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Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration

Regenerative Biomaterials 2023年第1期10卷 1248-1260页

作者： Rinat Nigmatullin Caroline STaylor Pooja Basnett Barbara Lukasiewicz Alexandra Paxinou lorena rlizarraga-valderrama John WHaycock Ipsita Roy Higher Steaks Ltd. 25 Cambridge Science Park RdMiltonCambridge CB40FWUK School of Life Sciences College of Liberal Arts and SciencesUniversity of WestminsterLondon W1B 2HWUK Department of Materials Science&and Engineering The University of SheffieldSheffield S37HQUK Foundation of Research and Technology Hellas Institute of Chemical Engineering and High Temperature Chemical Processes(FORTH/ICE-HT)P.O.Box 1414GR 26504RionPatrasGreece School of Life Sciences Queen’s Medical CentreUniversity of NottinghamNottingham NG72UHUK

Polyhydroxyalkanoates are natural,biodegradable,thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue *** describe a comparative evaluation of three medium chain length polyhydroxyalkanoates(mcl-PHAs),namely poly(3-hydroxyoctanoate),poly(3-hydroxyoctanoate-co-3-hydoxydecanoate)and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate),one short chain length polyhydroxyalkanoate,poly(3-hydroxybutyrate),P(3HB)and synthetic aliphatic polyesters(polycaprolactone and polylactide)with a specific focus on nerve regeneration,due to mechanical properties of mcl-PHAs closely matching nerve *** vitro biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell *** mcl-PHAs supported cell adhesion and *** the three mcl-PHAs,P(3HO-co-3HD)exhibited superior properties with regards to numbers of cells adhered and viable cells for both cell types,number of neurite extensions from NG108-15 cells,average length of neurite extensions and Schwann ***,similar characteristics were observed for flat P(3HB)surfaces,high rigidity of this biomaterial,and FDA-approved polymers such as PLLA,limits their applications in peripheral nerve ***,we have designed,synthesized and evaluated these materials for nerve tissue engineering and regenerative medicine,the interaction of mcl-PHAs with neuronal and Schwann cells,identifying mcl-PHAs as excellent materials to enhance nerve regeneration and potentially their clinical application in peripheral nerve repair.

关键词： peripheral nerve injury nerve regeneration biomaterials mcl-polyhydroxyalkanoates Schwann cells NG108-15

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