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A spirocyclic oxindole analogue:Synthesis and antitumor activities

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Chinese Chemical Letters 2011年第9期22卷 1009-1012页

作者： Hui Hong long jiang huang da wei teng College of Chemical Engineering Qingdao University of Science & Technology Qingdao 266042 China

A new synthesis of spirocyclic oxindole analogue spiro[piperidine-4,3＇-pyrrolol2,3-b]pyridin]-2＇（1＇H）-one 1 is described. The key steps involve dialkylation of arylacetonitrile and cyclization of the azaoxindole ring by an intramolecular Buchwald-Hartwig amidation of carboxylic amide and aryl chloride. A small library was obtained by reductive amination of 1 with various aldehydes and was screened against human lung cancer cell A549, human liver cancer cell BEL7402, and human colon cancer cell HCT-8. The results show that most of the library compounds 2 have some inhibitory activities. 2-（Trifluoromethoxy） benzylic substituted spirocyclic azaoxindole 2e was identified as a nanomolar inhibitor against human lung cancer cell A-549 （IC50 = 50 nmol/L）.

关键词： Spirocyclic oxindole Aryl amidation Dialkylation Antitumor activity

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong jiang-Shan huang Fei-long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-wei Lin Sui Chen Zhen-Yang Zhang jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou huang Jin-Jie Yu Feng Su Tian jiang Shao-Yuan Zhang Lu Lv Tao long Hui-Wen Pan Jun-Qing Qi Qiang Zhou wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi huang Jun-jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

Research on a MEMS pyrotechnic with a double-layer barrier safety and arming device

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Defence Technology（防务技术） 2022年第11期18卷 2034-2044页

作者： Ke-xin Wang teng-jiang Hu Yu-long Zhao wei Ren State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXi'an710049China Science and Technology on Applied Physical Chemistry Laboratory Shaanxi Applied Physical Chemistry Research InstituteXi'an710061China

As an essential component of ammunition, pyrotechnics can control ignition with high ***, due to limits of fabrication technology, traditional pyrotechnics are bulky. To achieve both functionality and miniaturization, MEMS pyrotechnics integrate initiator, safety-and-arming(S&A) device and lead charge and keep all components within a small size. MEMS S&A devices, as the core component to ensure system safety, are difficult to achieve active and rapid response to control signals with high safety and reliability. In order to overcome the difficulty, we propose the design and characterization of a MEMS pyrotechnic with a double-layer barrier S&A device. The MEMS pyrotechnic is a high-integrated device with an overall size of 13.4 × 8.5 × 5.2 mm^(3). The initiator is a Ni Cr bridge foil covered with an Al/Cu O energetic film, which can generate flame when ignited by an excitation *** match the flame energy, lead styphnate is chosen in this study as the lead charge. The S&A device contains four semi-circular barriers, which are directly driven by V-shape electro-thermal actuators to gain active control of the pyrotechnics’ ignition condition with rapid response. To improve the system’s reliability, the four barriers are axisymmetrically placed in two layers, two barriers for each layer, to constitute a double-layer structure with a thickness of 100 μm. The ignition test results show that the S&A device can prevent the initiator from detonating the lead charge in safety condition. In arming condition, the lead charge will be detonated.

关键词： MEMS Pyrotechnics Safety and arming device Initiator Electro-thermal actuator

Visualization of hydraulic fracture interacting with pre-existing fracture

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Petroleum Science 2023年第6期20卷 3723-3735页

作者： Zi-Xiao Xie Xiao-Guang Wu teng-da long Zhong-wei huang Gen-Sheng Li Wen-Chao Zou Zhao-wei Sun State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing102249China

Hydraulic fracturing is considered the main stimulation method to develop shale gas reservoirs. Due to its strong heterogeneity, the shale gas formation is typically embedded with geological discontinuities such as bedding planes and natural fractures. Many researchers realized that the interaction between natural fractures and hydraulic fractures plays a crucial role in generating a complex fracture network. In this paper, true tri-axial hydraulic fracturing tests were performed on polymethyl methacrylate (PMMA), on which pre-existing fracture was pre-manufactured to simulate natural fracture. A cohesive model has been developed to verify the results of the experimental tests. The key findings demonstrate that the experimental results agreed well with the numerical simulation outcomes where three main interaction modes were observed: crossing;being arrested by opening the pre-existing fracture;being arrested without dilating the pre-existing fracture. Crossing behavior is more likely to occur with the approaching angle, horizontal stress difference, and injection rate increase. Furthermore, the higher flow rate might assist in reactivating the natural fractures where both sides of the pre-existing fractures were reactivated as the injection rate increased from 5 to 20 mL/min. Additionally, hydraulic fractures show a tendency to extend vertically rather than along the direction of maximum horizontal stress when they are first terminated at the interface. This research may contribute to the field application of hydraulic fracturing in shale gas formation.

关键词： Hydraulic fracturing Natural fracture Fracture propagation Interaction mode PMMA

Numerical study of inhibition mechanism of high-pressure hydrogen leakage self-ignition with the addition of ammonia

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Petroleum Science 2023年第5期20卷 3184-3193页

作者： Lin teng Xi-Gui Li Zhi-wei Shan wei-Dong Li Xin huang Peng-Bo Yin Yong-Zhen Liu jiang Bian Yu Luo Li-long jiang National Engineering Research Center of Chemical Fertilizer Catalyst(NERC-CFC) College of Chemical EngineeringFuzhou UniversityFuzhou350000FujianChina Qingyuan Innovation Laboratory(QYIL Fujian Innovation Laboratory of Chemical Engineering)Quanzhou362000FujianChina cEngineering China University of Petroleum(East China)Qingdao266580ShandongChina State Key Laboratory of Automobile Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing100084China

Hydrogen and ammonia have attracted increasing attention as carbon-free *** is considered to be an effective energy storage and hydrogen storage ***,a small amount of unremoved NH3 is still present in the product during the decomposition of ammonia to produce ***,it is very essential to investigate the self-ignition of hydrogen-ammonia mixtures in order to accommodate the various scenarios of hydrogen energy *** this paper,the effect of NH3 addition on the self-ignition of high-pressure hydrogen release is numerically *** RNG k-εturbulence model,EDC combustion model,and 213-step detailed NH_(3)/H_(2) combustion mechanism are ***-Pro programs for zero-dimensional homogeneous and constant volume adiabatic reactor models are used for sensitivity analysis and ignition delay time of the chemical reaction *** results showed that the minimum burst pressure required for self-ignition increased significantly after the addition of *** maximum temperature and shock wave intensity inside the tube decreases with increasing ammonia *** ignition delay time and H,HO2,and OH radicals reduce with increasing ammonia concentration.H and HO2 radicals are suggested as indicators for tracking the second and third flame branches,respectively.

关键词： Ammonia-hydrogen energy Self-ignition Shock waves Diffusion ignition Computational fluid dynamics

Recent advances in distributed adaptive consensus control of uncertain nonlinear multi-agent systems

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Journal of Control and Decision 2020年第1期7卷 44-63页

作者： wei Wang jiang long Changyun Wen jiangshuai huang School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191People’s Republic of China Beijing Advanced Innovation Center for Big data and Brain Computing Beihang UniversityBeijing 100191People’s Republic of China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Chongqing UniversityChongqingPeople’s Republic of China

So far,distributed adaptive consensus problems for uncertain nonlinear multi-agent systems have not yet been extensively *** with centralised adaptive control,some new challenges need to be well addressed,for examples,(i)how to reach asymptotically consensus tracking with directed topology condition,by using totally distributed adaptive control strategies;(ii)how to ensure globally uniform boundedness of closed-loop systems while achieving leaderless consensus with semi-positive definite Laplacian matrix;(iii)how to maintain system performance while effectively reducing the communication burden among connected *** paper is mainly devoted to report some recent advances in distributed adaptive consensus ***,some interesting research topics which are worthy of further investigation will also be discussed.

关键词： Distributed adaptive control consensus nonlinear multi-agent systems uncertainties

Uncertainties of landslide susceptibility prediction: Influences of random errors in landslide conditioning factors and errors reduction by low pass filter method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 213-230页

作者： Faming huang Zuokui teng Chi Yao Shui-Hua jiang Filippo Catani wei Chen Jinsong huang School of Infrastructure Engineering Nanchang UniversityNanchang330031China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China Department of Geosciences University of PadovaPadovaItaly College of Geology and Environment Xi’an University of Science and TechnologyXi’an710054China Discipline of Civil Surveying and Conditioning EngineeringPriority Research Centre for Geotechnical Science and EngineeringUniversity of NewcastleNewcastleNSWAustralia

In the existing landslide susceptibility prediction(LSP)models,the influences of random errors in landslide conditioning factors on LSP are not considered,instead the original conditioning factors are directly taken as the model inputs,which brings uncertainties to LSP *** study aims to reveal the influence rules of the different proportional random errors in conditioning factors on the LSP un-certainties,and further explore a method which can effectively reduce the random errors in conditioning *** original conditioning factors are firstly used to construct original factors-based LSP models,and then different random errors of 5%,10%,15% and 20%are added to these original factors for con-structing relevant errors-based LSP ***,low-pass filter-based LSP models are constructed by eliminating the random errors using low-pass filter ***,the Ruijin County of China with 370 landslides and 16 conditioning factors are used as study *** typical machine learning models,*** perceptron(MLP),support vector machine(SVM)and random forest(RF),are selected as LSP ***,the LSP uncertainties are discussed and results show that:(1)The low-pass filter can effectively reduce the random errors in conditioning factors to decrease the LSP uncertainties.(2)With the proportions of random errors increasing from 5%to 20%,the LSP uncertainty increases continuously.(3)The original factors-based models are feasible for LSP in the absence of more accurate conditioning factors.(4)The influence degrees of two uncertainty issues,machine learning models and different proportions of random errors,on the LSP modeling are large and basically the same.(5)The Shapley values effectively explain the internal mechanism of machine learning model predicting landslide *** conclusion,greater proportion of random errors in conditioning factors results in higher LSP uncertainty,and low-pass filter can effectively reduce these random e

关键词： Landslide susceptibility prediction Conditioning factor errors Low-pass filter method Machine learning models Interpretability analysis