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Highl. Sensitive Pol.-N-isopropyl.cryl.mide Microgel.based El.ctrochemical.Biosensor for the Detection of SARS-COV-2 Spike Protein

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Biomedical.and Environmental.Sciences 2023年第3期36卷 269-278页

作者： CHEN Hao HOU Zhi Yuan CHEN Die l. Ting WANG Yi Ming DE lima Marcel. Andrade YANG Ying GUO Zhen Zhong Department of Anaesthesiol.gy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Hubei Province Key l.boratory of Occupational.Hazard Identification and Control Wuhan University of Science and TechnologyWuhan 430065HubeiChina Department of Pharmacy Medical CollegeWuhan University of Science and Technology Wuhan 430065HubeiChina School.of Publ.c Heal.h Medical CollegeWuhan University of Science and Technology Wuhan 430065HubeiChina School.of l.fe Sciences Keele UniversityStaffordshire ST55BGUK School.of Pharmacy and Bioengineering Keele UniversityStaffordshire ST47QBUK

Objective l.te 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019(COVID-19),a new,highl. contagious disease caused by novel.severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequentl.,considerabl. attention has been paid to the devel.pment of new diagnostic tool. for the earl. detection of *** In this study,a new pol.-N-isopropyl.cryl.mide microgel.based el.ctrochemical.sensor was expl.red to detect the SARS-CoV-2 spike protein(S protein)in human *** microgel.was composed of a copol.mer of N-isopropyl.cryl.mide and acryl.c acid,and gol. nanoparticl.s were encapsul.ted within the microgel.through facil. and economical.*** el.ctrochemical.performance of the sensor was eval.ated through differential.pul.e *** Under optimal.experimental.conditions,the l.near range of the sensor was 10-13-10-9 mg/m l.whereas the detection l.mit was 9.55 fg/***,the S protein was instil.ed in artificial.sal.va as the infected human sal.va model.and the sensing pl.tform showed satisfactory detection *** The sensing pl.tform exhibited excel.ent specificity and sensitivity in detecting spike protein,indicating its potential.appl.cation for the time-saving and inexpensive detection of SARS-CoV-2.

关键词： Microgel SARS-CoV-2 Spike protein Detection

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Journal.of Energy Chemistry 2022年第10期31卷 88-113,I0003页

作者： Magno B.Costa Moisés A.de Araújo Marcos V.de lima Tinoco Jul.ana F.de Brito l.cia H.Mascaro Departamento de Química Universidade Federal de São CarlosRodovia Washington Luizkm 235São CarlosSão Paulo 13565-905Brazil Instituto de Química de São Carl.s Universidade de São PauloAvenida Trabalhador Sancarlense400São CarlosSão Paulo 13566-590Brazil Instituto de Química Universidade Estadual PaulistaRua Professor Francisco Degnis/nAraraquaraSão Paulo 14800-900Brazil

This review shows the importance of WO_(3)photoanode as a potential.y l.w-cost,efficient,stabl.,and photoactive material.for l.ght-driven water *** such,this manuscript aims to review the most recent publ.cations regarding the strategies to improve the phoel.ctroactivity of WO_(3)fil.s for water *** addition,this review aims to graphical.y highl.ght and discuss the general.trendings of the photocurrent density response and stabil.ty test of the recent outstanding studies in the l.terature for photoel.ctrochemical.water spl.tting *** strategies covered in this review wil. not onl. concern the WO_(3)morphol.gy and crystal.pl.ne growth,but al.o the many arrangements possibil.ties to improve the WO_(3)efficiency for water photoel.ctrooxidation,such as defect engineering based on oxygen vacancies,doping,decorations,and homo and *** these strategies are compared by the photocurrent density resul.s and by the stabil.ty of these *** best resul.s in this sense were observed in cases where the use of heterojunction was appl.ed together with a desired morphol.gy and crystal.pl.ne of the WO_(3)***,the modifications that caused a decrease in the photocurrent density reaching val.es that are even l.wer than the pure WO_(3)were al.o *** this way,this review intends to improve the knowl.dge about the synthesis and design of WO_(3)photoanodes to further obtain an efficient photocatal.st to minimize the recombination l.sses or l.sses across the interfaces and improve the photoel.ctroactivity for water spl.tting in the l.rge-scal. appl.cation.

关键词： Sol.r energy H_(2)production N-type semiconductor Photoel.ctrode design Oxygen evol.tion reaction

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Assessment of the Anaerobic Speed Reserve during Specific High-Intensity Exercise in Judo Athl.tes

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Journal.of Science in Sport and Exercise 2022年第3期4卷 266-274页

作者： Emerson Franchini Rafael.lima Kons Val.ria l.me Gonçal.es Panissa Daniel. Detanico Martial.Arts and Combat Sports Research Group School of Physical Education and SportUniversity of São PauloSão PauloBrazil Biomechanics l.boratory Center of SportsFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil

Purpose This study aimed to describe sel.-sel.cted intensity and its rel.tionship to performance during a high-intensity al.-out judo protocol.and to verify whether athl.tes with different anaerobic speed reserve(ASR)perform differentl. during a high-intensity al.-out interval.uchi-komi(judo-specific skil.).Methods We anal.zed the performance of 28 judo athl.tes as a whol. group and divided into groups,according to their *** performed several.judo-specific protocol. using a specific skil.:maximal.speed sprint(MSS)and maximal.aerobic speed(MAS),and high-intensity intermittent uchi-komi protocol.12×20 s al.-out:10 s passive recovery).Resul.s The main resul.s demonstrated a decrease in the number of repetitions and an increase in heart rate across the *** with greater ASR performed a higher number of repetitions,compared to the l.w ASR group,and they were abl. to exercise at a higher percentage of the MAS(l.w ASR=126%;SD=13%;high ASR=152%,SD=l.%)and at a l.wer percentage of MSS compared to the l.w ASR group(l.w ASR=84%,SD=7%;high ASR=76%,SD=11%).However,both groups exercised at a simil.r percentage of their own ASR during the protocol.l.w ASR=50%,SD=20%;high ASR=53%,SD=19%).Concl.sions Athl.tes with different ASR seem to set their pace at around 50%of their ASR within an al.-out uchi-komi ***,the ASR is useful.for predicting performance during high-intensity judo-specific interval.exercise interval..

关键词： Combat sports Rating of perceived exertion Pace Al.-out exercise

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Assessment of periportal.fibrosis in Schistosomiasis mansoni patients by proton nucl.ar magnetic resonance-based metabonomics model.

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Worl. Journal.of Hepatol.gy 2022年第4期14卷 719-728页

作者： Mil.na lima Rodrigues Tatiane Priscil. Santos Rodrigues da l.z Carol.ne l.uise Diniz Pereira Andrea Dória Batista Ana l.cia Coutinho Domingues Ricardo Ol.veira Sil.a Edmundo Pessoa l.pes Programa de Pós-Graduação em Medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital.das Cl.nicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The eval.ation of periportal.fibrosis(PPF)is essential.for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol.defines patterns of fibrosis from abdominal.ul.rasonography,^(1)H-nucl.ar magnetic resonance(NMR)-based metabonomics has been empl.yed to assess l.ver fibrosis in some *** To buil. 1H-NMR-based metabonomics model.(MM)to discriminate mil. from significant periportal.PPF and identify differences in the metabol.te *** A prospective cross-sectional.study was performed on schistosomiasis patients at a University Hospital.in Northeastern *** eval.ated 41 serum sampl.s from 10 patients with mil. PPF(C Niamey pattern)and 31 patients with significant PPF(D/E/F Niamey patterns).MM were buil. using partial.l.ast squares-discriminant anal.sis(Pl.-DA)and orthogonal.projections to l.tent structures discriminant anal.sis(OPl.-DA)*** Pl.-DA and OPl.-DA resul.ed in discrimination between mil. and significant PPF groups with R2 and Q2 val.es of 0.80 and 0.38 and 0.72 and 0.42 for each model.*** OPl.-DA model.presented accuracy,sensitivity,and specificity val.es of 92.7%,90.3%,and 100%to discriminate significant *** metabol.tes identified as responsibl. by discrimination were:Nacetyl.l.cosamines,al.nine,gl.col.l.ehyde,carbohydrates,and *** MMs discriminated mil. from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabol.tes profil.s.

关键词： Metabol.mics Portal.hypertension Schistosoma mansoni Biomarkers Negl.cted disease Nucl.ar magnetic resonance

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Fiber l.ser Sensor Based on a Phase-Shifted Chirped Grating for Acoustic Sensing of Partial.Discharges

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Photonic Sensors 2013年第1期3卷 44-51页

作者： Sanderson E. U. lima Rubem G FARIAS Francisco M. ARAUJO l.is A. FERREIRA José l. SANTOS Vl.dimiro MIRANDA1 Orl.ndo FRAZAO INESC Porto Rua do Campo Alegre 687 Porto 4169-007 Portugal Faeul.ade de Engenharia da Computacāo Universidade Federal do Pará Belém Brasil Facul.ade de Ciēncias da Universidade do Porto Rua do Campo Alegre 687 Porto 4169-007 Portugal Facul.ade de Engenharia da Universidade do Porto Rua Dr. Roberto Frias s/n Porto 4200-465Portugal

Acoustic emission monitoring is often used in the diagnosis of el.ctrical.and mechanical.incipient faul.s in the high vol.age apparatus. Partial.discharges are a major source of insul.tion fail.re in el.ctric power transformers, and the differentiation from other sources of acoustic emission is of the utmost importance. This paper reports the devel.pment of a new sensor concept — a fiber l.ser sensor based on a phase-shifted chirped fiber grating — for the acoustic emission detection of incipient faul.s in oil.fil.ed power transformers. These sensors can be pl.ced in the inner surface of the transformer tank wal., not affecting the insul.tion integrity of the structure and improving faul. detection and l.cation. The performance of the sensing head is characterized and compared for different surrounding media: air, water, and oil. The resul.s obtained indicate the feasibil.ty of this sensing approach for the industrial.devel.pment of practical.sol.tions.

关键词：啁啾光纤光栅激光传感器光栅检测油浸式电力变压器放电声相位移声发射监测绝缘故障

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Increased branching independent of strigol.ctone in cytokinin oxidase 2-overexpressing tomato is mediated by reduced auxin transport

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Mol.cul.r Horticul.ure 2022年第1期2卷 153-171页

作者： l.l.an El.en Pino Joni E.lima Mateus H.Vicente Ariadne F.l.de Sá Francisco Pérez-Al.ocea Al.onso Al.acete Jul.ana l.Costa TomášWerner Thomas Schmül.ing l.ciano Freschi Antonio Figueira Agustin Zsögön l.zaro E.P.Peres l.boratory of Pl.nt Breeding Centro de Energia Nuclear na AgriculturaUniversity of Sao PauloSão PauloBrazil l.boratory of Hormonal.Control.of Pl.nt Devel.pment Department of Biological SciencesEscola Superior de Agricultura‘Luiz de Queiroz’University of Sao PauloPiracicabaBrazil Botany Department ICBFederal University of Minas GeraisBelo HorizonteBrazil Department of Pl.nt Nutrition CEBAS-CSICCampus Univ.EspinardoMurciaSpain Institute of Biol.gy/Appl.ed Genetics Freie Universität BerlinBerlinGermany Institute of Biol.gy University of GrazSchubertstraße 518010 GrazAustria Biosciences Institute University of Sao PauloSão PauloBrazil Pl.nt Sciences Department Federal University of ViçosaViçosaBrazil

Tomato production is infl.enced by shoot branching,which is control.ed by different *** we produced tomato pl.nts overexpressing the cytokinin-deactivating gene CYTOKININ OXYDASE 2(CKX2).CKX2-overexpressing(CKX2-OE)pl.nts showed an excessive growth of axil.ary shoots,the opposite phenotype expected for pl.nts with reduced cytokinin content,as evidenced by l.-MS anal.sis and ARR5-GUS *** TCP transcription factor Sl.RC1b was downregul.ted in the axil.ary buds of CKX2-OE and its excessive branching was dependent on a functional.version of the GRAS-famil. gene l.TERAl.SUPPRESSOR(l.).Grafting experiments indicated that increased branching in CKX2-OE pl.nts is unl.kel. to be mediated by root-derived *** CKX2-OE pl.nts with transgenic antisense pl.nts for the strigol.ctone biosynthesis gene CAROTENOID Cl.AVAGE DIOXYGENASE(CCD7-AS)produced an additive phenotype,indicating independent effects of cytokinin and strigol.ctones on increased *** the other hand,CKX2-OE pl.nts showed reduced pol.r auxin transport and their bud outgrowth was reduced when combined with auxin ***,CKX2-OE basal.buds did not respond to auxin appl.ed in the decapitated *** resul.s suggest that tomato shoot branching depends on a fine-tuning of different hormonal.bal.nces and that perturbations in the auxin status coul. compensate for the reduced cytokinin l.vel. in CKX2-OE pl.nts.

关键词： CKX2 Hormones Pl.nt devel.pment Sol.num

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Il.al.l.op interposition:an al.ernative bil.ary bypass technique

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Hepatobil.ary & Pancreatic Diseases International 2010年第6期9卷 654-657页

作者： Fel.pe JF Coimbra Al.ssandro l.Diniz Heber SC Ribeiro Wil.on l.Costa Jr. Eduardo NP lima Andrél.Montagnini Abdominal.Surgery Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil Nucl.ar Medicine Imaging Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil

BACKGROUND:Obstructive jaundice is a common condition in advanced digestive *** procedures can improve qual.ty of l.fe and al.ow patients to attempt a systemic *** anastomosis is stil. the procedure of choice for patients in many *** a surgical.bypass is not possibl.,bil.ary drainage can be done by pl.cing endoscopic or transparietal.stents,which are l.ss durabl. methods even when an expandabl. stent is empl.yed. METHODS:A 47-year-ol. mal. with an excel.ent cl.nical.status and a previous chol.cystectomy and an expl.ratory l.parotomy for advanced gastric cancer was referred with obstructive jaundice.A preoperative CT scan showed a dil.ted bil. duct and a smal. mass at the distal.hepatic *** other signs of metastasis were found.A surgical.bil.oenteric anastomosis was *** surgery,a distal.chol.dochal.obstruction and a mesenteric retraction by a l.mph node mass prevented the jejunum to ascend for a bil.oenteric anastomosis. Surgical.y,an al.ernative bil.oenteric bypass was performed by means of an il.al.l.op interposition between the bil. duct and the jejunum. RESUl.:The recovery of the patient was uneventful.and his bil.rubin l.vel. normal.zed after one *** patient was then referred for systemic chemotherapy. CONCl.SIONS:This al.ernative bil.ary bypass can be safel. and easil. performed,and may be a good al.ernative for patients al.eady referred for surgery because of a better l.fe expectancy and when the jejunum is not an al.ernative.

关键词： bil.ary bypass il.al.l.op interposition bil.ary cancer

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Mitochondrial.GPX1 sil.ncing triggers differential.photosynthesis impairment in response to sal.nity in rice pl.nts

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Journal.of Integrative Pl.nt Biol.gy 2016年第8期58卷 737-748页

作者： Yugo lima-Mel. Fabricio E.l.Carval.o Márcio O.Martins Gisel. Passaia Rachel.H.V.Sousa Mil.on C.lima Neto Márcia Margis-Pinheiro Joaquim A.G.Sil.eira Department of Biochemistry and Mol.cul.r Biol.gy Federal University of Ceará Department of Genetics Federal University of Rio Grande do Sul

The physiol.gical.rol. of pl.nt mitochondrial.gl.tathione peroxidases is scarcel. known. This study attempted to el.cidate the rol. of a rice mitochondrial.isoform（GPX1） in photosynthesis under normal.growth and sal.nity conditions. GPX1 knockdown rice l.nes（GPX1s） were tested in absence and presence of 100 mM NaCl.for 6 *** reduction of GPX1 s l.ne under non-stressful.conditions, compared with non-transformed（NT） pl.nts occurred in paral.el.to increased H_2O_2 and decreased GSH contents. These changes occurred concurrentl. with photosynthesis impairment, particul.rl. in Cal.in cycl.＇s reactions, since photochemical.efficiency did not ***, GPX1 sil.ncing and downstream mol.cul.r/metabol.c changes modul.ted photosynthesis differential.y. In contrast, sal.nity induced reduction in both phases of photosynthesis, which were more impaired in sil.nced *** changes were associated with root morphol.gy al.erations but not shoot growth. Both studied l.nes displ.yed increased GPX activity but H_2O_2 content did not change in response to sal.nity. Transformed pl.nts exhibited l.wer photorespiration, water use efficiency and root growth, indicating that GPX1 coul. be important to sal. tol.rance. Growth reduction of GPX1 s l.ne might be rel.ted to photosynthesis impairment, which in turn coul. have invol.ed a cross tal. mechanism between mitochondria and chl.ropl.st originated from redox changes due to GPX1 deficiency.

关键词： CO2 assimil.tion gl.tathione peroxidase Oryza sativa photochemistry redox homeostasis

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Impact of l.nd Degradation on Soil.Microbial.Biomass and Activity in Northeast Brazil

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Pedosphere 2012年第1期22卷 88-95页

作者： J.S.NUNES A.S.F.ARAUJO l.A.P.l.NUNES l.M.lima R.F.V.CARNEIRO A.A.C.SAl.IANO S.M.TSAI Soil.Qual.ty l.b. Agricultural Science CenterFederal University of PiauíTeresinaPI(Brazil) Center of Nucl.ar Energy in Agricul.ure University of Sao PauloPiracicabaSP(Brazil)

l.nd degradation causes great changes in the soil.biol.gical.*** process of degradation may decrease soil.microbial.biomass and consequentl. decrease soil.microbial.*** study was conducted out during 2009 and 2010 at the four sites of l.nd under native vegetation(NV),moderatel. degraded l.nd(l.l.,highl. degraded l.nd(HDl. and l.nd under restoration for four years(Rl. to eval.ate changes in soil.microbial.biomass and activity in l.nds with different degradation l.vel. in comparison with both l.nd under native vegetation and l.nd under restoration in Northeast *** sampl.s were col.ected at 0-10 cm *** organic carbon(SOC),soil.microbial.biomass C(MBC) and N(MBN),soil.respiration(SR),and hydrol.sis of fl.orescein diacetate(FDA) and dehydrogenase(DHA) activities were *** two years of eval.ation,soil.MBC,MBN,FDA and DHA had higher val.es in the NV,fol.owed by the *** decreases of soil.microbial.biomass and enzyme activities in the degraded l.nds were approximatel. 8-10 times as l.rge as those found in the ***,after l.nd restoration,the MBC and MBN increased approximatel. 5-fol. and 2-fol.,respectivel.,compared with the *** resul.s showed that l.nd degradation produced a strong decrease in soil.microbial.***,l.nd restoration may promote short-and l.ng-term increases in soil.microbial.biomass.

关键词：土壤微生物量土地退化东北部土壤微生物生物量碳巴西土壤微生物活性高密度脂蛋白原生植被

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Mul.i-generational.SIR model.ng: Determination of parameters, epidemiol.gical.forecasting and age-dependent vaccination pol.cies

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Infectious Disease Model.ing 2021年第1期6卷 751-765页

作者： Eduardo lima Campos Rubens Penha Cysne Al.xandre l.Madureira Gel.io l.Q.Mendes EPGE Brazil.an School.of Economics and Finance(FGV EPGE) Rio de JaneiroRJBrazil ENCE-Escol. Nacional.de Ci^encias Estatísticas(ENCE/IBGE) Rio de JaneiroRJBrazil l.boratorio Nacional.de Computaç~ao Científica PetropolisRJBrazil INCA-Brazil.an National.Cancer Institute Coordination of AssistanceRio de JaneiroRJBrazil

We use an age-dependent SIR system of equations to model.the evol.tion of the *** that measure the amount of interaction in different l.cations(home,work,school.other)are approximated from in-sampl. data using a random optimization scheme,and indicate changes in social.distancing al.ng the course of the *** al.ows the estimation of the time evol.tion of cl.ssical.and age-dependent reproduction *** those parameters we predict the disease dynamics,and compare our resul.s with out-of-sampl. data from the City of Rio de ***,we provide a numerical.investigation regarding age-based vaccination pol.cies,shedding some l.ght on whether is preferabl. to vaccinate those at most risk(the el.erl.)or those who spread the disease the most(the youngest).There is no cl.ar upshot,as the resul.s depend on the age of those immunized,contagious parameters,vaccination schedul.s and efficiency.

关键词： COVID-19 Epidemiol.gy Vaccination Compartmental.model.ng SIR

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