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The IL-17 family in diseases: from bench to bedside

Signal Transduction and Targeted Therapy 2023年第11期8卷 5211-5232页

作者： longjie huangfu Ruiying Li Yamei Huang Shan Wang School of Stomatology Harbin Medical UniversityHarbin150001P.R.China Department of Oral Pathology School of StomatologyHainan Medical UniversityHaikou571199P.R.China Department of Stomatology The Second Affiliated Hospital of Hainan Medical UniversityHaikou570216P.R.China

The interleukin-17(IL-17)family comprises six members(IL-17A–17F),and recently,all of its related receptors have been ***-17 was first discovered approximately 30 years *** of this family have various biological functions,including driving an inflammatory cascade during infections and autoimmune diseases,as well as boosting protective immunity against various ***-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses,tissue repair,inflammatory disease pathogenesis,and cancer ***,how IL-17 performs these functions remains *** multifunctional properties of IL-17 have attracted research interest,and emerging data have gradually improved our understanding of the IL-17 signaling ***,a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the *** review can aid researchers in better understanding the mechanisms underlying IL-17’s roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and *** review discusses recent progress in understanding the IL-17 signaling pathway and its physiological *** addition,we present the mechanism underlying IL-17’s role in various pathologies,particularly,in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and *** addition,we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.

关键词： diseases protective immunity

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