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Post-trans-arterial chemoembolization hepatic necrosis and biliary stenosis: Clinical charateristics and endoscopic approach

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World Journal of Clinical Cases 2023年第36期11卷 8434-8439页

作者： Silvia Cocca lorenzo carloni Margherita Marocchi Giuseppe Grande Marcello Bianchini Antonio Colecchia Rita Conigliaro Helga Bertani Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 00100Italy Department of Internal Medicine Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy

Liver cancer is the fifth most common tumor and the second highest death-related cancer in the ***(HCC)represents 90%of liver *** to the Barcelona Clinic Liver Cancer group,different treatment options could be offered to patients in consideration of tumor burden,liver function,pa-tient performance status and biochemical marker serum concentration such as ***-arterial chemoembolization(TACE)is the treatment of choice in patients with diagnosis of unresectable HCC not eligible for liver trans-plantation,and preserved arterial *** is known to be safe and its com-plications are generally mild such as post-TACE syndrome,a self-resolving adverse event that occurs in about 90%of patients after the ***,albeit rarely,more severe adverse events such as biloma,sepsis,hepatic failure,chemoagents induced toxicities,and post-TACE liver necrosis can occur.A prompt diagnosis of these clinical conditions is fundamental to prevent further *** a result,biliary stenosis could be a rare post-TACE necrosis complication and can be difficult to *** from untreated biliary strictures include recurring infections,jaundice,chronic cholestasis,and secon-dary biliary cirrhosis.

关键词： Hepatocarcinoma Trans-arterial Chemoembolization Biliary stenosis Multistenting

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Long-term survival of two patients with recurrent pancreatic acinar cell carcinoma treated with radiofrequency ablation:A case report

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World Journal of Clinical Cases 2020年第7期8卷 1241-1250页

作者： Mariacristina Di Marco Riccardo carloni Stefania De lorenzo Elisa Grassi Andrea Palloni Francesca Formica Stefano Brocchi Daria Maria Filippini Rita Golfieri Giovanni Brandi Department of Experimental Diagnosticand Specialty Medicine-DIMESSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Medical Oncology Ospedale degli InfermiFaenza 48018Italy Radiology Unit Department of Diagnostic Medicine and PreventionSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy

BACKGROUND Pancreatic acinar cell carcinoma (PACC) is a rare type of malignant pancreatic cancer that represents approximately 1%of all pancreatic *** to its very low incidence,only a few retrospective studies are *** surgery is the first choice for treatment,most patients experience recurrence(mainly in the liver) and there are no clear recommendations for patients with advanced *** SUMMARY We report two patients with PACC treated with sturgery who experienced tumour recurrence in the *** 1 carried a germline mutation in the APC *** patients were treated with gemcitabine plus oxaliplatin and gemcitabine plus capecitabine as first-and second-line therapies,*** a favoturable response to chemotherapy,the patients underwent radiofrequency ablation of the remaining liver *** patient 1,we documented a relapse in the liver after a disease-free period of 9 mo,and treatment with gemcitabine plus capecitabine was *** patient achieved a complete response,and he remains alive without evidence of disease recurrence after six *** radiofrequency ablation,patient 2 experienced disease-free survival for 21 mo,when peritoneal relapse was diagnosed and treated with *** patient achieved a stable disease state for nearly two years;nevertheless,further progressive disease was documented,and he died seven years after the first *** PACC presents different biological behaviours than pancreatic *** treatment involving local ablative therapies may be considered for PACC.

关键词： Acinar cell carcinoma Pancreas Liver metastasis Radiofrequency ablation Case report

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Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1456-1463页

作者： Mariacristina Di Marco Riccardo carloni Stefania De lorenzo Cristina Mosconi Andrea Palloni Elisa Grassi Daria Maria Filippini Angela Dalia Ricci Alessandro Rizzo Alessandro Di Federico Donatella Santini Daniela Turchetti Claudio Ricci Carlo Ingaldi Laura Alberici Francesco Minni Rita Golfieri Giovanni Brandi Riccardo Casadei Department of Experimental Diagnosticand Specialty Medicine-DIMESSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Oncology Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Radiology Unit Department of Diagnostic Medicine and PreventionSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Medical Oncology Ospedale Degli InfermiFaenza 48018Italy Pathology Unit Sant'Orsola-Malpighi HospitalBologna 40138Italy Unit of Medical Genetics Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Pancreatic Surgery Azienda Ospedaliero-Universitaria Di BolognaBologna 40138Italy Department of Internal Medicine and Surgery Alma Mater StudiorumUniversity of BolognaBologna 40138Italy

BACKGROUND Pancreatic mucinous cystadenocarcinoma(MCAC)is a rare malignancy with a poor prognosis when it presents metastases at *** to its very low incidence,there are no clear recommendations for the treatment of advanced ***(an oral PARP inhibitor)has been approved for the maintenance treatment of patients with metastatic pancreatic adenocarcinoma harbouring germline BRCA1/2 ***,we report the first case of a germline BRCA1 mutated unresectable MCAC which was effectively treated with *** SUMMARY A 41-year-old woman,without personal or family history of cancer,was diagnosed with ovarian and peritoneal metastases of *** underwent 12 cycles of gemcitabine plus oxaliplatin(GEMOX)obtaining a partial response and allowing radical *** year later,local recurrence was documented,and other 12 cycles of GEMOX were administered obtaining a complete *** years later,another local recurrence,not amenable to surgical resection,was *** started FOLFIRINOX(oxaliplatin,irinotecan,leucovorin and fluorouracil),obtaining a partial response after 8 *** the excellent response to platinum-based chemotherapy,BRCA testing was performed,and a BRCA1 germline mutation was *** was switched to maintenance olaparib due to chemotherapy-related toxicities and achieved an almost complete metabolic response,with a reduction in the diameter of the lesion,after three months of *** The current case suggests the beneficial effect of olaparib in BRCA mutated ***,further studies are required.

关键词： Mucinous cystadenocarcinoma Pancreatic cancer BRCA1 gene Olaparib Case report

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