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从胸外科视角看SiewertⅡ型食管胃结合部腺癌的治疗

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中华胃肠外科杂志 2022年第2期25卷 109-113页

作者：李珍艳顾一敏王文凭陈龙奇四川大学华西医院胸外科成都610041 四川大学华西医院消化内科成都610041

SiewertⅡ型食管胃结合部腺癌(AEG)相比较于SiewertⅠ、Ⅲ型,存在着较大的临床诊疗争议。《中华胃肠外科杂志》于2018年发表了首版《食管胃结合部腺癌外科治疗中国专家共识》,几年来,随着胸腔镜微创技术的发展已经证实,胸腔镜微创手术能... 详细信息

SiewertⅡ型食管胃结合部腺癌(AEG)相比较于SiewertⅠ、Ⅲ型,存在着较大的临床诊疗争议。《中华胃肠外科杂志》于2018年发表了首版《食管胃结合部腺癌外科治疗中国专家共识》,几年来,随着胸腔镜微创技术的发展已经证实,胸腔镜微创手术能使SiewertⅡ型AEG患者受到更小的胸部创伤,经胸行远端食管切除可以实现安全切缘,上腹-右胸入路可以保证纵隔淋巴结清扫效果并使患者生存获益。而内镜手术的发展以及综合治疗理念及其实践,也为SiewertⅡ型AEG治疗模式给予了新的补充。针对手术的残端安全问题和淋巴结清扫问题,应该开展更多的临床研究以寻求解决之道。

关键词：食管胃结合部腺癌 Siewert分型手术入路残端淋巴结清扫胸腔镜综合治疗内镜手术

Notch-1在人食管鳞癌和癌旁正常组织中的表达及其意义

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中国肿瘤临床 2010年第12期37卷 673-676页

作者：马瑞东诸葛雪朋刘伦旭陈龙奇四川大学华西医院胸心外科成都市610041

目的:研究Notch-1在食管鳞癌及癌旁正常组织中的表达,并联系临床病理特征,探讨Notch-1在食管癌发生、发展中的作用及其临床意义。方法:收集并保存2008年4月至2008年9月四川大学华西医院胸外科手术切除的食管鳞癌及癌旁正常组织(距离肿... 详细信息

目的:研究Notch-1在食管鳞癌及癌旁正常组织中的表达,并联系临床病理特征,探讨Notch-1在食管癌发生、发展中的作用及其临床意义。方法:收集并保存2008年4月至2008年9月四川大学华西医院胸外科手术切除的食管鳞癌及癌旁正常组织(距离肿瘤至少5cm之外的正常食管黏膜组织)标本,利用RT-PCR方法检测41例食管鳞癌及癌旁正常组织中Notch-1基因mRNA水平的相对表达强度,并分析其与肿瘤侵袭深度(T)、淋巴结转移(N)、TNM分期、分化程度等临床病理特征之间的关系。结果:所有标本中均可见到Notch-1的电泳条带,即均检测到Notch-1基因mRNA水平的表达。半定量分析显示食管鳞癌中Notch-1的相对表达强度为0.51±0.37,癌旁正常组织中为0.32±0.20,两者有显著性差异(t=3.52,P=0.001)。按照肿瘤侵袭深度(T)、淋巴结转移(N)、TNM分期分化程度等不同的临床病理特征划分亚组后,食管鳞癌与癌旁正常组织中的差异显著性仍然存在。而在食管鳞癌组中,各亚组之间的差异均无统计学意义。结论:Notch-1可能在食管鳞癌发生中起作用,而与食管鳞癌病变的进展可能关系不大。

关键词： RT-PCR Notch-1 mRNA 食管鳞癌

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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基于LSTM-SNP的命名实体识别

西华大学学报（自然科学版） 2023年第5期42卷 28-37页

作者：邓琴陈晓亮陈龙齐西华大学计算机与软件工程学院四川成都610039

脉冲神经P系统(SNPs)是抽象于生物神经元信息交互机制的高效并行计算系统。LSTM-SNP首次结合非线性SNP和长短期记忆神经网络(LSTM),从而形成门控机制可解释的深度学习通用模型。LSTM-SNP作为传统序列分析模型LSTM的最新变体,在处理典型... 详细信息

脉冲神经P系统(SNPs)是抽象于生物神经元信息交互机制的高效并行计算系统。LSTM-SNP首次结合非线性SNP和长短期记忆神经网络(LSTM),从而形成门控机制可解释的深度学习通用模型。LSTM-SNP作为传统序列分析模型LSTM的最新变体,在处理典型自然语言处理序列分析问题的性能表现未见相关研究。文章以命名实体识别任务为基础,通过在LSTM-SNP上增补不同的深度学习组件,对LSTM-SNP与传统LSTM以及其变体BiLSTM的性能差异进行了全面分析,为在自然语言处理任务中使用LSTM-SNP模型提供可靠的改进参考。通过以CoNLL-2003和OntoNotes5.0为标准数据集的对比实验,发现:LSTM-SNP模型与LSTM模型具有类似的实体识别性能,但随着预处理的操作,LSTM-SNP模型的整体性能提升更为显著;LSTM-SNP模型对命名实体的识别是一种行之有效的方法,且具有较大的应用潜力。

关键词： LSTM-SNP模型命名实体识别模型性能测评

A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

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脉管癌栓对食管鳞状细胞癌预后的影响

中华胸心血管外科杂志 2015年第11期31卷 656-659页

作者：杨玉赏胡伟鹏陈龙奇四川大学华西医院胸外科 610041

目的探讨食管鳞癌合并脉管癌栓患者的临床病理特点、生存率以及影响食管鳞癌患者预后的因素。方法回顾2005年6月至2008年12月手术治疗食管鳞癌患者的资料，分析其临床病理特点及脉管癌栓对术后生存的影响。结果共收集355例患者，其中脉... 详细信息

目的探讨食管鳞癌合并脉管癌栓患者的临床病理特点、生存率以及影响食管鳞癌患者预后的因素。方法回顾2005年6月至2008年12月手术治疗食管鳞癌患者的资料，分析其临床病理特点及脉管癌栓对术后生存的影响。结果共收集355例患者，其中脉管癌栓阳性患者46例（13．3％）。脉管癌栓阳性和阴性患者的5年生存率分别为20．3％和40．2％。单因素分析结果显示，影响总生存率的因素为T分期、N分期，体质指数、组织分化和脉管癌栓。多因素分析结果显示T分期、N分期、体质指数及脉管癌栓是影响预后的独立因素。结论食管鳞癌合并脉管癌栓患者具有较差的生物学特性，且脉管癌栓是影响食管鳞癌预后的独立因素。

关键词：食管肿瘤癌 ,鳞状细胞预后脉管癌栓

Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

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单孔胸腔镜食管癌切除术的现状与进展

中华消化外科杂志 2018年第8期17卷 800-803页

作者：刘清松胡伟鹏陈龙奇袁勇四川大学华西医院胸外科成都610041

食管癌切除术是胸外科复杂的手术之一，传统的开胸手术创伤大．并发症多，胸腔镜手术的开展有效地降低了术后并发症发生率，缩短了住院时间。单孔胸腔镜手术的发展则进一步体现了微创食管癌切除术的潜在优势。由于食管癌手术的复杂性，... 详细信息

食管癌切除术是胸外科复杂的手术之一，传统的开胸手术创伤大．并发症多，胸腔镜手术的开展有效地降低了术后并发症发生率，缩短了住院时间。单孔胸腔镜手术的发展则进一步体现了微创食管癌切除术的潜在优势。由于食管癌手术的复杂性，单孔胸腔镜食管癌切除术的技术难度较高。2015年台湾学者首次报道了单孔胸腹腔镜食管癌切除术。该手术方式随后在国内外多家单位相继开展。单孔胸腔镜食管癌切除术的发展目前还处于起步阶段，技术尚未成熟，相关研究较少．缺乏长期、大样本的对照研究。笔者将从单孔胸腔镜食管癌切除术的发展演变、技术特点、短期结果、笔者团队临床实践、优势与挑战等方面进行深入阐述。

关键词：食管肿瘤单孔胸腔镜手术微创食管癌切除术

Two-stage Planning Method for Energy Router Considering Its Optimal Operation in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 605-616页

作者： Meifu chen Mingchao Xia Qifang chen School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

An energy router can effectively optimize the network loss and power quality of distribution networks. The optimal configuration of the energy router is relatively complex because issues dynamically influence each other, such as the location of the energy router, optimal number and capacity of its ports, and building new distribution lines for the ports. Presently, there has been very few research studies on the practical problems for the energy router. In this paper, a planning model of an energy router combined with the distribution network is established, which fully exploits the active and reactive power control abilities of the energy router to optimize the operation of the grid. The configuration problem is decoupled into two stages. The upper layer determines the location of the energy router and the parameters of the candidate new distribution lines for the ports. The lower layer calculates the optimal configuration of the energy router by minimizing the total annual cost. Because of the same rated bus voltage in the distribution network, the existing structure of the energy router is changed to be more applicable for the distribution network, and then the power flow model of the energy router is also modified. Due to the nonlinearity of the model, the planning model is converted into a mixed-integer second-order cone model to solve efficiently. In addition, some core factors influencing the optimal scheme of the energy router are also analyzed in this paper. Simulation results show that the optimal scheme of the energy router can significantly improve the economic deployment of the energy router, and optimize the network loss and power quality of the distribution network.

关键词： Capacity allocation distribution network energy router optimal operation