicus feldeggii)是欧洲濒危程度最高的物种之一。其全球数量估计不超过几百对,不均匀分布于西西里至里海的广阔而片断化的地区。最近统计表明,西西里地中海隼在全部种群数量中占很大比例(>25%)。因此,意大利政府提... 详细信息

地中海隼(Falco biarmicus feldeggii)是欧洲濒危程度最高的物种之一。其全球数量估计不超过几百对,不均匀分布于西西里至里海的广阔而片断化的地区。最近统计表明,西西里地中海隼在全部种群数量中占很大比例(>25%)。因此,意大利政府提出一项国家行动计划。在这一计划框架下,我们在意大利进行了首次地中海隼种群数量的全国调查(2003～2004年)。本研究的地理范围包括地中海隼的整个繁殖区,即西西里和意大利半岛(n=2909栅格单元,10km×10km)。另外,我们尽量考虑了以往(1993～2001年)区域调查的结果。我们对各个繁殖亚群的大小和分布进行评估,鉴别在景观尺度上与巢址空间分布相关的主要环境特征。在184个栅格单元(全部栅格地图的6.4%)中发现有地中海隼的存在,但同一繁殖期内地中海隼数量估计不超过140～172对(其中70～80对分布于西西里)。大陆繁殖栅格的隔离程度较高,而西西里地区的单元更为密集。海拔高度是意大利单元聚集性的主要影响因素;另外气候、降水量和植被等环境因素对此也有重要影响。本研究表明保护区内的处于繁殖期的地中海隼数量较少(23%～28%),意大利政府的保护措施还不够完善。在适于地中海隼巢址不规则空间聚集的优先性生境保护方面,多个小型、分散分布的特定保育区(SAC)优于大型特定保护区(SPA)。

关键词：繁殖种群空间分布景观尺度地中海意大利种群数量不均匀分布地理范围

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Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis

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World Journal of Gastroenterology 2013年第34期19卷 5671-5677页

作者： Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia lorenzo Gentilini Gilberto Poggioli paolo Gionchetti Massimo Campieri Fernando Rizzello Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) University of Bologna

AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were *** underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of *** patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 *** endoscopists evaluated in a blinded manner the number and size of duodenal *** GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman ***>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and *** examined area was divided into 3 segments:duodenal bulb,second and third portion *** specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular *** was classified according to the updated Vienna ***:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was *** polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was *** 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal *** mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was *** agreement was ***>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in t

关键词： Familial adenomatous polyposis Ileal pouch-anal anastomosis Duodenal polyps Eviendep

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