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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong li Faqin li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni li Haojie An Shiyi Zeng Chunyan Wang li Yang Cheng long School of life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning li long Ye lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Successive Interference Cancellation and Alignment in K-User MIMO Interference Channels with Partial Unidirectional Strong Interference

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China Communications 2022年第2期19卷 118-130页

作者： long suo Hongyan li Shun Zhang Jiandong li State Key Laboratory of Integrated Service Networks Xidian UniversityXi’an 710071China Guangzhou Institute of Technology Xidian UniversityGuangzhou 510000China

Recently cellular networks have been densely and heterogeneously deployed indoors and outdoors to expand the network capacity,and thus the in-building propagation loss and the transmit power diversity of access points will exacerbate link heterogeneity and result in partial unidirectional strong *** make full use of the strong interference feature,we propose the successive interference cancellation and alignment(SICA)scheme in the K-user interference channel with partial unidirectional strong *** is designed to transmit two kinds of data streams simultaneously,the alignment streams and superposition *** alignment streams will follow the interference alignment criterion to maintain the optimal degrees of freedom(DoF)performance;the superposition streams are handled via successive interference cancellation at all the strongly interfered receivers to improve the overall achievable *** joint transceiver designs for SICA is modeled as a weighted sum rate(WSR)maximization problem,and then can be alternately solved for a local optimum according to the optimality equivalence between WSR and its corresponding weighted mean square error(WMMSE)*** results have confirmed the sum rate improvement and DoF optimality of the proposed SICA scheme.

关键词： interference alignment successive interference cancellation interference management ultra dense networks

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-long Zhou Wei-Jin Jiang Ji Yu Mao-Jun Yao Yun-Tong li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

基于SBAS-InSAR和光学遥感的天津市北部山区潜在滑坡识别研究

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灾害学 2025年第1期40卷 30-35页

作者：王勇邢振涛李锁闫勇司甜天津城建大学地质与测绘学院天津300384 天津市地质工程勘测设计院有限公司天津300191

以天津市北部山区为研究对象,开展潜在滑坡识别研究,利用差分干涉测量短基线集时序分析技术(SBAS-InSAR)处理2018-01—2022-08的56景Sentinel-1A数据,并结合2018—2022年的Landsat8光学遥感影像,分析形变与光学遥感影像特征以及NDVI,筛... 详细信息

以天津市北部山区为研究对象,开展潜在滑坡识别研究,利用差分干涉测量短基线集时序分析技术(SBAS-InSAR)处理2018-01—2022-08的56景Sentinel-1A数据,并结合2018—2022年的Landsat8光学遥感影像,分析形变与光学遥感影像特征以及NDVI,筛选出潜在滑坡区域。研究结果表明:基于SBAS-InSAR技术识别的天津北部山区的形变较大区域有20处,使用光学遥感影像结合各发育环境要素进行处理确定的区域有19处,其中5处经两种技术确认为滑坡隐患,通过对该5处沉降信息进行识别分析,该5处区域最大年形变速率可达-12 mm/a,需要进行重点监测预警,使用两种技术结合对滑坡隐患区域进行识别可以有效地提高识别准确度,为天津北部山区灾害监测提供新的方式。

关键词：潜在滑坡 SBAS-InSAR 光学遥感影像天津市北部山区

Robust PolinSAR optimal interferogram estimation method based on generalized scattering vector

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Journal of Systems Engineering and Electronics 2017年第3期28卷 457-471页

作者： Zhiyong suo Ming li National Lab of Radar Singal Processing Xidian UniversityXi’an 710071China Beijing Aerospace Automatic Control Institute Beijing 100854China National Key Laboratory of Science and Technology on Aerospace Intelligent Control Beijing 100854China

For the polarimetric synthetic aperture radar interferometry (PoIInSAR) processing, it is necessary to coregister all the images, including the coregistration of polarimetric SAR images and the coregistration of interferometric SAR images. Otherwise, the performance of the estimated optimal interferograms will be deteriorated. A generalized scattering vector (GSV) model is proposed to execute the PoIInSAR optimal interferograms estimation. The generalized scattering vector is constructed by the Pauli scattering vectors of the processing pixel and the surrounding pixels. Even though there are coregistration errors, all the polarimetric information of the current processing pixel is entirely included in the generalized scattering vector. Therefore, the GSV-based method can automatically recover the optimal scattering mechanisms of the processing pixel with coregistration errors either in interferoemetric channels or polarimetric channels. Theoretical analysis and processing results of simulated PoISARPro data and real PALSAR data validate the effectiveness and correctness of the proposed method.

关键词： polarimetric synthetic aperture radar interferometry (PoIInSAR) generalized scattering vector (GSV) optimal interferogram coregistration error Pauli basis

The Diterpenoid Quinones from Coleus forskohlii

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Chinese Chemical Letters 2001年第4期12卷 339-342页

作者： Chun suo YAO Yun long XU Laboratory of Phytochemistry Kunming Institute of BotanyAcademia SinicaKunming 650204

Two new diterpenoid quinones, colean S and T were isolated from the chloroform extract of the leaves of Coleus forskohlii, and based on spectroscopic data, their structures were identified as 1,4-phananthrenedione-4b,... 详细信息

关键词： Coleus forskohlii diterpenoid quinones Coleon S Coleon T.