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持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用

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中华高血压杂志 2016年第11期24卷 1083-1085页

作者： McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen g Du B McArdle N Mukherjee S Tripathi M Billot L Li Q lorenzi-filho g Barbe F Redline S Wang J Arima H Neal B White DP grunstein RR Zhong N Anderson CS 练桂丽叶鹏机构不详

阻塞性睡眠呼吸暂停（obstructive sleep apnea,OSA）导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,... 详细信息

阻塞性睡眠呼吸暂停（obstructive sleep apnea,OSA）导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。

关键词：心血管事件 CPAP 胸内负压正常血压炎症指标随机对照试验队列研究交感神经系统终点事件心血管病

系统性高血压患者中阻塞性睡眠呼吸暂停的特征及临床预测

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中华高血压杂志 2010年第9期18卷 899-899页

作者：张玲玉叶鹏 Drager LF genta PR Pedrosa RP Nerbass FB gonzaga CC Krieger EM lorenzi filho g

阻塞性睡眠呼吸暂停(obstructive sleep apnea hyponea,OSA)是高血压发生的一个次要原因,与高血压患者的靶器官损害独立相关。然而,0SA仍然在很大程度上未被诊断和缺乏足够的治疗。本研究是在连续随访的高血压患者中评估OSA的特征及临... 详细信息

阻塞性睡眠呼吸暂停(obstructive sleep apnea hyponea,OSA)是高血压发生的一个次要原因,与高血压患者的靶器官损害独立相关。然而,0SA仍然在很大程度上未被诊断和缺乏足够的治疗。本研究是在连续随访的高血压患者中评估OSA的特征及临床预测指标,总共99例患者[年龄(46±11)岁,[第一段]

关键词：阻塞性睡眠呼吸暂停高血压患者临床预测指标系统靶器官损害 OSA

老化、糖尿病和高血压与鼻腔黏液纤毛清除功能下降有关

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中华高血压杂志 2013年第6期21卷 599-599页

作者： de Oliveira-Maul JP de Carvalho HB Miyuki goto D Mendona Maia R Fló C Barnabé V Franco DR Benabou S Rodrigues Perracini M Jacob-filho W Nascimento Saldiva PH lorenzi-filho g Rubin BK Kondo Nakagawa N 刘莉叶鹏

该研究组以往的研究结果表明老年危重症患者鼻黏液纤毛清除功能下降，他们大部分都患有糖尿病和（或）高血压。为了确定上述改变是否与老化、疾病或危重症有关，研究人员对在门诊就诊的青年人和老年人、健康人群、糖尿病和（或）高血压... 详细信息

该研究组以往的研究结果表明老年危重症患者鼻黏液纤毛清除功能下降，他们大部分都患有糖尿病和（或）高血压。为了确定上述改变是否与老化、疾病或危重症有关，研究人员对在门诊就诊的青年人和老年人、健康人群、糖尿病和（或）高血压患者的鼻腔黏液纤毛清除功能以及黏液性质进行研究。方法：纳入研究对象252名，

关键词：纤毛清除功能高血压患者糖尿病黏液鼻腔老化危重症患者门诊就诊

Evaluation of HPV Molecular Tests in Primary Screening for Cervical Cancer in Brazil

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Open Journal of Obstetrics and gynecology 2014年第8期4卷 470-478页

作者： José E.Levi Adhemar Longatto-filho José Eluf-Neto Célia L.Rodrigues Cristina M.Oliveira Adriana C.Carloni Adriana T.lorenzi Maricy Tacla José H.Fregnani Alexandre M.Ab’Saber Cristovam Scapulatempo Luisa LVilla National Institute of Science and Technology for the Diseases Associated to Papillomaviruses(INCT-HPV) Sao PauloBrazil Virology Lab Tropical Medicine InstituteUniversidade de Sao PauloSao PauloBrazil Laboratory of Medical Investigation(LIM)14 Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil ICVS/3B’s-PT government Associate Laboratory Life and Health Sciences Research Institute(ICVS)School of Health SciencesUniversity of MinhoBragaPortugal Molecular Oncology Research Center Pio XII FoundationBarretosBrazil Department of Preventive Medicine Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Infectious Diseases Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of ginecology and Obstetrics Faculdade de MedicinaUniversidade de São PauloSao PauloBrazil Center for the Researcher Support Pio XII FoundationBarretos Cancer HospitalBarretosBrazil Department of Pathology Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Radiology Center on Translational Oncology InvestigationSao Paulo State Cancer InstituteFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Santa Casa de Sao Paulo Medical School Sao PauloBrazil

Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed. Objectives: To conduct an evaluation of commercially available molecular HPV tests in Brazilian women. Study design: Two groups were recruited: group A was composed of 511 women referred to the clinics because of a previous abnormal Pap test while group B consisted of 2464 subjects under routine screening. Cervical samples were collected using SurePath liquid cytology (LBC) device, and split into aliquots which were submitted to molecular testing by Hybrid Capture and cobas HPV. Colposcopy and biopsies were made according to the standard guidelines, directed by cytological diagnosis. Results: Prevalence of HSIL was 5.97% and 0.7% in group A and B respectively. High-Risk HPV DNA was found in about 9% of group B women, while in group A this frequency was 24%. Having CIN3+ as the study end-point, the negative predictive values for molecular methods were above 99.8%. All “in-situ” and invasive cervical carcinomas were detected by both HPV nucleic acid assays. Conclusion: Use of HPV DNA testing was feasible and highly sensitive in cancer screening settings of Brazil.

关键词： High-Risk HPV Test HPV-DNA Cervical Cancer Screening