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Effect of Carbon Content on Stacking Fault Energy of Fe-20Mn-3Cu TWIP Steel

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Journal of Iron and Steel Research International 2014年第1期21卷 116-120页

作者： Xian PENG Ding-yi ZHU Zhen-ming HU Ming-jie WANG long-long liu Hai-jun liu College of Materials Science and Engineering Fuzhou University Chengdu Aircraft Industrial(Group)Co. Ltd.AVIC Fujian San Ming Iron and Steel Group Co. Ltd. College of Materials Science and Engineering Fujian University of Technology

The influence of carbon content on the stacking fault energy （SFE） of Fe-20Mn-3Cu twinning-induced plasticity （TWIP） steel was investigated by means of X-ray diffraction peak-shift method and thermodynamic modeling. The experimental result indicated that the stacking fault probability decreases with increasing carbon addition, the SFE increases linearly when the carbon content in mass percent is between 0.23 M and 1.41%. The thermody namic calculation results showed that the SFE varied from 22.40 to 29.64 mJ ~ m 2 when the carbon content in mass percent changes from 0.23 % to 1.41%. The XRD analysis revealed that all steels were fully austenitic before and after deformation, which suggested that TWIP effect is the predominant mechanism during the tensile deformation process of Fe-20Mn-3Cu-XC steels.

关键词： stacking fault energy carbon content peak-shift method thermodynamic modeling TWIP steel

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan long Jiajia liu Yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

1951～2014年中国北方地区气温突变与变暖停滞的时空变异性

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中国环境科学 2018年第5期38卷 1601-1615页

作者：梁珑腾马龙刘廷玺孙柏林周莹内蒙古农业大学水利与土木建筑工程学院内蒙古呼和浩特010018

基于1951~2014年中国北方及周边地区357个气象站点平均最低气温、平均气温和平均最高气温年(月)数据,采用M^K检验等方法,分析了中国北方地区3类气温突变和变暖停滞特征的时空变异性.结果表明:研究区3类气温整体突变年(1978~1999年、1981... 详细信息

基于1951~2014年中国北方及周边地区357个气象站点平均最低气温、平均气温和平均最高气温年(月)数据,采用M^K检验等方法,分析了中国北方地区3类气温突变和变暖停滞特征的时空变异性.结果表明:研究区3类气温整体突变年(1978~1999年、1981~2002年、1981~2005年)、分布广泛的普遍突变年(1988年、1989年、1997年)及范围(3a)均依次变晚.整体上,突变年随纬度降低变晚,东北突变早于西北和华北地区.变暖停滞集中于1998和2007年及其前后,3类气温亦依次变晚(1994~2007年、1995~2009年、1998~2010年),由黄河流域中段向其他方向越来越晚.突变至变暖停滞周期整体随纬度降低缩短(3~30a),突变越早周期越长.西北地区突变与变暖停滞前后各时段均值温差最大(2.4℃),温差在1℃左右站点分布最广泛.各时段升(降)温速率整体依次在0.01℃/10a、0.05℃/10a、-0.03℃/10a左右站点分布最广泛,突变后升温最快(0.02~0.16℃/10a),且西北地区对升温贡献最大,变暖停滞后东北地区对降温贡献最大,2时段按平均最低气温、平均最高气温、平均气温顺序升(降)温速率递减.3类气温波动程度减弱,整体随纬度降低.高纬度、高海拔和山地地区突变和变暖停滞较周边地区偏早或偏晚,特征值较大.整个北方地区3类气温突变、变暖停滞、突变与变暖停滞时间及各时段特征值各自具有自身一致性的普遍规律.

关键词：气温突变变暖停滞时空变异性中国北方地区

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang Zhao Yuanjie liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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沙棘籽粕中蛋白质提取工艺研究

辽宁中医药大学学报 2017年第7期19卷 63-66页

作者：龙晓燕龙谭刘玉林陈益家西南科技大学生命科学与工程学院四川绵阳621010 绵阳市中医医院四川绵阳621000

目的:探讨沙棘籽粕中蛋白质提取工艺研究。方法:以蛋白质含量为24.97%的沙棘籽粕为原料,对沙棘籽粕进行粉碎,得到过80目标准药筛的沙棘粉末。将沙棘粉末进行醇提,其最佳工艺如下:乙醇浓度75%、料液比1∶6、提取温度50℃、提取3次每次60 ... 详细信息

目的:探讨沙棘籽粕中蛋白质提取工艺研究。方法:以蛋白质含量为24.97%的沙棘籽粕为原料,对沙棘籽粕进行粉碎,得到过80目标准药筛的沙棘粉末。将沙棘粉末进行醇提,其最佳工艺如下:乙醇浓度75%、料液比1∶6、提取温度50℃、提取3次每次60 min。然后用碱提酸沉法及双氧水脱色法对醇提沙棘蛋白进行精制,其工艺参数为:pH=10、料液比1∶12、碱提温度50℃、碱提3次每次50 min、30%双氧水与碱提液比例1∶20、脱色温度45℃、脱色时间60 min,酸沉pH=5。结果:经过粉碎过筛、醇、碱及脱色三步法提取后,得到了沙棘蛋白产品,其蛋白质纯度为84.18%,产品得率为11.39%。结论:该提取工艺效果更好。

关键词：沙棘籽粕提取工艺蛋白质

Optimal Resource Allocation and Feasible Hexagonal Topology for Cyber-Physical Systems

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Journal of Systems Science & Complexity 2023年第4期36卷 1583-1608页

作者： liu Yifa CHENG long State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

Networked cyber-physical systems are facing serious security threats from malicious *** is noted that the networked cyber-physical system should take defense measures into account at the beginning of its *** the conservative defensive perspective,this paper proposes a robust optimal defense resource allocation strategy to reduce the maximum possible losses of the networked cyber-physical system caused by potential ***,based on the robust optimal allocation strategy,it can be proved that the topology of the networked cyber-physical system has a great influence on the loss *** order to further improve security,the effects of adding redundant connections are ***,by taking geographical knowledge into account,a hexagonal construction scheme is proposed for providing a geographically-feasible and economically-viable solution for building networked cyber-physical systems,where the loss function has a cubic decay.

关键词： Cyber-physical system hexagonal city planning optimization resource allocation

Mathematical Model of Hydrodynamic Torque Converter and Analytic Description of Streamline

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Chinese Journal of Mechanical Engineering 2009年第1期22卷 70-77页

作者： liu Shiping QUAN long Institute of Mechatronics Engineering Taiyuan University of Technology Taiyuan 030024 China

The mathematical model of a 3-element centripetal-turbine hydrodynamic torque converter and analytic description of fluid flow inside the hydrodynamic torque converter are investigated. A new torus coordinate system is proposed so as to quantitatively describe fluid movement inside the hydrodynamic torque converter. The particle movement inside the hydrodynamic torque converter is decomposed into meridional component movement and torus component movement, and a universal meridional streamline equation is derived. According to the relationship between the converter wheel velocity polygon and its blade angle, a torus streamline differential equation is established. The universal meridional streamline equation is approximated with square polynomials. The approximation error curve is given and the percentage error is not greater than 0.86%. Considered as a function of polar angle, the blade angle cotangent of each converter wheel varies linearly with polar angle. By using integral calculus, torus streamline equations are obtained. As a result, the problem of difficult flow description of the hydrodynamic torque converter is solved and a new analytic research system is established.

关键词： hydrodynamic torque converter toms coordinate system analytic description meridional streamline equation toms streamline equation

Respirable nano-particulate generations and their pathogenesis in mining workplaces:a review

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International Journal of Coal Science & Technology 2021年第2期8卷 179-198页

作者： long Fan Shimin liu Department of Energy and Mineral Engineering G3 Center and EMS Energy InstituteThe Pennsylvania State UniversityUniversity ParkPA 16802USA

There is a growing concern in mining community about the contribution of nano-particulates to miner's *** the health influence of respirable dusts and associated lung diseases have been recognized for decades in the mining industry,the nano-scale particulates accompanying with complicated physiochemical properties and their enor-mous contribution in quantity have been drawing attentions only in recent a few years because of the advancement of nano-science *** this review,we examine the current regulations of dusts exposure and the dominant mass-based monitoring methods to point out the ignorance of nano-particulates in mining *** recognized mining-related nano-particulates sources are summarized to identify the mechanically generated finer particulates including particles and *** addition,the mechanism of adverse health impact on miner with exposure to nano-scale particulates is discussed in a detail to emphasize their substantial detriment as a potential respiratory *** of the complex physiochemical properties of nano-particulates are then summarized and discussed because these properties could be different from regular respirable dusts due to their dramatically increased surface area and particulate *** intent of this review is to demonstrate the potential of adverse health effect of nano-particulate on the mine personals throughout the mining cycle and to identify the research gaps of the mine nano-particulate characterization and *** suggest that further understanding of the mining induced nano-particulate properties and their pathogenesis are critical for the future engineering control measure to mitigate the potential health threat for future miners.

关键词： Nano-particulate Lung diseases Generation sources Nano-scale characterization