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Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw(MRONJ)

International Journal of Oral Science 2022年第3期14卷 245-258页

作者： Ran Yan Ruixue Jiang longwei hu Yuwei Deng Jin Wen Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina College of Stomatology Shanghai Jiao Tong UniversityShanghaiChina National Center for Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina d 4Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Medication-related osteonecrosis of the jaw(MRONJ)is primarily associated with administering antiresorptive or antiangiogenic drugs.Despite significant research on MRONJ,its pathogenesis and effective treatments are still not fully understood.Animal models can be used to simulate the pathophysiological features of MRONJ,serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ.Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ,but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ.Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic.This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency.Currently,there is a lack of a unified assessment system for MRONJ models,which hinders a standard definition of MRONJ-like lesions in rodents.Therefore,this review comprehensively summarizes assessment systems based on published peer-review articles,including new approaches in gross observation,histological assessments,radiographic assessments,and serological assessments.This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.

关键词： Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw MRONJ

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Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

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Bone Research 2022年第4期10卷 816-825页

作者： Qianju Wu longwei hu Ran Yan Junfeng Shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina Stomatological Hospital of Xiamen Medical College XiamenFujian 361008China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina

The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis.

关键词： osteoporosis treatment regeneration

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莺歌海盆地黄流组一段沉积物源综合识别

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海洋地质前沿 2024年第6期40卷 62-74页

作者：胡高伟刘显童陈杨邱隆伟李彦丽中海石油(中国)有限公司海南分公司海口570100 中国石油大学(华东)地球科学与技术学院青岛266000

通过重矿物直观比对法确定了莺歌海盆地黄流组一段沉积物中各物源区的重矿物特征,并初步认识了其古母岩特征。研究区周围存在三大主要物源区,即海南岛、越南北部(红河)及越南中部。结果表明,越南物源以铁矿物、钛矿等沉积岩型重矿物组... 详细信息

通过重矿物直观比对法确定了莺歌海盆地黄流组一段沉积物中各物源区的重矿物特征,并初步认识了其古母岩特征。研究区周围存在三大主要物源区,即海南岛、越南北部(红河)及越南中部。结果表明,越南物源以铁矿物、钛矿等沉积岩型重矿物组合为主;海南物源以锆石、电气石、金红石等酸性火山岩型重矿物组合为主。基于余弦距离及皮尔森相关系数的谱系聚类结果表明,莺歌海盆地黄流组一段锆石、电气石、金红石、锐钛矿、白钛矿等矿物受成岩作用影响较小,为该时期的稳定矿物组合。综合稳定重矿物复杂拓扑网络、地震属性、地震剖面及锆石年龄等方法对主导物源区进行划分,确定了莺歌海盆地东方13区及东方1区的部分扇体主要受控于越北红河物源,东方13区及东方29区的绝大多数扇体主要受越中物源及海南北部物源的双重影响,乐东区受控于海南南部物源。基于海南南部物源的古物源分布模式,建立了重矿物-地震特征-锆石年代学的物源识别方法。

关键词：物源识别重矿物指数拓扑复杂网络地震属性莺歌海盆地

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建筑工人产业化培训制约因素研究

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哈尔滨商业大学学报（自然科学版） 2024年第3期40卷 354-361页

作者：潘锐胡龙伟孙晓莹青岛理工大学管理工程学院山东青岛266520

通过调查访问23位不同岗位的业内专业人士,基于扎根理论,分析出了15个影响建筑工人产业化培训的制约因素.通过DEMATEL法即决策实验法,研究制约因素之间的相互作用,求出中心度和原因度,识别出关键因素,进一步用ISM数学模型对制约因素进... 详细信息

通过调查访问23位不同岗位的业内专业人士,基于扎根理论,分析出了15个影响建筑工人产业化培训的制约因素.通过DEMATEL法即决策实验法,研究制约因素之间的相互作用,求出中心度和原因度,识别出关键因素,进一步用ISM数学模型对制约因素进行层次分级,得到五个影响层级.结果表明,接受培训意愿和培训性价比是制约建筑工人产业化培训的直接因素,企业发展需要和企业社会责任是制约培训进程的本质因素,其余因素则是中间过渡因素.最后根据计算的结果从直接制约因素、中间制约因素和深层制约因素三个层次分别突破分析和提出建议,帮助推动建筑工人产业化转型,促进建筑业高质量发展.

关键词：建筑工人产业化培训扎根理论制约因素 DEMATEL ISM模型

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临床触诊阴性的乳腺良性结节麦默通微创手术与传统手术的临床疗效对比

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系统医学 2024年第10期9卷 108-111页

作者：龚龙伟李江海黄鹄江南大学附属医院甲乳外科江苏无锡214122

目的探讨麦默通微创旋切技术在实际的触诊阴性乳腺良性结节治疗过程中的运用。方法回顾性选取江南大学附属医院甲乳外科于2019年6月—2021年6月收治的100例临床触诊阴性的乳腺良性结节患者的临床资料,按照手术方式的不同分为观察组(麦... 详细信息

目的探讨麦默通微创旋切技术在实际的触诊阴性乳腺良性结节治疗过程中的运用。方法回顾性选取江南大学附属医院甲乳外科于2019年6月—2021年6月收治的100例临床触诊阴性的乳腺良性结节患者的临床资料,按照手术方式的不同分为观察组(麦默通微创旋切术)与对照组(传统开放手术),每组50例,对比分析两组患者手术指标、术后乳腺外形满意度、术后原位复发率、术后切口内血肿形成等观察指标。结果观察组手术时长、切口长度、伤口愈合期、住院时间、疼痛视觉模拟评分均优于对照组,差异有统计学意义(P均0.05)。观察组切口内血肿发生率低于对照组,差异有统计学意义(P<0.05)。结论超声引导下的麦默通微创旋切术在治疗临床触诊阴性乳腺良性结节应用上具有手术时长短、切口长度短、术后疼痛轻、伤口愈合时间短、术后并发症少、住院时间短、术后乳腺外形满意度高等技术优势。

关键词：麦默通旋切临床触诊阴性乳腺良性结节超声

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Integrated Rabies Surveillance-hunan Province,China,2020

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China CDC weekly 2022年第44期4卷 986-989页

作者： Hao Yang Shengbao Chen Zhihui Dai longwei Luo Qianlai Sun Shanlu Zhao Ge Zeng Ziyan Liu Shixiong hu Center for Disease Control and Prevention of hunan Province Changsha CityHunan ProvinceChina

Introduction:The objective of this paper was to assess the epidemiology of rabies in hunan Province,analyze the associated factors,understand the status of prevention and treatment after rabies exposure,evaluate the effectiveness of prevention and treatment,and provide a scientific basis for formulating effective prevention and control measures.Methods:The surveillance data of rabies in hunan Province in 2020 were collected and analyzed by descriptive epidemiological method.Results:In 2020,a total of 59 cases of rabies were reported in hunan Province,with an incidence rate of 0.09/100,000.Overall,42 cases(71.19%)were due to animal bites and 43 cases(72.88%)were of grade III.The proportion of hand and combined injury of hand was the highest(40.68%).A total of 603,261 cases of rabies exposure were reported from the rabies post-exposure prophylaxis(PEP)clinic in hunan Province.Dogs were the main animal causing injuries,accounting for 74.21%.Only 83,418(13.84%)of the animals had a clear immune history,and a total of 11 dog attacks were reported in hunan Province.The average immunity rate of dogs in the whole province was 30.98%.In 2020,554 dogs were sampled in the whole province;20 of them were positive for a positivity rate of 3.61%.Conclusions:Rabies in hunan Province in 2020 had a relatively low prevalence.Failure to treat wounds,immunoglobulin injections,and vaccination after exposure were the main causes of rabies.Therefore,post-exposure management of rabies should be further strengthened to reduce the risk of rabies for high-risk populations.

关键词： hunan prevention strengthened

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智能艾灸机器人模拟雀啄灸法治疗膝骨关节炎的临床效果

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临床医学研究与实践 2024年第18期9卷 90-93页

作者：胡梦雨冉龙薇卓翠丽苏同生万兆新中国人民解放军63750部队医院陕西西安710005 陕西中医药大学陕西咸阳712046 宁波市江北区中医院浙江宁波315000 陕西省中医医院陕西西安710003

目的探讨智能艾灸机器人模拟雀啄灸法治疗膝骨关节炎(KOA)的临床效果。方法选取2020年7月至2022年12月就诊的64例KOA患者作为研究对象,随机将其分为试验组和对照组,每组32例。试验组采用智能艾灸机器人模拟雀啄灸法治疗,对照组采用传统... 详细信息

目的探讨智能艾灸机器人模拟雀啄灸法治疗膝骨关节炎(KOA)的临床效果。方法选取2020年7月至2022年12月就诊的64例KOA患者作为研究对象,随机将其分为试验组和对照组,每组32例。试验组采用智能艾灸机器人模拟雀啄灸法治疗,对照组采用传统雀啄灸法治疗。比较两组的治疗效果。结果治疗2、4周后,两组的视觉模拟量表(VAS)评分低于治疗前,且试验组低于对照组,差异具有统计学意义(P<0.05)。治疗2、4周后,两组的西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分中僵硬程度、活动障碍评分均低于治疗前,且试验组低于对照组,差异具有统计学意义(P<0.05)。试验组的治疗总依从率显著高于对照组,差异具有统计学意义(P<0.05)。试验组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论智能艾灸机器人模拟雀啄灸法治疗KOA安全有效,可以有效缓解患者的疼痛,改善膝关节僵硬与活动障碍,具有较高的临床应用价值。

关键词：智能艾灸机器人雀啄灸膝骨关节炎西安大略和麦克马斯特大学骨关节炎指数

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Selection of logistics distribution center location for SDN enterprises

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Journal of Management Analytics 2015年第3期2卷 202-215页

作者： Wei hu Ye Hou longwei Tian Yuan Li Antai College of Economics and Management Shanghai Jiao Tong UniversityShanghaiChina School of Economics and Management Shanghai University of Electric PowerShanghaiChina Institution for Development Policy and Management School of Environment and Education DevelopmentUniversity of MachesterManchesterUK

The location selection of the logistics distribution center for a supply and demand network(SDN)enterprises directly affected the efficiency of the logistics system operation and the customer service level.In this paper,we present a location selection model of the logistics distribution center for SDN enterprises.In order to improve the optimization effectiveness of the traditional methods in solving the location selection problem,an improved firefly algorithm was presented.By introducing a coordination factor,the search step can be automatically adjusted,and the accuracy of the algorithm can be improved.By introducing a chaotic search strategy,the diversity of firefly populations and the global optimization ability of the algorithm can be improved.The simulation experiments showed that the improved firefly algorithm achieved a more favorable effectiveness than three other algorithms we tested.

关键词： SDN logistics distribution center firefly algorithm chaos optimization

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Metallic vanadium trioxide intercalated with phase transformation for advanced aqueous zinc-ion batteries

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Journal of Energy Chemistry 2021年第10期30卷 594-601,I0015页

作者： Kang hu Danqing Jin Yao Zhang longwei Ke huan Shang Yan Yan huijuan Lin Kun Rui Jixin Zhu Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816JiangsuChina

Aqueous zinc-ion batteries have broad application prospects due to the eco-friendliness,cost-economy and high safety.However,the scarcity of high-performance cathodes with outstanding rate capability and long lifespan has affected their development.Herein,we report a metallic vanadium trioxide material intercalated with phase transformation as cathode applied in aqueous zinc-ion batteries.It offers satisfactory electrochemical performances with a high specific capacity(435 mAh g^(-1) at 0.5 A g^(-1)),decent power density(5.23 kW kg^(-1))and desired energy density(331 Wh kg^(-1)),as well as good cyclability.The superior performance originates from the stable structure and fast Zn^(2+)diffusion,enabled by the pre-intercalation of Zn^(2+)and water molecules.

关键词： Metallic vanadium trioxide Intercalated reaction Cathode Aqueous zinc-ion batteries Phase transformation

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Effects of biotic and abiotic factors on forest biomass fractions

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National Science Review 2021年第10期8卷 79-88页

作者： Renfei Chen Jinzhi Ran Weigang hu longwei Dong Mingfei Ji Xin Jia Jingli Lu Haiyang Gong Muhammad Aqeel Shuran Yao Lizhe An Jin-Sheng He Karl J.Niklas Jianming Deng State Key Laboratory of Grassland Agro-Ecosystem School of Life Sciences Lanzhou University Yanchi Research Station School of Soil and Water Conservation Beijing Forestry University Plant Biology Section School of Integrative Plant Science Cornell University

The extent to which key factors at the global scale influence plant biomass allocation patterns remains unclear. Here, we provide a theory about how biotic and abiotic factors influence plant biomass allocation and evaluate its predictions using a large global database for forested communities. Our analyses confirm theoretical predictions that temperature, precipitation, and plant height and density jointly regulate the quotient of leaf biomass and total biomass, and that they have a much weaker effect on shoot(leaf plus stem) biomass fractions at a global scale. Moreover, biotic factors have larger effects than abiotic factors.Climatic variables act equally on shoot and root growth, and differences in plant body size and age, as well as community species composition, which vary with climate in ways that drown out the variations in biomass fractions. The theory and data presented here provide mechanistic explanations of why climate has little effect on biomass fractions.

关键词： biomass allocation leaf biomass allometry plant density plant height scaling exponents

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