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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Extremely thin but very robust:Surprising cryptogam trait combinations at the end of the leaf economics spectrum

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Plant Diversity 2024年第5期46卷 621-629页

作者： Tana Wuyun Lu Zhang Tiina Tosens Bin Liu Kristiina Mark JoséÁngel Morales-Sanchez Jesamine Jöneva Rikisahedew Vivian Kuusk Ülo Niinemets Institute of Agricultural and Environmental Sciences Estonian University of Life SciencesKreutzwaldi 1Tartu 51014Estonia College of Landscape and Architecture Zhejiang A&F University666 Wusu StreetHangzhou 311300China Estonian Academy of Sciences Kohtu 6Tallinn 10130Estonia

Leaf economics spectrum(LES)describes the fundamental trade-offs between leaf structural,chemical,and physiological ***,structurally robust thick leaves with high leaf dry mass per unit area(LMA)exhibit lower photosynthetic capacity per dry mass(Amass).Paradoxically,“soft and thinleaved”mosses and spikemosses have very low Amass,but due to minute-size foliage elements,their LMA and its components,leaf thickness(LT)and density(LD),have not been systematically ***,we characterized LES and associated traits in cryptogams in unprecedented details,covering five evolutionarily different *** found that mosses and spikemosses had the lowest LMA and LT values ever measured for terrestrial *** a broad range of species from different lineages,Amass and LD were negatively *** contrast,Amass was only related to LMA when LMA was greater than 14 g cm^(-2).In fact,low Amass reflected high LD and cell wall thickness in the studied *** conclude that evolutionarily old plant lineages attained poorly differentiated,ultrathin mesophyll by increasing *** plant lineages,LD,not LMA,is the trait that represents the trade-off between leaf robustness and physiology in the LES.

关键词： Investment strategy Leaf density Leaf structural traits LMA estimation bias Non-seed plants Trait trade-offs

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung Wong Hoi She Siu Lun Ho Albert Chi Yan Chan Chung Mau lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

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Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN TRISTAN MELTON DONG IL LEE ALLEN CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG lo DIM-LEE KWONG CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

Green synthesis of biocompatible Gd^(3+)-doped ultrasmall carbon-based nanohybrids from coffee wastes

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Carbon Resources Conversion 2024年第2期7卷 64-73页

作者： Konstantin Paliienko Anna Topchylo Sergei Alekseev Alain Géloën Yurii Milovanov Tetiana Lysenko Valeriy Skryshevsky Tatiana Borisova Vladimir Lysenko Department of Neurochemistry Palladin Institute of BiochemistryNational Academy of Sciences of Ukraine9 Leontovicha strKyiv 01054Ukraine Corporation Science Park Taras Shevchenko University of Kyiv60 Volodymyrska Str.Kyiv 01033Ukraine Institute of High Technologies Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine Faculty of Chemistry Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine UMR Ecologie Microbienne Lyon(LEM) CNRS 5557INRAE 1418Claude Bernard University of LyonVetAgro SupResearch Team“Bacterial Opportunistic Pathogens and Environment”(BPOE)University of LyonF-69622 VilleurbanneFrance Light Matter Institute UMR-5306Claude Bernard University of Lyon/CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is *** gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis *** sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and *** particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.

关键词： Carbon dots from coffee waste Carbon dots for MRI Gadolinium-doped carbon dots Microwave-assisted synthesis

Impact of sleep on gastrointestinal cancer

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World Journal of Clinical Oncology 2024年第6期15卷 677-683页

作者： Joshua lo Pahnwat T Taweesedt Makoto Kawai Department of Internal Medicine Santa Clara Valley Medical CenterSan JoseCA 95128United States Department of Psychiatry and Behavioral Sciences Stanford UniversityStanfordCA 94305United States Sierra Pacific Mental Illness Research Educationand Clinical Center(MIRECC)VA Palo Alto Health Care SystemPalo AltoCA 94304United States Department of Psychiatry and Behavioral Sciences School of MedicineStanford UniversityRedwood CityCA 94063United States

Sleep problems have become a significant public health concern,affecting a large portion of the global population and have been linked to increased morbidity and *** incidence of gastrointestinal(GI)cancers continues to rise,posing a substantial burden on healthcare systems *** editorial aims to delve into the impact of sleep on GI cancers,including esophageal,gastric,colorectal,hepatobiliary,and pancreatic *** literature investigating the potential connections between GI cancers and sleep was *** considered aspects such as sleep duration,sleep disorders,and circadian rhythmicity,in order to explore the underlying mechanisms that can contribute to the development of GI cancers and propose avenues for future research.

关键词： Sleep Cancer Gastrointestinal cancer Esophagus Stomach Colon Liver

Mental health in the virtual world:Are we ready for the metaverse era?

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World Journal of Methodology 2024年第4期14卷 1-5页

作者： Tuffy Mamede Patrícia lordêlo Post Graduation in Medicine and Human Health Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Pelvic Floor Care Center and Postgraduate Patricia Lordelo InstituteBahiana School of Medicine and Public HealthSalvador 40290-000Brazil

The advent of the metaverse,including virtual reality,augmented reality,andartificial intelligence,is an undeniable issue that health care scientists need *** influences all fields of knowledge,interpersonal relationships,*** mental health since the post-coronavirus disease 2019 pandemic,it is necessary to consider and understand the potential,possibilities,weaknesses,and consequences arising from and provided by this new *** tothe increasing need for mental health monitoring and care,mental health treatmentsrequire in-depth training and preparation to achieve the maximum use of themetaverse advantages and ***,very little is known about theeffectiveness of remote mental health treatment,but it is certainly suggested thataccessibility and the characteristics associated with the use of metaverse technologiesmay represent new horizons for accessibility and approach tools,as long asmore studies are carried out and more evidence is collected to develop accurateguidelines,safe training,solve ethical concerns,and overcome limitations.

关键词： Mental health Metaverse Artificial intelligence Augmented reality Virtualreality

^(15)N tracers and microbial analyses reveal in situ N_(2)O sources in contrasting water regimes of a drained peatland forest

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Pedosphere 2024年第4期34卷 749-758页

作者： Mohit MASTA Mikk ESPENBERG Laura KUUSEMETS Jaan PÄRN Sandeep THAYAMKOTTU Holar SEPP Kalle KIRSIMÄE Fotis SGOURIDIS Kuno KASAK Kaido SOOSAAR Ülo MANDER Institute of Ecology and Earth Sciences University of TartuVanemuise Street 46Tartu 51003Estonia School of Geographical Sciences University of BristolUniversity RoadBristol BS81SSUK

Managed peatlands are a significant source of nitrous oxide(N_(2)O),a powerful greenhouse gas and stratospheric ozone *** to the complexity and diversity of microbial N_(2)O processes,different methods such as tracer,isotopomer,and microbiological technologies are required to understand these *** combined application of different methods helps to precisely estimate these processes,which is crucial for the future management of drained peatlands,and to mitigate soil degradation and negative atmospheric *** this study,we investigated N_(2)O sources by combining tracer,isotopomer,and microbial analysis in a drained peatland forest under flooded and drained *** average,the nitrification genes showed higher abundances in the drained treatment,and the denitrification genes showed higher abundances in the flooded *** is consistent with the underlying chemistry,as nitrification requires oxygen while denitrification is *** observed significant differences in labelled N_(2)O fluxes between the drained and flooded *** emissions of N_(2)O from the flooded treatment were nearly negligible,whereas the N_(2)O evolved from the nitrogen-15(^(15)N)-labelled ammonium(^(15)NH4+)in the drained treatment peaked at 147μg ^(15)N m^(-2) h^(-1).This initially suggested nitrification as the driving mechanism behind N_(2)O fluxes in drained peatlands,but based on the genetic data,isotopic analysis,and N_(2)O mass enrichment,we conclude that hybrid N_(2)O formation involving ammonia oxidation was the main source of N_(2)O emissions in the drained *** on the ^(15)N-labelled nitrate(^(15)NO3-)tracer addition and gene copy numbers,the low N_(2)O emissions in the flooded treatment came possibly from complete denitrification producing inert *** atomic level,we observed selective enrichment of mass 45 of N_(2)O molecule under ^(15)NH4+amendment in the drained treatment and enrichment of both masses 45 and 46 under

关键词： denitrification nitrification N_(2)O quantitative polymerase chain reaction

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement