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Causal Relationship Between Complement C3,C4,and Nonalcoholic Fatty liver Disease:Bidirectional Mendelian Randomization Analysis

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Phenomics 2021年第5期1卷 211-221页

作者： longman li Lulu Huang Aimin Yang Xiuming Feng Zengnan Mo Haiying Zhang Xiaobo Yang Center for Genomic and Personalized Medicine Guangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Medical UniversityNanning 530021GuangxiChina Nanhu Zhuxi Community Healthcare Center Qingxiu DistrictNanning 530021GuangxiChina School of Public Health The University of Hong KongHong Kong SAR 999077China Department of Occupational Health and Environmental Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Department of Urology Institute of Urology and NephrologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Public Health School of MedicineGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina

The complement system is activated during the development of nonalcoholic fatty liver disease(NAFLD).We aimed to evaluate the causal relationship between serum C3 and C4 levels and *** exclusion criteria,a total of 1600 Chinese Han men from the Fangchenggang Area Male Health and Examination Survey cohort were enrolled in cross-sectional analysis,while 572 participants were included in the longitudinal analysis(average follow-up of 4 years).We performed a bidirectional Mendelian randomization(MR)analysis using two C3-related,eight C4-related and three NAFLD-related gene loci as instrumental variables to evaluate the causal associations between C3,C4,and NAFLD risk in cross-sectional *** SD increase in C3 levels was significantly associated with higher risk of NAFLD(OR=1.65,95%CI 1.40,1.94)in cross-sectional analysis while C4 was not(OR=1.04,95%CI 0.89,1.21).Longitudinal analysis produced similar results(HR_(C3)=1.20,95%CI 1.02,1.42;HR_(C4)=1.10,95%CI 0.94,1.28).In MR analysis,there were no causal relation-ships for genetically determined C3 levels and NAFLD risk using unweighted or weighted GRS_C3(β_(E_unweighted)=−0.019,95%CI−0.019,−0.019,p=0.202;β_(E_weighted)=−0.019,95%CI−0.019,−0.019,p=0.322).Conversely,serum C3 lev-els were significantly effected by the genetically determined NAFLD(β_(E_unweighted)=0.020,95%CI 0.020,0.020,p=0.004;β_(E_weighted)=0.021,95%CI 0.020,0.021,p=0.004).Neither the direction from C4 to NAFLD nor the one from NAFLD to C4 showed significant *** results support that the change in serum C3 levels but not C4 levels might be caused by NAFLD in Chinese Han men.

关键词： Nonalcoholic fatty liver disease C3 C4 Mendelian randomization

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Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study

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Phenomics 2022年第4期2卷 242-253页

作者： Xiuming Feng Wenjun Yang Lulu Huang Hong Cheng Xiaoting Ge Gaohui Zan Yanli Tan lili Xiao Chaoqun liu Xing Chen Zengnan Mo longman li Xiaobo Yang Department of Occupational Health and Environmental Health Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory for Genomic and Personalized Medicine Center for Genomic and Personalized MedicineGuangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Medical UniversityNanning 530021GuangxiChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021GuangxiChina Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Department of Public Health School of MedicineGuangxi University of Science and TechnologyGuangxi 545006China Department of Nutrition and Food Hygiene School of Public HealthGuangxi Medical UniversityNanningGuangxiChina School of Public Health Guangxi Medical UniversityNanningGuangxiChina Department of Urology Institute of Urology and NephrologyFirst Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China

Exposures to copper have become a health *** aim to explore the broad clinical effects of blood copper concentrations.A total of 376,346 Caucasian subjects were *** performed a Mendelian randomization and phenome-wide association study(MR-PheWAS)to evaluate the causal association between copper and a wide range of outcomes in UK Biobank,and we constructed a protein-protein interaction *** found association between blood copper concentrations and five diseases in the overall population and nine diseases in *** analysis implicated a causal role of blood copper in five diseases(overall population),including prostate cancer(OR=0.87,95%CI 0.77-0.98),malignant and unknown neoplasms of the brain and nervous system(OR=0.58,95%CI 0.38-0.89),and hypertension(OR=0.94,95%CI 0.90-0.98),essential hypertension(OR=0.94,95%CI 0.90-0.98)and cancer of brain and nervous system(OR=0.63,95%CI 0.41-0.98).For male,except for dysphagia being newly associated with blood copper(OR=1.39,95%CI 1.18-1.63),other MR results were consistent with the overall *** addition,the PPI network showed possible relationship between blood copper and four outcomes,namely brain cancer,prostate cancer,hypertension,and *** copper may have causal association with prostate cancer,malignant and unknown neoplasms of the brain and nervous system,hypertension,and *** that copper is modifiable,exploring whether regulation of copper levels can be used to optimize health outcomes might have public health importance.

关键词： Copper Disease Mendelian randomization Phenome-wide association study

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Development of Prognostic Indicator Based on RNA-binding proteins related lncRNAs in bladder urothelial carcinoma

Development of Prognostic Indicator Based on RNA-binding pro...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Chunmeng Wei Caihong Huang Yexin li Xiaojie Wang Qiang ling Shengzhu Huang Weixia liang linjian Mo Jiwen Cheng Fubo Wang Zengnan Mo longman li Center for Genomic and Personalized Medicine Guangxi Medical University Guangxi key Laboratory for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Department of Urology Institute of Urology and Nephrology The First Affiliated Hospital of Guangxi Medical University

Background: Numerous evidences have shown RNA-binding proteins(RBPs) were closely related to tumor survival, suggesting that RBPs might be used as prognostic predictors, while lncRNAs had been known as powerful biomarker in predicting the prognosis of cancer. Bladder urothelial cancer(BLCA)shown a high recurrence risk that approximately 70% in non-muscle-invasive type and roughly up to21% with high-risk disease will progress to muscle invasive bladder cancer, which leads to a poor prognosis. Regrettably, so far, no ideal markers were found to monitor the prognostic survival of BLCA. Besides, the construction of prognostic markers based on RBPs-related lncRNAs has not been reported in BLCA yet. To address these challenging issues, we aim to develop a prognostic indicator to predict BLCA patient prognostic survival based on RBPs-related ***: This study was based on tissue transcriptome data obtain from The Cancer Genome Atlas(TCGA) database(https://***/). After inclusion and exclusion criteria, a total of 396 pairs of BLCA patients’ tumor tissues and normal tissues were enrolled in our final analyses. The Cox proportional hazards regression and least absolute shrinkage and selection operator(LASSO)regression were used to screen RBPs-related lncRNAs based on differentially expressed lncRNAs(DELs) between BLCA and normal control to construct a risk score and build an independent prognostic model. Using the median risk score as cut-off, the patients were classified into two groups:high-risk and low-risk groups. Nomogram was utilized to predict survival for the patients. Moreover,the index of concordance(C-index), calibration curves, and receiver operating characteristic(ROC)curves were applied to explore the accuracy of the model. The TIMER, CIBERSORT, CIBERSORT–ABS, QUANTISEQ, MCPCOUNTER, XCELL and EPIC algorithms were used to assess cellular components or cell immune responses between high-and low-risk groups based on RBPS-related lncRNAs

关键词： prognostic indicator BLCA immunity

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DNA修复基因hOGG1多态性、HBV感染交互作用与肝细胞癌易感性的关系

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卫生研究 2011年第6期40卷 705-708页

作者：纪龙曾小云李龙嫚仇小强陈似霞余红平泰山医学院公共卫生学院泰安271000 广西医科大学公共卫生学院桂林医学院广西医科大学第一附属医院肝胆血管外科

目的探讨广西肝癌高发区人群DNA修复基因8-羟基鸟嘌呤糖苷酶1单核苷酸多态性与肝细胞癌易感性的关系,并分析与环境危险因素的交互作用。方法采用以医院为基础的病例-对照研究,对广西壮族自治区500例肝细胞癌和507例正常对照进行流行病... 详细信息

目的探讨广西肝癌高发区人群DNA修复基因8-羟基鸟嘌呤糖苷酶1单核苷酸多态性与肝细胞癌易感性的关系,并分析与环境危险因素的交互作用。方法采用以医院为基础的病例-对照研究,对广西壮族自治区500例肝细胞癌和507例正常对照进行流行病学调查,并应用TaqMan MGB荧光定量PCR方法检测hOGG1-Ser326Cys位点基因型。结果病例组和对照组中hOGG1-326Cys突变等位基因分布频率为24.60%和10.75%(P<0.05);该位点3种基因型Ser/Ser、Ser/Cys和Cys/Cys在病例组和对照组中分布频率分别为71.40%、8.00%、20.60%和84.22%、10.06%、5.72%(P<0.05);与携带hOGG1基因326位点野生纯合子Ser/Ser基因型者比较,携带至少一个hOGG1-326Cys突变等位基因的个体患肝癌风险显著增加(OR=2.14,95%CI:1.57～2.91);交互作用分析结果表明hOGG1基因326位点多态性与慢性HBV感染之间在肝细胞癌发生中具有交互作用,相乘模型交互作用指数为0.61,相加模型交互作用指数为1.31。结论 hOGG1-326Cys突变等位基因是肝细胞癌发生的危险等位基因;携带至少一个hOGG1-326Cys突变等位基因的个体若同时暴露于HBV慢性感染,患肝癌的风险显著增加。

关键词： hOGG1 单核苷酸多态性环境因素交互作用肝细胞癌

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong li li Dan Jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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