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孕期、幼年交通相关空气污染暴露可能增加儿童期癌症风险

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中华预防医学杂志 2014年第7期48卷 591-591页

作者： Heck JE Wu J lombardi c 胡佳不详华中科技大学同济医学院公共卫生学院环境医学研究所

机动车尾气排放是环境空气污染的重要来源，汽车尾气中包含大量氮氧化物、碳氧化物、苯、甲醛及颗粒物等，其中颗粒物中又包含大量金属及其化合物，其中一些物质已经被证实为职业性致癌物或可疑性致癌物。最近一项研究表明探讨孕期、童... 详细信息

机动车尾气排放是环境空气污染的重要来源，汽车尾气中包含大量氮氧化物、碳氧化物、苯、甲醛及颗粒物等，其中颗粒物中又包含大量金属及其化合物，其中一些物质已经被证实为职业性致癌物或可疑性致癌物。最近一项研究表明探讨孕期、童年交通相关空气污染暴露可能增加儿童癌症风险，尤其一些少见的癌症类型。

关键词：空气污染儿童癌症孕期风险交通儿童期职业性致癌物幼年

日本和欧洲高血压患者血压晨峰的种族差异及其决定因素

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中华高血压杂志 2015年第9期23卷 805-805页

作者：刘莉叶鹏 Hoshide S Kario K de la Sierra A Bilo G Schillaci G Banegas JR Gorostidi M Segura J lombardi c Omboni S Ruilope L Mancia G Parati G

血压晨峰（morning blood pressure surge）是心血管事件的预测因素。然而,血压晨峰的决定因素尚不清楚,尤其是种族差异对其水平的影响。该研究探讨日本和西欧高血压患者的血压晨峰水平是否存在差异。方法：按照相同的入选标准,纳入欧... 详细信息

血压晨峰（morning blood pressure surge）是心血管事件的预测因素。然而,血压晨峰的决定因素尚不清楚,尤其是种族差异对其水平的影响。该研究探讨日本和西欧高血压患者的血压晨峰水平是否存在差异。方法：按照相同的入选标准,纳入欧洲动态血压监测数据库的2887例[（62.3±8.8）岁]和日本自治医科大学动态血压监测数据库的811例[（72.3±9.8）岁]未经治疗的高血压患者,分析其24h动态血压监测记录,尤其是血压晨峰情况。

关键词：高血压患者血压晨峰种族差异 24h动态血压监测日本欧洲监测数据库心血管事件

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Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： Alessandro Mantovani Rosa lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine c and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic

An internal control applied to RT-PcR detection of HcV and HIV-1 in human pooled plasma and plasma-derived medicinal products

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BIOcELL 2015年第2期39卷 15-23页

作者： Gonzalo RODRÍGUEZ-lombardi Luciana REYNA María Susana VITALI Susana GENTI-RAIMONDI Laboratorio de Hemoderivados Universidad Nacional de Córdoba centro de Investigaciones en Bioquímica clínica e Inmunología Departamento de Bioquímica ClínicaFacultad de Ciencias QuímicasUniversidad Nacional de Córdoba-Consejo Nacional de Investigaciones Científicas y TécnicasX5000HUA CórdobaArgentina

A competitive internal control(Ic)adapted to RT-PcR in-house assay was developed for HcV RNA detection in human pooled ***,it was applied in a multiplex RT-PcR for the HIV-1 and HcV RNA screening in human pooled plasma and plasma-derived products.A 258-bp PcR product from the 5´non-coding region of HcV genome was obtained.A competitive Ic template was constructed by inserting a 52-bp double strand sequence into the NheI site of the 258-bp *** sequence was cloned and the obtained plasmid was used to generate a synthetic *** Ic/RNA was incorporated in in-house HcV and/or HIV PcR technique to monitor the efficiency of extraction,reverse transcription,and PcR amplification *** was also used to detect all major genotypes of HcV and HIV-1 strains with similar *** detection limit of the assay for HcV and HIV-1 was 52.7 IU/mL and 164.2 IU/mL,*** techniques have been evaluated in international programs of external quality assurance with highly satisfactory *** Ic is an essential reagent in PcR techniques to detect and identify HcV and HIV-1 in pooled plasma samples involved in the manufacture of plasma-derived products as well as in the field of clinical microbiology with limited resources.

关键词： HcV HIV internal control RT-PcR

Failure mode analysis on compression of lattice structures with internal cooling channels produced by laser powder bed fusion

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Advances in Manufacturing 2021年第3期9卷 403-413页

作者： E.Virgillito A.Aversa F.calignano M.lombardi D.Manfredi D.Ugues P.Fino Department of Applied Science and Technology Polytechnic University of Turin10129TurinItaly center for Sustainable Future Technologies IIT Italian Institute of Technology10144TurinItaly

conformal cooling coils have been developed during the last decades through the use of additive manufacturing(AM)*** main goal of this study was to analyze how the presence of an internal channel that could act as a conformal cooling coil could affect compressive strength and quasi-elastic gradient of AlSi10Mg lattice structures produced by laser powder bed fusion(LPBF).Three different configurations of samples were tested in compression at 25℃ and 200℃.The reference structures were body centered cubic(BBc)in the core of the samples with vertical struts along Z(BccZ)lattices in the outer perimeter,labelled as Nc *** main novelty consisted in inserting a straight elliptical channel and a 45°elliptical channel inside the BccZ lattice structures,labelled as Sc and 45c samples *** the samples were then tested in as-built(AB)condition,and after two post process heat treatments,commonly used for AlSi10Mg LPBF industrial components,a stress relieving(SR)and a T6 *** lattice structures AB exhibited an overall fragile fracture and therefore the Sc and 45c configuration samples were tested only after thermal *** test at 25℃ showed that all types of samples were characterized by negligible variations in their quasi-elastic gradients and yield *** the contrary,the general trend of stress-strain curves was influenced by the presence of the channel and its *** test at 200℃ showed that Nc,Sc and 45c samples after SR and T6 treatments exhibited a metal-foam like deformation.

关键词： Laser powder bed fusion(LPBF) conformal cooling channel Lattice structures Failure mode analysis Mechanical properties at 200℃

cu3Ti原子簇结构与光谱的密度泛函理论研究

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光谱学与光谱分析 2008年第7期28卷 1488-1491页

作者：魏永慧程建波赵冰 lombardi John R 北华大学化学与生物学院吉林吉林市132013 吉林大学超分子结构与材料国家重点实验室吉林长春130012 烟台大学化学生物理工学院山东烟台264005 美国纽约市立大学化学系纽约10031

异核金属合金是非常重要的材料,cu3Ti具有形状记忆、高强度和声音吸收特性。由于实验中只观察到一条拉曼谱线,但其稳定结构并不清晰。文章利用密度泛函理论中的SVWN5,B3LYP和BPW91方法,分别采用lanl2dz,6-31g,6-311g,6-311g(d),6-311+g(... 详细信息

异核金属合金是非常重要的材料,cu3Ti具有形状记忆、高强度和声音吸收特性。由于实验中只观察到一条拉曼谱线,但其稳定结构并不清晰。文章利用密度泛函理论中的SVWN5,B3LYP和BPW91方法,分别采用lanl2dz,6-31g,6-311g,6-311g(d),6-311+g(2df)和6-311+g(3d2f)基组对cu3Ti多种可能的结构和振动光谱进行了研究。结合实验结果分析,表明其基态为自旋多重度为4的e型c2v对称性结构,基组对于频率和原子间距的影响比较大;并与实验拉曼光谱进行了对比。

关键词： cu3Ti DFT 原子簇分子结构振动光谱

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Graphene-Oxide Mediated chemodivergent Ring-Opening of cyclobutanols

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chinese Journal of chemistry 2023年第11期41卷 1333-1340页

作者： Andrea Brunetti Angela Pintus Lorenzo lombardi Alessandro Kovtun Federico Mascietti Francesco Bruno Enrico Ravera Manuela Melucci Giulio Bertuzzi Marco Bandini Dipartimento di chimica“Giacomo ciamician” Alma Mater StudiorumUniversitàdi BolognaVia Selmi 240126BolognaItaly Istituto per la Sintesi e la Fotoreattività(ISOF)–cNR Via Gobetti10140129BolognaItaly Magnetic Resonance center(cERM) University of FlorenceVia L.Sacconi 650019 Sesto FiorentinoItaly Department of chemistry“Ugo Schiff” University of FlorenceVia della Lastruccia 350019 Sesto FiorentinoItaly center for chemical catalysis–c3 Alma Mater StudiorumUniversitàdi Bolognavia Selmi 240126BolognaItaly

The chemodivergent ring-opening of cyclobutanols is described under the carbocatalytic assistance of graphene oxide(GO).The protocol enables the synthesis of diversely functionalized dienes or indenes(26 examples)based on the amount of GO ***(XPS and ssNMR)as well as experimental investigations revealed a direct involvement of theπ-domains of GO in tuning the stability of carbocationic intermediates during the reaction.

关键词： carbocatalysis c-c activation Graphene carbocations Methodology and reactions

Assessing the response of human primary macrophages to defined fibrous architectures fabricated by melt electrowriting

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Bioactive Materials 2023年第3期21卷 209-222页

作者： carlotta Mondadori Amit chandrakar Silvia Lopa Paul Wieringa Giuseppe Tal`o Silvia Perego Giovanni lombardi Alessandra colombini Matteo Moretti Lorenzo Moroni IRccS Istituto Ortopedico Galeazzi Cell and Tissue Engineering LaboratoryMilanItaly complex Tissue Regeneration Department MERLN Institute for Technology-Inspired Regenerative MedicineMaastrichtthe Netherlands IRccS Istituto Ortopedico Galeazzi Laboratory of Experimental Biochemistry and Molecular BiologyMilanItaly Department of Athletics Strength and ConditioningPozna´n University of Physical EducationPozna´nPoland IRccS Istituto Ortopedico Galeazzi Orthopaedic Biotechnology LabMilanItaly Regenerative Medicine Technologies Lab Ente Ospedaliero CantonaleBellinzonaSwitzerland Service of Orthopaedics and Traumatology Department of SurgeryEnte Ospedaliero CantonaleLuganoSwitzerland Euler Institute Faculty of Biomedical SciencesUniversit`a della Svizzera ItalianaLuganoSwitzerland

The dual role of macrophages in the healing process depends on macrophage ability to polarize into phenotypes that can propagate inflammation or exert anti-inflammatory and tissue-remodeling *** scaf-fold geometry has been proposed as a strategy to influence macrophage behavior and favor the positive host response to ***,we fabricated Polycaprolactone(PcL)scaffolds by Melt Electrowriting(MEW)to investigate the ability of scaffold architecture to modulate macrophage *** human macrophages unpolarized(M0)or polarized into M1,M2a,and M2c phenotypes were cultured on PcL films and MEW scaffolds with pore geometries(square,triangle,and rhombus grid)characterized by different angles.M0,M2a,and M2c macrophages wrapped along the fibers,while M1 macrophages formed clusters with rounded *** bridges were formed only for angles up to 90◦.No relevant differences were found among PcL films and 3D scaffolds in terms of surface ***206 and cD163 were highly expressed by M2a and M2c macrophages,with M2a macrophages presenting also high levels of cD86.M1 macrophages expressed moderate levels of all *** rhombus architecture promoted an increased release by M2a macrophages of IL10,IL13,and scD163 compared to PcL *** proangiogenic factor IL18 was also upregulated by the rhombus configuration in M0 and M2a macrophages compared to PcL *** interesting findings obtained for the rhombus architecture represent a starting point for the design of scaffolds able to modulate macrophage phenotype,prompting investigations addressed to verify their ability to facilitate the healing process in vivo.

关键词： Macrophage Melt electrowriting Additive manufacturing Scaffold design Scaffold geometry

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含铌石墨铸钢的制备与热处理(英文)

金属热处理 2008年第2期33卷 16-19页

作者： c. A. Soufen L. c. casteletti A. lombardi Neto G. E. Totten UNESP Bauru Sao Paulo Brazil Escola de Eng. de Sao carlos-USP Sao carlos Sao Paulo Brazil Portland State University Portland Oregon USA)

利用现代铸造技术以及等温球化处理,使球状石墨铸钢的力学性能达到最佳组合,这是一项既经济又有发展前景的成果。这些钢的最大使用潜力与其制造技术和特征技术参数有关,其中最重要的一项是冷却曲线图(TTT曲线)。在本试验中,冶炼了3炉不... 详细信息

利用现代铸造技术以及等温球化处理,使球状石墨铸钢的力学性能达到最佳组合,这是一项既经济又有发展前景的成果。这些钢的最大使用潜力与其制造技术和特征技术参数有关,其中最重要的一项是冷却曲线图(TTT曲线)。在本试验中,冶炼了3炉不同铌含量(0.0%、0.5%和1.0%)及其它元素名义成分(质量分数)为1.0%c、2.3%Si、0.4%Mn的石墨铸钢。用热膨胀试验测定了TTT曲线,各组试验用钢的试样都进行了等温淬火。将试样进行了硬度测试及用光镜和扫描电镜进行了组织观察,并进行了拉伸、无缺口试样冲击及磨损试验。结果表明,铌的加入明显改变了TTT曲线,随着铌含量的增加,使得珠光体转变鼻尖右移,贝氏体转变鼻尖左移。这些合金的抗拉强度都很高,在1700 MPa左右,含1%铌的合金的冲击值为45 J,含0.5%铌合金的为49 J,不含铌的无缺口试样没有被冲断。

关键词：球状石墨铸钢含铌热处理缺口试样制备试验测定等温淬火 TTT曲线

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