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Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature

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World Journal of Hepatology 2020年第2期12卷 64-71页

作者： Mariano Piazzolla Nicola Castellaneta Antonio Novelli Emanuele Agolini Dario Cocciadiferro Leonardo Resta loren duda Michele Barone Enzo Ierardi Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Laboratory of Medical Genetics Ospedale Pediatrico Bambino GesùRome 00165Italy Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy

BACKGROUND Benign recurrent intrahepatic cholestasis is a genetic disorder with recurrent cholestatic jaundice due to ATP8B1 and ABCB11 gene mutations encoding for hepato-canalicular ***,we firstly provide the evidence that a nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygous form is involved in BRIC *** SUMMARY A 29-year-old male showed severe jaundice and laboratory tests consistent with intrahepatic cholestasis despite normal *** and chronic liver diseases with viral,metabolic and autoimmune etiology were *** intra/extra-hepatic bile ducts were demonstrated by magnetic *** biopsy showed:Cholestasis in the centrilobular and intermediate zones with bile plugs and intra-hepatocyte pigment,Kupffer’s cell activation/hyperplasia and preserved biliary *** satisfied benign recurrent intrahepatic cholestasis diagnostic criteria,ATP8B1 and ABCB11 gene analysis was ***,we found a novel nonsense variant of ATP8B1 gene(c.1558A>T)in *** variant was confirmed by Sanger sequencing following a standard protocol and tested for familial segregation,showing a maternal *** confirmed a significant reduction of mutated gene related protein(familial intrahepatic cholestasis 1).The patient was treated with ursodeoxycholic acid 15 mg/kg per day and colestyramine 8 g daily with total bilirubin decrease and normalization at the 6th and 12th *** A genetic abnormality,different from those already known,could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition,thus encouraging further mutation detection in this field.

关键词： Benign recurrent intrahepatic cholestasis ATP8B1/ABCB11 genes Jaundice Heterozygous variant of ATP8B1 gene(c.1558A>T) Familial inheritance Case report

A new section of Kaili Formation (Cambrian) and a biostratigraphic study of the boundary interval across the undefined Cambrian Series 2 and Series 3 at Jianshan,Jianhe County,China with a discussion of global correlation based on the first appearance dat

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Progress in Natural Science:Materials International 2008年第12期18卷 1549-1556页

作者： loren E.Babcock School of Earth Sciences Ohio State UniversityColumbusOH 43210USA

A trilobite biostratigraphic study of a new section of the Kaili Formation at Jianshan,Chuandong Village,Jianhe County, Guizhou is *** occurrences of key species associated with the Ovatoryctocara granulata-Bathynotus holopygus Zone and the overlying Oryctocephalus indicus Zone that were originally defined from the trilobite assemblages at the Wuliu- Zengjiayan section of the Kaili are reported from this new *** first appearance datum (FAD) of Oryctocephalus indicus occurs at the 44.52 m above the base of the *** on study of abundant specimens (n=800) from the Kaili Formation, we argue that Oryctocephalus indicus is a widespread taxon with a global *** (Lermontova,1940) from the middle part of the Kounamkites Zone of the Amganian Stage in the Molodo River region of Siberia and *** (Sundberg and McCollum,2003) from Nevada,North America are similar to representatives of *** which occur in the *** Zone of the Kaili *** and *** are here synonymized with *** (Reed,1910).This study strengthens the Wuliu-Zengjiayan section of the Kaili Formation as a candidate section for a Global Stratotype for the base of the unnamed Cambrian Series 3.

关键词： Jianshan section Kaili Formation Boundary Cambrian Series 3 Guizhou China

A new model of speciation

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National Science Review 2019年第2期6卷 289-290页

作者： loren H.Rieseberg Department of Botany and Biodiversity Research Centre University of British Columbia NSR

In the first paragraph of ‘On the origin of species’, Darwin [1]refers to speciation as that ‘mystery of mysteries’. Although the means by which new species arise is no longer mysterious, some puzzles remain. One such puzzle, which is addressed in a recent paper from Chung-I Wu’s group on mangrove speciation [2],concerns the popular allopatric speciation model. In this model,

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Proposed GSSP for the base of Cambrian Stage 9,coinciding with the first appearance of Agnostotes orientalis, at Duibian, Zhejiang, China

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Science China Earth Sciences 2009年第4期52卷 434-451页

作者： loren E. BABCOCK Gabriella BAGNOLI School of Earth Sciences The Ohio State University Department of Earth Sciences of Pisa University

Exposed in natural outcrops near the Duibian Village, Jiangshan County, Zhejiang Province, China, the Duibian B section is proposed as the boundary stratotype for the base of an unnamed stage termed provisionally Cambrian Stage 9. The proposed position of the GSSP is 108.12 m above the base of the Huayansi Formation, at a horizon coinciding with the first appearance of the cosmopolitan agnostoid trilobite Agnostotes orientalis. This horizon coincides also with the first appearance of the cosmopoli-tan polymerid trilobite Irvingella angustilimbata. The section fulfills all the requirements for a GSSP, and the horizon can be constrained not only by the primary stratigraphic marker (A. orientalis) but also with secondary biostratigraphic, chemostratigraphic, and sequence-stratigraphic correlation tools. The first appearance of A. orientalis is one of the most readily recognizable levels in Cambrian, and can be correlated with precision to all paleocontinents.

关键词： Cambrian GSSP FAD of Agnostotes orientalis China chronostratigraphy

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While neither universally applicable nor practical operationally, the biological species concept continues to offer a compelling framework for studying species and speciation

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National Science Review 2020年第8期7卷 1398-1400页

作者： Lexuan Gao loren H.Rieseberg CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Chinese Academy of Sciences Department of Botany and Biodiversity Research Centre University of British Columbia

Few topics in evolutionary biology have received as much scrutiny and debate as the nature of species and species concepts. This is partly because species are central to many fields of biology(but especially evolution, ecology, systematics, and conservation biology), and there does not appear to be a single concept that can satisfy the needs of these different disciplines [1].

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Probabilistic Adaptive Anonymous Authentication in Vehicular Networks

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Journal of Computer Science & Technology 2008年第6期23卷 916-928页

作者：习勇沙科伟施巍松 loren Schwiebert 张涛 Department of Computer Science Wayne State UniversityDetroitMichiganU.S.A. Telcordia Technologies Inc.New JerseyU.S.A.

Vehicular networks have attracted extensive attention in recent years for their promises in improving safety and enabling other value-added services. Most previous work focuses on designing the media access and physical layer protocols. Privacy issues in vehicular systems have not been well addressed. We argue that privacy is a user-specific concept, and a good privacy protection mechanism should allow users to select the levels of privacy they wish to have. To address this requirement, we propose an adaptive anonymous authentication mechanism that can trade off the anonymity level with computational and communication overheads （resource usage）. This mechanism, to our knowledge, is the first effort on adaptive anonymous authentication. The resources used by our protocol are few. A high traffic volume of 2000 vehicles per hour consumes about 60kbps bandwidth, which is less than one percent of the bandwidth of DSRC （Dedicated Short Range Communications）. By using adaptive anonymity, the protocol response time can further be improved 2-4 times with less than 20% bandwidth overheads.

关键词： anonymous authentication vehicular network privacy adaptive anonymity

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Oxidative stress and stress signaling: menace of diabetic cardiomyopathy

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Acta Pharmacologica Sinica 2005年第8期26卷 908-917页

作者： loren E WOLD Asli F CEYLAN-ISIK Jun REN Department of Pharmacology Physiology and Therapeutics University of North Dakota Grand Forks ND 58203 USA Center for Cardiovascular Research and Alternative Medicine University of Wyoming Laramie WY 82071 USA Department of Pharmacology Physiology and Therapeutics University of North Dakota Grand Forks ND 58203 USA Center for Cardiovascular Research and Alternative Medicine University of Wyoming Laramie WY 82071 USA

Cardiovascular disease is the most common cause of death in the diabetic population and is currently one of the leading causes of death in the United States and other industrialized countries. The health care expenses associated with cardiovascular disease are staggering, reaching more than US$350 billion in 2003. The risk factors for cardiovascular disease include high fat/cholesterol levels, alcoholism, smoking, genetics, environmental factors and hypertension, which are commonly used to gauge an individual's risk of cardiovascular disease and to track their progress during therapy. Most recently, these factors have become important in the early prevention of cardiovascular diseases. Oxidative stress, the imbalance between reactive oxygen species production and breakdown by en- dogenous antioxidants, has been implicated in the onset and progression of car- diovascular diseases such as congestive heart failure and diabetes-associated heart dysfunction (diabetic cardiomyopathy). Antioxidant therapy has shown promise in preventing the development of diabetic heart complications. This review focuses on recent advances in oxidative stress theory and antioxidant therapy in diabetic cardiomyopathy, with an emphasis on the stress signaling pathways hypothesized to be involved. Many of these stress signaling pathways lead to activation of reactive oxygen species, major players in the development and progression of diabetic cardiomyopathy.

关键词： diabetes: heart cardiomyopathy oxidative stress: signal transduction

1968年至今,Signatone探针设备的发展——访Signatone市场营销部副总裁loren Dickson先生

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半导体技术 2006年第3期31卷 201-202,216页

作者：陈亮 loren Dickson Signatone市场营销部

自1968年以来,Signatone公司一直支持着半导体工业,通过提供探针设备来解决多种不同的测量要求,以其高质量、高效率的探针设备而闻名世界。如今Signatone已为晶圆和部件的各个市场提供最先进的解决方案,技术上不断升级,当人们为了更快... 详细信息

自1968年以来,Signatone公司一直支持着半导体工业,通过提供探针设备来解决多种不同的测量要求,以其高质量、高效率的探针设备而闻名世界。如今Signatone已为晶圆和部件的各个市场提供最先进的解决方案,技术上不断升级,当人们为了更快、更好、更智能的设备而慢慢地加大自己的成本时,Signatone全心全意地为每一个客户提供全方位的检测解决方案,并尽可能地降低成本去优化检测解决方案,为客户所信赖。在中国Signatone还不是个耳熟能详的企业。它的发展进程是怎样的,竞争优势在哪里,市场侧重点在哪里,将采取怎样的措施尽快赢得中国市场,带着以上疑问,本刊通讯员有幸采访了 Signatone市场营销部副总裁loren Dickson先生。

关键词： Dickson 市场营销设备探针总裁降低成本中国市场半导体工业测量要求竞争优势

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Plant Evolutionary Adaptation

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Plant Communications 2020年第6期1卷 1-3页

作者： loren H.Rieseberg Lexuan Gao Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouver BC V6T1Z4Canada CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

In 1973,evolutionary biologist Theodosius Dobzhansky penned a famous essay titled“Nothing in Biology Makes Sense Except in the Light of Evolution”(Dobzhansky,1973).In the essay,he described how many features of biology,such as the adaptive radiations of Drosophila fruit flies and the similarity of embryo development across animal species,are best explained by *** Dobzhansky’s examples largely came from the animal kingdom,evolution is also the chief unifying theory in plant biology,linking molecular,cell,and whole organism-level *** Communications is intended to represent all of the plant sciences,and evolution can provide connections between the diverse studies published in the *** is illustrated by this special issue on Plant Evolutionary Adaptation,in which evolutionary approaches are employed to explain phenomena ranging from the geographic distribution of genomic variation to patterns of plant dispersal to the success of invasive *** we provide background for the topics addressed by these studies and highlight their main conclusions,moving from molecular to organismal-level studies.

关键词： journal linking explain