检索结果-南通市图书馆

Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases:Mechanisms and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第5期30卷 429-439页

作者： Ya-Wei Bi long-song li Nan Ru Bo Zhang Xiao Lei Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Radiation Oncology Chinese PLA General HospitalBeijing 100853China

Pancreatitis and pancreatic cancer(PC)stand as the most worrisome ailments affecting the *** have dedicated efforts to unraveling the mechanisms underlying these diseases,yet their true nature continues to elude their *** this realm,oxidative stress is often believed to play a causal and contributory role in the development of pancreatitis and *** accumulation of reactive oxygen species(ROS)can cause oxidative stress,and the key enzyme responsible for inducing ROS production in cells is nicotinamide adenine dinucleotide phosphate hydrogen oxides(NOX).NOX contribute to pancreatic fibrosis and inflammation by generating ROS that injure acinar cells,activate pancreatic stellate cells,and mediate macrophage *** ROS production occurs during malignant transformation and pancreatic carcinogenesis,creating an oxidative microenvironment that can cause abnormal apoptosis,epithelial to mesenchymal transition and genomic ***,understanding the role of NOX in pancreatic diseases contributes to a more in-depth exploration of the exact pathogenesis of these *** this review,we aim to summarize the potential roles of NOX and its mechanism in pancreatic disorders,aiming to provide novel insights into understanding the mechanisms underlying these diseases.

关键词： Nicotinamide adenine dinucleotide phosphate hydrogen oxides Pancreatitis Pancreatic cancer Reactive oxygen species Mechanism

Effect of polyglycolic acid sheet plus esophageal stent placement in preventing esophageal stricture after endoscopic submucosal dissection in patients with earlystage esophageal cancer: A randomized, controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第9期24卷 1046-1055页

作者： Ning-li Chai Jia Feng long-song li Sheng-Zhen liu Chen Du Qi Zhang En-Qiang linghu Department of Gastroenterology Chinese PLA General Hospital

AIM To assess the effect of polyglycolic acid(PGA) plus stent placement compared with stent placement alone in the prevention of post-endoscopic submucosal dissection(ESD) esophageal stricture in early-stage esophageal cancer(EC) patients. METHODS Seventy EC patients undergoing ESD were enrolled in this randomized, controlled study. Patients were allocated randomly at a 1:1 ratio into two groups as follows:(1) PGA plus stent group(PGA sheet-coated stent placement was performed); and(2) Stent group(only stent placement was performed). This study was registered on http://***(No. chictrinr-16008709). RESULTS The occurrence rate of esophageal stricture in the PGA plus stent group was 20.5%(n = 7), which was lower than that in the stent group(46.9%, n = 15)(P = 0.024). The mean value of esophageal stricture time was 59.6 ± 16.1 d and 70.7 ± 28.6 d in the PGA plus stent group and stent group(P = 0.174), respectively. Times of balloon dilatation in the PGA plus stent group were less than those in the stent group [4(2-5) vs 6(1-14), P = 0.007]. The length(P = 0.080) and diameter(P = 0.061) of esophageal strictures were numerically decreased in the PGA plus stent group, whereas no difference in location(P = 0.232) between the two groups was found. Multivariate logistic analysis suggested that PGA plus stent placement(P = 0.026) was an independent predictive factor for a lower risk of esophageal stricture, while location in the middle third(P = 0.034) and circumferential range = 1/1(P = 0.028) could independently predict a higher risk of esophageal stricture in EC patients after ESD. CONCLUSION PGA plus stent placement is more effective in preventing post-ESD esophageal stricture compared with stent placement alone in EC patients with earlystage disease.

关键词： Esophageal cancer Endoscopic submucosal dissection Polyglycolic acid plus stent placement Esophageal stricture

Clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第3期14卷 724-733页

作者： Nan-Jun Wang Ning-li Chai Xiao-Wei Tang long-song li Wen-Gang Zhang En-Qiang linghu Department of Gastroenterology and Hepatology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND The use of radiofrequency ablation(RFA)has been reported in the treatment of gastric low-grade intraepithelial neoplasia(LGIN).However,its efficacy and prognostic risk factors have not been well *** To explore the efficacy and prognostic risk factors of RFA for gastric LGIN in a large,long-term follow-up clinical *** The clinical data of 271 consecutive cases from 198 patients who received RFA for treatment of gastric LGIN at the Chinese PLA General Hospital from October 2014 to October 2020 were reviewed in this retrospective *** on operative parameters,complications,and follow-up outcomes including curative rates were recorded and *** The curative rates of endoscopic RFA for gastric LGIN at 3 mo,6 mo,and 1-5 years after the operation were 93.3%,92.8%,91.5%,90.3%,88.5%,85.7%,and 83.3%,*** analyses revealed that Helicobacter pylori(***)infection and disease duration>1 year had a significant effect on the curative rate(Plications after RFA,and the main discomfort was postoperative abdominal *** RFA was safe and effective for gastric LGIN during long-term *** infection and disease course>1 year may be the main risk factors for relapse of LGIN after RFA.

关键词： Endoscopic radiofrequency ablation Gastric low-grade intraepithelial neoplasia Clinical efficacy Prognostic risk factors

SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia:A long-term study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第23期29卷 3658-3667页

作者： Ning Xu long-song li Hui li li-Hua Zhang Nan Zhang Peng-Ju Wang Ya-Xuan Cheng Jing-Yuan Xiang En-Qiang linghu Ning-li Chai Senior Department of Gastroenterology The First Medical Center of PLA General HospitalBeijing 100853China Department of Gastroenterology Air Force Medical CenterBeijing 100142China Department of Pathology The Fourth Medical Center of PLA General HospitalBeijing 100142China

BACKGROUND The expression status of serum and glucocorticoid-induced protein kinase 3(SGK3)in superficial esophageal squamous cell neoplasia(ESCN)remains *** To evaluate the SGK3 overexpression rate in ESCN and its influence on the prognosis and outcomes of patients with endoscopic *** A total of 92 patients who had undergone endoscopic resection for ESCN with more than 8 years of follow-up were *** was used to evaluate SGK3 *** SGK3 was overexpressed in 55(59.8%)patients with ***3 overexpression showed a significant correlation with death(P=0.031).Overall survival and disease-free survival rates were higher in the normal SGK3 expression group than in the SGK3 overexpression group(P=0.013 and P=0.004,respectively).Cox regression analysis models demonstrated that SGK3 overexpression was an independent predictor of poor prognosis in ESCN patients(hazard ratio 4.729;95% confidence interval:1.042-21.458).CONCLUSION SGK3 overexpression was detected in the majority of patients with endoscopically resected ESCN and was significantly associated with shortened ***,it might be a new prognostic factor for ESCN.

关键词： Superficial esophageal squamous cell neoplasia Serum and glucocorticoid-induced protein kinase Endoscopic submucosal dissection Immunohistochemistry Overall survival

Per-oral endoscopic myotomy is safe and effective for pediatric patients with achalasia:A long-term follow-up study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第22期29卷 3497-3507页

作者： Ya-Wei Bi Xiao Lei Nan Ru long-song li Nan-Jun Wang Bo Zhang Yi Yao En-Qiang linghu Ning-li Chai Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Senior Department of Oncology The Fifth Medical Center of PLA General HospitalBeijing 100859China

BACKGROUND Per-oral endoscopic myotomy(POEM)is emerging as a prefer treatment option for pediatric ***,data are limited on the long-term efficacy of POEM in children and adolescents with *** To evaluate the safety and long-term efficacy of POEM for pediatric patients with achalasia and compare those outcomes with adult *** This retrospective cohort study was conducted in patients with achalasia who underwent *** aged under 18 years were included in the pediatric group;patients aged between 18 to 65 years who underwent POEM in the same period were assigned to the control *** investigation of long-term followup,the pediatric group were matched with patients from the control group in a 1:1 *** procedure-related parameters,adverse events,clinical success,gastroesophageal reflux disease(GERD)after POEM,and quality of life(QoL)were *** From January 2012 to March 2020,POEM was performed in 1025 patients aged under 65 years old(48 in the pediatric group,1025 in the control group).No significant differences were observed in the occurrence of POEM complications between the two groups(14.6%vs 14.6%;P=0.99).Among the 34 pediatric patients(70.8%)who underwent follow-up for 5.7 years(range 2.6-10.6 years),clinical success was achieved in 35 patients(35/36;97.2%).No differences were observed in post-POEM GERD occurrence(17.6%vs 35.3%;P=0.10).QoL was significantly improved in both groups after *** POEM is safe and effective for pediatric patients with *** can achieve significant symptoms relief and improve QoL.

关键词： Achalasia Pediatric Per-oral endoscopic myotomy long-term outcomes

Repeat peroral endoscopic myotomy with simultaneous submucosal and muscle dissection as a salvage option for recurrent achalasia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第15期29卷 2349-2358页

作者： Yun-Juan lin Sheng-Zhen liu long-song li Ke Han Bo-Zong Shao En-Qiang linghu Ning-li Chai Department of Gastroenterology and Hepatology Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND For recurrent achalasia after initial peroral endoscopic myotomy(POEM)failure,repeat POEM(Re-POEM)has been reported as a treatment ***,severe esophageal interlayer adhesions caused by previous procedures impede the successful establishment of a submucosal tunnel and lead to aborted Re-POEM *** team previously described POEM with simultaneous submucosal and muscle dissection(POEM-SSMD)as a feasible solution for achalasia with severe interlayer *** To investigate the effectiveness and safety of Re-POEM with simultaneous submucosal and muscle dissection(Re-POEM-SSMD).METHODS A total of 1049 patients with achalasia who underwent successful endoscopic myotomy at the Digestive Endoscopic Center of Chinese PLA General Hospital from December 2014 to May 2022 were *** with recurrent achalasia who experienced initial POEM clinical failure were retrospectively included in this *** primary endpoint was retreatment clinical success,defined as an Eckardt score≤3 during the postretreatment follow-up and no need for additional ***-related adverse events,changes in manometric lower esophageal sphincter(LES)pressure and reflux complications,as well as procedure-related parameters,were *** Sixteen patients underwent Re-POEM(9 patients)or Re-POEM-SSMD(7 patients)successfully at a median of 45.5 mo(range,4-95 mo)after initial *** a median followup period of 31 mo(range,7-96 mo),clinical success(Eckardt score≤3)was achieved in 8(88.9%)and 6(85.7%)patients after Re-POEM and Re-POEM-SSMD,respectively(P=0.849).The median Eckardt score dropped from 4(range,3-8)at preretreatment to 1(range,0-5)at postretreatment in the Re-POEM group(P=0.025)and from 5(range,2-8)to 2(range,0-4)in the Re-POEM-SSMD group(P<0.001).The mean manometric LES pressure decreased from 23.78±9.04 mmHg to 11.45±5.37 mmHg after Re-POEM(P<0.001)and from 26.80±7.48 mmHg to 11.05±4.38 mmHg after Re-POEM-SSMD(P<0.001).No serious

关键词： Esophageal achalasia Recurrence Peroral endoscopic myotomy Simultaneous submucosal and muscle dissection Interlayer adhesion Salvage therapy

Submucosal tunneling endoscopic resection: An effective and safe therapy for upper gastrointestinal submucosal tumors originating from the muscularis propria layer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第2期25卷 245-257页

作者： Chen Du Ning-li Chai En-Qiang ling-Hu Zhen-Juan li long-song li Jia-Le Zou Lei Jiang Zhong-Sheng Lu Jiang-Yun Meng Ping Tang Department of Gastroenterology and Hepatology Chinese PLA General Hospital

AIM To evaluate the effectiveness and safety of submucosal tunneling endoscopic resection(STER) and compare its outcomes in esophageal and cardial submucosal tumors(SMTs) of the muscularis propria(MP) *** From May 2012 to November 2017, 173 consecutive patients with upper gastrointestinal(GI) SMTs of the MP layer underwent STER. Overall, 165 patients were included, and 8 were excluded. The baseline characteristics of the patients and SMTs were recorded. The en bloc resection rate, complete resection rate,residual rate, and recurrence rate were calculated to evaluate the effectiveness of STER, and the complication rate was recorded to evaluate its safety. Effectiveness and safety outcomes were compared between esophageal and cardial *** One hundred and twelve men and 53 women with a mean age of 46.9 ± 10.8 years were included. The mean tumor size was 22.6 ± 13.6 mm. Eleven SMTs were located in the upper esophagus(6.7%), 49 in the middle esophagus(29.7%), 46 in the lower esophagus(27.9%), and 59 in the cardia(35.7%). Irregular lesions accounted for 48.5% of all lesions. STER achieved an en bloc resection rate of78.7%(128/165) for GI SMTs with an overall complication rate of 21.2%(35/165).All complications resolved without intervention or were treated conservatively without the need for surgery. The en bloc resection rates of esophageal and cardial SMTs were 81.1%(86/106) and 72.1%(42/59), respectively(P = 0.142), and the complication rates were 19.8%(21/106) and 23.7%(14/59), respectively,(P =0.555). The most common complications for esophageal SMTs were gas-related complications and fever, while mucosal injury was the most common for cardial *** STER is an effective and safe therapy for GI SMTs of the MP layer. Its effectiveness and safety are comparable between SMTs of the esophagus and cardia.

关键词： Endoscopic resection Submucosal tunnel Submucosal tumor Muscularis propria layer Esophagus Cardia

Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第22期29卷 3482-3496页

作者： Xiao li Yan-li lin Jia-Kang Shao Xiao-Jie Wu Xiang li He Yao Fa-liang Shi long-song li Wen-Gang Zhang Zheng-Yao Chang Ning-li Chai You-liang Wang En-Qiang linghu Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Beijing Institute of Biotechnology Beijing 100071China

BACKGROUND Due to the poor prognosis of gastric cancer(GC),early detection methods are urgently *** exosomal circular RNAs(circRNAs)have been suggested as novel biomarkers for *** To identify a novel biomarker for early detection of *** Healthy donors(HDs)and GC patients diagnosed by pathology were *** GC patients and three HDs were selected for exosomal whole-transcriptome RNA *** expression profiles of circRNAs were analyzed by bioinformatics methods and validated by droplet digital polymerase chain *** expression levels and area under receiver operating characteristic curve values of plasma exosomal circRNAs and standard serum biomarkers were used to compare their diagnostic *** There were 303 participants,including 240 GC patients and 63 HDs,involved in the *** expression levels of exosomal hsa_circ_0079439 were significantly higher in GC patients than in HDs(P<0.0001).However,the levels of standard serum biomarkers were similar between the two *** area under the curve value of exosomal hsa_circ_0079439 was higher than those of standard biomarkers,including carcinoembryonic antigen,carbohydrate antigen(CA)19-9,CA72-4,alpha-fetoprotein,and CA125(0.8595 vs 0.5862,0.5660,0.5360,0.5082,and 0.5018,respectively).The expression levels of exosomal hsa_circ_0079439 were significantly decreased after treatment(P<0.05).Moreover,the expression levels of exosomal hsa_circ_0079439 were obviously higher in early GC(EGC)patients than in HDs(P<0.0001).CONCLUSION Our results suggest that plasma exosomal hsa_circ_0079439 is upregulated in GC ***,the levels of exosomal hsa_circ_0079439 could distinguish EGC and advanced GC patients from ***,plasma exosomal hsa_circ_0079439 might be a potential biomarker for the diagnosis of GC during both the early and late stages.

关键词： Gastric cancer Exosomes Circular RNA Droplet digital polymerase chain reaction Biomarker

linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第12期29卷 1899-1910页

作者： Zi-Xin Wang long-song li song Su Jin-Ping li Bo Zhang Nan-Jun Wang Sheng-Zhen liu Sha-Sha Wang Shuai Zhang Ya-Wei Bi Fei Gao Qun Shao Ning Xu Bo-Zong Shao Yi Yao Fang liu En-Qiang linghu Ning-li Chai Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal ***,LCE is not suitable for general population screening given its side *** color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal *** To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic *** In this prospective study,we enrolled 543 patients who underwent white light imaging(Wli),LCI and LCE *** compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic *** features and color analysis of lesions were *** In total,43 patients(45 neoplastic lesions)were *** them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with *** sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,P<0.001].The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with ***,the color difference in LCI was similar in different pathological types of esophageal squamous cell *** LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions,and LCI represents a promising screening strategy for general populations.

关键词： linked color imaging Lugol chromoendoscopy Esophageal squamous cell cancer Precancerous lesions Color difference