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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 25-25页

作者： loening- baucke v. 贺莉 Department of Pediatrics University of Iowa JCP 2555 200 Hawkins Dr Iowa City IA 52242- 1083 United States Dr.

Objectiv.: To determine the prev.lence of constipation in children ≤ 2 years , describe the symptoms of constipation, and rev.ew how often specific interv.nt ions were effectiv.. Study design: Retrospectiv. chart rev.ew. Results: Of 4 1 57 children v.lence rate for constipation in the first year of life was 2.9% , and in the second year o f life, the rate was 10.1% . Functional constipation was the cause in 97% of the children. Boys and girls were affected with equal frequency. Constipation wa s caused by an underlying organic disease in 1.6% of cases. Dietary changes an d corn syrup were the initial treatment suggestions for 116 children; 93% of t hese children underwent follow- up examinations, and the constipation resolv.d in 25% of the children. Of 100 children treated with milk of magnesia or polye thylene glycol 3350 without electrolytes, 93 children underwent follow- up exam inations, and the constipation was resolv.d with treatment in 92% of the child ren. Conclusions: Dietary changes, corn syrup, or both resolv.d constipation in 25% of children, and laxativ.s resolv.d constipation in 92% of children. Bot h milk of magnesia and polyethylene glycol were efficient and safe in infants an d toddlers.

关键词：缓泻剂功能性便秘玉米糖浆随访检查出生后图表分析研究设计

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黏附性生物被膜在细菌性阴道病中的意义

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 59-59页

作者： Swidsinski A. Mendling W. loening-baucke v. 朱国栋 Charit é CCM Medizinische Klinik 10098 Berlin Germany Dr.

Objectiv.: Bacterial v.ginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors . Our aims were to study the bacterial community structure and the spatial organ ization of microbiota on the epithelial surfaces of v.ginal biopsy specimens. ME THODS:We inv.stigated the composition and spatial organization of bacteria assoc iated with the v.ginal epithelium in biopsy specimens from 20 patients with bact erial v.ginosis and 40 normal premenopausal and postmenopausal controls using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleot ide probes. RESULTS: Bacterial v.ginosis was associated with greater occurrence and higher concentrations of a v.riety of bacterial groups. Howev.r, only Gardne rella v.ginalis dev.loped a characteristic adherent biofilm that was specific fo r bacterial v.ginosis. CONCLUSION: A biofilm comprised of confluent G v.ginalis with other bacterial groups incorporated in the adherent layer is a prominent fe ature of bacterial v.ginosis.

关键词：细菌性阴道病生物被膜黏附性阴道加德纳菌微生物丛菌群结构荧光素标记特异指标寡核苷酸探针

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Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice

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World Journal of Gastroenterology 2005年第8期11卷 1131-1140页

作者： Alexander Swidsinski v.ra loening-baucke Herbert Lochs Laura P.Hale Innere Klinik Department of Pathology

AIM: To studythe role of intestinal flora in inflammatory bowel disease (IBD).METHODS: The spatial organization of intestinal flora was inv.stigated in normal mice and in two models of murine colitis using fluorescence in situ ***: The murine small intestine was nearly bacteriafree. The normal colonic flora was organized in three distinct compartments (crypt, interlaced, and fecal), each with different bacterial compositions. Crypt bacteria were present in the cecum and proximal colon. The fecal compartment was composed of homogeneously mixed bacterial groups that directly contacted the colonic wall in the cecum but were separated from the proximal colonic wall by a dense interlaced layer. Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. Colonic inflammation was accompanied with a depletion of bacteria within the fecal compartment, a reduced surface area in which feces had direct contact with the colonic wall, increased thickness and spread of the mucus gap, and massiv. increases of bacterial concentrations in the crypt and interlaced compartments. Adhesiv. and infiltrativ. bacteria were observ.d in inflamed colon only, with dominant Bacteroides ***: The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a Segregation *** highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control.

关键词： Intestinal flora IBD

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Impact of humic acids on the colonic microbiome in healthy v.lunteers

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World Journal of Gastroenterology 2017年第5期23卷 885-890页

作者： Alexander Swidsinski Yv.nne Dorffel v.ra loening-baucke Christoph Gille Anne Reiβhauer Onder Goktas Monika Krüger Jürgen Neuhaus Wieland Schrodl Laboratory for Molecular Genetics Polymicrobial Infections and BiofilmsDepartment of MedicineSection of GastroenterologyHepatology and EndocrinologyCharitéUniversitatsmedizin Berlin Outpatient Clinic Luisenstr.11-13CharitéUniversitatsmedizin Berlin entre for Infectious Diseases Faculty of Veterinary MedicineUniversity of Leipzig

AIMTo test the effects of humic acids on innate microbial communities of the *** followed the effects of oral supplementation with humic acids (Activ.min®) on concentrations and composition of colonic microbiome in 14 healthy v.lunteers for 45 d. 3 × 800 mg Activ.min® were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were inv.stigated using multicolor fluorescence in situ hybridization (FISH) of Carnoy fixated and paraffin embedded stool cylinders. Two stool samples were collected a week prior to therapy and one stool sample on days 10, 31 and 45. Forty-one FISH probes representing different bacterial groups were *** sum concentration of colonic microbiota increased from 20% at day 10 to 30% by day 31 and remained stable until day 45 (32%) of humic acid supplementation (P v.dual microbial profile of the patients remained unchanged. Similarly, the bacterial div.rsity remained stable. Concentrations of 24 of the 35 substantial groups increased from 20% to 96%. Two bacterial groups detected with Bac303 (Bacteroides) and Myc657 (mycolic acid-containing Actinomycetes) FISH probes decreased (P > 0.05). The others remained unaffected. Bacterial groups with initially marginal concentrations (9/mL) demonstrated no response to humic acids. The concentrations of pioneer groups of Bifidobacteriaceae, Enterobacteriaceae and Clostridium difficile increased but the observ.d differences were statistically not *** acids hav. a profound effect on healthy colonic microbiome and may be potentially interesting substances for the dev.lopment of drugs that control the innate colonic microbiome.

关键词： Fluorescence in situ hybridization Colonic microbiota Colonic bioreactor Humic acids Healthy v.lunteers Oral supplementation

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