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Robot-assisted laparoscopic vs open gastrectomy for gastric cancer:Systematic review and meta-analysis

World Journal of Clinical Oncology 2017年第3期8卷 273-284页

作者： Stefano Caruso Alberto Patriti franco Roviello lorenzo de franco franco Franceschini Graziano Ceccarelli Andrea Coratti department of General Surgery and Surgical Specialties Unit of General Surgery"Santa Maria Annunziata" HospitalLocal Health Unit Center Tuscany Company department of Surgery Division of General SurgeryHospitals of Pesaro and Fano"Ospedali Riuniti Marche Nord" Hospital Company department of Medical Surgical and NeuroscienceUnit of General and Minimally Invasive SurgeryUniversity of Siena department of Medicine and General Surgery Unit of Minimally Invasive and General SurgeryLocal health Unit South-Est Tuscany Company"San Donato" Hospital Division of Oncological and Robotic General Surgery "Careggi" University Hospital

AIM To evaluate the potential effectiveness of robot-assisted gastrectomy(RAG) in comparison to open gastrectomy(OG) for gastric cancer *** A comprehensive systematic literature search using PubM ed,EMBASE,and the Cochrane Library was carried out to identify studies comparing RAG and OG in gastric *** of any age and sex were considered for inclusion in comparative studies of the two techniques independently from type of gastrectomy.A meta-analysis of short-term perioperative outcomes was performed to evaluate whether RAG is equivalent to *** primary outcome measures were set for estimated blood loss,operative time,conversion rate,morbidity,and hospital *** among postoperative complications,wound infection,bleeding and anastomotic leakage were also *** A total of 6 articles,5 retrospective and 1 randomized controlled study,involving 6123 patients overall,with 689(11.3%) cases submitted to RAG and 5434(88.7%) to OG,satisfied the eligibility criteria and were included in the *** was associated with longer operation time than OG(weighted mean difference 72.20 min;P des were found(weighted mean difference-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid alternative to OG for performing radical gastrectomy in gastric cancer resulting in safe complications.

关键词： Robot-assisted gastrectomy Gastric resection Open gastrectomy Gastric cancer

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Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations

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World Journal of Gastroenterology 2016年第25期22卷 5694-5717页

作者： Stefano Caruso Alberto Patriti franco Roviello lorenzo de franco franco Franceschini Andrea Coratti Graziano Ceccarelli department of General Surgery and Surgical Specialties Unit of General Surgery 'Santa Maria Annunziata' Hospital ASL Firenze 50012 Florence Italy department of Surgery General Minimally Invasive and Robotic Surgery 'San Matteo degli Infermi' Hospital 06049 Spoleto (PG) Italy department of Medical Surgical and Neuroscience/ Unit of General and Minimally Invasive Surgery University of Siena 53100 Siena Italy Division of Oncological and Robotic General Surgery 'Careggi' University Hospital 50134 Florence Italy department of Medicine and General Surgery Unit of Minimally Invasive and General Surgery ASL8 Arezzo 'San Donato' Hospital 52100 Arezzo Italy

Radical gastrectomy with an adequate lymph-adenectomy is the main procedure which makes it possible to cure patients with resectable gastric cancer(GC). A number of randomized controlled trials and meta-analysis provide phase Ⅲ evidence that laparoscopic gastrectomy is technically safe and that it yields better short-term outcomes than conventional open gastrectomy for early-stage GC. While laparoscopic gastrectomy has become standard therapy for early-stage GC, especially in Asian countries such as Japan and South Korea, the use of minimally invasive techniques is still controversial for the treatment of more advanced tumours, principally due to existing concerns about its oncological adequacy and capacity to carry out an adequately extended lymphadenectomy. Some intrinsic drawbacks of the conventional laparoscopic technique have prevented the worldwide spread of laparoscopic gastrectomyfor cancer and, despite technological advances in recent year, it remains a technically challenging procedure. The introduction of robotic surgery over the last ten years has implied a notable mutation of certain minimally invasive procedures, making it possible to overcome some limitations of the traditional laparoscopic technique. Robot-assisted gastric resection with D2 lymph node dissection has been shown to be safe and feasible in prospective and retrospective studies. However, to date there are no high quality comparative studies investigating the advantages of a robotic approach to GC over traditional laparoscopic and open gastrectomy. On the basis of the literature review here presented, robot-assisted surgery seems to fulfill oncologic criteria for D2 dissection and has a comparable oncologic outcome to traditional laparoscopic and open procedure. Robot-assisted gastrectomy was associated with the trend toward a shorter hospital stay with a comparable morbidity of conventional laparoscopic and open gastrectomy, but randomized clinical trials and longer follow-ups are needed

关键词： Gastric cancer Gastric resection Minimally invasive surgery Laparoscopic gastrectomy Robotassisted g

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Effect of the Inclusion of Chestnut in the Finishing Diet on Volatile Compounds of Dry-Cured Ham from Celta Pig Breed

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Journal of Integrative Agriculture 2013年第11期12卷 2002-2012页

作者： José M lorenzo Javier Carballo Daniel franco Centro Tecnológico de la Carne de Galicia Rúa Galicia No 4Parque Tecnológico de GaliciaSan Cibrán das Vias rea de Tecnología de los Alimentos Facultad de Ciencias de OurenseUniversidad de Vigo

The effect of the inclusion of chestnut in pigs ifnishing diet on volatile compounds of dry-cured Celta ham was studied. Twelve hams of each type （from three different pigs ifnishing diets：concentrate （CO）, mixed （MI） and chestnut （CH）） were used. Volatiles were extracted using a purge-and-trap method and analyzed by gas chromatography/mass spectrometry （GC/MS）. Thirty-nine volatile compounds were identified in dry-cured Celta ham samples. Most abundant volatiles in ham samples were aldehydes, which represented respectively, 53% （CO）, 51% （MI） and 46% （CH） of the total volatile composition. With the exception of 2-butenal, 2-methyl, all aldehydes were affected by feeding system. On the other hand, hydrocarbons n-alkanes were the second major group in the volatile proifle of dry-cured Celta hams and represented 28.9, 35.7 and 32.4%of the total volatile composition for CO, MI and CH groups, respectively. Ham samples from chestnut group showed a higher content of alcohols and this result could be related with the inclusion of chestnut in the ifnishing diet of pigs. Principal component analysis showed a good separation among groups. The discriminant analysis selected eight variables （butanoic acid, hexanal, octanal, nonenal （E）, decenal （E）, tetradecane, decane trimethyl and pyridine 2-methyl） and calculated two discriminating functions to predict if chestnut has been included in the ifnishing diet. Thus, it was possible to discriminate between groups fed with ifnishing diets containing chestnuts in their composition （mixed and chestnut group）.

关键词： dry-cured ham chestnut volatile compound finishing diet discriminant analysis

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Vertical stratification of ichneumonid wasp communities： the effects of forest structure and life-history traits

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Insect Science 2015年第5期22卷 688-699页

作者： Filippo Di Giovanni Pierfilippo Cerretti franco Mason Emma Minari lorenzo Marini Dipartimento di Biologia e Biotecnologie 'Charles Darwin' Universita di Roma 'La Sapienza' Piazzale A. Moro 5 00185 Rome Italy Centro Nazionale per lo Studio e la Conservazione della Biodiversita Forestale Corpo Forestale dello Stato via Carlo Ederle 161A 37100 Verona Italy and DAFNAE Universit& di Padova viale dell'Universita 16 35020 Legnaro Padua Italy

Parasitoid wasp communities of the canopy of temperate forests are still largely unexplored. Very little is known about the community composition ofparasitoids between canopy and understory and how much of this difference is related to forest structure or parasitoid biological strategies. In this study we investigated upon the difference in the community composition of the parasitic wasps Ichneumonidae between canopy and understory in a lowland temperate forest in northern Italy. We used general linear models to test whether parasitic strategy modifies species vertical stratification and the effect of forest structure. We also tested differences in β-diversity between canopy and understory traps and over time within single forest layers. We found that stand basal area was positively related to species richness, suggesting that the presence of mature trees can influence local wasp diversity, providing a higher number of microhabitats and hosts. The ichneumonid community of the canopy was different from that of the understory, and theβ-diversity analysis showed higher values for the canopy, due to a higher degree of species turnover between traps. In our analyses, the vertical stratification was different between groups of ichneumonids sharing different parasitic strategies. Idiobiont parasitoids of weakly or deeply concealed hosts were more diverse in the understory than in the canopy while parasitoids of spiders were equally distributed between the two layers. Even though the ichneumonid community was not particularly species-rich in the canopy of the temperate forests, the extension of sampling to that habitat significantly increased the number of species recorded.

关键词： β-diversity biological traits canopy forest structure Ichneumonidae vertical stratification

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Impact of a colorectal cancer screening program implantation on delays and prognosis of non-screening detected colorectal cancer

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World Journal of Gastroenterology 2021年第39期27卷 6689-6700页

作者： Joaquin Cubiella María lorenzo franco Baiocchi Coral Tejido Alejandro Conde María Sande-Meijide Margarita Castro department of Gastroenterology Complexo Hospitalario Universitario de OurenseOurense 32005OrenseSpain department of Preventive Medicine Complexo Hospitalario Universitario de OurenseOurense 32003OrenseSpain department of Gastroenterology Hospital del BierzoPonferrada 24404LeonSpain Dirección Xeral de Saúde Pública Conselleria de SanidadeSantiago de Compostela 15703Spain

BACKGROUND The implementation of a colorectal cancer(CRC)screening programme may increase the awareness of Primary Care Physicians,reduce the diagnostic delay in CRC detected outside the scope of the screening programme and thus improve *** To determine the effect of implementation of a CRC screening programme on diagnostic delays and prognosis of CRC detected outside the scope of a screening *** We performed a retrospective intervention study with a pre-post *** identified 322 patients with incident and confirmed CRC in the pre-implantation cohort(June 2014–May 2015)and 285 in the post-implantation cohort(June 2017-May 2018)in the Cancer Registry detected outside the scope of a CRC screening *** each patient we calculated the different healthcare diagnostics delays:global,primary and secondary healthcare,referral and colonoscopyrelated *** addition,we collected the initial healthcare that evaluated the patient,the home location(urban/rural),and the CRC stage at *** determined the two-year survival and we performed a multivariate proportional hazard regression analysis to determine the variables associated with *** We did not detect any differences in the patient or CRC baseline-related variables.A total of 20.1%of patients was detected with metastatic *** was a significant increase in direct referral to colonoscopy from primary healthcare(25.5%,35.8%;P=0.04)in the post-implantation *** delay was reduced by 24 d(106.64±148.84 days,82.84±109.31 d;P=0.02)due to the reduction in secondary healthcare delay(46.01±111.65 d;29.20±60.83 d;P=0.02).However,we did not find any differences in CRC stage at diagnosis or in two-year survival(70.3%;P=0.9).Variables independently associated with twoyear risk of death were age(Hazard Ratio-HR:1.06,95%CI:1.04-1.07),CRC stage(II HR:2.17,95%CI:1.07-4.40;III HR:3.07,95%CI:1.56-6.08;IV HR:19.22,95%CI:9.86-37.44;unknown HR:9.24,95%CI:4.27-19.99),init

关键词： Colorectal cancer Population based screening Primary healthcare Diagnostic delay Prognosis

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Transcatheter mitral valve repair in nonagenarians

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Journal of Geriatric Cardiology 2022年第1期19卷 90-94页

作者： Pedro Luis Cepas-Guillén Isaac Pascual Eulogio Garcia Pilar Jimenez-Quevedo Alfonso Jurado-Roman Tomás Benito-González Rodrigo Estevez-Loureiro Pedro Li Dabit Arzamendi Bruno Melica Eduardo Infante de Oliveira Pedro Martín lorenzo Felipe Fernández-Vázquez Guillermo Galeote Luis Nombela-franco Leire Unzue Pablo Avanzas Manel Sabate Xavier Freixa Cardiology department Cardiovascular Institute(ICCV)Hospital ClinicIDIBAPSUniversity of BarcelonaBarcelonaSpain Interventional Cardiology Unit Hospital Universitario Central de AsturiasDepartment of MedicineUniversity of OviedoOviedoSpain Servicio de Hemodinámica y Cardiología Intervencionista HM CIEC-Centro Integral de Enfermedades CardiovascularesHospital Universitario HM MontepríncipeHM HospitalesMadridSpain Facultad de Medicina Universidad CEU San PabloMadridSpain Cardiology department Cardiovascular InstituteHospital Clínico San CarlosIdISSCMadridSpain Division of Interventional Cardiology University Hospital La PazIdiPAZCIBER-CVMadridSpain department of Cardiology University Hospital of LeónLeónSpain Interventional Cardiology Unit HospitalÁlvaro CunqueiroVigoSpain Interventional Cardiology Unit Hospital Sant Pau i Santa CreuBarcelonaSpain Serviço de Cardiologia Centro Hospitalar de Vila Nova de Gaia/Espinho-EPEVila Nova de GaiaPortugal Serviço de Cardiologia Hospital de Santa MariaCentro Hospitalar Lisboa NorteCentro Académico Médico de LisboaLisboaPortugal Servicio de Cardiología Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran CanariaSpain

Given the increase in life expectancy indeveloped countries,nonagenarian population will become clinically and numerically relevant in our daily routine practice in the near *** has been observed to exert a profound influence on the prevalence of severe mitral regurgitation (MR) in the population.[1]Mitral valve surgery remains the gold standard of care for patients with symptomatic severe MR.

关键词： mitral routine surgery

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Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel Manuel Méndez-Bailón JoséPérez-Silvestre JoséMaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-franco Alicia Conde-Martel Sara Carrascosa-García Marta Sánchez-Marteles JoséManuel Cerqueiro-González Noel lorenzo-Villalba Manuel Montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

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From Monoculture to Norfolk System: How the Number of Crops in Rotation Can Influence the Biodiversity of Arbuscular Mycorrhiza Assemblages in the Soil

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Open Journal of Ecology 2014年第17期4卷 1080-1088页

作者： franco Magurno Zita Sasvári lorenzo Barchi Katalin Posta Microbiology and Environmental Toxicology Group Institute of Plant Protection Szent István University Godollo Hungary DISAFA (Dipartimento di Scienze Agrarie Forestali e Alimentari) Plant Genetics and Breeding University of Torino Torino Italy

Given the attention drawn since several decades by arbuscular mycorrhizal fungi (AMF) as potential biological alternatives to chemicals in a low-input agriculture, much effort has been spent in the investigation of mechanisms influencing the dynamics inside AMF communities. In the present study we evaluated the influence of different crop rotations on the AMF soil community, after a 50 y long-term field experiment established at Martonvásár, Hungary. Four types of crop rotation were chosen for sampling: corn monocropping, corn-alfalfa, corn-wheat, and corn-spring barley-peas-wheat. Community composition of AMF in soil was analyzed with a molecular approach amplifying a portion of 28S rDNA. The crop rotation practice didn’t show an influence on identity of the species composing AMF assemblages, but on the other hand seemed to affect positively the true diversity, defined as number of MOTUs present in the communities.

关键词： Arbuscular Mycorrhizal Fungi Soil Diversity Crop Rotation

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Gastric cancer, Helicobacter pylori infection and other risk factors

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 342-347页

作者： lorenzo Fuccio Leonardo Henry Eusebi franco Bazzoli department of Internal Medicine and Gastroenterology University of Bologna

Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identif ied for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The def inition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients.

关键词： Helicobacter pylori Eradication treatment Diet Gastric cancer

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Intestinal ischemic manifestations of SARS-CoV-2:Results from the ABDOCOVID multicentre study

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World Journal of Gastroenterology 2021年第32期27卷 5448-5459页

作者： lorenzo Norsa Pietro Andrea Bonaffini Maja Caldato Cristiana Bonifacio Aurelio Sonzogni Amedeo Indriolo Clarissa Valle Federica Furfaro Alice Bonanomi Paolo Niccolòfranco Mauro Gori Veronica Smania Lucia Scaramella Laura Forzenigo Maurizio Vecchi Monica Solbiati Giorgio Costantino Silvio Danese lorenzo D'Antiga Sandro Sironi Luca Elli department of Pediatric Gastroenterology Hepatology and Transplantation ASST Papa Giovanni XXIIIBergamo 24127Italy department of Radiology Papa Giovanni XXIII Bergamo University of Milano-BicoccaMilan 20126Italy Fondazione IRCCS Ca’Granda Department of Emergency MedicineOspedale Maggiore PoliclinicoMilano 20122Italy department of Radiology Humanitas Clinical and Research CenterIRCCSRozzano 20089Italy department of Pathology ASST Papa Giovanni XXIIIBergamo 24127Italy department of Gastroenterology and Endoscopy ASST Papa Giovanni XXIIIBergamo 24127Italy IBD Center Humanitas Clinical and Research Center IRCCSHumanitas UniversityRozzano 20089Italy Post-Graduate School of Diagnostic Radiology University of Milano-BicoccaMilano 20126Italy Cardiovascular department ASST Papa Giovanni XXIIIBergamo 24127Italy department of Gastroenterology and Endoscopy Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilano 20122Italy department of Pathophysiology and Transplantation University of MilanMilano 20122Italy department of Radiology Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilano 20122Italy Fondazione IRCCS Ca’Granda Department of Emergency MedicineOspedale Maggiore PoliclinicoDepartment of Clinical Sciences and Community HealthUniversity of MilanMilano 20122Italy

BACKGROUND Intestinal ischemia has been described in case reports of patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)disease(coronavirus disease 19,COVID-19).AIM To define the clinical and histological,characteristics,as well as the outcome of ischemic gastrointestinal manifestations of SARS-CoV-2 *** A structured retrospective collection was promoted among three tertiary referral centres during the first wave of the pandemic in northern ***,radiological,endoscopic and histological data of patients hospitalized for COVID-19 between March 1st and May 30th were *** diagnosis was established by consecutive analysis of all abdominal computed tomography(CT)scans *** Among 2929 patients,21(0.7%)showed gastrointestinal ischemic manifestations either as presenting symptom or during *** CT showed bowel distention in 6 patients while signs of colitis/enteritis in *** patients presented thrombosis of main abdominal ***,when feasible,confirmed the diagnosis(6 patients).Surgical resection was necessary in 4/21 *** tissue examination showed distinctive features of endothelial inflammation in the small bowel and *** hospital stay was 9 d with a mortality rate of 39%.CONCLUSION Gastrointestinal ischemia represents a rare manifestation of COVID-19.A high index of suspicion should lead to investigate this complication by CT scan,in the attempt to reduce its high mortality *** shows atypical feature of ischemia with important endotheliitis,probably linked to thrombotic microangiopathies.

关键词： Coronavirus COVID-19 Ischemic colitis Small bowel ischemia Endothelial inflammation

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