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Darunavir Resistance in HIV Infecting Protease Inhibitor-Experienced Mexican Patients

World Journal of AIDS 2013年第3期3卷 280-286页

作者： Carlos AAgudelo Luis ESoto-Ramirez Abraham Katime-Zuniga lorena cabrera-ruiz Hugo Lara-Sanchez Juan JCalva Department of Infectious Diseases “Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran”Mexico CityMexico Department of Infectious Diseases Hospital Medica Sur and GUIAR GroupMexico CityMexico The Clinical Epidemiology Unit “Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran”Mexico CityMexico.

Background: Darunavir (DRV) is a useful antiretroviral treatment in the salvage therapy of multiclass-resistant HIV-infected patients. This study’s aim was to determine the frequency and risk factors for DRV resistance-associated mutations (DRV-RAM) among DRV-naive Mexican patients with virologic failure after extensive antiretroviral treatment and exposure to at least one protease inhibitor (PI). Methods: HIV-infected patients with a history of at least 2 failed regimes were included and their clinical histories and genotype resistance tests were analyzed. Major PI resistance-associated mutations (PI-RAM), DRV-RAM and resistance to DRV were defined according to the IAS-USA criteria. Previous exposure to PI was compared between patients with DRV-resistant HIV and DRV-susceptible HIV-infected controls. Results: The median number of major PI-RAM was 2 (IQR = 0?- 3). In 54.7% (95% CI = 50.0% - 59.4%) of 631 subjects, no DRV-RAM were found on viral genotyping and 6.7% (95% CI = 4.8% - 8.6%) had 3 or more DRV-RAM. The two most frequently found DRV-RAM were in codons I84V (in 22.7% of cases) and L33F (in 20% of cases) in the viral protease gene. The number of major PI-RAM (as a surrogate marker of duration and number of PI used) and previous exposure to (fos) amprenavir or tipranavir were independently associated with DRV-resistant HIV infection. Conclusions: In this Mexican population, despite a high prior PI exposure, HIV-DRV resistance rate is relatively low and successful viral control with DRV-containing combined salvage therapy is expected in most patients.

关键词： Darunavir Resistance Risk Factors Prevalence Mexico

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Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges

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Neural Regeneration Research 2025年第7期20卷 2003-2004页

作者： lorena Decker Sonja Menge Axel Freischmidt Department of Neurology Ulm UniversityUlmGermany

TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and ***-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the *** diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and *** neuropathology is the hallmark of most individuals suffering from amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD)with TDP-43-immunoreactive pathology(FTD-TDP),limbic-predominant age-related TDP-43 encephalopathy(LATE)and Perry syndrome,but also coexists with the primary pathology in subsets of patients suffering from other NDs,such as Alzheimer’s disease,Lewy body dementias,or Huntington’s *** in the gene encoding TDP-43(TARDBP)are the cause of ALS and/or FTD in some rare cases substantiating the importance of this protein in aging *** is still controversial if loss of nuclear,or increased cytoplasmic and/or aggregating TDP-43 is more harmful to neurons(Nag and Schneider,2023).Recently,the role of nuclear TDP-43 in repressing the inclusion of intronic sequences,named cryptic exons(CEs),into mature mRNAs gained much attention.

关键词： Huntington metabolism TDP

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A New Vision of Late Imperial China Law and Society： Sommer＇s Cases Studies Shred Light on China＇s Legal Practices - Matthew Sommer： Sex, Law, and Society in Late Imperial China

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Fudan Journal of the Humanities and Social Sciences 2016年第2期9卷 357-362页

作者： lorena Miera ruiz LLM Law Department Fudan University Xinjiangwancheng Fudan Campus Shanghai China

1 Summary Sex, Law, and Society in Late Imperial China is a book with academic purposes based on the research of the opened archives, in the 1980s and 1990s, on legal case records and judicial administration of China. This fact has been crucial to enable a deeper and more accurate research based on first-hand information reflecting the reality of the situations common people faced on their daily lives and how law was actually enforced on those situations.

关键词：中国法律明清时期社会切丝案例晚期性别

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Restoring expression of Stathmin-2:a novel strategy to treat TDP-43 proteinopathies

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3553-3554页

作者： Sonja Menge lorena Decker Axel Freischmidt Department of Neurology Ulm University89081 UlmGermany

In a recent study published in Science,Baughn et *** that TDP-43 acts as a steric block in STMN2 pre-mRNA processing preventing inclusion of a deleterious cryptic exon,and present strategies for substituting this function to compensate for the loss of nuclear TDP-43 in a variety of neurodegenerative diseases(NDs)including amyotrophic lateral sclerosis(ALS).1 Stathmin-2(STMN2)is a microtubule-associated protein speci-fically expressed in neurons and required for axon outgrowth and maintenance,as well as for axon regeneration after injury in vitro.

关键词： Stathmin diseases

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New discriminant-function-based multidimensional discrimination of mid-ocean ridge and oceanic plateau

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Geoscience Frontiers 2020年第5期11卷 1681-1693页

作者： Surendra P.Verma lorena Diaz-Gonzalez Instituto de Energias Renovables Universidad Nacional Autonoma de MexicoPriv.Xochicalco S/no.Col.CentroApartado Postal 34TemixcoMor62580Mexico Centro de Investigacion en Ciencias Universidad Autonoma de Estado de MorelosCuernavacaMorelos62209Mexico

From a compilation of geochemical data for the discrimination of the tectonic settings of mid-ocean ridge(MOR;3730 samples)and oceanic plateau(OP;3656 samples),we present two new discriminant functions and diagrams obtained from censored multivariate discordant outlier-free *** different sets of data(original concentrations as well as isometric log-ratio transformed(ilr)variables;all 10 major(M)elements as well as all 10 major and 6 trace elements MT)were used to evaluate the quality of discrimination from linear discriminant analysis(LDA)and canonical *** selected multidimensional models ilrM(9 ilr transformed variables of multi-normally distributed 10 major elements)and ilrMT(15 ilr transformed variables of multi-normally distributed combined 10 major and 6 trace elements),considered as the best or most representative(total of5650 samples for ilrM and 2858 for ilrMT),provided percent success values,respectively,of 80.9%for the MOR and 81.1%for the OP(ilrM)and 88.5%for the MOR and 90.1%for the OP(ilrMT).Both processes(log-ratio transformation and multi-normality)rendered the percent success values similar for both groups(MOR and OP).The respective discriminant functions were successfully used for four tests from known tectonic settings and four application cases(two for ophiolites and two for Precambrian rocks),documenting thus the utility of the new discrimination procedure for the MOR and OP tectonic ***,we showed that our multidimensional procedure is robust against analytical errors or uncertainties,as well as post-emplacement compositional changes caused by element mobility from both low or high temperature *** robustness against the gain or loss of a single element at a time was also documented,from which the ilrMT model was evaluated as more robust than the ilrM model.A new online computer program MOROPdisc was written in Java Framework ZK,which is freely available for use at our web portal http://***

关键词： MORB Multivariate discordant outliers Log-ratio transformation Multidimensional discrimination Analytical uncertainties Post-emplacement changes

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Chemical-Abrasion U-Pb zircon geochronology reveals 150 Myr of partial melting events in the Archean crust of the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 169-189页

作者： lorena Martins Cristiano Lana Ariela Mazoz Tiago Novo Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoMorro do CruzeiroOuro PretoMG35400-000Brazil Universidade Federal de Minas Gerais Programa de Pós-Graduação em GeologiaIGC-CPMTCCampus PampulhaAv.Antônio Carlos 6627Belo HorizonteMG31270-901Brazil

Field observations and CA-LA-ICP-MS U–Pb zircon ages and Hf isotope compositions obtained from migmatitic orthogneisses and granitoids from the Belo Horizonte Complex,southern São Francisco Craton,indicate a major period of partial melting and production of felsic rocks in the *** observations show that the complex is an important site for studying partial melting processes of Archean crystalline *** of the complex exposes fine-grained stromatic migmatites that are intruded by multiple leucogranitic veins and sheeted *** migmatites and leucogranite sheets are crosscut by several phases of granitoid batholiths and small granitic bodies;both of which are closely associated with the host banded *** abrasion followed by detailed cathodoluminescence imaging revealed a wide variety of zircon textures that are consistent with a long-lived period of partial melting and crustal *** of U-Pb and Hf isotopes disclose the complex as part of a much wider crustal segment,encompassing the entire southern part of the São Francisco *** of available U-Pb ages suggests that this crustal segment was consolidated sometime between 3000 Ma and 2900 Ma and that it experienced three main episodes of partial melting before stabilization at 2600 *** partial melting episodes took place between 2750 Ma and 2600 Ma as a result of tectonic accretion and peeling off the lithospheric mantle and lower *** process is likely responsible for the emplacement of voluminous potassic granitoids across the entire São Francisco *** believe that the partial melting of Meso-Archean crystalline crust and production of potassic granitoids are linked to a fundamental shift in the tectonics of the craton,which was also responsible for the widespread intrusion of large syenitic bodies in the northern part of the craton,and the construction of layered mafic–ultramafic intrusions to the south of the BHC.

关键词： Archean São Francisco Craton Crustal reworking U-Pb geochronology Lu-Hf isotopes

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RESIDENTIAL SOLAR ENERGY POTENTIAL FOR PUBLIC DISSEMINATION:A CASE STUDY IN CONCEPCION,CHILE

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Journal of Green Building 2016年第1期11卷 118-133页

作者： Rodrigo García Alvarado lorena Troncoso Pablo Campos University of Bio-Bío Department of Design and Theory of ArchitectureConcepciónChile University of Concepción Department of Mechanical EngineeringConcepciónChile

This paper presents a method for estimating the solar capture capacity of dwell-ings using the central urban area of Concepción,Chile,as a case study in order to promote self-generation of energy by *** method takes into account the growing domestic energy demand and the possibility of meeting this demand through integrated solar energy collection into buildings using different *** methodology considers a study of the potential incoming solar radiation on buildings according to their geographical location and the surrounding *** capacity for solar capture is then estimated for different dwelling types accord-ing to their ***,the energy contribution provided by differ-ent technologies(solar thermal,photovoltaic and hybrid)is identified in relation to the main average energy demands for electricity,water and space ***,systems for each dwelling are recommended in an urban map available *** development is based on climate information,cartography,aerial photo-graphs,surveys,housing models,technical standards,standardised calculations and dynamic simulations,implemented according to building layouts from an online Geographic Information System(GIS).The housing types are categorised in an urban map that relates household demands and the contribution of different solar energy *** to the estimates calculated,the residential units in the study offer sufficient solar capacity to supply between 40 and 60%of their energy consumption,especially in detached houses using roof-mounted hybrid systems.

关键词： solar energy urban area housing solar map Concepción Chile

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A study on monoterpenoid-based natural deep eutectic solvents

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Green Chemical Engineering 2023年第1期4卷 99-114页

作者： Sara Rozas lorena Zamora Cristina Benito Mert Atilhan Santiago Aparicio Department of Chemistry University of BurgosBurgos09001Spain Department of Chemical and Paper Engineering Western Michigan UniversityKalamazooMI49008-5462USA

Herein,the synthesis and characterization methods of natural deep eutectic solvents based on monoterpenoids have been *** viscous fluids with suitable physicochemical properties are *** materials are non-toxic,biodegradable,and ***,they can be used to develop sustainable solvents for various processes and can find their applications in various fields.A theoretical study based on quantum chemistry and classical molecular dynamics is used for the nanoscopic characterization of structure,dynamics,and hydrogen *** reported results help analyze the properties of this new family of *** required information for developing structure–property relationships for proper solvent design to form a sustainable chemistry framework is obtained.

关键词： Natural deep eutectic solvents Terpenes DFT MD COSMO-RS CO_(2)solubility

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The power of microRNAs as diagnostic and prognostic biomarkers in liquid biopsies

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Cancer Drug Resistance 2020年第2期3卷 117-139页

作者： lorena Quirico Francesca Orso Department of Molecular Biotechnology and Health Sciences University of TorinoTorino 10126Italy Molecular Biotechnology Center(MBC) University of TorinoTorino 10126Italy Center for Complex Systems in Molecular Biology and Medicine University of TorinoTorino 10126Italy

In the last decades,progresses in medical oncology have ameliorated the treatment of patients and their ***,further improvements are still necessary,in particular for certain types of tumors such as pancreatic,gastric,and lung cancer as well as acute myeloid leukemia where early detection and monitoring of the disease are crucial for final patient *** biopsy represents a great advance in the field because it is less invasive,less time-consuming,and safer compared to classical biopsies and it can be useful to monitor the evolution of the disease as well as the response of patients to *** biopsy allows the detection of circulating tumor cells,nucleic acids,and exosomes not only in blood but also in different biological fluids:urine,saliva,pleural effusions,cerebrospinal fluid,and *** the potential biomarkers detectable in liquid biopsies,microRNAs(miRNAs)are gaining more and more attention,since they are easily detectable,quite stable in biological fluids,and show high *** data demonstrate that miRNAs alone or in combination with other biomarkers could improve the diagnostic and prognostic power for many different *** this,standardization of methods,sample preparation,and analysis remain challenging and a huge effort should be made to address these issues before miRNA biomarkers can enter the *** review summarizes the main findings in the field of circulating miRNAs in both solid and hematological tumors.

关键词： MicroRNAs liquid biopsies diagnosis prognosis therapy

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Does cryptic dichromatism exist in the Saffron Finch(Sicalis flaveola)?Colorimetric variables and the avian visual model

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Avian Research 2023年第3期14卷 405-415页

作者： lorena Cruz-Bernate Camilo Espinosa-Bravo Hector Fabio Rivera-Gutierrez Ornithology and Animal Behavior Laboratory-OYCA GEAHNA GroupBiology Department of the Natural and Exact Sciences FacultyUniversidad del ValleCaliColombia Ecology and Evolution Vertebrates Group Biology InstituteNatural and Exact Sciences FacultyUniversidad de AntioquiaMedellínColombia

Sexual dichromatism,a particular type of sexual dimorphism,occurs in several species and has been associated with sexual *** some cases,the differences are so small that they are imperceptible to humans,but possibly detected by *** objective measurement of color with spectrophotometers and detailed analyses according to the perception ability of the avian eye have revealed that some species that were once considered to be monochromatic,are in fact dichromatic and able to perceive these *** the tropics,the Saffron Finch(Sicalis flaveola) does not present marked sexual dimorphism in coloration,which makes studies in behavioral ecology,natural history and population dynamics *** assess whether there is dichromatism in the species,the reflectance(between 300 and 700 nm) of ten body regions was measured in 196 wild adults in *** was determined using the CHD1 gene on the sex *** spectra were analyzed using:colorimetric variables and the avian visual *** found that reflectance shows a bimodal curve in all body regions,except the *** presented higher reflectance at long wavelengths,while for females this occurred in ultraviolet *** the visual model,we found that there are significant intrasexual differences;however only in crown coloration is there a possible perceived difference between *** conclude that in the Saffron Finch there are color differences between the sexes in all regions considering the physical phenomenon(reflectance),but in general,when evaluating color perception(avian visual model),there are no differences between the sexes in most of the body *** intrasexual differences are significant,indicating the possibility of these being signals that influence social interactions in the species.

关键词： Carotenoids Color discrimination Colombia Intrasexual signals Social selection Tanagers Tropical region

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