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Isolation and identification of symbiotic bacteria from the skin, mouth, and rectum of wild and captive tree shrews

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Zoological Research 2014年第6期35卷 492-499页

作者： Gui LI Ren LAI Gang DUAN long-Bao LYU Zhi-ye ZHANG Huang LIU Xun XIANG Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of Zoology 650223 China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Chinese Academy of Sciences Kunming Yunnan 650223 China Yunnan Agricultural University Kunming Yunnan 650201 China Chinese Academy of Sciences Kunming Yunnan Yunnan Province Kunming Institute of Zoology

Endosymbionts influence many aspects of their hosts’ health conditions, including physiology, development, immunity, metabolism, etc. Tree shrews(Tupaia belangeri chinensis) have attracted increasing attention in modeling human diseases and therapeutic responses due to their close relationship with primates. To clarify the situation of symbiotic bacteria from their body surface, oral cavity, and anus, 12 wild and 12 the third generation of captive tree shrews were examined. Based on morphological and cultural characteristics, physiological and biochemical tests, as well as the 16 S rDNA full sequence analysis, 12 bacteria strains were isolated and identified from the wild tree shrews: body surface: Bacillus subtilis(detection rate 42%), Pseudomonas aeruginosa(25%), Staphlococcus aureus(33%), S. Epidermidis(75%), Micrococcus luteus(25%), Kurthia gibsonii(17%); oral cavity: Neisseria mucosa(58%), Streptococcus pneumonia(17%); anus: Enterococcus faecalis(17%), Lactococus lactis(33%), Escherichia coli(92%), Salmonella typhosa(17%); whereas, four were indentified from the third generation captive tree shrews: body surface: S. epidermidis(75%); oral cavity: ***(67%); anus: L. lactis(33%), E. coli(100%). These results indicate that S. epidermidis, N. mucosa, L. lactis and E. coli were major bacteria in tree shrews, whereas, S. aureus, M. luteus, K. gibsonii, E. faecalis and S. typhosa were species-specific flora. This study facilitates the future use of tree shrews as a standard experimental animal and improves our understanding of the relationship between endosymbionts and their hosts.

关键词： Tree shrew Microbial Separation Identification

项目制研究何以成为“显学”:概念辨析、性质定位与实践探索

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内蒙古社会科学 2019年第4期40卷 24-35页

作者：豆书龙叶敬忠中国农业大学人文与发展学院

只有当作为治理体制的项目制概念被提出后,项目制研究才受到各界的广泛关注而成为“显学”。与其他项目概念相比,项目制概念具有承继性、创新性和独特性,是一种有中国特色的学术概念;与其他治理模式相比,项目制属于一种兼具集权与分权... 详细信息

只有当作为治理体制的项目制概念被提出后,项目制研究才受到各界的广泛关注而成为“显学”。与其他项目概念相比,项目制概念具有承继性、创新性和独特性,是一种有中国特色的学术概念;与其他治理模式相比,项目制属于一种兼具集权与分权优势的治理模式。从国家治理体系视角出发,项目制的作用媒介可以划分为政府间项目制、社会组织项目制和企业项目制三种媒介类型。虽然三种项目制媒介在实践过程中存在一些问题,但整体上三者相继实现了有效协调政府层级关系、政府与社会组织关系和政府与企业关系的目标。“项目制”可以作为促进国家治理体系现代化的着力点。同时,虽然项目制的研究成果丰富,但依然存在项目制应用限度如何突破、项目制资金如何整合和项目制概念外延能否开拓等亟待解决的问题。

关键词：项目治理项目干预项目制国家治理

东天山梅岭铜矿床黄铁矿Re-Os等时线年龄：Os同位素不均一的结果

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地球科学 2018年第9期43卷 2966-2979页

作者：赵冰爽李杰龙晓平袁超中国科学院广州地球化学研究所同位素地球化学国家重点实验室广东广州510640 中国科学院大学北京100049 西北大学地质系大陆动力学国家重点实验室陕西西安710069

金属硫化物Re-Os等时线年龄的合理解释是揭示金属矿床成矿时代的关键.通过对新疆东天山梅岭铜矿床开展Re-Os同位素定年研究,结果表明浸染状和脉状矿石中黄铁矿样品在Os浓度和Os同位素比值方面都有很大的变化,这两类样品定义了很好的Re-O... 详细信息

金属硫化物Re-Os等时线年龄的合理解释是揭示金属矿床成矿时代的关键.通过对新疆东天山梅岭铜矿床开展Re-Os同位素定年研究,结果表明浸染状和脉状矿石中黄铁矿样品在Os浓度和Os同位素比值方面都有很大的变化,这两类样品定义了很好的Re-Os等时线年龄,分别为523±59Ma和707±99Ma.由于得到的等时线年龄明显老于它们的实际地质成矿年龄,且^(187) Os/^(188) Os与普通Os的倒数(以1/^(192) Os为例)之间存在着很好的相关性(R^2分别为0.997 3和0.994 5),因此这些样品存在着初始Os同位素组成不均一的现象,这些Re-Os等时线是混合等时线,没有地质意义.理论和数学公式推导显示观测到的Re-Os等时相关性是在形成时期没有达到完全的同位素平衡的二元混合的结果,这种同位素扩散不平衡产生的原因主要是在矿床形成时期Os同位素在金属硫化物与硅酸盐矿物之间的同位素扩散存在限制性.回归得到的Os的初始值更偏向于地壳值,表明矿床形成时期的地壳混染可能造成金属硫化物体系中的这种初始Os同位素不均一.因此,将Re-Os同位素体系应用于金属硫化物样品定年时,^(187) Os/^(188) Os与1/^(192) Os之间是否存在相关关系可以作为Re-Os等时线年龄是否具有地质意义的判断标准.

关键词：金属硫化物 Re-Os同位素初始Os同位素等时线年龄混合等时线年代学

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重视原发性肝癌的多学科综合治疗

中华肝脏病杂志 2013年第5期21卷 321-323页

作者：叶胜龙复旦大学附属中山医院肝肿瘤内科复旦大学肝癌研究所上海200032

我国是原发性肝癌的高发地区，全世界每年新增和死亡的肝癌患者54％左右发生在中国。根据最新公布的2012年《中国肿瘤登记年报》，在我国所有恶性肿瘤中，原发性肝癌的发病率居第四位，而病死率仍高居第二位。肝癌防治任务艰巨，探索适... 详细信息

我国是原发性肝癌的高发地区，全世界每年新增和死亡的肝癌患者54％左右发生在中国。根据最新公布的2012年《中国肿瘤登记年报》，在我国所有恶性肿瘤中，原发性肝癌的发病率居第四位，而病死率仍高居第二位。肝癌防治任务艰巨，探索适合我国国情、合理规范的肝癌诊治策略具有重要的现实意义。原发性肝癌恶性程度高，起病隐匿，病情进展快，容易复发转移；而且我国肝癌多发生在肝炎、肝硬化基础之上，不仅造成机体的损伤，还降低肝脏的储备功能，严重影响肿瘤的治疗和预后。

关键词：肝肿瘤癌肝细胞治疗循证医学

曲拉西利预防肺癌化疗引起的骨髓抑制1例及文献分析

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中国新药杂志 2024年第1期33卷 68-72页

作者：黄豪杰陈韬谢晓原池秀盈孙佳婷陈理明汕头大学医学院第一附属医院汕头515041 汕头大学医学院汕头515041 中山大学中山医学院广州510080

肺癌是我国恶性肿瘤中发病率和死亡率最高的癌症,非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌最主要的病理类型,约占肺癌总数的80%~85%。含铂双药化疗是驱动基因阴性晚期NSCLC标准的一线化疗方案。骨髓抑制(chemotherapy-ind... 详细信息

肺癌是我国恶性肿瘤中发病率和死亡率最高的癌症,非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌最主要的病理类型,约占肺癌总数的80%~85%。含铂双药化疗是驱动基因阴性晚期NSCLC标准的一线化疗方案。骨髓抑制(chemotherapy-induced myelosuppression,CIM)是肿瘤化疗最常见的毒性反应,包括中性粒细胞减少症、血小板减少症和贫血。目前,CIM的传统治疗手段都有一定的局限性,主要包括仅针对单一谱系、存在其他不良事件发生风险、治疗时间长、起效慢、易导致骨髓耗竭等。曲拉西利(trilaciclib)作为新型细胞周期蛋白依赖性激酶4/6(cyclin-dependent kinase 4/6,CDK4/6)抑制剂,通过诱导造血干/祖细胞(hematopoietic stem and progenitor cells,HSPCs)短暂停滞在G1期,保护其免受化疗损伤,在全系骨髓上起显著预防保护作用,显著降低三系骨髓抑制的发生率,具有高效性、选择性与可逆性,且安全性良好。本文报道1例曲拉西利预防肺癌化疗引发的骨髓抑制病例,以供同行参考。

关键词：非小细胞肺癌化疗骨髓抑制曲拉西利

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进气道跨音速流场的计算

数值计算与计算机应用 1999年第4期20卷 283-292页

作者：欧阳洁叶昌业西北工业大学应用数学系

In this paper, the implicit approximate factorization schemes is combined with themultigrid method for computing the transonic flow fields of A-27 inlet. The numericalresults have shown that the multigrid method based on the approximate factorizationschemes can eliminate numerical vibration, simplify parametric choice and accelerateconvergent rate.

关键词：跨音速进气道流场空气动力学

A Rapid-Ab/Desorption and Portable Photothermal MIL- 101(Cr) Nanofibrous Composite Membrane Fabricated by Spray-Electrospinning for Atmosphere Water Harvesting

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Energy & Environmental Materials 2023年第1期6卷 111-118页

作者： Ailin Li Jian Xiong ye Liu Liming Wang Xiaohong Qin Jianyong Yu Key Laboratory of Textile Science and Technology of Ministry of Education College of TextilesDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

MIL-101(Cr)is a promising moisture absorbent for solar-driven water harvesting from moisture to tackle the worldwide water shortage ***,the MIL-101(Cr)powder suffers from a long ab/desorption cycle due to the crystal aggregation caused by its inherent powder ***,we demonstrate a MIL-101(Cr)nanofibrous composite membrane with a nanofibrous matrix where MIL-101(Cr)is monodisperse in the 3D porous nanofibrous matrix through a simple spray-electrospinning *** continuous porous nanofibrous matrix not only offers sufficient sites for MIL-101(Cr)loading but also provides rapid moisture transport channels,resulting in a super-rapid ab/desorption duration of 50 min(including an absorption process for 40 min and a desorption process for 10 min)and multicycle daily water production of 15.9 L kg^(−1) d^(−1).Besides,the MIL-101(Cr)nanofibrous composite membrane establishes a high solar absorption of 92.8%,and excellent photothermal conversion with the surface temperature of 70.7°C under one-sun *** addition,the MIL-101(Cr)nanofibrous composite membrane shows excellent potential for practical application due to its flexibility,portability,and use *** work provides a new perspective of shortening MOF ab/desorption duration by introducing a porous nanofibrous matrix to improve the specific water production for the solar-driven ab/desorption water harvesting technique.

关键词： electrospinning fast vapor transport MIL-101(Cr) MOF composite membrane solar-driven moisture harvesting

Mechanism of the Xuefu Zhuyu decoction in treating diabetes mellitus erectile dysfunction based on the CaSR/Gq-PLC-PKC pathway

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Traditional Medicine Research 2023年第10期8卷 11-18页

作者： Chao-Hong Zhang Guang-jie Li Li-Xing Jiang Hai-Qing Fan Hui-long Fang Yu-ye Wu Department of Urology The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 353003China

Background:To investigate the mechanism of Xuefu Zhuyu decoction in the treatment of diabetes mellitus erectile ***:Rats with diabetes mellitus erectile dysfunction were developed using streptozocin and randomly assigned into model,low-dose herbal,and high-dose herbal *** rats were administered normal saline or the corresponding drugs by oral gavage for 4 *** related indices were detected using enzyme-linked immunosorbent assays,immunohistochemistry,western blotting,and transmission electron ***:The levels of lectin-like oxidized low-density protein receptor-1,endothelin-1,NADH oxidase,vascular cell adhesion molecule-1,and intercellular adhesion molecule-1 in the model group were significantly higher than they were in the mock group but lower than they were in the herbal treatment *** level of nitric oxide was lower in the model group than was in the mock group but higher than the level in the herbal treatment *** calcium-sensitive receptor,phospho-protein kinase Cδ/protein kinase Cδ,phosphorylated c-Jun amino-terminal kinase/c-Jun amino-terminal kinase,and phospho-P38 mitogen-activated protein kinase/P38 mitogen-activated protein kinase expression levels in the model group were higher than were in the mock group but lower than were in the herbal treatment *** structures of the Corpus cavernosum penis endothelial cells were significantly improved in the herbal treatment group than they did in the model ***:Xuefu Zhuyu decoction can decrease injury to the endothelium,improve vascular endothelial diastolic and contractive function,and inhibit vascular fibrosis in rats with diabetes mellitus erectile *** mechanism may be related to the CaSR/Gq-PLC-PKC pathway.

关键词： Xuefu Zhuyu decoction diabetes mellitus erectile dysfunction CaSR/Gq-PLC-PKC JNK P38

凋亡细胞清除过程中相关信号及机制的研究进展

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中国免疫学杂志 2018年第6期34卷 944-948,952页

作者：张少龙樊竑冶中国药科大学生命科学与技术学院南京210009

机体中每时每刻都有大量的凋亡细胞产生,及时清除这些凋亡细胞对于维持机体的免疫平衡至关重要。在凋亡细胞的清除中,巨噬细胞发挥主要作用,其清除过程分为3个阶段:招募,识别,吞噬。招募阶段,凋亡细胞会分泌"find me"信号,吞噬细胞则会... 详细信息

机体中每时每刻都有大量的凋亡细胞产生,及时清除这些凋亡细胞对于维持机体的免疫平衡至关重要。在凋亡细胞的清除中,巨噬细胞发挥主要作用,其清除过程分为3个阶段:招募,识别,吞噬。招募阶段,凋亡细胞会分泌"find me"信号,吞噬细胞则会做出响应然后被招募到凋亡细胞处。识别阶段,凋亡细胞表面的"eat-me"信号与吞噬细胞表面的吞噬受体相互识别结合。吞噬阶段,"eat-me"信号向吞噬细胞内传导信号,例如激活GTPase Rac1,引起肌动蛋白聚合和细胞骨架的重排,促进对凋亡细胞的吞噬。若凋亡细胞的清除机制出现障碍,未被及时清除的凋亡细胞将进入次级坏死状态而释放胞内的自身抗原。这些自身抗原可能刺激机体免疫活化而产生自身抗体,进而引发自身免疫性疾病如SLE。本文就吞噬细胞对凋亡细胞清除机制的研究进展作详细综述。

关键词：凋亡细胞巨噬细胞 “find me”信号 “eat-me”信号 GTPase Rac1 SLE