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Operation optimization of plugged screen cleanup by rotary water jetting

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Petroleum Science 2014年第1期11卷 122-130页

作者： Dong Changyin Li Yanlong long jiajia Zhang Qinghua Wang Dengqing Wu Jianping College of Petroleum Engineering China University of Petroleum Qingdao Research Institute of Production Technology Shengli Oilfield SINOPEC

The rotary water jetting is one of the most important techniques for horizontal well *** jet flow is used to remove plugging particles from sand control screens to recover their ***,the operation optimization of this technique depends mainly on experience due to absence of applicable evaluation and design models for removing plugging *** paper presents an experimental setup to simulate the cleanup process of plugged screens by rotary water jetting on the surface and to evaluate the performance of a jetting *** real plugged screens pulled from damaged wells,a series of tests were performed,and the qualitative relationships between the cleanup efficiency and various operational parameters,such as the type of fluids used,flow rate,mode of tool movement,etc.,were *** test results indicated that the cleanup performance was much better when the rotary jetting tool moved and stopped periodically for a certain time than that when it reciprocated at a constant *** be exact,it was desirable for the rotary jetting tool to move for 1.5-2 m and stop for 2-4 min,which was called the ＂move-stop-move＂ *** cleanup performance could be obtained at high flow rates,and the flow rate was recommended to be no lower than 550-600 L/*** test results also indicated that complex mud acid was better than clean water in terms of cleanup *** cleanup efficiency and high screen permeability recovery could be achieved for severely plugged *** jetting is preferred for the cleanup of horizontal wells with severely plugged screens,and the screen permeability recovery ratio may reach 20％ if optimized operation parameters were used.

关键词： Sand control screen cleanup performance rotary jetting operation optimization experimental simulation

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胜利济阳页岩油开发进展与攻关方向

油气地质与采收率 2024年第5期31卷 77-98页

作者：杜玉山蒋龙程紫燕李伟忠任敏华刘巍倪良田陈建勋蔡鑫郭士博王云鹤刘艳方正彭艳霞隆佳佳中国石化胜利油田分公司勘探开发研究院山东东营257015 页岩油气富集机理与高效开发全国重点实验室北京102206

为了实现济阳陆相断陷盆地中低演化程度页岩油的有效开发,2019年以来,依托万米系统取心、十万余块次的岩心测试,在博兴、牛庄、民丰等洼陷同时开展系统评价,单井评价及立体井组开发均取得突破。博兴洼陷开展了3层楼8口井的先导试验,建... 详细信息

为了实现济阳陆相断陷盆地中低演化程度页岩油的有效开发,2019年以来,依托万米系统取心、十万余块次的岩心测试,在博兴、牛庄、民丰等洼陷同时开展系统评价,单井评价及立体井组开发均取得突破。博兴洼陷开展了3层楼8口井的先导试验,建成中国石化首个10万吨级页岩油开发井组;牛庄洼陷开展了5层楼20口井大平台立体开发井组试验,已全部投产;民丰洼陷按照“大平台整体部署、小井组分步实施”的模式,整体评价、立体开发试验全面展开。樊页平1、丰页1-1HF井等28口井峰值日产油量超百吨,30口井累计产油量超万吨。基于基础研究与开发实践,提出了济阳页岩油“储-缝-压”三元储渗理论认识,攻关形成了页岩油开发实验技术、开发甜点立体精细评价技术、建模数模一体化技术、立体开发优化调控技术,初步构建了胜利特色的陆相断陷盆地页岩油立体开发理论技术体系,有效支撑了胜利济阳页岩油国家级示范区建设。

关键词：陆相断陷盆地页岩油立体开发开发进展济阳坳陷攻关方向

四海理论指导的针刺联合认知-运动双任务训练对中风后认知功能障碍患者感知控制及注意力的影响

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针灸临床杂志 2024年第8期40卷 27-31页

作者：谢青杨胜玲磨雪玲何琳龙佳佳黄金艳广西壮族自治区民族医院广西医科大学附属民族医院广西南宁530001 广西壮族自治区江滨医院广西南宁530021

目的:探讨四海理论指导的针刺联合认知-运动双任务训练对中风后认知功能障碍患者感知控制及注意力的影响。方法:将80例中风后认知功能障碍患者随机分为两组。对照组给予认知-运动双任务训练干预,研究组于对照组基础上联合四海理论指导... 详细信息

目的:探讨四海理论指导的针刺联合认知-运动双任务训练对中风后认知功能障碍患者感知控制及注意力的影响。方法:将80例中风后认知功能障碍患者随机分为两组。对照组给予认知-运动双任务训练干预,研究组于对照组基础上联合四海理论指导的针刺治疗,比较两组患者感知控制及注意力情况。结果:治疗后两组患者疾病感知控制量表各维度评分均较治疗前降低,且研究组患者均低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者数字符号测试(SDMT)量表评分、数字惊觉测试(DVT)量表评分、数字广度(DS)量表评分、简易智能精神状态检查量表(MMSE)及蒙特利尔认知评估量表(MoCA)评分均较治疗前升高,且研究组均高于对照组,差异具有统计学意义(P<0.05)。结论:四海理论指导的针刺联合认知-运动双任务训练治疗中风后认知功能障碍患者疗效确切,能够明显改善患者感知控制及注意力。

关键词：中风认知功能障碍四海理论针刺认知-运动双任务训练

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan long jiajia Liu Yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Regulating the non-effective carriers transport for high-performance lithium metal batteries

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Journal of Energy Chemistry 2024年第5期92卷 132-141页

作者： Simeng Wang Youchun Yu Shaotong Fu Hongtao Li jiajia Huang Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Haike Group Research Institute of Innovation&Technology Dongying 257000ShangdongChina

The absence of control over carriers transport during electrochemical cycling,accompanied by the deterioration of the solid electrolyte interphase(SEI)and the growth of lithium dendrites,has hindered the development of lithium metal ***,a separator complexion consisting of polyacrylonitrile(PAN)nanofiber and MIL-101(Cr)particles prepared by electrospinning is proposed to bind the anions from the electrolyte utilizing abundant effective open metal sites in the MIL-101(Cr)particles to modulate the transport of non-effective *** binding effect of the PANM separator promotes uniform lithium metal deposition and enhances the stability of the SEI layer and long cycling stability of ultra-high nickel layered oxide *** PANM as the Li||NCM96 separator enables high-voltage cycling stability,maintaining 72%capacity retention after 800 cycles at a charging and discharging rate of 0.2 C at a cut-off voltage of 4.5 V and 0°***,the excellent high-rate performance delivers a specific capacity of 156.3 mA h g^(-1) at 10 *** addition,outstanding cycling performance is realized from−20 to 60°*** separator engineering facilitates the electrochemical performance of lithium metal batteries and enlightens a facile and promising strategy to develop fast charge/discharge over a wide range of temperatures.

关键词： Functional separators Metal-organic frameworks 3D continuous ion transport networks Electrospinning Lithium metal batteries

Natural variation of GmFNSII-2 contributes to drought resistance by modulating enzyme activity in soybean

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The Crop Journal 2024年第2期12卷 529-539页

作者： Huihui Gao Pengcheng Wei Yongzhe Gu Pengbin Tang Yifan Shen Lei Yang Linxin Dong Haowei Zheng Kuo Shu Mayamiko Masangano Bin Dong long Miao jiajia Li Lijuan Qiu Xiaobo Wang School of Agronomy Anhui Agricultural UniversityHefei 230036AnhuiChina State Key Laboratory of Crop Gene Resources and Breeding The National Key Facility for Crop Gene Resources and Genetic Improvement(NFCRI)/Key Laboratory of Crop Gene Resource and Germplasm Enhancement(MOA)Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

As an essential crop that provides vegetable oil and protein,soybean(Glycine max(L.)Merr.)is widely planted all over the ***,the scarcity of water resources worldwide has seriously impacted on the quality and yield of *** address this,exploring excellent genes for improving drought resistance in soybean is *** this study,we identified natural variations of GmFNSII-2(flavone synthase II)significantly affect the drought resistance of *** sequence analysis of GmFNSII-2 in 632 cultivated and 44 wild soybeans nine haplotypes were *** full-length allele GmFNSII-2^(C),but not the truncated allele GmFNSII-2^(A) possessing a nonsense nucleotide variation,increased enzyme *** research found that GmDREB3,known to increase soybean drought resistance,bound to the promoter region of GmFNSII-2^(C).GmDREB3 positively regulated the expression of GmFNSII-2^(C),increased flavone synthase abundance and improved the drought ***,a singlebase mutation in the GmFNSII-2^(C) promoter generated an additional drought response element(CCCCT),which had stronger interaction strength with GmDREB3 and increased its transcriptional activity under drought *** frequency of drought-resistant soybean varieties with Hap 1(Pro:GmFNSII-2^(C))has increased,suggesting that this haplotype may be selected during soybean *** summary,GmFNSII-2^(C) could be used for molecular breeding of drought-tolerant soybean.

关键词： Drought stress Flavone synthase GmFNSII-2 Natural variation Drought response element

RpL 38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis

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Science China Life Sciences 2024年

作者： Yang Fang Fengchao Zhang Fangzhen Zhao jiajia Wang Xinkai Cheng Fei Ye Jiayu He long Zhao Ying Su Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China College of Marine Life Sciences Ocean University of China Fisheries College Ocean University of China

Switching from mitotic spermatogonia to meiotic spermatocytes is critical to producing haploid sperms during male germ cell differentiation. However, the underlying mechanisms of this switch remain largely unexplored. In Drosophila melanogaster, the gene RpL38encodes the ribosomal protein L38, one component of the 60S subunit of ribosomes. We found that its depletion in spermatogonia severely diminished the production of mature sperms and thus led to the infertility of male flies. By examining the germ cell differentiation in testes,we found that RpL38-knockdown blocked the transition from spermatogonia to spermatocytes and accumulated spermatogonia in the testis. To understand the intrinsic reason for this blockage, we conducted proteomic analysis for these spermatogonia populations. Differing from the control spermatogonia, the accumulated spermatogonia in RpL38-knockdown testes already expressed many spermatocyte markers but lacked many meiosis-related proteins, suggesting that spermatogonia need to prepare some important proteins for meiosis to complete their switch into spermatocytes. Mechanistically, we found that the expression of bag of marbles (bam), a crucial determinant in the transition from spermatogonia to spermatocytes, was inhibited at both the mRNA and protein levels upon RpL38 depletion. We also confirmed that the bam loss phenocopied RpL38 RNAi in the testis phenotype and transcriptomic profiling. Strikingly, overexpressing bam was able to fully rescue the testis abnormality and infertility of RpL38-knockdown flies, indicating that bam is the key effector downstream of RpL38 to regulate spermatogonia differentiation. Overall, our data suggested that germ cells start to prepare meiosis-related proteins as early as the spermatogonial stage, and RpL38 in spermatogonia is required to regulate their transition toward spermatocytes in a bamdependent manner, providing new knowledge for our understanding of the transition process from spermatogonia to spe

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Free-standingβ-Ta_(2)O_(5)/SWCNTs composite film for high-rate Li-ion storage

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Science China(Technological Sciences) 2024年第2期67卷 616-626页

作者： WU ZhiMin LIU jiajia HE XingYu BIAN Jing ZHU XianJun CHEN JianMei LI JianMin College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing Universityof Posts and TelecommunicationsNanjing 210023China Department of Pathology College of Medicine University of CincinnatiCincinnatiOH 45267USA

The rapid development of portable and wearable electronic devices is responding to the urgent demand for high-efficiency flexible energy storage *** supercapacitors,showing long cycle life,high power density,and good safety,are considered ideal ***,the relatively low energy density restricts their practical *** a large dielectric constant of 18-46,Ta_(2)O_(5)-based materials typically exhibit excellent electron-binding ability,which is critical for enhancing the energy density of *** this work,the free-standingβ-Ta_(2)O_(5)/single-walled carbon nanotubes(SWCNTs)composite film was prepared,with a highβ-Ta_(2)O_(5)loading of over 70%.By anchoringβ-Ta_(2)O_(5)nanoparticles onto the surface of SWCNTs,the system’s flexibility and conductivity were significantly enhanced,which also facilitated the intercalation electrodynamics of metal *** a result,the flexibleβ-Ta_(2)O_(5)/SWCNTs film exhibits excellent Li-ion storage performance,with a high volumetric specific capacitance of 392.3 F cm^(-3)at the scan rate of 10 mV s^(-1)and 198.9 F cm^(-3)at 500 mV s^(-1).In addition,the asymmetric device,assembled by theβ-Ta_(2)O_(5)/SWCNTs and activated carbon films,shows a high energy density of 45.5 Wh kg^(-1)at the power density of 10.8 kW kg^(-1).This technique opens up a new avenue for improving the energy density and rate performance of flexible supercapacitors.

关键词： pseudocapacitor Li-ion storage β-Ta_(2)O_(5)/SWCNTs film flexible device high-rate capability

An improved transfer learning strategy for short-term cross-building energy prediction usingdata incremental

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Building Simulation 2024年第1期17卷 165-183页

作者： Guannan Li Yubei Wu Chengchu Yan Xi Fang Tao Li jiajia Gao Chengliang Xu Zixi Wang School of Urban Construction Wuhan University of Science and TechnologyWuhan 430065China Anhui Province Key Laboratory of Intelligent Building and Building Energy-saving Anhui Jianzhu UniversityHefei 230601China State Key Laboratory of Green Building in Western China Xi'an University of Architecture and TechnologyXi'an 710055China College of Urban Construction Nanjing Tech UniversityNo.200North Zhongshan RoadNanjing 210009China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Chongqing University) Ministry of Education of ChinaChongqing UniversityChongqing 400044China College of Civil Engineering Hunan UniversityChangsha 410082China Hubei Provincial Engineering Research Center of Urban Regeneration Wuhan University of Science and TechnologyWuhan 430065China

The available modelling data shortage issue makes it difficult to guarantee the performance of data-driven building energy prediction(BEP)models for both the newly built buildings and existing information-poor *** knowledge transfer learning(KTL)and data incremental learning(DIL)can address the data shortage issue of such *** new building scenarios with continuous data accumulation,the performance of BEP models has not been fully investigated considering the data accumulation ***,which can learn dynamic features from accumulated data adapting to the developing trend of new building time-series data and extend BEP model's knowledge,has been rarely *** studies have shown that the performance of KTL models trained with fixed data can be further improved in scenarios with dynamically changing ***,this study proposes an improved transfer learning cross-BEP strategy continuously updated using the coarse data incremental(CDI)*** hybrid KTL-DIL strategy(LSTM-DANN-CDI)uses domain adversarial neural network(DANN)for KLT and long short-term memory(LSTM)as the Baseline BEP *** evaluation is conducted to systematically qualify the effectiveness and applicability of KTL and improved ***-world data from six-type 36 buildings of six types are adopted to evaluate the performance of KTL and KTL-DIL in data-driven BEP tasks considering factors like the model increment time interval,the available target and source building data *** with LSTM,results indicate that KTL(LSTM-DANN)and the proposed KTL-DIL(LSTM-DANN-CDI)can significantly improve the BEP performance for new buildings with limited *** with the pure KTL strategy LSTM-DANN,the improved KTL-DIL strategy LSTM-DANN-CDI has better prediction performance with an average performance improvement ratio of 60%.

关键词： building energy prediction(BEP) cross-building data incremental learning(DIL) domain adversarial neural network(DANN) knowledge transfer learning(KTL)