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Cytomegalovirus in inflammatory bowel disease： Asystematic review

World Journal of Gastroenterology 2016年第3期22卷 1321-1330页

作者： Tessa EH Römkens Geert J Bulte loes hc nissen Joost PH Drenth Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre6500 HB NijmegenThe Netherlands Department of Gastroenterology and Hepatology Jeroen Bosch Hospital5200 ME HertogenboschThe Netherlands

AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these ***: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used "cytomegalovirus" OR "CMV" OR "cytomegalo virus" AND "inflammatory bowel disease" OR "IBD" OR "ulcerative colitis" OR "colitis ulcerosa" OR "Crohn's disease". Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in ***: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East ***: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials.

关键词： Inflammatory bowel disease Cytomegalovirus Ulcerative colitis Crohn's disease Systematicreview

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Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy

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World Journal of Gastroenterology 2016年第47期22卷 10465-10470页

作者： Maartje M van de Meeberg Lauranne AAP Derikx Harm AM Sinnige Peet Nooijen D Lucette Schipper loes hc nissen Department of Gastroenterology and Hepatology Jeroen Bosch Hospital Department of Hematology Jeroen Bosch Hospital Department of Pathology Jeroen Bosch Hospital

Hepatosplenic T-cell lymphoma(HSTCL) is a rare nonHodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger than 35 years, and have been treated with thiopurine and tumor necrosis factor(TNF)-α inhibitor combination therapy for over 2 years. In this case report we describe a 47-year-old patient with Crohn's disease(CD) who developed HSTCL after having been treated with thiopurine monotherapy for 14 years. To our best knowledge, only eleven cases exist of patients with CD who developed HSTCL while on thiopurine monotherapy. We report the first patient with CD, older than 35 years, who developed HSTCL while on thiopurine monotherapy. This emphasizes that HSTCL risk is not limited to young men receiving both thiopurines and TNF-α inhibitors.

关键词： Hepatosplenic T-cell lymphoma Thiopurine Crohn’s disease Immunosuppression

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