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Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

Bone Research 2024年第1期12卷 1-19页

作者： Xiwei Fan Antonia Rujia Sun Reuben S.E.Young Isaac o.Afara Brett R.Hamilton lo.is.jun ye o.g Ross Crawford Indira Prasadam Centre for Biomedical Technologies Queensland University of TechnologyBrisbaneQLDAustralia School of Mechanical Medical&Process EngineeringQueensland University of TechnologyBrisbaneQLDAustralia Central Analytical Research Facility Queensland University of TechnologyBrisbaneQLDAustralia Molecular Horizons University of WollongongWollongongNSWAustralia Department of Technical Physics University of Eastern FinlandKuopioFinland School of Electrical Engineering and Computer Science Faculty of EngineeringArchitecture and Information TechnologyUniversity of QueenslandBrisbaneQLDAustralia Centre for Microscopy and Microanalysis University of QueenslandBrisbaneQLDAustralia The Prince Charles Hospital BrisbaneQLDAustralia

osteoarthritis(oA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose *** presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial ***,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic *** analysis of bulk oA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint *** issue has led to standardization difficulties and hindered the success of clinical *** insights into the spatial variations of the cellular and molecular structures in oA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease *** resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular *** advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial *** fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial ***,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and *** these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease *** review summarizes the rec

关键词： insight Spatial enable

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Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SEN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jo.g Un Lee Hyun Ji Kim Sang-Cheol Jin ye Jin Kim Young Min Kim Bo.g Sun You jun Ho Bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research Institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SEN alloys)recently developed at the Korea Institute of Materials *** alloys are produced by adding small amounts of Ca and Y(eacho commercial Mg–Al based alloys,resulting in exceptional ignition and corrosion resistances and impressive mechanical *** main advantages of SEN alloys are as follows.(1)A dense multi-oxide layer of SEN alloys comprising Mgo,Cao,and Y_(2)o_(3) impedes the outward dispersion of Mg vapor and the inward penetration of o_(2) during oxidation,thereby enhancing the oxidation and ignition resistances.(2)The presence of Ca-and Y-based second-phase particles in SEN alloys can enhance their corrosion resistance because Ca-containing particles prevent the spread of corrosion,and the replacement of Al-containing particles with less noble ones containing Y(e.g.,Al–Mn–Y or Al–Y particles)retards corrosion.(3)The addition of minor amounts of Ca and Y renders excellent mechanical properties due to improved strengthening *** enhanced properties are attributed to more pronounced dynamic recrystallization and grain refining behaviors caused by the second-phase particles during extrusion.(4)Despite the presence of various types of second-phase particles,the fatigue properties of SEN9 alloys are similar to those of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elo.gation of aged SEN alloys.(6)Adding mischmetal into the SEN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SEN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SEN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties Extrudability.

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Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding

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Nano Research 2024年第7期17卷 6560-6566页

作者： Cheng-Xin Yu Yu-Feng Meng Bo Yang jun Pang Xiang-Sen Meng Zi-ye Zhao Qing-Yue Wang Li-Bo Mao Zhi-Kun Wu Shu-Ho.g Yu Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Biological structural materials,despite consisting of limited kinds of compounds,display multifunctionalities due to their complex hierarchical *** some biomimetic strategies have been applied in artificial materials to enhance their mechanical stability,the simultaneous optimization of other functions alo.g with the mechanical properties via biomimetic designs has not been thoro.ghly ***,iron oxide/carbon nanotube(CNT)-based artificial nacre with both improved mechanical and electromagnetic interference(EMI)shielding performance is fabricated via the mineralization of Fe_(3)o_(4)onto a CNTincorporated *** micro-and nano-structures of the artificial nacre are similar to those of natural nacre,which in turn improves its mechanical *** alternating electromagnetic wave-reflective CNT layers and the wave-absorptive iron oxide layers can improve the multiple reflections of the waves on the surfaces of the reflection layers,which then allows sufficient interactions between the waves and the absorption ***,compared with the reflection-dependent EMI-shielding of the non-structured material,the artificial nacre exhibits stro.g absorption-dependent shielding behavior even with a very low content of wave-absorptive *** to the high mechanical stability,the shielding effectiveness of the artificial nacre that deeply cut by a blade is still maintained at approximately 70%−96%depending on the incident wave *** present work provides a new way for designing structural materials with concurrently enhanced mechanical and functional properties,and a path to combine structural design and intrinsic properties of specific materials via a biomimetic strategy.

关键词： artificial nacre electromagnetic interference shielding biomineralization biomimetic material hierarchical structure

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graphene oxide/Al2o3-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu jun-Cheng Jin Yi-Ke Xiao Xin-Xin Wang Ping-Yuan Yan Yan-Qiang Cao Li-Yo.g Jiang Chuan-Xiang Sheng ye-Feng Yu School of Microelectronics Nanjing University of Science and Technology School of Science Nanjing University of Science and Technology School of Information Science and Technology Fudan University

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： graphene

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Theoretical analysis of the double-differential cross-sections of neutron,proton,deuteron,^(3)He,andαfor the p+^(6) Li reaction

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Nuclear Science and Techniques 2024年第3期35卷 181-197页

作者： Fang-Lei Zou Xiao-jun Sun Jing-Shang Zhang Hai-Rui guo Yin-Lu Han Rui-Rui Xu Xi Tao Ji-Min Wang Xiao-Do.g Sun Yuan Tian Tao ye Yo.g-Li Xu Chun-Tian Liang College of Physics Guangxi Normal University541004 GuilinChina guangxi Key Laboratory of Nuclear Physics and Nuclear Technology 541004 GuilinChina China Institute of Atomic Energy P.O.Box 275(41)102413 BeijingChina Institute of Applied Physics and Computational Mathematics 10094 BeijingChina College of Physics and Electronic Shanxi Datong University037009 DatongChina School of Science Tianjin Chengjian University300384 TianjinChina

Based on the unified Hauser–Feshbach and exciton model,which can describe the particle emission processes between discrete energy levels with energy,angular momentum,and parity conservations,a statistical theory of light nucleus reaction(STLN)is developed to calculate the double-differential cross-sections of the outgoing neutron and light charged particles for the proton-induced^(6) Li reaction.A significant difference is observed between the p+^(6) Li and p+^(7) Li reactions owing to the discrepancies in the energy-level structures of the *** reaction channels,including sequential and simultaneous emission processes,are analyzed in *** the double-differential cross-sections of the outgoing proton as an example,the influence of contaminations(such as^(1) H,^(7)Li,^(12)C,and^(16)o)on the target is identified in terms of the kinetic energy of the first emitted *** optical potential parameters of the proton are obtained by fitting the elastic scattering differential *** calculated total double-differential cross-sections of the outgoing proton and deuteron at E_(p)=14 MeV agree well with the experimental data for different outgoing ***,the mixed double differential cross-sections of^(3) He andαare in good agreement with the *** agreement between the measured data and calculated results indicates that the two-body and three-body breakup reactions need to be considered,and the pre-equilibrium reaction mechanism dominates the reaction *** on the STLN model,a PLUNF code for the p+^(6) Li reaction is developed to obtain an ENDF-6-formatted file of the double-differential cross-sections of the nucleon and light composite charged particles.

关键词： Statistical theory of light nucleus reaction p+^(6)Li reaction Light composite charged particle Double-differential cross-sections Two-body breakup Three-body breakup

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大豆分离蛋白-蔗糖酯对不同油脂制备的乳液稳定性的影响

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食品工业科技 2024年第8期45卷 110-118页

作者：徐亦青詹伟牛军王冶卞丹正大食品研发有限公司浙江慈溪315300

为探究复合乳化剂对不同油脂乳化效果的影响,以大豆分离蛋白(SPI)和蔗糖酯(SE)为复合乳化剂,猪油(LA)、大豆油(So)、亚麻籽油(lo)、鱼油(Fo)为油相制备乳液。通过测定乳液的乳化活性、结构特性、热特性、稳定性等指标,研究了不同油相制... 详细信息

为探究复合乳化剂对不同油脂乳化效果的影响,以大豆分离蛋白(SPI)和蔗糖酯(SE)为复合乳化剂,猪油(LA)、大豆油(So)、亚麻籽油(lo)、鱼油(Fo)为油相制备乳液。通过测定乳液的乳化活性、结构特性、热特性、稳定性等指标,研究了不同油相制备的乳液之间稳定性的差异。结果表明,四种乳液中乳液_(LA)有最高的乳化活性和乳液稳定性(27.374 m_2/g,361.243 min),且其乳液液滴平均粒径(D)最小(8.411±0.670μm)。微观结构结果显示,四种乳液颗粒的均匀性为乳液_(LA)>乳液_(So)>乳液_(lo)>乳液_(Fo)。DSC结果表明,乳液_(LA)熔融时需要最多的能量(ΔH=-57.67±1.28 J/g),而乳液_(Fo)的焓值仅为-10.18±0.10 J/g。储藏及氧化稳定性的结果表明,乳液_(LA)的稳定性最佳。油脂中不饱和脂肪酸的差异会影响SPI-SE对乳液的稳定效果,油相的不饱和脂肪酸比例越大、不饱和程度越高,乳液稳定性越差。该结果可丰富SPI-SE在油脂乳化上的研究,为油脂的乳化应用提供一定的参考依据。

关键词：大豆分离蛋白蔗糖酯油脂结构特性稳定性

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钻孔桩施工用聚合物制备技术优化与应用研究

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化学工程师 2024年第4期38卷 114-119页

作者：叶必军福建冶地恒元建设有限公司福建泉州362000

本文设计合成出一种用于钻孔桩施工的高效护壁聚合物PZH-4,并采用正交实验优化出其合成的最优条件,以N,N-二甲基丙烯酰胺、2-丙烯酰胺基-2-甲基丙磺酸、乙烯吡咯烷酮、丙烯酰氧乙基三甲基氯化铵为聚合单体,聚合质量比为3∶1∶1∶1且总... 详细信息

本文设计合成出一种用于钻孔桩施工的高效护壁聚合物PZH-4,并采用正交实验优化出其合成的最优条件,以N,N-二甲基丙烯酰胺、2-丙烯酰胺基-2-甲基丙磺酸、乙烯吡咯烷酮、丙烯酰氧乙基三甲基氯化铵为聚合单体,聚合质量比为3∶1∶1∶1且总占比为30%,引发剂浓度为0.2wt%、碳酰胺浓度为0.2wt%,余量为去离子水,在60℃下反应8h,可得到分子量高于1200万的PZH-4聚合物分子,且聚合物粉末通过140目过筛后可在清水中12s内充分溶解。其配制的泥浆体系在稠化性、含砂率、胶体率、失水量等方面效果极佳,远优于膨润土泥浆体系。同时,废弃聚合物钻孔泥浆体系可使用5%NaClo溶液与3%H_(2)o_(2)溶液高效处理。

关键词：钻孔桩施工护壁聚合物制备技术应用研究

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超声与MRI对四肢腱鞘巨细胞瘤的诊断一致性比较

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中国医学影像学杂志 2024年第8期32卷 836-840页

作者：刘荣玮陈花曾君汪清王焱叶军赣南医学院第一附属医院超声医学科江西赣州341000

目的探讨超声与MRI对四肢腱鞘巨细胞瘤诊断的一致性及临床价值。资料与方法回顾性分析2020年1月—2022年12月因手足部肿物于赣南医学院第一附属医院就诊,同时接受超声和MRI检查并经手术或者穿刺细胞学检查确诊的35例患者。以病理结果作... 详细信息

目的探讨超声与MRI对四肢腱鞘巨细胞瘤诊断的一致性及临床价值。资料与方法回顾性分析2020年1月—2022年12月因手足部肿物于赣南医学院第一附属医院就诊,同时接受超声和MRI检查并经手术或者穿刺细胞学检查确诊的35例患者。以病理结果作为“金标准”,比较两种检查方法敏感度、特异度和阳性似然比,分析诊断分类的一致性和临床价值。结果35例手足部肿物中,超声诊断腱鞘巨细胞瘤17例,MRI诊断16例,病理诊断15例。超声和MRI对手足部肿物的诊断分类一致30例,分类不一致5例,两者一致性较强(Kappa=0.714)。超声诊断四肢腱鞘巨细胞瘤的敏感度、特异度、符合率分别为73.3.%、70.0%、71.4%,MRI诊断的敏感度、特异度、符合率分别为80.0%、80.0%、80.0%,两者联合诊断的敏感度、特异度、符合率分别为86.7%、70.0%、77.1%。超声、MRI、两者联合诊断与病理检查诊断准确度比较差异均无统计学意义(P>0.05)。超声、MRI及两者联合诊断手足部肿物的敏感度、特异度、阳性似然比差异均无统计学意义(P>0.05)。结论超声与MRI在四肢腱鞘巨细胞瘤的分类诊断中具有较好的一致性,两者在四肢腱鞘巨细胞瘤诊断效能上差异无统计学意义。

关键词：腱鞘巨细胞瘤超声检查磁共振成像四肢诊断

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不同水分调控对沿黄灌区向日葵水分利用影响研究

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节水灌溉 2024年第7期 8-15页

作者：何锐佟长福王军张晔栗永水利部牧区水利科学研究所呼和浩特010020 内蒙古农业大学水利与土木建筑工程学院呼和浩特010018 乌审旗水利事业发展中心内蒙古鄂尔多斯017300 鄂尔多斯市水利事业发展中心内蒙古鄂尔多斯017200

为探究达拉特旗黄河南岸灌区向日葵根系吸水来源及其利用策略,通过测定达拉特旗黄河南岸灌区向日葵木质部水及其各种潜在水源(降水、土壤水和地下水)的氢氧同位素组成(δD和δ18o),利用直接对比法和MixSIAR模型研究对比不同灌溉制度下... 详细信息

为探究达拉特旗黄河南岸灌区向日葵根系吸水来源及其利用策略,通过测定达拉特旗黄河南岸灌区向日葵木质部水及其各种潜在水源(降水、土壤水和地下水)的氢氧同位素组成(δD和δ18o),利用直接对比法和MixSIAR模型研究对比不同灌溉制度下向日葵不同生育期水分来源及各水源利用差异。结果表明,向日葵在苗期、拔节期、灌浆期和成熟期的吸水深度分别在0~30、0~50、0~70和30~90 cm土层。不同灌溉量下,向日葵的主要吸水层具有一定的差异。0~10、10~30、30~50、50~70、70~90 cm深度土壤水和地下水对向日葵平均贡献比例分别为22.17%、17.99%、18.74%、14.68%、15.97%和10.45%。通过相关性分析,50 cm以下土层水分贡献对产量提高有利,0~10 cm土壤水、30~50 cm土壤水和地下水利用对灌溉水利用效率具有正相关关系。设置灌溉定额为187.5 mm时能显著提高产量,灌溉定额为100 mm时,能显著提升灌溉水利用效率。

关键词：氢氧同位素水分来源根系吸水吸水深度水分调控黄河南岸灌区向日葵

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Residual index for measurement configuration optimization in robot kinematic calibration

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Science China(Technological Sciences) 2023年第7期66卷 1899-1915页

作者： ye Hao WU jun State Key Laboratory of Tribology in Advanced Equipment and Institute of Manufacturing Engineering Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipment and Control Beijing 100084China

To improve the efficiency and accuracy of kinematic calibration,the selection of measurement configurations is an important *** previous research,optimal measurement configurations mainly are selected by maximizing observability ***,the traditional observability indices only focus on the identification efficiency of the error parameters,while the purpose of robot kinematic calibration is to improve *** solve the inconsistency of the purpose between the observability index and calibration,the concept of the residual index to represent the residual distribution of the end effector after robot kinematic calibration with the measurement noise is *** on the quadratic form minimization of residuals,this article defines a specific residual index,o^(r),which is dimensionless and strictly better with the increase of measurement *** indices are used to select measurement configurations in the kinematic calibration of a 5-DoF 2UPU/SP-RR hybrid robot,and the calibration results show that the proposed residual index is better than the traditional indices in the accuracy and stability of the end effector residual.

关键词： residual index observability index kinematic calibration measurement configuration optimization

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