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基于超滤膜辅助的糖蛋白全O-连接糖链的富集和MALDI-TOF/TOF质谱结构解析

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生物化学与生物物理进展 2017年第1期44卷 70-79页

作者：武艳丽杨刚龙缪明永关锋江南大学糖化学与生物技术教育部重点实验室无锡214122 第二军医大学生物化学与分子生物学教研室上海200433

哺乳动物中约有50%以上的蛋白质都发生了糖基化修饰.连接在丝氨酸或苏氨酸上的O-连接糖链是常见的蛋白质糖基化修饰方式之一,其主要功能是维持与其连接的蛋白质部分的空间构象,保护其免受蛋白酶水解及覆盖某些抗原决定簇.糖链结构的解... 详细信息

哺乳动物中约有50%以上的蛋白质都发生了糖基化修饰.连接在丝氨酸或苏氨酸上的O-连接糖链是常见的蛋白质糖基化修饰方式之一,其主要功能是维持与其连接的蛋白质部分的空间构象,保护其免受蛋白酶水解及覆盖某些抗原决定簇.糖链结构的解析有助于更清楚地认识糖蛋白及其功能.本研究建立了一种基于超滤膜辅助(FASP)富集细胞、血清和尿液中糖蛋白全O-连接糖链的方法,根据糖蛋白与其糖链结构之间的分子质量差异,利用10 KD超滤膜富集蛋白质样品中由β消除反应释放的全O-连接糖链,将糖链甲基化修饰后再使用MALDI-TOF/TOF-MS进行解析,同时利用二级质谱进行结构确认.通过上述方法可从标准糖蛋白mucin、细胞、血清和尿液样本中分别鉴定到83、29、33和85种O-连接糖链结构,利用该方法可以从复杂样品中富集和解析糖蛋白全O-连接糖链,实现快速、高效、高通量地解析糖蛋白O-连接糖链的目的.

关键词： O-连接糖链糖组学超滤膜辅助(FASP) MALDI—TOF/TOF—MS

Study on Image Recognition Algorithm for Residual Snow and Ice on Photovoltaic Modules

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Energy Engineering 2024年第4期121卷 895-911页

作者： Yongcan Zhu JiawenWang Ye Zhang long Zhao Botao Jiang Xinbo Huang College of Electronics and Information Xi’an Polytechnic UniversityXi’an710048China Xi’an Key Laboratory of Interconnected Sensing and Intelligent Diagnosis for Electrical Equipment Xi’an710048China

The accumulation of snow and ice on PV modules can have a detrimental impact on power generation,leading to reduced efficiency for prolonged ***,it becomes imperative to develop an intelligent system capable of accurately assessing the extent of snow and ice coverage on PV *** address this issue,the article proposes an innovative ice and snow recognition algorithm that effectively segments the ice and snow areas within the collected ***,the algorithm incorporates an analysis of the morphological characteristics of ice and snow coverage on PV modules,allowing for the establishment of a residual ice and snow recognition *** process utilizes both the external ellipse method and the pixel statistical method to refine the identification *** effectiveness of the proposed algorithm is validated through extensive testing with isolated and continuous snow area *** results demonstrate the algorithm’s accuracy and reliability in identifying and quantifying residual snow and ice on PV *** conclusion,this research presents a valuable method for accurately detecting and quantifying snow and ice coverage on PV *** breakthrough is of utmost significance for PV power plants,as it enables predictions of power generation efficiency and facilitates efficient PV maintenance during the challenging winter conditions characterized by snow and *** proactively managing snow and ice coverage,PV power plants can optimize energy production and minimize downtime,ensuring a sustainable and reliable renewable energy supply.

关键词： Photovoltaic(PV)module residual snow and ice snow detection feature extraction image processing

Mapping species assemblages of tropical forests at different hierarchical levels based on multivariate regression trees

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Forest Ecosystems 2023年第3期10卷 387-397页

作者： Qi Yang Maaike Y.Bader Guang Feng Jialing Li Dexu Zhang Wenxing long Wuzhishan National long Term Forest Ecosystem Research Station College of ForestryHainan UniversityHaikou570228China Ecological Plant Geography Faculty of GeographyUniversity of MarburgDeutschhausstrasse 1035032MarburgGermany Wuzhishan Division of Hainan Tropical Rainforest National Park Bureau Wuzhishan572200China

Background: Vegetation distribution maps are of great significance for nature protection and management. In diverse tropical forests, accurate spatial mapping of vegetation types is challenging;the high species diversity and abundance of rare species challenge classification concepts, while remote sensing signals may not vary systematically with species composition, complicating the technical capability for delineating vegetation types in the ***: We used a combination of field-based compositional data and their relations to environmental variables to predict the distribution of forest types in the Wuzhishan National Natural Reserve(WNNR), Hainan Island,China, using multivariate regression trees(MRT). The MRT was based on arboreal vegetation composition in 132plots of 20 m×20 m with a regular spacing of 1 km. Apart from the MRT, non-metric multidimensional scaling(NMDS) was used to evaluate vegetation-environment ***: The MRT model worked best when using 14 key environmental variables including topography, climate,latitude and soil, although the difference with the simpler model including only topographical variables was small. The full model classified the 132 plots into 3 vegetation types, 6 formation groups, 20 formations and 65associations at different hierarchical syntaxonomic levels. This model was the basis for forest vegetation maps for the WNNR. MRT and NMDS showed that elevation was the main driving force for the distribution of vegetation types and formation groups. Climate, latitude, and soil(especially available P), together with topographic variables, all influenced the distribution of formations and ***: While elevation determines forest-type distributions, lower-level syntaxonomic forest classes respond to the topographic diversity typical for mountains. Apart from providing the first detailed forest vegetation map for any part of WNNR, we show how, in spite of limitations, MRT with existing enviro

关键词： Species assemblages Tropical forest Mapping Multivariate regression trees Non-metric multidimensional scaling

A federated learning scheme meets dynamic differential privacy

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 1087-1100页

作者： Shengnan Guo Xibin Wang Shigong long Hai Liu Liu Hai Toong Hai Sam State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyangChina School of Big Data Key Laboratory of Electric Power Big Data of Guizhou ProvinceGuizhou Institute of TechnologyGuiyangChina School of Information Guizhou University of Finance and EconomicsGuiyangChina Faculty of Business and Communication INTI International UniversityNilaiMalaysia

Federated learning is a widely used distributed learning approach in recent years,however,despite model training from collecting data become to gathering parameters,privacy violations may occur when publishing and sharing models.A dynamic approach is pro-posed to add Gaussian noise more effectively and apply differential privacy to federal deep ***,it is abandoning the traditional way of equally distributing the privacy budget e and adjusting the privacy budget to accommodate gradient descent federation learning dynamically,where the parameters depend on computation derived to avoid the impact on the algorithm that hyperparameters are created *** also incorporates adaptive threshold cropping to control the sensitivity,and finally,moments accountant is used to counting the∈consumed on the privacy‐preserving,and learning is stopped only if the∈_(total)by clients setting is reached,this allows the privacy budget to be adequately explored for model *** experimental results on real datasets show that the method training has almost the same effect as the model learning of non‐privacy,which is significantly better than the differential privacy method used by TensorFlow.

关键词： data privacy machine learning security of data

Revisiting the mechanisms of mid-Tertiary uplift of the NE Tibetan Plateau

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National Science Review 2023年第4期10卷 169-190页

作者： Hong-Hong Wei Guo-Li Wu Lin Ding long-Gang Fan Lin Li Qing-Ren Meng State Key Laboratory of Tibetan Plateau Earth System Environment and Resources (TPESER) Institute of Tibetan Plateau Research Chinese Academy of Sciences Institute of Geomechanics Chinese Academy of Geological Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Department of Geosciences University of Arizona University of Chinese Academy of Sciences

Contrasting views exist on timing and mechanisms of Tertiary crustal uplift in the NE Tibetan Plateau based on different approaches, with many models atributing surface uplift to crustal shortening. We carry out a comprehensive investigation of mid-Tertiary stratigraphy, sedimentology, and volcanism in the West Qinling, Hoh Xil and Qaidam basin, and the results challenge previous views. It was held that the discordance between Oligocene and Miocene strata is an angular unconformity in the West Qinling, but our field observations show that it is actually a disconformity, indicative of vertical crustal uplifting rather than crustal shortening at the Oligocene to Miocene transition. Widespread occurrence of synsedimentary normal faults in mid-Tertiary successions implicates supracrustal stretching. Miocene potassic–ultrapassic and mafic–ultramafic volcanics in the Hoh Xil and West Qinling suggest a crucial role of deep thermomechanical processes in generating crust-and mantle-sourced magmatism. Also noticeable are the continuity of mid-Tertiary successions and absence of volcanics in the Qaidam basin. Based on a holistic assessment of stratigraphic–sedimentary processes, volcanic petrogenesis, and spatial variations of lithospheric thicknesses, we speculate that small-sale mantle convection might have been operating beneath northeast Tibet in the mid-Tertiary. It is assumed that northward asthenospheric flow was impeded by thicker cratonic lithosphere of the Qaidam and Alxa blocks, thereby leading to edge convection. The edge-driven convection could bring about surface uplift, induce supracrustal stretching, and trigger vigorous volcanism in the Hoh Xil and West Qinling in the mid-Tertiary period. This mechanism satisfactorily explains many key geologic phenomena that are hardly reconciled by previous models.

关键词： NE Tibetan Plateau mid-Tertiary unconformity volcanism edge convection

One stone three birds:Ni-catalyzed asymmetric allenylic substitution of allenic ethers,hydroalkylation of 1,3-enynes and double alkylation of enynyl ethers

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Chinese Chemical Letters 2024年第8期35卷 282-287页

作者： Zhirong Yang Shan Wang Ming Jiang Gengchen Li long Li Fangzhi Peng Zhihui Shao Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologyYunnan Provincial Center for Research&Development of Natural Productsand State Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China

The development of low-cost,earth-abundant and environmentally benign transition metal catalysts,which can catalyze multiple different types of asymmetric reactions,is an important objective in mod-ern asymmetric *** we demonstrate that a chiral Ni/P-Phos catalyst achieves three types of asymmetric reactions:allenylic substitution of racemic allenic ethers,1,4-hydroalkylation of prochiral 1,3-enynes and double alkylation of newly designed enynyl ether *** methods complement each other and produce various axially chiral allene derivatives bearing a pyrazolidine-3,5-dione unit,which is widely present in drugs and biologically active molecules with versatile pharmacological activities.

关键词： Nickel Asymmetric catalysis Allenylic substitution Hydroalkylation Double alkylation Allene 1,3-Enyne Pyrazolidine-3,5-dione

Data Bucket-Based Fragment Management for Solid State Drive Storage System

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Journal of Electronic Science and Technology 2020年第4期18卷 330-340页

作者： Wei Jiang Jun-long Wang Jin-Yu Zhan Jing-Huan Yu Hai-Bo Hu School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054 Computer Science Department City University of Hong KongHong Kong 999077

The current storage mechanism considered little in data’s keeping *** can produce fragments of various sizes among data *** some cases,these fragments may be serious and harm system *** this paper,we manage to modify the current storage *** introduce an extra storage unit called data bucket into the classical data manage ***,we modify the data manage mechanism to improve our *** keeping data according to their visited information,both the number of fragments and the fragment size are greatly *** different data features and storage device conditions,we also improve the solid state drive(SSD)lifetime by keeping data into different *** show that our designs have a positive influence on the SSD storage density and actual service time.

关键词： Data structure erasing time fragment solid state driver(SSD)

Global, regional, and cladistic patterns of variation in climatic niche breadths in terrestrial elapid snakes

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Current Zoology 2019年第1期65卷 1-9页

作者： long-Hui Lin Xia-Ming Zhu Yu Du Meng-Chao Fang Xiang Ji Hangzhou Key Laboratory for Ecosystem Protection and Restoration College of Life and Environmental SciencesHangzhou Normal University Hangzhou Zhejiang 310036 China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing Jiangsu 210023 China Hainan Key Laboratory for Herpetology College of Tropical Biology and Agronomy Hainan Tropical Ocean UniversitySanya 572022 China

We obtai ned geo-refere need occurre nee and climatic data from in dividual localities for 59 species of terrestrial elapid snakes, used phylogenetic generalized least squares regression to investigate spatial and cladistic patter ns of variation in climatic niche breadths, and compared patter ns within and across regions and clades to see if they parallel or differ from each other. Specifically, we test (1) whether a species' climatic niche breadth on a given niche axis relates to its position along that axis, and to its climatic niche breadth on another niche axis, and (2) whether variation in niche breadths among species is explained by within-locality variation in climatic conditions or by among-locality variation. We found that:(1) there is an overall global patter n, and patter ns in individual regi ons or clades gen erally parallel each other and global patter ns;(2) species in wanner environments have narrower temperature niche breadths (TNBs);(3) precipitation niche breadth (PNB) and position are positively related;⑷ TNB and PNB are not related;and ⑸ within-locality variation in climatic conditions explains most variation in TNBs, whereas among-locality variation explains most variation in PNBs. Our results are consistent with those reported for lizards of the families Phrynosomatidae and Varanidae, con firm the importance of withi n-locality n iche breadth to species n iche breadth, and show a more im porta nt role of amon g-locality n iche breadth in affecting species niche breadth in terrestrial elapids than in lizards.

关键词： climate Elapidae niche breadth niche position niche variance precipitation temperature

Roles of integrin in tumor development and the target inhibitors

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Chinese Journal of Natural Medicines 2019年第4期17卷 241-251页

作者： LI Zhao-He ZHOU You DING You-Xiang GUO Qing-long ZHAO Li State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University

Integrin is a large family of cell adhesion molecules(CAMs) which involves in the interaction of cells/cells and cells/extracellular matrix(ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.

关键词： Integrin Tumor development Target therapy Natural medicines