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Impact of chemical elements on heart failure progression in coronary heart disease patients

Health 2011年第5期3卷 263-270页

作者： Karaskov Alexander Kamenskaya Oksana Levicheva Elena loginova irina Okuneva Galina Cherniavsky Aleksander Kliver Evgeni Volkov Alexander 不详

Background. The high prevalence, poor prog-nosis of patients with coronary heart disease with chronic heart failure determine the relevance of the study pathophysiological and molecular mechanisms of this pathology. Researches of the trace element metabolism in the myocardium are scarce. With this in mind, an attempt was made to analyze the relationship of macro and trace elements metabolism with the functional state of the myocardium in coronary heart disease patients against the background of chronic heart failure progression. Methods and Results. To study the content of the chemical elements (S, K, Ca, Cr, Fe, Ni, Cu, Zn, Se, Rb, Sr) in the myocardium of 43 patients with coronary heart disease, use was made of X-ray fluorescence with synchrotron radiation. While doing autopsy, 43 samples of left ventricle myocardium were taken off the cardiac callosity. Myocardium samples were subjected to histological examination. Dynamics of macro and trace elements content in the myocardium reflects the development of energy deficiency and disorders of myocardial microcirculation with a decrease of systolic myocardial function. Structural/functional disorders in the myocardium of the left ventricle of patients with coronary heart disease that accompany the progression of chronic heart failure are associated with profound changes of metabolic processes in heart muscle. Conclusions. The structural/ functional changes accompanying chronic heart failure progression are associated with wide variations of metabolic processes in the myocardium, which could be evaluated by the content of chemical elements in tissue.

关键词： Heart Failure Tissue Myocardium

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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

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Reproductive and Developmental Medicine 2023年第3期7卷 189-192页

作者： irina L.Puppo Ziravard N.Tonyan Alsu F.Saifitdinova Julia A.loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuhova Olga A.Leonteva Olga G.Chiryaeva Olga V.Malysheva Oleg S.Glotov irina V.Poliakova Andrey V.Tikhonove Tatyana V.Vavilova irina L.Menshikova Elvira V.Isakova Andrey S.Glotov Natalya K.Bichevaya International Centre for Reproductive Medicine Saint-Petersburg 197350Russia Department of Laboratory Medicine and Genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department of Genomic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department of Biology.Herzen State Pedagogical University of Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 St.Petersburg Centre for Medical Genetics Saint Petersburg194044Russia Department of ExperimentalMedical Virology MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute of Surgut State University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous *** are facilitated by the creation of quadrivalent structures during the first meiotic division,which are characterized by the length of the translocated and centric segments,asymmetry,and the presence of terminal breakpoints,all of which may impact segregation ***,we report a rare case of multiple reciprocal translocations within a single *** includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their *** obtained results will be of interest to fundamental biology,as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

关键词： Embryo viability Genetic counseling Pre-implantation genetic testing Quadrivalent characteristics

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The Role of Orthotic Service in Modern Rehabilitation of Patients with Charcot-Marie-Tooth Disease

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Journal of Biosciences and Medicines 2018年第7期6卷 23-34页

作者： Olga V. Petryaeva Natalia A. Shnayder Ivan P. Artyukhov Margarita R. Sapronova irina O. loginova V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk Russia V.M. Bechterev National Medical Research Center of Psychiatry and Neurology Sankt-Petersburg Russia

Charcot-Marie-Tooth (CMT) disease, which encompasses several hereditary motor and sensory neuropathies, is one of the most common neuro-muscular disorders. 80% of patients having CMT disease are diagnosed with per cavus deformity. Orthosis is widespread and varies widely in forms. The paper arises the necessity of habilitation at the earliest possible stage as only a few patients use it. The meta-analysis of 412 scientific papers concerning this problem demonstrates the getting better gate, balance and the stopping CMT progression which is scientifically proven. It is also shown that patients with CMT use low prevalence of orthotics, and demonstrate low compliance of patients (for various reasons), high expectations from this habilitation technique.

关键词： Charcot-Marie-Tooth Disease (CMT) Habilitation Rehabilitation Heredi-tary Sensori-Motor Neuropathies (HSMN) Contractures Orthosis Demye-linating Diseases (DMD) Orthotic Management Ankle-Foot Orthoses (AFOs)

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