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中国口腔颌面外科杂志 2009年第5期7卷 427-427页

作者： Caponigro f longo f Perri f

头颈鳞癌严重危害人类健康。最近,对无法切除的局部晚期肿瘤的治疗研究取得了长足进展,主要在于放化疗的结合及多西他赛在诱导化疗中的应

关键词：头颈癌多西他赛诱导化疗

Probiotics to counteract biofilm-associated infections: promising and conflicting data

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International Journal of Oral Science 2014年第4期6卷 189-194页

作者： Claudia Vuotto francesca longo Gianfranco Donelli Microbial Biofilm Laboratory IRCCS Fondazione Santa Lucia Rome Italy

Altered bowel flora is currently thought to play a role in a variety of disease conditions, and the use of Bifidobacterium spp. and Lactobacillus spp. as probiotics has been demonstrated to be health-promoting, even if the success of their administration depends on the applied bacterial strain（s） and the targeted disease. In the last few decades, specific probiotics have been shown to be effective in the treatment or the prevention of acute viral gastroenteritis, pediatric post-antibiotic-associated diarrhea, some pediatric allergic disorders, necrotizing enterocolitis in preterm infants, inflammatory bowel diseases and postsurgical pouchitis. The potential application of probiotics is continuously widening, with new evidence accumulating to support their effect on the prevention and treatment of other disease conditions, including several oral diseases, such as dental caries, periodontal diseases and oral malodor, as well as genitourinary and wound infections. Considering the increasingly widespread ability of pathogens to generate persistent biofilm-related infections, an even more attractive proposal is to administer probiotics to prevent or counteract biofilm *** response of biofilm-based oral, intestinal, vaginal and wound infections to probiotics treatment will be reviewed here in light of the most recent results obtained in this field.

关键词： biofilm genitourinary tract gut infections oral cavity probiotics wounds

Mayombian ethnic,vegetables low intake,insulin treatment,diabetic nephropathy and severe diabetic retinopathy are determinants of blindness in diabetic Africans

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 727-732页

作者： Mvitu Muaka Moise longo-Mbenza Benjamin Cibanda Yokobo Enoch longo Phemba Igor Department of Ophthalmology Faculty of MedicineUniversity of Kinshasa Walter Sisulu University Faculty of Health Sciences Department of Anaesthesiology Nelson Mandela Academic Hospital School of International Studies Wenzhou Medical College

AIMTo determine the frequency and causes of blindness in diabetic Africans.

关键词： diabetes mellitus blindness ethnicity Mayombe diabetic retinopathy insulin treatment Africans

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The East London glaucoma prediction score: web-based validation of glaucoma risk screening tool

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 95-102页

作者： Cook Stephen longo-Mbenza Benjamin The Eye Centre East London Eastern Cape Province faculty of Health Sciences Walter Sisulu University

AIM:It is difficult for Optometrists and General Practitioners to know which patients are at risk. The East London glaucoma prediction score (ELGPS) is a web based risk calculator that has been developed to determine Glaucoma risk at the time of screening. Multiple risk factors that are available in a low tech environment are assessed to provide a risk assessment. This is extremely useful in settings where access to specialist care is difficult. Use of the calculator is educational. It is a free web based service. Data capture is user specific. METHODS:The scoring system is a web based questionnaire that captures and subsequently calculates the relative risk for the presence of Glaucoma at the time of screening. Three categories of patient are described:Unlikely to have Glaucoma; Glaucoma Suspect and Glaucoma. A case review methodology of patients with known diagnosis is employed to validate the calculator risk assessment. RESULTS:Data from the patient records of 400 patients with an established diagnosis has been captured and used to validate the screening tool. The website reports that the calculated diagnosis correlates with the actual diagnosis 82% of the time. Biostatistics analysis showed:Sensitivity = 88% ; Positive predictive value = 97%; Specificity = 75%. CONCLUSION:Analysis of the first 400 patients validates the web based screening tool as being a good method of screening for the at risk population. The validation is ongoing. The web based format will allow a more widespread recruitment for different geographic, population and personnel variables.

关键词： glaucoma score diagnosis tomography management South Africa

AN APPLICATION Of MODELING AND SIMULATION TO SUPPORT INDUSTRIAL PLANTS DESIGN

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 90-115页

作者： fRANCESCO longo MARINA MASSEI LETIZIA NICOLETTI Modeling&Simulation Center—Laboratory of Enterprise Solutions(MSC–LES)M&S Net Center Mechanical EngineeringUniversity of Calabria Via Pietro BucciRende87036Italy MISS-DIPTEM University of GenoaVia Molinero 1–17100 SavonaItaly CAL-TEK Srl Via Spagna 70Rende87036Italy

The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based *** industrial plant design is initially based on a traditional approach(production process flow charts analysis and plant layout study)and it is then supported by a simulation model mainly used to investigate the system behavior in different operative *** industrial plant simulation model(called HAZIMUT,HAZelnuts Industrial plant design and man-agement based on advanced simulation Models Utilization)recreates the entire hazelnuts production process(based on nine different production lines).The HAZIMUT simulation model is used to evaluate the effects—caused by multiple changes in the production lines capacities—on multiple performance measures based on machines levels utilization,work in process and production system *** simulation results show how variations in production lines capacities generate an over-reaction of the system with major changes in some of the performance measures therefore stressing the importance to use the HAZIMUT simulator to tune the system correctly to improve the overall plant performances.

关键词： Industrial plants production capacity design modeling simulation

Anastomotic disruption after large bowel resection

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World Journal of Gastroenterology 2006年第16期12卷 2497-2504页

作者： Mohammad U NasirKhan farshad Abir Walter longo Robert Kozol Departments of Surgery University of Connecticut School of Medicine and Health CenterUnited StatesYale University School of MedicineUnited States

Anastomotic disruption is a feared and serious complication of colon surgery. Decades of research have identified factors favoring successful healing of anastomoses as well as risk factors for anastomotic disruption. However, some factors, such as the role of mechanical bowel preparation, remain controversial. Despite proper caution and excellent surgical technique, some anastomotic leaks are inevitable. The rapid identification of anastomotic leaks and the timely treatment in these cases are paramount.

关键词： Colon Colectomy Anastomosis Surgical complications

ALD growth of ultra-thin Co layers on the topological insulator Sb2Te3

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Nano Research 2020年第2期13卷 570-575页

作者： Emanuele longo Roberto Mantovan Raimondo Cecchini Michael D.Overbeek Massimo longo Giovanna Trevisi Laura Lazzarini Graziella Tallarida Marco fanciulli Charles H.Winter Claudia Wiemer CNR-IMM Unit of Agrate BrianzaVia C.Olivetti 2Agrate Brianza(MB)20864Italy Universitàdegli Studi di Milano-Bicocca Dipartimento di Scienza dei MaterialiVia R.Cozzi 55Milano 20125Italy Department of chemistry Wayne State UniversityDetroitMichigan 48202USA CNR-IMEM Parco Area delle Scienze 37/AParma 43124Italy

Taking the full advantage of the conformal growth characterizing atomic layer deposition(ALD),the possibility to grow Co thin films,with thickness from several tens down to few nanometers on top of a granular topological insulator(TI)Sb2Tes film,exhibiting a quite high surface roughness(2-5 nm),was *** study the Co growth on the Sb2Tes substrate,we performed simultaneous Co depositions also on sputtered Pt substrates for *** conducted a thorough chemical-structural characterization of the Co/Sb2Tes and Co/Pt heterostructures,confirming for both cases,not only an excellent conformality,but also the structural continuity of the Co layers.X-ray diffraction(XRD)and high-resolution transmission electron microscope(HRTEM)analyses evidenced that Co on Sb2Te3 grows preferentially oriented along the[0oe]direction,following the underlying rhombohedric ***,Co crystallizes in a cubic phase oriented along the[111]direction when deposited on *** work shows that,in case of deposition of crystalline materials,the ALD surface selectivity and conformality can be extended to the definition of local epitaxy,where in-plane ordering of the crystal structure and mosaicity of the developed crystallized grains are dictated by the underlying ***,a highly sharp and chemically-pure Co/Sb2Tes interface was evidenced,which is promising for the application of this growth process for spintronics.

关键词： atomic layer deposition X-ray diffraction Co-fcc Co-hep antimony telluride metal organic chemical vapor deposition spintronics

Update in management of mesenteric ischemia

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World Journal of Gastroenterology 2006年第20期12卷 3243-3247页

作者： Robert W Chang John B Chang Walter E longo Professor Department of Surgery Yale University School of Medicine333 Cedar StreetNew Haven 06510United States

Mesenteric ischemia disorders are precipitated by a circulation insufficiency event that deprives one or several abdominal organs of adequate respiration to meet metabolic demands. Although mesenteric ischemia occurs infrequently, the mortality rate is from 60% to 100%, depending on the source of obstruction. The successful outcome is dependent upon a high index of suspicion and prompt management. We briefly review the pathophysiology and presentation of the various ischemic entities and review the current state of the art in diagnosis and treatment. Despite advances in both diagnosis and treatment, prompt diagnosis and supportive care remain critical for successful outcome. New imaging techniques, endovascular therapy and emerging research may improve our approach to this deadly condition.

关键词： Mesenteric ischemia Duplex ultrasonography Plasma D-dimer Computed tomography

Management of parastomal ulcers

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World Journal of Gastroenterology 2006年第20期12卷 3133-3137页

作者： Heather Yeo farshad Abir Walter E longo Department of Surgery Yale University School of Medicine United States

Management of surgically placed ostomies is an important aspect of any general surgical or colon and rectal surgery practice. Complications with surgically placed ostomies are common and their causes are multifactorial. Parastomal ulceration, although rare, is a particularly difficult management problem. We conducted a literature search using MD Consult, Science Direct, OVID, Medline, and Cochrane Databases to review the causes and management options of parastomal ulceration. Both the etiology and treatments are varied. Different physicians and ostomy specialists have used a large array of methods to manage parastomal ulcers; these including local wound care; steroid creams; systemic steroids; and, when conservative measures fail, surgery. Most patients with parastomal ulcers who do not have associated IBD or peristomal pyoderma gangrenosum （PPG） often respond quickly to local wound care and conservative management. Patients with PPG, IBD, or other systemic causes of their ulceration need both systemic and local care and are more likely to need long term treatment and possibly surgical revision of the ostomy. The treatment is complicated, but improved with the help of ostomy specialists.

关键词： Parastomal ulcers Peristomal ulcers Ostomies Complications

Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 293-301页

作者： Benjamin longo-Mbenza Moise Mvitu Muaka Wayiza Masamba Lucien Muizila Kini Igor longo Phemba Dalida Kibokela Ndembe Doris Tulomba Mona Walter Sisulu University faculty of Health Sciences Walter Sisulu University Department of Ophthalmology University of Kinshasa Department of Chemistry and Chemical Technology Walter Sisulu University Department of family Medicine Umtata General HospitalWalter Sisulu University School of International Studies Wendzou Medical College Department of Neuropsychiatry University of Kinshasa Biostatistics Unit Lomo Medical Center and Heart of Africa Center of Cardiology

AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk ***:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),*** levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in *** lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in *** the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with ***:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type *** of oxidative stress and abdominal obesity is *** in vitamin C,D,and E should be recommended as complement therapies of T2DM.

关键词： anticipation apolipoprotein B diabetic retinopathy oxidative stress discriminant analysis Africa