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Modeling of recrystallization behaviour of AA6xxx aluminum alloy during extrusion process

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Transactions of Nonferrous Metals Society of China 2024年第10期34卷 3170-3184页

作者： Marco NEGOZIO Antonio SEGATORI Riccardo PELACCIA Barbara REGGIANI Sara Di DONATO lorenzo donati University of Parma-Department of Engineering and Architecture Parco Area delle Scienze181/A43124 ParmaItaly Hydro Innovation and TechnologyMyrkärrsvägen 161231 FinspångSweden DISMI Department of Sciences and Methods for Engineering University of Modena and Reggio EmiliaVia Amendola 242122Reggio EmiliaItaly InterMech-MO.RE–University of Modena and Reggio Emilia Piazzale Europa 1Reggio Emilia 42124Italy DIN Department of Industrial Engineering–University of Bologna Viale Risorgimento 240136BolognaItaly

An innovative approach was introduced for the development of a AA6063 recrystallization *** method incorporated a regression-based technique for the determination of material constants and introduced novel equations for assessing the grain size *** and validation of this methodology involved a combination of experimentally acquired microstructural data from the extrusion of three different AA6063 profiles and results from the simulation using the Qform Extrusion UK finite element *** outcomes proved the agreement between experimental findings and numerical prediction of the microstructural *** trend of the grain size variation based on different process parameters was accurately simulated,both after dynamic and static recrystallization,with an error of less than 25% in almost the whole sampling computations.

关键词： recrystallization simulation aluminum alloy extrusion finite element method microstructure prediction

挤压过程中AA6xxx铝合金型材的再结晶行为模拟（英文）

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Transactions of Nonferrous Metals Society of China 2024年第10期 3170-3184页

作者： Marco NEGOZIO Antonio SEGATORI Riccardo PELACCIA Barbara REGGIANI Sara Di DONATO lorenzo donati University of Parma-Department of Engineering and Architecture Hydro Innovation and Technology DISMI Department of Sciences and Methods for Engineering University of Modena and Reggio Emilia InterMech-MO.RE–University of Modena and Reggio Emilia DIN Department of Industrial Engineering–University of Bologna

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extr... 详细信息

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extrusion UK有限元代码模拟的结果。结果表明，显微组织演化的实验结果与数值模拟的预测结果相吻合。该方法准确模拟了动态再结晶和静态再结晶后晶粒尺寸随不同工业参数变化的趋势，在几乎整个抽样计算中，误差都小于25%。

关键词：再结晶模拟铝合金挤压有限元法显微组织预测

Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology research 2025年第1期33卷 45-55页

作者： Enrico Caliman Sara Fancelli Federico Scolari Adriano Pasqui Clara Manneschi Daniele Lavacchi Francesca Mazzoni Francesca Gensini Valeria Pasini Camilla Eva Comin Luca Voltolini Serena Pillozzi lorenzo Antonuzzo Clinical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy. Department of Health Sciences University of Florence Florence 50134 Italy. Medical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Florence 50134 Italy. Section of Anatomic Pathology Department of Health Sciences University of Florence Florence 50139 Italy. Section of Surgery Histopathology and Molecular Pathology University of Florence Florence 50139 Italy. Thoracic Surgery Unit Careggi University Hospital Florence 50134 Italy.

Background:Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients' survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes-namely , , and -were performed on patient tumor samples.Results:Overall, elevated expression of genes was observed in SCLC patients compared to healthy controls. Patients with low and expression levels exhibited a better median progression-free survival (mPFS = 7.1 . 4.9 months, = 0.39 for and mPFS = 6.9 . 4.8 months, = 0.093 for ) and overall survival (mOS = 8.7 . 6.0 months, = 0.4 for and mOS = 7.2 . 6.2 months, = 0.13 for ). Genotyping analysis of five SNPs of genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the rs11615 SNP ( = 0.24 for PFS and = 0.14 for OS) and of the rs13181 and rs1799793 SNPs ( = 0.43 and = 0.26 for PFS and = 0.21 and = 0.16 for OS, respectively) compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： ERCC genes Nucleotide excision repair (NER) pathway Platinum-chemotherapy (CT) Single nucleotide polymorphisms (SNPs) Small cell lung cancer (SCLC)

Spectroscopic detection of forest diseases:a review(1970–2020)

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Journal of Forestry Research 2022年第1期33卷 21-38页

作者： lorenzo Cotrozzi Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8056124 PisaItaly

Sustainable forest management is essential to confront the detrimental impacts of diseases on forest *** review highlights the potential of vegetation spectroscopy in improving the feasibility of assessing forest disturbances induced by diseases in a timely and cost-effective *** basic concepts of vegetation spectroscopy and its application in phytopathology are first outlined then the literature on the topic is *** several optical sensors from leaf to landscape-level,a number of forest diseases characterized by variable pathogenic processes have been detected,identified and quantified in many country sites ***,these reviewed studies have pointed out the green and red regions of the visible spectrum,the red-edge and the early near-infrared as the spectral regions most sensitive to the disease development as they are mostly related to chlorophyll changes and symptom *** disease conditions particularly affect the shortwave-infrared region,mostly related to water *** review also highlights some major issues to be addressed such as the need to explore other major forest diseases and geographic areas,to further develop hyperspectral sensors for early detection and discrimination of forest disturbances,to improve devices for remote sensing,to implement longterm monitoring,and to advance algorithms for exploitation of spectral *** of these goals will enhance the capability of vegetation spectroscopy in early detection of forest stress and in managing forest diseases.

关键词： Forest management Plant disease detection Refectance Remote sensing Spectral imaging

Silicon nanocrystals to enable silicon photonics

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Chinese Optics Letters 2009年第4期7卷 319-324页

作者： lorenzo Pavesi Nanoscience Laboratory Department of PhysicsUniversity of Trento

Low dimensional silicon, where quantum size effects play significant roles, enables silicon with new photonic functionalities. In this short review, we discuss the way that silicon nanocrystals are produced, their optoelectronic properties and a few device applications. We demonstrate that low dimensional silicon is an optimum material for developing silicon photonics.

关键词： Nanocrystals Photonic devices

Growth associated protein 43 and neurofilament immunolabeling in the transected lumbar spinal cord of lizard indicates limited axonal regeneration

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Neural Regeneration Research 2022年第5期17卷 1034-1041页

作者： lorenzo Alibardi Comparative Histolab Padova and Department of Biology University of BolognaBolognaItaly

Previous cytological studies on the transected lumbar spinal cord of lizards have shown the presence of differentiating glial cells,few neurons and axons in the bridge region between the proximal and distal stumps of the spinal cord in some cases.A limited number of axons(20-50)can cross the bridge and re-connect the caudal stump of the spinal cord with small neurons located in the rostral stump of the spinal *** axonal regeneration appears to be related to the recovery of hind-limb movements after initial *** present study extends previous studies and shows that after transection of the lumbar spinal cord in lizards,a glial-connective tissue bridge that reconnects the rostral and caudal stumps of the interrupted spinal cord is formed at 11-34 days *** an initial paralysis some recovery of hindlimb movements occurs within 1-3 months *** and ultrastructural analysis for a growth associated protein 43(GAP-43)of 48-50 k Da shows that sparse GAP-43 positive axons are present in the proximal stump of the spinal cord but their number decreased in the bridge at 11-34 days *** immunolabeled axons with a neurofilament protein of 200-220 k Da were seen in the bridge at 11-22 days post-transection but their number increased at 34 days and 3 months post-amputation in lizards that have recovered some hindlimb *** neurons in the rostral and caudal stumps of the spinal cord were also labeled for GAP43,a cytoplasmic protein that is trans-located into their axonal growth *** indicates that GAP-43 biosynthesis is related to axonal regeneration and sprouting from neurons that were damaged by the *** together,previous studies that utilized tract-tracing technique to label the present observations confirm that a limited axonal re-connection of the transected spinal cord occurs 1-3 months post-injury in *** few regenerating-sprouting axons within the bridge reconnect

关键词： GAP-43 immunocytochemistry lizard neurofilaments regeneration spinal cord

Brain network modulation in Alzheimer’s disease:clinical phenotypes and windows of opportunity

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Neural Regeneration Research 2023年第1期18卷 115-116页

作者： lorenzo Pini Padova Neuroscience Center University of PadovaPadovaItaly

Dementia,for which there is no cure or effective treatment,is the leading cause of disability and death *** to the high global prevalence and economic impact on families,caregivers,and communities,this condition represents one of the most significant public health challenges of our *** is an umbrella term describing a range of progressive neurodegenerative diseases,including Alzheimer’s disease(AD),which is the most common cause of cognitive and functional impairment among older *** presence of misfolded protein aggregates characterizes neurodegenerative disorders(e.g.,amyloid-beta(Aβ)and tau in AD).

关键词： Alzheimer Aβ death tau

Immunodetection of ephrin receptors in the regenerating tail of the lizard Podarcis muralis suggests stimulation of differentiation and muscle segmentation

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Zoological Research 2019年第5期40卷 416-426页

作者： lorenzo Alibardi Comparative Histolab Padova and Department of Biology University of Bologna

Ephrin receptors are the most common tyrosine kinase effectors operating during development. Ephrin receptor genes are reported to be up-regulated in the regenerating tail of the Podarcis muralis lizard. Thus, in the current study, we investigated immunolocalization of ephrin receptors in the Podarcis muralis tail during regeneration. Weak immunolabelled bands for ephrin receptors were detected at 15–17 kDa, with a stronger band also detected at 60–65 kDa. Labelled cells and nuclei were seen in the basal layer of the apical wound epidermis and ependyma, two key tissues stimulating tail regeneration. Strong nuclear and cytoplasmic labelling were present in the segmental muscles of the regenerating tail, sparse blood vessels, and perichondrium of regenerating cartilage. The immunolocalization of ephrin receptors in muscle that gives rise to large portions of new tail tissue was correlated with their segmentation. This study suggests that the high localization of ephrin receptors in differentiating epidermis, ependyma, muscle, and cartilaginous cells is connected to the regulation of cell proliferation through the activation of programs for cell differentiation in the proximal regions of the regenerating tail. The lower immunolabelling of ephrin receptors in the apical blastema, where signaling proteins stimulating cell proliferation are instead present, helps maintain the continuous growth of this region.

关键词： Lizard Regenerating blastema Ephrin receptors Immunolabelling Western blotting

Human Mobility in the Sendai Framework for Disaster Risk Reduction

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International Journal of Disaster Risk Science 2016年第1期7卷 30-40页

作者： lorenzo Guadagno Department of Operations and Emergencies International Organization for Migration(IOM)

This article looks at how population movements are addressed by the Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR), and highlights some of the potential implications of the SFDRR on disaster risk reduction(DRR) and mobility management work. The article looks at the operational implications of the SFDRR text and covers issues of including migrants in DRR work;informing urban development about current and future mobility trends; managing relocations, evacuations, and displacement to prevent future risks and reduce existing ones; and preparing for and managing disaster-induced population movements to reduce the direct and indirect impacts of natural hazards. Overall, the references to human mobility within the SFDRR show an evolution in the way the issue is considered within global policy dialogues. Both the potential of population movements to produce risk and their role in strengthening the resilience of people and communities are now clearly recognized. This is an evolution of previously prevailing views of mobility as the consequence of disasters or as a driver of risk. While some implications of the DRR-mobility nexus might still be missing from DRR policy, population movements are now recognized as a key global risk dynamic.

关键词： Disaster risk reduction Displacement Human mobility Migration Relocation Sendai framework for disaster risk reduction