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Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng H.lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

Fault Diagnosis Scheme for Railway Switch Machine Using Multi-Sensor Fusion Tensor Machine

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Computers, Materials & Continua 2024年第6期79卷 4533-4549页

作者： Chen Chen Zhongwei Xu Meng Mei Kai Huang Siu Ming lo School of Electronic and Information Engineering Tongji UniversityShanghai201804China Department of Architecture and Civil Engineering City University of Hong KongHong KongChina School of Computer Engineering Jimei UniversityXiamen361021China

Railway switch machine is essential for maintaining the safety and punctuality of train operations.A data-driven fault diagnosis scheme for railway switch machine using tensor machine and multi-representation monitoring data is developed *** existing methods,this approach takes into account the spatial information of the time series monitoring data,aligning with the domain expertise of on-site manual ***,a multi-sensor fusion tensor machine is designed to improve single signal data’s limitations in insufficient ***,one-dimensional signal data is preprocessed and transformed into two-dimensional ***,the fusion feature tensor is created by utilizing the images of the three-phase current and employing the CANDE-COMP/PARAFAC(CP)decomposition ***,the tensor learning-based model is built using the extracted fusion feature *** developed fault diagnosis scheme is valid with the field three-phase current *** experiment indicates an enhanced performance of the developed fault diagnosis scheme over the current approach,particularly in terms of recall,precision,and F1-score.

关键词： Railway switch machine tensor machine fault diagnosis

Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

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Communications on Applied Mathematics and Computation 2024年第1期6卷 218-235页

作者： Yue Liu Jun Xie Hay-Oak Park Wing-Cheong lo Department of Mathematics City University of Hong KongTat Chee AvenueKowloonHong KongChina Department of Molecular Genetics The Ohio State UniversityColumbusOHUSA

The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity *** cell polarization process is regulated by signaling molecules,which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or *** of these signaling molecules involves complex regulation,so the mathematical models become a useful tool to investigate the mechanism behind the *** this review,we discuss how mathematical modeling has shed light on different regulations in the cell *** also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

关键词： Budding yeast Cdc42 Morphogenesis Septin Mathematical models

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron Chih Hung lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

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Refill friction stir spot welding (RFSSW): a review of processing, similar/dissimilar materials joining, mechanical properties and fracture mechanism

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Journal of Iron and Steel Research International 2024年第8期31卷 1825-1839页

作者： Yun-qiang Zhao Hao-kun Yang Aloshyn Andriia Hong-hang lo Jia-xin Li Guangdong Provincial Key Laboratory of Advanced Welding Technology China-Ukraine Institute of WeldingGuangdong Academy of SciencesGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China E.O.Paton Electric Welding Institute of National Academy of Sciences of Ukraine Kiev 01001KievanUkraine

Refill friction stir spot welding(RFSSW)provides a novel method to join similar and/or dissimilar metallic materials without a key-hole in the center of the *** the key-hole free characterization,the similar/dissimilar RFSSW joint exhibits remarkable and endurable characteristics,including high shear strength,long fatigue life,and strong corrosion *** the meanwhile,as the key-hole free joint has different microstructures compared with conventional friction stir spot welding,thus the RFSSW joint shall possess different shear and fatigue fracture mechanisms,which needs further *** explore the underlying failure mechanism,the similar/dissimilar metallic material joining parameters and pre-treatment,mechanical properties,as well as fracture mechanisms under this novel technology will be *** details,the welding tool design,welding parameters setting,and the influence of processing on the lap shear and fatigue properties,as well as the corrosion resistance will be mainly ***,the roadmap of RFFSW is also discussed.

关键词： Refill friction stir spot welding Processing Mechanism Similar materials joining Dissimilar materials joining Microstructure Mechanical property Fracture mechanism

How Can Practitioners Support Citizen Volunteers in Disaster Risk Reduction? Insight from “Good and Ready” in Aotearoa New Zealand

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International Journal of Disaster Risk Science 2024年第3期15卷 374-387页

作者： lo?c Le Dé Steve Ronoh Ei Mon Thinn Kyu Brigitte Rive School of Public Health and Interdisciplinary Studies Auckland University of Technology Pacific Health Research Centre Auckland University of Technology New Zealand Red Cross

Global and national policy frameworks emphasize the importance of people's participation and volunteers' role in disaster risk reduction. While research has extensively focused on volunteers in disaster response and recovery, less attention has been paid on how organizations involved in disaster risk management can support volunteers in leading and coordinating communitybased disaster risk reduction. In 2019, the New Zealand Red Cross piloted the Good and Ready initiative in Auckland,Aotearoa New Zealand, with the objective to empower local people in resilience building with a focus on volunteers and community participation. This research examined the positive and negative outcomes of Good and Ready and investigated volunteers' experiences in the disaster resilience initiative. It involved the codesign of a questionnaire-based survey using participatory methods with Good and Ready volunteers, the dissemination of the survey to gather volunteers' viewpoints, and a focus group discussion with participatory activities with Red Cross volunteers. The findings highlight that a key challenge lies in finding a balance between a program that provides flexibility to address contextual issues and fosters communities' ownership, versus a prescriptive and standardized approach that leaves little room for creativity and self-initiative. It pinpoints that supporting volunteers with technical training is critical but that soft skills training such as coordinating, communicating,or facilitating activities at the local level are needed. It concludes that the sustainability of Good and Ready requires understanding and meeting volunteers' motivations and expectations and that enhancing partnerships with local emergency management agencies would strengthen the program.

关键词： Community-based approach Disaster risk reduction New Zealand Participation Volunteers

Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY Ho Wong Hoi She Simon HY Tsang Kevin S lo Tan To Cheung Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery

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Corporate Social Responsibility and Shipping Supply Chain Risks

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Economics World 2024年第3期11卷 145-155页

作者： Wen-Chi lo Ming Chuan University TaoyuanTaiwan

This study aims to investigate whether Corporate Social Responsibility(CSR)activities reduce supply chain disruptions by examining the impact of the Suez Canal obstruction on the Ever Given container ship in March *** study conclude that the more responsible companies have higher returns and are less affected by this event than the less responsible companies;the less responsible companies have lower *** companies with better CSR have a lower impact on their supply chains when faced with disruptions in the supply chain.

关键词： Suez Canal obstruction corporate social responsibility supply chain risks event study Ever Given container ships

Assembling the RNA therapeutics toolbox

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Medical Review 2024年第2期4卷 110-128页

作者： Mona Teng Ziting Judy Xia Nicholas lo Kashif Daud Housheng Hansen He Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoTorontoONCanada Princess Margaret Cancer Centre University Health NetworkTorontoONCanada Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoToronto M2J 4A6ONCanada Princess Margaret Cancer Centre University Health NetworkToronto M2J 4A6ONCanada

From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications,RNA therapeutics have entered the spotlight and are transforming drug *** the term“RNA therapeutics”has been used in various contexts,this review focuses on treatments that utilize RNA as a component or target RNA for therapeutic *** summarize the latest advances in RNA-targeting tools and RNA-based technologies,including but not limited to mRNA,antisense oligos,siRNAs,small molecules and RNA *** focus on the mechanisms of current FDA-approved therapeutics but also provide a discussion on the upcoming *** clinical utility of RNA-based therapeutics is enabled not only by the advances in RNA technologies but in conjunction with the significant improvements in chemical modifications and delivery platforms,which are also briefly discussed in the *** summarize the latest RNA therapeutics based on their mechanisms and therapeutic effects,which include expressing proteins for vaccination and protein replacement therapies,degrading deleterious RNA,modulating transcription and translation efficiency,targeting noncoding RNAs,binding and modulating protein activity and editing RNA sequences and *** review emphasizes the concept of an RNA therapeutic toolbox,pinpointing the readers to all the tools available for their desired research and clinical *** the field advances,the catalog of RNA therapeutic tools continues to grow,further allowing researchers to combine appropriate RNA technologies with suitable chemical modifications and delivery platforms to develop therapeutics tailored to their specific clinical challenges.

关键词： RNA therapeutics delivery of nucleic acids chemical modifications