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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy Krishna reddy c.V. Department of Physics Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physics Government PolytechnicRayachotiA.P516269India

Lanthanum doped nickel-cobalt nano ferrites with chemical formula Ni_(0.5)co_(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto combustion *** basic structural properties were determined by X-ray diffraction method and the formation of single phased spinel ferrite was *** crystalline size decreased from 25 to 11 nm and lattice parameter a increases with increase of La *** surface morphology of these ferrites was observed by field-emission scanning electron microscopy(FESEM) and agglomerated irregular grains are observed with increase of the rare earth element La ***-dispersive X-ray spectroscopy(EDX) result confirms the presence of the required *** Fourier transform infrared spectroscopy(FTIR) spectrum indicates the formation of the spinel ferrite structure with M-O *** direct band measurements from ultraviolet-visible spectroscopy(UV-Vis) spectroscopy indicate that the direct band gap decreases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then increases to 1.28 eV for x=*** room temperature magnetic properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanced saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually decreased for x=0.15 and x=*** the remanent magnetization and coercivity also follow the same trend.

关键词： Ferrites Sol-gel auto combustion La doping Magnetic properties Rare earths

Aldo-keto reductases:Role in cancer development and theranostics

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Oncology Research 2024年第8期32卷 1287-1308页

作者： SIDDAVARAM NAGINI PRATHAP reddy KALLAMADI KRANTHI KIRAN KISHORE TANAGALA GEEreddy BHANUPRAKASH reddy World Neem Organization Mumbai400101India Department of Biochemistry ICMR-National Institute of NutritionHyderabad500007India Department of Pathology and cell Biology Columbia University Irving Medical CenterNew York10032USA

Aldo-keto reductases(AKRs)are a superfamily of enzymes that play crucial roles in various cellular processes,including the metabolism of xenobiotics,steroids,and carbohydrates.A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various *** are aberrantly expressed in a wide range of malignant *** expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to *** have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and *** of aldose reductase(AR),either alone or in combination with chemotherapeutic drugs,has evolved as a pragmatic therapeutic option for *** classes of synthetic aldo-keto reductase(AKR)inhibitors have been developed as potential anticancer agents,some of which have shown promise in clinical *** AKR inhibitors from natural sources also exhibit anticancer *** molecule inhibitors targeting speciﬁc AKR isoforms have shown promise in preclinical *** inhibitors disrupt the activation of oncogenic signaling by modulating transcription factors and kinases and sensitizing cancer cells to *** this review,we discuss the physiological functions of human AKRs,the aberrant expression of AKRs in malignancies,the involvement of AKRs in the acquisition of cancer hallmarks,and the role of AKRs in oncogenic signaling,and drug ***,the potential of aldose reductase inhibitors(ARIs)as anticancer drugs is summarized.

关键词： Aldo-keto reductases(AKRs) Aldo-keto reductase(AKR)inhibitors cancer Drug-resistance Xenobiotics

Explainable-AI-based two-stage solution for WSN object localization using zero-touch mobile transceivers

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Science china(Information Sciences) 2024年第7期67卷 27-45页

作者： Kai FANG Junxin cHEN Han ZHU Thippa reddy GADEKALLU Xiaoping WU Wei WANG School of Mathematics and computer Science Zhejiang A&F University School of Software Dalian University of Technology Faculty of Applied Sciences Macao Polytechnic University Department of Electrical and computer Engineering Lebanese American University School of Information Engineering Huzhou University Guangdong-Hong Kong-Macao Joint Laboratory for Emotional Intelligence and Pervasive computing Artificial Intelligence Research Institute Shenzhen MSU-BIT University

Artificial intelligence technology is widely used in the field of wireless sensor networks(WSN).Due to its inexplicability, the interference factors in the process of WSN object localization cannot be effectively eliminated. In this paper, an explainable-AI-based two-stage solution is proposed for WSN object localization. In this solution, mobile transceivers are used to enlarge the positioning range and eliminate the blind area for object localization. The motion parameters of transceivers are considered to be unavailable,and the localization problem is highly nonlinear with respect to the unknown parameters. To address this,an explainable AI model is proposed to solve the localization problem. Since the relationship among the variables is difficult to fully include in the first-stage traditional model, we develop a two-stage explainable AI solution for this localization problem. The two-stage solution is actually a comprehensive consideration of the relationship between variables. The solution can continue to use the constraints unused in the firststage during the second-stage, thereby improving the performance of the solution. Therefore, the two-stage solution has stronger robustness compared to the closed-form solution. Experimental results show that the performance of both the two-stage solution and the traditional solution will be affected by numerical changes in unknown parameters. However, the two-stage solution performs better than the traditional solution, especially with a small number of mobile transceivers and sensors or in the presence of high noise. Furthermore,we have also verified the feasibility of the proposed explainable-AI-based two-stage solution.

关键词： explainable AI object localization semidefinite relaxation mobile transceiver two-stage solution closed-form solution

Direct-Seeded Rice: Genetic Improvement of Game-changing Traits for Better Adaption

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Rice science 2024年第4期31卷 417-433页

作者： Priyanka NEGI Jagadish RANE Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV c.ANILKUMAR Dasari SREEKANTH K.SAMMI reddy Sharad Ramrao GADAKH K.M.BORAIH c.B.HARISHA P.S.BASAVARAJ Indian council of Agricultural Research(IcAR)-National Institute of Abiotic Stress Management Baramati 413115India Mahatma Phule Krishi Vidyapeeth Rahuri 413722India IcAR-central Institute for Arid Horticulture Bikaner 334006India IcAR-National Rice Research Institute Cuttack 753006India IcAR-Directorate of Weed Research Jabalpur 482004India Dr.Panjabrao Deshmukh Krishi Vidyapeeth Akola 444104India

The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices.

关键词： climate change direct-seeded rice aerobic rice early vigor trait

Serum tumor markers:can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar reddy Ilakkiya Priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(cA19-9,cA242,and cEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(cA19-9),cA242,and carcinoembryonic antigen,in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in cA19-9 and cA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： cancer antigen 19-9 cancer antigen 242 carcinoembryonic antigen Tumor markers Type 2 diabetes mellitus

changes in post-keratoplasty astigmatism after suture removal:refraction vs tomography vs aberrometry

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1707-1713页

作者： Suraj Kumar chaurasiya Jagadesh c.reddy Pravin K.Vaddavalli christopher J.Rapuano Brien Holden School of Optometry and Vision Sciences L V Prasad Eye Institute(LVPEI)Hyderabad 500034India cataract and Refractive Surgery Services The Cornea InstituteL V Prasad Eye Institute(LVPEI)Hyderabad 500034India comea Service Wills Eye HospitalPhiladelphiaPennsylvania 19107USA

AIM:To analyse the changes in magnitude and orientation of astigmatism after suture removal(SR)in keratoplasty eyes as measured by refraction,tomography,and ***:Twenty-six eyes of 25 patients after optical keratoplasty requiring SR to reduce the astigmatism during the follow-up period were prospectively *** with poor quality topography scans or if there were no sutures in the steepest semi meridian were *** distance visual acuity(cDVA),manifest refraction,corneal tomography and aberrometr y were per formed on all patients before and after ***:The mean age of the patients was 40.8±14.4 *** keratoplasty was performed in 23 eyes(89%)and deep anterior lamellar keratoplasty was done in 3 eyes(11%).There was a statistically significant reduction in the magnitude of refractive,tomographic and aberrometry astigmatism after SR(Pction of the astigmatism was greater as measured by corneal tomography compared to refractive astigmatism(Pcally significant change in refractive astigmatism between 2 h and 2 mo after SR(P=0.55).Vector calculations demonstrated a greater amount of undercorrection in the tomography group and the rotational error was more towards counterclockwise *** monocular log MAR cDVA improved from 0.57 D to 0.49 D after SR(P=0.002).cONcLUSION:The net reduction in the magnitude of astigmatism after SR is greater in the tomography and aberrometry *** one episode of SR,there is no difference in the aberration profile.

关键词： keratoplasty astigmatism suture removal

Early results of circularity and centration of capsulotomy prepared by three different methods

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 76-82页

作者： Jagadesh c.reddy Soumya Devta Kiran Kumar Vupparaboina Mohammad Hasnat Ali Pravin K.Vaddavalli cataract and Refractive Services Cornea InstituteL V Prasad Eye Institute(LVPEI)Hyderabad 500034India Senior Scientific Officer Srujana Centre for InnovationL V Prasad Eye Institute(LVPEI)Hyderabad 500034India Biostatistician Clinical Epidemiology and BiostatisticsL V Prasad Eye Institute(LVPEI)Hyderabad 500034India

AIM:To compare the difference of capsulotomy produced by precision pulse capsulotomy(PPc),manual(M-ccc),and femtosecond laser assisted capsulotomy(FLAc)in relation to intraocular lens(IOL)centration,circularity and its effect on visual ***:Prospective,non-randomized comparative study conducted at LV Prasad Eye Institute,Hyderabad,*** eyes of 52 patients were grouped into 3(FLAc,PPc and M-ccc)based on capsulotomy techniques *** consecutive eyes with uneventful phacoemulsification and with no comorbidities affecting the capsulotomy or visual outcome were included in each *** main outcome measure was IOL centration in relation to capsulotomy and *** outcome measures were post-operative visual acuity,manifest refraction and aberration profile between ***:At 5 wk the visual,refractive outcomes and endothelial cell density were comparable between the 3 *** median circularity index of FLAc was statistically significantly different to M-ccc or PPc(1-10)groups(Pc(11-20)was comparable to *** of IOL center in relation to capsulotomy was seen only between the PPc(1-10)group and FLAc group(P=0.02).The IOL was well centered in relation to the pupil in all the groups(P=0.46).The quality of vision parameters like the higher order aberrations,spherical aberration,coma,trefoil,modular transfer function,and Strehl ratio were comparable between the ***:Our study shows that despite differences in the morphology of capsulotomy produced by PPc,M-ccc,FLAc a well-centered IOL can be *** measured capsular morphology parameters do not affect visual outcomes.

关键词： phacoemulsification capsulotomy intraocular lens centration precision pulse capsulotomy femtosecond laser assisted capsulotomy

Paleo-Mesoarchean sedimentary record in the Dharwar craton,India:Implications for Archean ocean oxygenation

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Geoscience Frontiers 2024年第1期15卷 126-154页

作者： G.Harshitha c.Manikyamba M.Santosh cheng-Xue Yang A.Keshav Krishna V.V.Sesha Sai I.Panduranga reddy cSIR-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India Department of Geology Osmania UniversityHyderabad 500007India School of Earth Science and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA5005Australia Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea Geological Survey of India State UnitNagpurIndia

The early Archean oceans were marked by significant redox changes which have subsequently shaped the Earth’s *** chemical sediments of banded Iron and Manganese formations provide important geochemical proxies for these historical shifts in the redox conditions and to trace the ancient sedimentation patterns and *** this study,we investigate the proto-ore of the Archean Mn-formations of the Sandur,chitradurga and Shimoga greenstone belts of Dharwar craton of southern Peninsular India,which is geochemically characterised as quartz arenites,Mn-arenites,Fe-arenites,Mn-argillites and *** geochemical systematics suggest their deposition in shallow to deeper shelf in the Archean *** detrital zircon U-Pb systematics of Mn arenites and argillites indicate their maximum depositional age of 3230±52 Ma representing the oldest onset of sedimentation during the Paleo-Mesoarchean timeframe in the chitradurga Group of Dharwar *** detrital influx proxies suggest variations in sedimentation rates associated with the Archean transgressive-regressive cycles and fluctuating hydrodynamic conditions,together reflecting an increasing trend in the contributions of recycled sediment from Sandur to chitradurga and Shimoga greenstone *** available detrital zircon ages of the Mn arenites and argillites from these greenstone belts indicate a~600 Ma prolonged period of Mn deposition for which high-T hydrothermal fluids from Archean mid-oceanic ridges supplied the *** trace element compositions of the concordant detrital zircons suggest 3.3-3.1 Ga Dharwar basement TTG/granitoid source which is corroborated by the zircon crystallization temperatures of 690-820℃.The source-normalisedα-dose rates of the detrital zircons signify greater degrees of sediment transport and multi-cycle nature which correspond to the earliest episode of crustal growth in the Indian sub-continent associated with the Mesoarchean Ur supercontinent.T

关键词： Mn-arenites-argillites Dharwar craton Zircon U-Pb geochronology Passive margin sediments Ocean oxygenation

Reversed-Phase-HPLc Assay Method for Simultaneous Estimation of Sorbitol, Sodium Lactate, and Sodium chlorides in Pharmaceutical Formulations and Drug Solution for Infusion

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American Journal of Analytical chemistry 2024年第2期15卷 57-71页

作者： Sreenivas Pippalla Venugopal Komreddy Srinivasulu Kasa Vaishnavi chintala Poluri Venkata reddy Department of chemistry Sikkim Professional University Gangtok India Analytical Research & Development Hikma Pharmaceuticals USA Inc. Bedford USA Department of chemistry Osmania University Hyderabad India Analytical Research & Development Cambrex High Point High Point USA Department of Analytical chemistry Annamalai University Annamalai Nagar India

A rapid, straightforward, sensitive, efficient, and cost-effective reverse-phase high-performance liquid chromatographic method was employed for the simultaneous determination of Sorbitol, Sodium Lactate, and chlorides in a drug solution for infusion. Sorbitol, Sodium lactate, and chloride are all officially recognized in the USP monograph. Assay methods are provided through various techniques, with titrations being ineffective for trace-level quantification. Alternatively, Ic, AAS, and IcP-MS, though highly accurate, are costly and often unavailable to most testing facilities. When considering methods, it’s important to prioritize both quality control requirements and user-friendly techniques. A simple HPLc simultaneous method was developed for the quantification of chlorides, Sorbitol, and Sodium Lactate with a shorter run time. The separation utilized a Shimpack ScR-102(H) ion exclusion analytical column (7.9 mm × 300 mm, 7 μm), with a flow rate of 0.6 mL per min. The column compartment temperature was maintained at 40°c, and the injection volume was set at 10 μL, with detection at 200 nm. All measurements were conducted in a 0.1% solution of phosphoric acid. The analytical curves demonstrated linearity (r > 0.9999) in the concentration range of 0.79 to 3.8 mg per mL for Sodium Lactate (SL), 0.16 to 0.79 mg per mL for Sodium chloride (Sc), and 1.5 to 7.2 mg per mL for Sorbitol. Validation of the developed method followed the guidelines of the International conference on Harmonization (IcH Q2B) and USP. The method exhibited precision, robustness, accuracy, and selectivity. In accelerated stability testing over 6 months, no significant variations were observed in organoleptic analysis and pH. consequently, the developed method is deemed suitable for routine quality control analyses, enabling the simultaneous determination of Sodium Lactate, Sodium chloride, and Sorbitol in pharmaceutical formulations and infusions.

关键词： Sorbitol Sodium Lactate and chloride Assay Analytical Validation HPLc