检索结果-南通市图书馆

Effect of intramuscular injection of hepatocyte growth factor plasmid DNA with electroporation on bleomycin-induced lung fibrosis in rats

引用

Chinese Medical Journal 2007年第16期120卷 1432-1437页

作者： long xiang XIONG sheng-dao XIONG Wei-ning XU Yong-jian Institute of Pulmonary Disease Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China

Background So far, there is no efficient treatment for pulmonary fibrosis. The objective of this study was to determine whether intramuscular injection of the hepatocyte growth factor （HGF） pfasmid DNA by in vivo electroporation could prevent bleomycin-induced pulmonary fibrosis in rats, and to investigate the possible mechanisms. Methods Twenty male Wistar rats were randomly divided into four groups： control group （group C）, model group （group M）, early intervention group （group Ⅰ ） and late intervention group （groupⅡ）. Groups M, Ⅰ and Ⅱ were intratracheally infused with bleomycin, then injected the plasmid pcDNA3.1-hHGF to group Ⅰ on day 7, 14 and 21. Group Ⅱ received the same treatment like Group Ⅰ on day 14 and 21. All the rats were killed on day 28 after bleomycin injection. We detected Homo HGF expression in the rats with ELISA method and estimated the pathological fibrosis score of lung tissue using hematoxylin eosin （HE） and Massion staining. The mRNA expression of transforming growth factor-β1 （TGF-β1）, cycloxygenase-2 （COX-2）, and rat HGF in rat pulmonary parenchyma were evaluated by RT-PCR. Immunohistochemistry and Western blotting were performed to determine the protein expression of transforming TGF-β1 and COX-2 in lung parenchyma. Results The plasmid pcDNA3.1-hHGF could express hHGF in NIH3T3 cells and the hHGF protein is secreted into the culture medium. The expression of hHGF protein could be monitored in quadriceps muscle, plasma and lung in Groups Ⅰ and Ⅱ. Pulmonary fibrosis levels of Groups Ⅰ and Ⅱ were obviously lower than that of group M （P〈0.05）. Expression of TGF-β1 protein and mRNA in lung tissue was markedly decreased in Groups Ⅰ and Ⅱ compared with Group M （P〈0.05）. The level of expression of HGF and COX-2 mRNA was higher in Groups Ⅰ and Ⅱ than in Group M （P〈0.05）. Conclusions Injection of the plasmid pcDNA3.1-hHGF into skeletal muscle with electroporation has a potential role in the treatment of bleomycin-induced lung fibrosis. Exog

关键词： pulmonary fibrosis hepatocyte growth factor electroporation gene therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Flavonoid from Oxytropis kansuensis

引用

Chinese Chemical Letters 2006年第12期17卷 1576-1578页

作者： Jun Xi LIU Xin Yi HUANG Duo long DI sheng xiang JIANG Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000

A new flavonoid 1 rhamnocitrin-3-O-（6＂-femloyl）-β-D-galactopyranoside-4＇-O-β-D- glucospyranoside called kansuensisoside A together with a known flavonoid 2 （rhamnocitrin- 3-O-β-D-galactopyranoside-4＇-O-β-D-glucospyranoside） were isolated from the extract of the whole plant of Oxytropis kansuensis Bunge. The structure of 1 was elucidated by spectroscopic methods including 2D-NMR techniques （COSY, HMQC, HMBC） and HR-ESIMS.

关键词： Oxytropis kansuensis Bunge leguminosae flavonoid kansuensisoside A

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Securing offshore resources development: A mathematical investigation into gas leakage in long-distance flexible pipes

引用

Petroleum Science 2024年第4期21卷 2734-2744页

作者： xiang-An Lu Liang-Liang Jiang Jian-sheng Zhang Min-Gui Wang Guangling College of Yangzhou University Department of Chemical and Petroleum Engineering University of Calgary Department of Energy and Power Engineering Tsinghua University

Gas flexible pipes are critical multi-layered equipment for offshore oil and gas development. Under high pressure conditions, small molecular components of natural gas dissolve into the polymer inner liner of the flexible pipes and further diffuse into the annular space, incurring annular pressure build-up and/or production of acidic environment, which poses serious challenges to the structure and integrity of the flexible pipes. Gas permeation in pipes is a complex phenomenon governed by various factors such as internal pressure and temperature, annular structure, external temperature. In a long-distance gas flexible pipe, moreover, gas permeation exhibits non-uniform features, and the gas permeated into the annular space flows along the metal gap. To assess the complex gas transport behavior in long-distance gas flexible pipes, a mathematical model is established in this paper considering the multiphase flow phenomena inside the flexible pipes, the diffusion of gas in the inner liner, and the gas seepage in the annular space under varying permeable properties of the annulus. In addition, the effect of a variable temperature is accounted. A numerical calculation method is accordingly constructed to solve the coupling mathematical equations. The annular permeability was shown to significantly influence the distribution of annular pressure. As permeability increases, the annular pressure tends to become more uniform, and the annular pressure at the wellhead rises more rapidly. After annular pressure relief followed by shut-in, the pressure increase follows a convex function. By simulating the pressure recovery pattern after pressure relief and comparing it with test results, we deduce that the annular permeability lies between 123 and 512 m D. The results help shed light upon assessing the annular pressure in long distance gas flexible pipes and thus ensure the security of gas transport in the emerging development of offshore resources.

关键词： Offshore resources development Transport security long-distance flexible pipes Gas leakage Heat and mass transfer model Finite difference calculation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Anchoring heterometallic cluster on P-doped carbon nitride for efficient photocatalytic nitrogen fixation in water and air ambient

引用

Chinese Chemical Letters 2024年第4期35卷 176-180页

作者： Chao-long Chen Rong Chen La-sheng long Lan-Sun Zheng xiang-Jian Kong Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Light-driven nitrogen fixation to produce ammonia is a green and economical technology of nitrogen reduction but is still quite challenging, especially in an air atmosphere without any sacrificial ***, we demonstrate efficient photocatalytic nitrogen fixation using water and air directly by loading lanthanide–transition metal(4f–3d) cluster NdCo_(3) on two-dimensional P-doped graphitic carbon nitrides(PCN) material surface. Benefiting from the increase in the number of nitrogen vacancies(NVs) and highly matched band gap structure and excellent hole trapping ability of clusters, the NdCo_(3)/PCN photocatalyst exhibits efficient nitrogen reduction activity with 371(in air) and 825 μmol h^(-1)g^(-1)(in pure nitrogen)without any sacrificial reagents. The introduction of potassium sulfate inhibits hydrogen production and promotes nitrogen reduction activation. This work suggests that anchoring precisely structured clusters on 2D materials may enhance photocatalytic nitrogen reduction under normal temperature and pressure.

关键词： Photocatalytic Nitrogen fixation 4f-3d Cluster Air atmosphere

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of Seismic Azimuth Anisotropic Technique in Fractural Detection of Lower Triassic Jia-2 Reservoir in TNB Area

引用

石油地球物理勘探 2009年第2期44卷 72-78页

作者： Bi Yan-bin long sheng-xiang Guo Tong-lou Liu Bin SINOPEC Research Institute of Petroleum Exploration and Development Beijing 100083 China South Branch of Exploration and Development of SINOPEC Kunming Yunnan Province 650233 China

低渗致密碳酸盐岩油气藏常与储层中裂缝的发育有着密切关系.在对岩心裂缝发育特征分析和叠前地震资料评价的基础上,本文利用叠前地震方位各向异性技术对TNB构造带嘉二段储层裂缝发育密度和方向进行了区域上的检测,分析了裂缝相对发育带... 详细信息

低渗致密碳酸盐岩油气藏常与储层中裂缝的发育有着密切关系.在对岩心裂缝发育特征分析和叠前地震资料评价的基础上,本文利用叠前地震方位各向异性技术对TNB构造带嘉二段储层裂缝发育密度和方向进行了区域上的检测,分析了裂缝相对发育带的分布规律.研究表明,裂缝发育带在区域上呈现一定的分区性,既受TNB背斜带的宏观控制,又受后期叠加局部构造的影响.研究成果为下一步该地区的井位部署提供了参考依据,同时也展现了叠前地震方位各向异性技术在储层裂缝检测中的应用前景.

关键词：叠前地震数据方位各向异性技术检测下三叠统裂缝检测水库应用碳酸盐岩储层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrathin surface coating of Cu enabling long-life Zn metal anodes

引用

Rare Metals 2024年第5期43卷 2125-2135页

作者： Sang-Sang Liu Ya-Ru Liang Wen-long Chen Ze-Hua Wang Yi-long Dai Fu-Gang Qi Zeng-sheng Ma Xiao-Ping Ouyang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education Xiangtan UniversityXiangtan 411105China

Aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage devices due to their low cost,high capacity,and ecological ***,the severe dendritic growth and side reactions hinder their practical applicability ***,an ultrathin Cu coating layer(~200 nm)is decorated on zinc foils via filtered cathodic vacuum arc deposition technology,aiming to achieve high-performance *** Cu layer effectively suppresses chemical corrosion and hydrogen evolution reactions and enables preferential(002)Zn deposition during the stripping/plating ***,the Cu@Zn anode represents an elongated cycle life over 4,000 h at 2 mA·cm^(-2)/2 mAh·cm^(-2).Even in conditions of high current density of 5 and 10 mA·cm^(-2),the Cu@Zn anode shows prolonged cycling stability exceeding 4000 and 2000 h,*** advantages also bring high Coulombic efficiency of 99.87%under 5 mAh·cm^(-2)in Cu@Ti||Zn half-cell over 1500 ***,the Cu@Zn||MnO_(2)full cell demonstrates a superior cyclability with a specific capacity of 203 mAh·g^(-1)after 500 cycles a1 A·g^(-1).

关键词： Zn ion battery Zn metal anode Zn(002)plane Cu coating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Analysis of A Deepwater Drilling Riser with A New Hang-off System

引用

China Ocean Engineering 2024年第1期38卷 29-41页

作者： LI Yan-wei LIU Xiu-quan WANG Jin-long CHEN Guo-ming CHANG Yuan-jiang sheng Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drilling riser new hang-off system dynamic analysis finite element method penalty function method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy flux and waveform of gravitational wave generated by coalescing slow-spinning binary system in effective one-body theory

引用

Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 73-83页

作者： Weike Deng sheng long Jiliang Jing Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Educationand Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China

We extend our research on the energy flux and waveform characteristics of gravitational waves generated by merging nonspinning binary black holes through self-consistent effective one-body theory to include binary systems with slowly spinning black ***,we decompose the equation for the null tetrad component of the gravitationally perturbed Weyl tensorψ_4~B into radial and angular parts,leveraging the second-order approximation of the rotation parameter ***,we derive an analytical solution for the radial equation and observe that our results are contingent upon the parameters a_(2),a_(3),and a,which represent the second-and third-order correction parameters,***,we calculate the energy flux,the radiation-reaction force and the waveform for the“plus”and“cross”modes of the gravitational waves generated by merging slowly spinning binary black holes.

关键词： post-Minkowskian approximation effective-one-body theory gravitational waveform template

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy flux and waveforms by coalescing spinless binary system in effective one-body theory

引用

Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 58-68页

作者： sheng long Weike Deng Jiliang Jing Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China

We present a study on the energy radiation rate and waveforms of the gravitational wave generated by coalescing spinless binary systems up to the third post-Minkowskian approximation in the effective one-body *** derive an analytical expansion of the null tetrad components of the gravitational perturbed Weyl tensorΨ4in the effective spacetime,we utilize the method proposed by Sasaki et *** this investigation,we discover more general integral formulas that provide a theoretical framework for computing the results in any ***,we successfully compute the energy radiation rate and waveforms of the gravitational wave,which include the results of the Schwarzschild case and the correction terms resulting from the dimensionless parameters a2and a3in the effective metric.

关键词： post-Minkowskian approximation effective one-body theory gravitational waveform template

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An analytical model to estimate the time delay to reach spontaneous ignition considering heat loss in oil reservoirs

引用

Petroleum Science 2024年第4期21卷 2469-2474页

作者： James J.sheng Er-long Yang College of Petroleum Engineering Northeast Petroleum University

During air injection into an oil reservoir, an oxidation reaction generates some heat to raise the reservoir temperature. When the reservoir temperature reaches an ignition temperature, spontaneous ignition occurs. There is a time delay from the injection to ignition. There are mixed results regarding the feasibility of spontaneous ignition in real-field projects and in laboratory experiments. No analytical model is available in the literature to estimate the oxidation time required to reach spontaneous ignition with heat *** paper discusses the feasibility of spontaneous ignition from theoretical points and experimental and field project observations. An analytical model considering heat loss is proposed. Analytical models with and without heat loss investigate the factors that affect spontaneous ignition. Based on the discussion and investigations, we find that it is more difficult for spontaneous ignition to occur in laboratory experiments than in oil reservoirs; spontaneous ignition is strongly affected by the initial reservoir temperature, oil activity, and heat loss; spontaneous ignition is only possible when the initial reservoir temperature is high, the oil oxidation rate is high, and the heat loss is low.

关键词： Spontaneous ignition Time delay Air injection Heat loss Low temperature oxidation Combustion

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：