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Advancing hepatic recompensation:Baveno VII criteria and therapeutic innovations in liver cirrhosis management

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World Journal of Gastroenterology 2024年第23期30卷 2954-2958页

作者： lorenzo Ridola Sara Del cioppo Department of Medical and Surgical Sciences and Biotechnologies Sapienza University of RomePolo PontinoRome 00185Italy

The Baveno VII criteria redefine the management of decompensated liver cirrhosis,introducing the concept of hepatic recompensation marking a significant departure from the conventional view of irreversible *** to this concept is addressing the underlying cause of cirrhosis through tailored therapies,including antivirals and lifestyle *** on alcohol,hepatitis c virus,and hepatitis B virus-related cirrhosis demonstrate the efficacy of these interventions in improving liver function and patient *** intrahepatic portosystemic shunt(TIPS)emerges as a promising intervention,effectively resolving complications of portal hypertension and facilitating ***,optimal timing and patient selection for TIPS remain *** challenges,TIPS offers renewed hope for hepatic recompensation,marking a significant advancement in cirrhosis *** research is needed to refine its implementation and maximize its *** conclusion,TIPS stands as a promising avenue for improving hepatic function and patient outcomes in decompensated liver cirrhosis within the framework of the Baveno VII criteria.

关键词： Hepatic recompensation Baveno VII Transjugular intrahepatic portosystemic shunt Portal hypertension cirrhosis Decompensation

Epidemicity indices and reproduction numbers from infectious disease data in connected human populations

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Infectious Disease Modelling 2024年第3期9卷 875-891页

作者： cristiano Trevisin lorenzo Mari Marino Gatto Andrea Rinaldo Laboratory of Ecohydrology École Polytechnique Fédérale de LausanneStation 2Lausanne1015Switzerland Dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di MilanoVia Ponzio 34/5Milano20133Italy Dipartimento di Ingegneria civile Edile e Ambientale(ICEA)Universitàdi PadovaStation 2Padova35131Italy

We focus on distinctive data-driven measures of the fate of ongoing *** relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to the maximum instantaneous growth rate of new infections,echoing concepts and tools developed to study the reactivity of *** epidemicity indices can showcase the dynamics of infections,together with commonly employed effective reproduction numbers,especially when the latter assume values less than *** particular,epidemicity evaluates the short-term reactivity to perturbations of a disease-free ***,we show that sufficient epidemicity thresholds to prevent transient epidemic outbreaks in a spatially connected setting can be estimated by generalizing existing analogues derived when spatial effects are *** specifically account for the discrete nature,in both space and time,of surveillance data of the type typically employed to estimate effective reproduction numbers that formed the bulk of the communication of the state of the cOVID-19 pandemic and its *** analyzing the effects of spatial heterogeneity on the considered prognostic indicators,we perform a short-and long-term analysis on the cOVID-19 pandemic in Italy,showing that endemic conditions were maintained throughout the duration of our simulation despite stringent control *** method provides a portfolio of prognostic indices that are essential to pinpoint the ongoing pandemic in both a qualitative and quantitative manner,as our results *** base our conclusions on extended investigations of the effects of spatial fragmentation of communities of different sizes owing to connectivity by human mobility and contact scenarios,within real geographic contexts and synthetic setups designed to test our framework.

关键词： cOVID-19 Ecological reactivity Epidemicity Reproduction numbersLeslie matrix Metapopulation Mobility

Reconstructing hourly residential electrical load profiles for Renewable Energy communities using non-intrusive machine learning techniques

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Energy and AI 2024年第1期15卷 217-235页

作者： lorenzo Giannuzzo Francesco Demetrio Minuto Daniele Salvatore Schiera Andrea Lanzini Energy center Lab Polytechnic of Turinvia Paolo Borsellino 38/1610152TurinItaly Department of Energy(DENERG) Polytechnic of TurinCorso Duca degli Abruzzi 2410129TurinItaly

The successful implementation of Renewable Energy communities(REcs)involves maximizing the self-consumption within a community,particularly in regulatory contexts in which shared energy is *** many countries,the absence of a metering infrastructure that provides data at an hourly or sub-hourly resolution level for low-voltage users(e.g.,residential and commercial users)makes the design of a new energy community a challenging *** study proposes a non-intrusive machine learning methodology that can be used to generate residential electrical consumption profiles at an hourly resolution level using only monthly consumption data(i.e.,billed energy),with the aim of estimating the energy shared by *** proposed methodology involves three phases:first,identifying the typical load patterns of residential users through k-Means clustering,then implementing a Random Forest algorithm,based on monthly energy bills,to identify typical load patterns and,finally,reconstructing the hourly electrical load profile through a data-driven rescaling *** effectiveness of the proposed methodology has been evaluated through an REc case study composed by 37 residential users powered by a 70 kWp photovoltaic *** Normalized Mean Absolute Error(NMAE)and the Normalized Root Mean Squared Error(NRMSE)were evaluated over an entire year and whenever the energy was shared within the *** Relative Absolute Error was also measured when estimating the shared energy at both a monthly(MRAE)and at an annual basis.(RAE).A comparison between the REc load profile reconstructed using the proposed methodology and the real load profile yielded an overall NMAE of 20.04%,an NRMSE of 26.17%,and errors of 18.34%and 23.87%during shared energy timeframes,***,our model delivered relative absolute errors for the estimation of the shared energy at a monthly and annual scale of 8.31%and 0.12%,respectively.

关键词： Renewable Energy community Load profiling Non-intrusive machine learning Data-driven models Data analytics Shared energy estimation

Pull the fuzes:Processing protein precursors to generate apoplastic danger signals for triggering plant immunity

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Plant communications 2024年第8期5卷 113-136页

作者： Daniele Del corpo Daniele coculo Marco Greco Giulia De lorenzo Vincenzo Lionetti Department of Biology and Biotechnology“charles Darwin ”Sapienza University of RomeRomeItaly

The apoplast is one of the first cellular compartments outside the plasma membrane encountered by phytopathogenic microbes in the early stages of plant tissue *** have developed sophisticated surveillance mechanisms to sense danger events at the cell surface and promptly activate ***,a fine tuning of the activation of immune pathways is necessary to mount a robust and effective defense *** endogenous proteins and enzymes are synthesized as inactive precursors,and their post-translational processing has emerged as a critical mechanism for triggering alarms in the *** this review,we focus on the precursors of phytocytokines,cell wall remodeling enzymes,and *** physiological events that convert inactive precursors into immunomodulatory active peptides or enzymes are *** review also explores the functional synergies among phytocytokines,cell wall damage-associated molecular patterns,and remodeling,highlighting their roles in boosting extracellular immunity and reinforcing defenses against pests.

关键词： apoplast immunity activation post-translational processing cell wall proteases pro-peptides proenzymes phytocytokines cell-wall remodeling enzymes phytopathogenic microbes plant immunity

Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures

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Neural Regeneration Research 2024年第6期19卷 1199-1200页

作者： Francesco Margiotta lorenzo Di cesare Mannelli Antonino Morabito carla Ghelardini Elena Lucarini Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBAUniversity of FlorenceFlorenceItaly Meyer children’s Hospital IRccS FlorenceItaly

Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20%of the global population(Grundy et al.,2019).current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects,hence the need to identify novel molecular and cellular targets for drug development.

关键词： pain visceral colon

Emergingγ-soft-like spectrum in^(196)Pt in the SU3-IBM(Ⅰ)

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chinese Physics c 2024年第9期48卷 150-163页

作者： Tao Wang Bing-cheng He chun-Xiao Zhou Dong-Kang Li lorenzo Fortunato college of Physics Tonghua Normal UniversityTonghua 134000China Physics Division Argonne National LaboratoryLemontIllinois 60439USA college of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China Dipartimento di Fisica e Astronomia"G.Galilei"-Universitàdi Padova via Marzolo 8I-35131 PadovaItaly INFN-Sez.di Padova via Marzolo 8I-35131 PadovaItaly

Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic *** a previous study,γ-softness with degeneracy of the ground and quasi-y bands was *** this paper,another special point connected to the middle degenerate point is *** is found to be related to the properties of^(196)*** emergentγ-softness is also shown to be important for understanding the prolate-oblate asymmetric shape phase *** low-lying spectra,B(E2)values,and quadrupole moments in^(196)Pt are discussed,and we show that the new model can account for several observed *** is the first part of the discussion on theγ-soft-like spectrum of^(196)Pt.

关键词： SU3-IBM ^(196)Pt γ-soft-like spectrum

Lithium-Metal Free Sulfur Battery Based on Waste Biomass Anode and Nano-Sized Li_(2)S cathode

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Energy & Environmental Materials 2024年第2期7卷 39-47页

作者： Pejman Salimi Eleonora Venezia Somayeh Taghavi Sebastiano Tieuli lorenzo carbone Mirko Prato Michela Signoretto Jianfeng Qiu Remo Proietti Zaccaria Istituto Italiano di Tecnologia via Morego 30Genoa 16163Italy Department of chemistry and Industrial chemistry University of Genovavia Dodecaneso 311-16146Genoa Italy cATMAT Lab Department of Molecular Sciences and NanosystemsCa'Foscari University Venice and INSTM ConsortiumRU of VeniceVia Torino 15530172Venezia Mestre Italy Department of Physics Shaoxing UniversityShaoxing 312000China

The realization of a stable lithium-metal free(LiMF)sulfur battery based on amorphous carbon anode and lithium sulfide(Li_(2)S)cathode is here *** particular,a biomass waste originating full-cell combining a carbonized brewer's spent grain(cBSG)biochar anode with a Li_(2)S-graphene composite cathode(Li_(2)S70Gr30)is *** design is particularly attractive for applying a cost-effective,high performance,environment friendly,and safe anode material,as an alternative to standard graphite and metallic lithium in emerging battery *** anodic and cathodic materials are characterized in terms of structure,morphology and composition through X-ray diffraction,scanning and transmission electron microscopy,X-ray photoelectron and Raman ***,an electrochemical characterization comprising galvanostatic cycling,rate capability and cyclic voltammetry tests were carried out both in half-cell and full-cell *** systematic investigation reveals that unlike graphite,the biochar electrode displays good compatibility with the electrolyte typically employed in sulfur *** cBSG/Li_(2)S70Gr30 full-cell demonstrates an initial charge and discharge capacities of 726 and 537 mAh g^(-1),respectively,at 0.05c with a coulombic efficiency of 74%.Moreover,it discloses a reversible capacity of 330 mAh g^(-1)(0.1 c)after over 300 *** on these achievements,the cBSG/Li_(2)S70Gr30 battery system can be considered as a promising energy storage solution for electric vehicles(EVs),especially when taking into account its easy scalability to an industrial level.

关键词： biochars ether-based electrolytes lithium sulfide lithium-metal free batteries superior cycling stability

Sphincteroplasty for anal incontinence

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Gastroenterology Report 2014年第2期2卷 92-97页

作者： lorenzo carlo pescatori Mario pescatori coloproctology Unit Parioli ClinicRomeItaly

Sphincteroplasty(SP)is the operation most frequently performed in patients suffering from moderate-to-severe anal incontinence(AI)who do not respond to conservative *** costly surgeries,such as artificial bowel sphincter(ABS)and electro-stimulated graciloplasty,have been more or less abandoned due to their high morbidity *** invasive procedures are widely used,such as sacral neuromodulation and injection of bulking agents,but both are costly and the latter may cure only mild *** early outcome of SP is usually good if the sphincters are not markedly denervated,but its effect diminishes over *** is more often performed for post-traumatic than for idiopathic *** may also be associated to the Altemeier procedure,aimed at reducing the recurrence rate of rectal prolapse,and may be useful when AI is due either to injury to the sphincter,or to a narrowed rectum following the procedure for prolapse and haemorrhoids(PPH)and stapled transanal rectal resection(STARR).The outcome of SP is likely to be improved with biological meshes and post-operative pelvic floor *** is more effective in males than in multiparous women,whose sphincters are often denervated,and its post-operative morbidity is *** conclusion,SP,being both low-cost and safe,remains a good option in the treatment of selected patients with AI.

关键词： anal incontinence sphincteroplasty sphincter plication pelvic floor repair

Vertebroplasty and delayed subdural cauda equina hematoma: Review of literature and case report

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World Journal of clinical cases 2017年第8期5卷 333-339页

作者： Maria Pia Tropeano Biagia La Pira lorenzo pescatori Manolo Piccirilli Department of Neurology and Psichiatry-Neurosurgery Policlinico Umberto I-Sapienza University of Rome

Vertebroplasy is considered an alternative and effective treatment of painful oncologic spine disease. Major complications are very rare, but with high morbidity and occur in less than 1% of patients who undergo vertebroplasty. Spinal subdural hematoma(SDH) is an extremely rare complication, usual developing within 12 h to 24 h after the procedure. We report the case of a tardive SDH in an oncologic patient who underwent VP for Myxoid Liposarcoma metastasis. Trying to explain the pathogenesis, we support the hypothesis that both venous congestion of the vertebral venous plexus of the vertebral body and venous congestion due to a traumatic injury can provoke SDH. To our best knowledge, only 4 cases of spinal subdural hematoma following a transpedicular vertebroplasty have been previously described in International literature and only one of them occurred two weeks after that surgical procedures. Percutaneous verteboplasty is a wellknown treatment of pain oncologic spine disease, used to provide pain relief and improvement of quality life and is considered a simple surgical procedure, involving a low risk of complications, but related to high morbidity, such as SDH. Therefore it has to be performed by experienced and skilled surgeons, that should also recognize possible risk factors, making SDH more risky.

关键词： Subdural hematoma Liposarcoma Surgery Radiotherapy Vertebroplasty