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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li longqing cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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Terahertz bound states in the continuum with incident angle robustness induced by a dual period metagrating

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Photonics Research 2022年第3期10卷 810-819页

作者： Wenqiao Shi Jianqiang Gu Xingyuan Zhang Quan Xu Jiaguang Han Quanlong Yang longqing cong Weili Zhang Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Tianjin Universityand Key Laboratory of Optoelectronics Information and TechnologyMinistry of EducationTianjin 300072China Nonlinear Physics Centre Australian National UniversityCanberraACT 2601Australia Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

Metasurface-empowered bound state in the continuum(BIC)provides a unique route for fascinating functional devices with infinitely high quality factors.This method is particularly attractive to the terahertz community because it may essentially solve the deficiencies in terahertz filters,sensors,lasers,and nonlinear sources.However,most BIC metasurfaces are limited to specified incident angles that seriously dim their application prospects.Here,we propose that a dual-period dielectric metagrating can support multiple families of BICs that originate from guided mode resonances in the dielectric grating and exhibit infinite quality factors at arbitrarily tilted incidence.This robustness was analyzed based on the Bloch theory and verified at tilted incident angles.We also demonstrate that inducing geometric asymmetry is an efficient way to manipulate the leakage and coupling of these BICs,which can mimic the electromagnetically induced transparency(EIT)effect in our dual-period metagrating.In this demonstration,a slow-light effect with a measured group delay of 117 ps was achieved.The incidence-insensitive BICs proposed here may greatly extend the application scenarios of the BIC effect.The high Q factor and outstanding slow-light effect in the metagrating show exciting prospects in realizing high-performance filters,sensors,and modulators for prompting terahertz applications.

关键词： incident dielectric continuum

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Electrically Programmable Terahertz Diatomic Metamolecules for Chiral Optical Control

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Research 2019年第1期2019卷 1123-1133页

作者： longqing cong Prakash Pitchappa Nan Wang Ranjan Singh Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Centre for Disruptive Photonic Technologies Te Photonics InstituteNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Institute of Microelectronics 11 Science Park Road117685Singapore

Optical chirality is central to many industrial photonic technologies including enantiomer identifcation,ellipsometry-based tomography,and spin multiplexing in optical communications.However,a substantial chiral response requires a threedimensional constituent,thereby making the morphology highly complex to realize structural reconfguration.Moreover,an active reconfguration demands intense dosage of external stimuli that pose a major limitation for on-chip integration.Here,we report a low bias,electrically programmable synthetic chiral paradigm with a remarkable reconfguration among levorotatory,dextrorotatory,achiral,and racemic conformations.Te switchable optical activity induced by the chiral conformations enables a transmission-type duplex spatial light modulator for terahertz single pixel imaging.Te prototype delivers a new strategy towards reconfgurable stereoselective photonic applications and opens up avenues for on-chip programmable chiral devices with tremendous applications in biology,medicine,chemistry,and photonics.

关键词： chiral thereby Chiral

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All-optical active THz metasurfaces for ultrafast polarization switching and dynamic beam splitting

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Light(Science & Applications) 2018年第1期7卷 766-774页

作者： longqing cong Yogesh Kumar Srivastava Huifang Zhang Xueqian Zhang Jiaguang Han Ranjan Singh Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Centre for Disruptive Photonic Technologies The Photonics InstituteNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Key Laboratory of Optoelectronic Information TechnologyMinistry of EducationTianjin University300072 TianjinPeople’s Republic of China

Miniaturized ultrafast switchable optical components with an extremely compact size and a high-speed response will be the core of next-generation all-optical devices instead of traditional integrated circuits,which are approaching the bottleneck of Moore’s Law.Metasurfaces have emerged as fascinating subwavelength flat optical components and devices for light focusing and holography applications.However,these devices exhibit a severe limitation due to their natural passive response.Here we introduce an active hybrid metasurface integrated with patterned semiconductor inclusions for all-optical active control of terahertz waves.Ultrafast modulation of polarization states and the beam splitting ratio are experimentally demonstrated on a time scale of 667 ps.This scheme of hybrid metasurfaces could also be extended to the design of various free-space all-optical active devices,such as varifocal planar lenses,switchable vector beam generators,and components for holography in ultrafast imaging,display,and high-fidelity terahertz wireless communication systems.

关键词： polarization optical beam

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Recent Advances and Perspective of Photonic Bound States in the Continuum

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Ultrafast Science 2023年第5期3卷 25-41页

作者： Guizhen Xu Hongyang Xing Zhanqiang Xue Dan Lu Jinying Fan Junxing Fan Perry Ping Shum longqing cong Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China

Recent advancements in photonic bound states in the continuum(BICs)have opened up exciting new possibilities for the design of optoelectronic devices with improved performance.In this perspective article,we provide an overview of recent progress in photonic BICs based on metamaterials and photonic crystals,focusing on both the underlying physics and their practical applications.The first part of this article introduces 2 different interpretations of BICs,based on far-field interference of multipoles and near-field analysis of topological charges.We then discuss recent research on manipulating the far-field radiation properties of BICs through engineering topological charges.The second part of the article summarizes recent developments in the applications of BICs,including chiral light and vortex beam generation,nonlinear optical frequency conversion,sensors,and nanolasers.Finally,we conclude with a discussion of the potential of photonic BICs to advance terahertz applications in areas such as generation and detection,modulation,sensing,and isolation.Webelieve that continued researchinthis area will lead to exciting new advancements in optoelectronics,particularly in the field of terahertz devices.

关键词： optoelectronic charges continued

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Broadband terahertz rotator with an all-dielectric metasurface

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Photonics Research 2018年第11期6卷 1056-1061页

作者： QUANLONG YANG XIEYU CHEN QUAN XU CHUNXIU TIAN YUEHONG XU longqing cong XUEQIAN ZHANG YANFENG LI CAIHONG ZHANG XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Tianjin University and the Key Laboratory of Optoelectronics Information and Technology Tianjin Ministry of Education of China Physical Science and Engineering Division King Abdullah University of Science and Technology Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Research Institute of Superconductor Electronics (RISE) School of Electronic Science and Engineering Nanjing University School of Electrical and Computer Engineering Oklahoma State University

Polarization manipulation is essential in developing cutting-edge photonic devices ranging from optical communication displays to solar energy harvesting. Most previous works for efficient polarization control cannot avoid utilizing metallic components that inevitably suffer from large ohmic loss and thus low operational efficiency.Replacing metallic components with Mie resonance-based dielectric resonators will largely suppress the ohmic loss toward high-efficiency metamaterial devices. Here, we propose an efficient approach for broadband, highquality polarization rotation operating in transmission mode with all-dielectric metamaterials in the terahertz regime. By separating the orthogonal polarization components in space, we obtain rotated output waves with a conversion efficiency of 67.5%. The proposed polarization manipulation strategy shows impressive robustness and flexibility in designing metadevices of both linear-and circular-polarization incidences.

关键词： Broadband terahertz rotator THz all-dielectric metasurface

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Hybrid bound states in the continuum in terahertz metasurfaces

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Opto-Electronic Science 2023年第4期2卷 12-20页

作者： Junxing Fan Zuolong Li Zhanqiang Xue Hongyang Xing Dan Lu Guizhen Xu Jianqiang Gu Jiaguang Han longqing cong Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityTianjin 300072China Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China

Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical switches.The most common strategy to apply BICs in a metasurface is by breaking symmetry of resonators in the uniform array that leaks the otherwise uncoupled mode to free space and exhibits an inverse quadratic relationship between quality factor(Q)and asymmetry.Here,we propose a scheme to further reduce scattering losses and improve the robustness of symmetry-protected BICs by decreasing the radiation density with a hybrid BIC lattice.We observe a significant increase of radiative Q in the hybrid lattice compared to the uniform lattice with a factor larger than 14.6.In the hybrid BIC lattice,modes are transferred toГpoint inherited from high symmetric X,Y,and M points in the Brillouin zone that reveal as multiple Fano resonances in the far field and would find applications in hyperspectral sensing.This work initiates a novel and generalized path toward reducing scattering losses and improving the robustness of BICs in terms of lattice engineering that would release the rigid requirements of fabrication accuracy and benefit applications of photonics and optoelectronic devices.

关键词： bound states in the continuum metasurfaces terahertz photonics radiative losses Fano resonances

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杂化连续域内束缚态中的环形偶极子

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激光与光电子学进展 2023年第18期60卷 223-228页

作者：丛龙庆许桂珍南方科技大学工学院电子与电气工程系广东深圳518055

基于连续域内束缚态(BIC)的超表面具备在时间和空间上实现高效光场调控的能力.在时间维度上,BIC理论上可实现无穷长的辐射光子寿命,因此在激光谐振腔、非线性光学、传感等领域展现了极好的应用价值.为深入理解BIC及衍生谐振特性,基于双... 详细信息

基于连续域内束缚态(BIC)的超表面具备在时间和空间上实现高效光场调控的能力.在时间维度上,BIC理论上可实现无穷长的辐射光子寿命,因此在激光谐振腔、非线性光学、传感等领域展现了极好的应用价值.为深入理解BIC及衍生谐振特性,基于双开口金属谐振器构成的杂化BIC超表面,探讨由于能带折叠引起的折叠谐振与准BIC谐振之间的特性.利用数值模拟、多极子分析和太赫兹光谱实验验证环形偶极子在这两类谐振辐射特性中的重要作用.此外,通过对比两种不同能带折叠方式的超晶格,进一步确认环形偶极子对折叠谐振品质因数的调制特性.深入理解谐振中多极子的散射特性对获取高品质因数谐振腔具有重要作用,为切实推动超表面在太赫兹传感、调制器和非线性相互作用等领域的应用奠定理论基础.

关键词：连续域束缚态环形偶极子超表面多极子分析太赫兹

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主动式太赫兹超材料器件综述

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中国激光 2021年第19期48卷 151-167页

作者：丛龙庆南方科技大学工学院电子与电气工程系广东深圳518055

主要总结了目前利用超材料与不同的材料或者技术结合实现太赫兹波动态调制器件的研究进展。太赫兹波动态调制器件的功能性来源于超材料,其动态响应机制则来源于器件集成的材料和外加驱动。基于超材料对局域电场的多阶增强效应,这种复合... 详细信息

主要总结了目前利用超材料与不同的材料或者技术结合实现太赫兹波动态调制器件的研究进展。太赫兹波动态调制器件的功能性来源于超材料,其动态响应机制则来源于器件集成的材料和外加驱动。基于超材料对局域电场的多阶增强效应,这种复合式调制器可以实现更低的调制能量消耗、更大的调制深度、更快的调制速度和更丰富的功能。本文以不同的材料或者技术为基础进行分类阐述,分别介绍了太赫兹波动态调制器件的基本调制原理、主要性能参数、驱动方式和研究进展。

关键词：材料超材料太赫兹调制器主动式器件液晶微机电系统半导体石墨烯

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基于灰色理论的底板突水危险性评价

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矿业安全与环保 2016年第5期43卷 45-49,61页

作者：刘磊于小鸽王丹丹施龙青丛培章季良军江西应用技术职业学院资源环境与珠宝学院江西赣州341000 山东科技大学资源与土木工程系山东泰安271000 山东科技大学地球科学与工程学院山东青岛266590 招金矿业股份有限公司山东招远265400 兖州煤业股份有限公司南屯煤矿山东邹城273515

为了解决底板突水预测预报评价的难题,在建立煤层底板突水主控指标基础上,采用端点三角白化权函数和中心点三角白化权函数灰色评价对矿区某一小块进行评价,并通过比较得出中心点白化权函数灰色评价的结果更可靠。运用中心点白化权函数... 详细信息

为了解决底板突水预测预报评价的难题,在建立煤层底板突水主控指标基础上,采用端点三角白化权函数和中心点三角白化权函数灰色评价对矿区某一小块进行评价,并通过比较得出中心点白化权函数灰色评价的结果更可靠。运用中心点白化权函数对古汉山矿底板突水危险性进行灰色评价分析,得出底板突水危险性分布图,同时对底板突水危险性趋势进行了预测。

关键词：煤矿底板突水突水系数灰色理论危险性评价

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