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Prevalence of Potential Drug-Drug Interactions in Hospitalized Surgical Patients

Journal of Pharmacy and Pharmacology 2016年第12期4卷 658-666页

作者： Virginia Aleyda Sanchez-Lopez lorena michele brennan-bourdon Ana Rosa Rincon-Sanchez Maria CristinaIslas-Carbajal Andres Navarro-Ruiz Selene Guadalupe Huerta-Olvera Departamento de Fisiologia Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara 44340Jalisco Mdxico Comisi6n para la Protecci6n contra Riesgos Sanitarios del Estado de Jalisco (COPRISJAL) Guadalajara 44500 Jalisco Mdxico Departamento de Biologia Molecular y Genomica Centro Universitario de Ciencias de la Salud Universidad de GuadalajaraGuadalajara 44340 Jalisco Mexico Servicio de Farmacia Hospital General Universitario de Elche Elche (Alicante) 03203 Spain Departamento de Ciencias Medicas y de la Vida Centro Universitario de la Cienega Universidad de Guadalajara Ocotlan47820 Jalisco. Mexico

The objective of this study is to estimate the prevalence and describe the characteristics of pDDIs （potential drug-drug interactions） in medical prescriptions of hospitalized surgical patients. In this cross-sectional study, we analyzed 370 medical prescriptions from the surgery unit of a Mexican public teaching hospital. The identification and classification of potential drug-drug interactions were performed with the Micromedex 2.0 electronic drug information database. Results were analyzed with descriptive statistics and we estimated OR （odds ratio） to determine associated risk factors. From the study, it was found that the prevalence of potential drug-drug interactions was 45.9%. A total of 385 interactions were identified. Of these, 54.3% were classified as major and 60.5% as pharmacodynamic. Prescriptions for more than seven drugs （OR =7.33, CI （confidence interval） = 4.59-11.71） and advanced age 〉 60 years, （OR = 1.79, CI = 1.06-2.74） were positively associated with the presence of potential drug-drug interactions. We found a high prevalence of clinically relevant pDDIs in the surgery unit. In view of this outcome, the safety of drug combinations in hospitalized surgical patients should be evaluated during the prescription process in order to prevent adverse events.

关键词： Potential drug-drug interactions medical prescriptions concomitant drugs surgery.

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Glutamine transporters as pharmacological targets: From function to drug design

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 207-219页

作者： Mariafrancesca Scalise lorena Pochini michele Galluccio Lara Console Cesare Indiveri Department of DiBEST(Biologia Ecologia e Scienze della Terra)University of CalabriaArcavacata di Rende(CS)87036Italy

Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and ***,drug-transporter interactions are responsible for off-target effects of drugs underlying their *** improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body *** interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous ***,glutamine transporters provide cells with this special *** the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological *** 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational *** with drugs have been described for several transporters of this *** some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives.

关键词： Glutamine transporters Drug delivery Pharmacokinetics Screening Proteoliposome

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Formation of TiO_(2) Nanotube Layer by Anodization of Titanium in Ethylene Glycol-H_(2)O Electrolyte

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Journal of Surface Engineered Materials and Advanced Technology 2014年第3期4卷 123-130页

作者： Alain Robin michele Bernardes de Almeida Ribeiro Jorge Luiz Rosa Roberto Zenhei Nakazato Messias Borges Silva Escola de Engenharia de lorena Universidade de Sao PauloLorenaBrazil Faculdade de Engenharia de Guaratingueta Universidade Estadual PaulistaGuaratinguetaBrazil

In orthopaedics and orthodontics, the growth of nanotubes of titanium oxide on titanium implants is a promising route for improving the osseointegration. Among the fabrication routes to produce nanotubes, anodization was generally preferred due to its simplicity and low cost. TiO2 nanotubes are formed by the simultaneous anodic reaction and chemical dissolution due to the fluoride species present in the anodization bath. In this work, the formation of TiO2 nanotubes was studied in stirred ethylene glycol-H2O electrolyte (90 - 10 v/v) containing NH4F at room temperature. In order to study the effect of NH4F concentration, voltage and anodization time, and to reduce the number of experiments, a design of experiments (DOE) based on a 2k factorial design with four replicates at the center point was used. The analysis of variance (ANOVA) was used to evaluate the effects of the factors of control and their interactions on the percentage of the titanium surface coated by nanotubes. The dimensions of nanotubes (length and diameter) were also evaluated using field emission gun scanning electron microscopy. The cristallinity and phase composition of the oxide layers was investigated by X-ray diffractometry. The electrochemical behavior of as-received and anodized titanium specimens was studied in Ringer’s solution. The statistical analysis showed that fluoride concentration is the most significant factor. The best condition according to the response surface analysis is the center point (1% NH4F, 20 V, 2 h). The nanotubular oxide layers presented an amorphous structure. Electrochemical tests showed that TiO2 nanotubes coated titanium is less corrosion resistant than as-received titanium.

关键词： Nanotubes Titanium Anodization Implants

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