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Modulation by Divalent Cations of GABAρ1 Receptor From Human Retina Expressed in Xenopus Oocytes

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Biomedical and Environmental Sciences 2001年第4期14卷 269-277页

作者： wangQIN－WEN lizhi－wang 等 ResearchCenterofBasicMedicine WuhanInstituteofChildrenDIseaseWuhan430016China ResearchCenterofExperimentalMedicine TongjiMedicalUniversityWuhan430030China

Objective To investigate functional homooligomeric GABAρ1 receptors expressed in Xenopus oocytes and the modulation of divalent cations. Methods GABAρ1 cDNA from human retina was transcribed in vitro to obtain sense ρ1 mRNA, which was microinjected into Xenopus oocytes. Two-electrodes voltage clamp technique was performed to record GABA-induced currents. Results Expressed receptors were found to have similar properties to GABA C receptors characterized in the retina. Cl-currents induced by GABA were blocked by picrotoxin instead of bicuculline. GABA-induced currents reversed at -19±2.5 mV, and EC 50 was 3.3 μmol/L. Zn ++ modulated GABA-induced currents with an IC 50=9.6 μ mol/L. Ni ++, Cu ++ and Cd ++ inhibited GABA ρ1 obviously, too. Their rank order of potency was Zn ++>Ni ++>Cu ++>Cd ++. Conclusion Zinc(10 μmol/L) inhibited GABA-induced currents in a competitive manner, and its action was sensitive to extracellular pH. Site-directed mutagenesis revealed that substitution of a single histidine residue (H44 and H48) failed to affect zinc sensitivity.

关键词：二价阳离子 Zn^++ Ni^++ Cu^++ GABAρ1受体人视网膜爪蟾卵母细胞表达调控作用

Unmanned aerial vehicle swarm mission reliability modeling and evaluation method oriented to systematic and networked mission

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Chinese Journal of Aeronautics 2021年第2期34卷 466-478页

作者： lizhi wang Xuejiao ZHAO Yuan ZHANG Xiaohong wang Tielin MA Xia GAO Unmanned System Institute Beihang UniversityBejing 100083China School of Reliability and Systems Engineering Beihang UniversityBeijing 100083China Digital Twinning and System Engineering Research Center Yunnan Innovation InstituteBeihang UniversityBejing 650233China Key Laboratory of Advanced Technology of Intelligent Unmanned Flight System of M inistry of Industry and Information Technology Beijing 100083China School of Astronautics Beihang UniversityBejing 100083China

With the development of Unmanned Aerial Vehicle(UAV) system autonomy, network communication technology and group intelligence theory, mission execution in the form of a UAV swarm will be an important realization of future applications. Traditional single-UAV mission reliability modeling methods have been unable to meet the requirements of UAV swarm mission reliability modeling. Therefore, the UAV swarm mission reliability modeling and evaluation method is proposed. First, aimed at the interdependence among the multiple layers, a multi-layer network model of a UAV swarm is established. At the same time, based on the system having the following characteristics—using a mission chain to complete the mission and applying the connectivity of the mission network—the mission network model of a UAV swarm is established. Second, vulnerability and connectivity are selected as two indicators to reflect the reliability of the mission, and aimed at random attack and deliberate attack, vulnerability and connectivity evaluation methods are proposed. Finally, the validity and accuracy of the constructed model are verified through simulations,and the model and selected indicators can meet the reliability requirements of the UAV swarm mission. In this way, this study provides quantitative reference for UAV-swarm-related decisionmaking work and supports the development of UAV-swarm-related work.

关键词： Complex networks Connectivity Mission reliability Unmanned Aerial Vehicles(UAV) Vulnerability

Recent progress in porous organic polymers and their application for CO_(2) capture

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Chinese Journal of Chemical Engineering 2022年第2期35卷 91-103页

作者： Jiajia wang lizhi wang You wang Du Zhang Qin Xiao Jianhan Huang You-Nian Liu College of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of Micro and Nano Material Interface ScienceCentral South UniversityChangsha 410083China

Carbon capture,storage,and utilization(CCSU)is recognized as an effective method to reduce the excessive emission of CO_(2).Absorption by amine aqueous solutions is considered highly efficient for CO_(2) capture from the flue gas because of the large CO_(2) capture capacity and high ***,it is often limited by the equipment corrosion and the high desorption energy consumption,and adsorption of CO_(2) using solid adsorbents has been receiving more attention in recent years due to its simplicity and high *** recently,a great number of porous organic polymers(POPs)have been designed and constructed for CO_(2) capture,and they are proven promising solid adsorbents for CO_(2) capture due to their high Brunauer-Emmett-Teller(BET)surface area(SBET),adjustable pore size and easy *** particular,they usually have rigid skeleton,permanent porosity,and good physiochemical *** this review,we have a detailed review for the different POPs developed in recent years,not only the design strategy,but also the special structure for CO_(2) *** outlook of the opportunities and challenges of the POPs is also proposed.

关键词： Porous organic polymers Selectivity Adsorbent CO_(2)capture

Integrated energy corridor:a comprehensive proposal of the low-carbon transition for China Energy Group

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Clean Energy 2023年第1期7卷 132-138页

作者： Min Gao Haiming Nan Haijun Ren Yonggang Liu lizhi wang Zhaoyang Xu Pengfei Zhao Shenhua Engineering Technology Co. LtdDongcheng DistrictBeijing 100011China

New energy is considered to be an indispensable means to significantly reduce carbon emissions and to achieve the temperature-control goals defined by the Paris Climate *** the bright future,the inherent characteristics,including volatility,intermittency and uneven seasonal and geographical distributions,and the rapid growth of installations make it increasingly difficult to connect green electricity to *** becomes a dominating bottleneck for the low-carbon transition of China Energy Group(CE).This paper aims to help with the implementation of the new-energy development plan and to define the low-carbon energy-transition path for *** on the current industry structure of CE,Shenhua Engineering Technology Co.,Ltd proposes the concept of an‘integrated energy corridor’.The integrated energy corridor represents a comprehensive energy-transmission channel with coal,green electricity,green hydrogen,green oxygen and other green energy products such as transmission media,railways,pipelines and power grids as transmission means and thermal power,coal chemical plants,cities,*** the route as new-energy consumers and *** integrated energy corridor can support the rapid development of new-energy assets and the low-carbon transition of CE.

关键词： integrated energy corridor new energy low carbon hydrogen energy transition

Hopkinson Effect in Soft Magnetic Materials

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Journal of Materials Science & Technology 2000年第2期16卷 145-147页

作者： Kaiyuan HE, Hui XU, Zhi wang and lizhi CHENG (Department of Materials Science and Engineering, Northeastern University, Shenyang 110006, China) Department of Materials Science and Engineering Northeastern University Shenyang 110006 China

The μi-T curves of the alloy Fe73.5Cu1 Nb3Si13.5B9 in the amorphous state and in the nanocrys-talline state have been investigated. For comparison, μi-T curves of the other two kinds of typical soft magnetic alloys also have been measured. It was found that a sharp Hopkinson peak appeared at the Curie point for each amorphous and crystalline alloy but there was no Hopkinson peak for the nanocrystalline alloy at the Curie point of the residual amorphous phase. This phenomenon has been explained in terms of the characteristic temperature dependence of the effective magnetic anisotropy.

关键词： Hopkinson Effect in Soft Magnetic Materials

Active dry yeast supplementation improves the growth performance,rumen fermentation, and immune response of weaned beef calves

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Animal Nutrition 2021年第4期7卷 1352-1359页

作者： Jian Ma Cheng wang Zhisheng wang Guang Cao Rui Hu Xueying wang Huawei Zou Kun Kang Quanhui Peng Bai Xue lizhi wang Yueming Zhu Xiaopeng Zhu Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China Angel Yeast Co. Ltd.Yichang 443000China Zhangye Comprehensive Experimental Station of National Yak and Beef Industrial Technology System Zhangye 734000China

The objective of this experiment was to investigate the potential benefits of active dry yeast(ADY)on the growth performance,rumen fermentation,nutrient digestibility,and serum parameters of weaned beef *** Simmental crossbred male calves(body weight=86.47±4.41 kg and 70±4 d of age)were randomly divided into 2 groups:control(CON)(fed basal ration)and ADY(fed basal ration and 5 g/d ADY per calf).The dietary concentrate-to-roughage ratio was 35:*** the calves were regularly provided rations 3 times a day at 07:00,13:00,and 19:00 and had free access to wate *** experiment lasted for 60 *** average daily gain of ADY group was higher(P=0.007)than that of the CON group,and the ratio of feed intake to average daily gain in the ADY group was reduced(P=0.022)as compared to the CON *** concentration of ruminal ammonia-N was higher(P=0.023)in the CON group than that in the ADY group,but an opposite trend of microbial protein was found between the 2 ***,the ruminal concentrations of propionate and butyrate were higher(P<0.05)in the ADY group than those in the CON *** fed ADY exhibited higher(P<0.05)crude protein and neutral detergent fiber *** of ADY increased(P<0.05)the contents of glucose,glutathione peroxidase,superoxide dismutase,immunoglobulin A,immunoglobulin M,and interleukin 10 in the serum of calves,but an opposite trend was observed in malondialdehyde,interleukin 1 beta,and tumor necrosis factor alpha contents between the 2 *** conclusion,dietary supplementation with ADY could improve the growth performance,rumen fermentation,nutrient digestibility,antioxidant ability,and immune response of weaned beef calves.

关键词： Active dry yeast Weaned beef calf Growth performance Rumen fermentation Nutrient digestibility Immune response

A failure criterion for shale considering the anisotropy and hydration based on the shear slide failure model

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International Journal of Mining Science and Technology 2023年第4期33卷 447-462页

作者： Qiangui Zhang Bowei Yao Xiangyu Fan Yong Li Nicholas Fantuzzi Tianshou Ma Yufei Chen Feitao Zeng Xing Li lizhi wang Petroleum Engineering School Southwest Petroleum UniversityChengdu 610500China Department of Civil Geological and Mining EngineeringÉcole Polytechnique de MontréalMontreal H3T 1J4Canada State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China Department of Civil ChemicalEnvironmental and Materials EngineeringUniversity of BolognaBologna 40136Italy Department of Civil and Mineral Engineering University of TorontoToronto M5S 1A4Canada

A failure criterion fully considering the anisotropy and hydration of shale is essential for shale formation stability ***,a novel failure criterion for hydration shale is developed by using Jaeger’s shear failure criterion to describe the anisotropy and using the shear strength reduction caused by clay minerals hydration to evaluate the *** failure criterion is defined with four parameters in Jaeger’s shear failure criterion(S_(1),S_(2),a andφ),three hydration parameters(k,ω_(sh)andσ_(s))and two material size parameters(d and l0).The physical meanings and determining procedures of these parameters are *** accuracy and applicability of this failure criterion are examined using the published experimental data,showing a cohesive agreement between the predicted values and the testing results,R^(2)=0.916 and AAREP(average absolute relative error percentage)of 9.260%.The error(|D_(p)|)is then discussed considering the effects ofβ(angle between bedding plane versus axial loading),moisture content and confining pressure,presenting that|Dp|increases whenβis closer to 30°,and|D_(p)|decreases with decreasing moisture content and with increasing confining ***,|D_(p)|is demonstrated as being sensitive to S1and being steady with decrease in the data set whenβis 0°,30°,45°and 90°.

关键词： Shale Failure criterion Mechanical strength Shear slide failure Anisotropy Hydration

Genome sequencing provides potential strategies for drug discovery and synthesis

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Acupuncture and Herbal Medicine 2023年第4期3卷 244-255页

作者： Chunsheng Zhao Ziwei Zhang Linlin Sun Ronglu Bai lizhi wang Shilin Chen School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjinChina School of Chinese Materia Medica Chengdu University of Traditional Chinese MedicineChengduChina

Medicinal plants are renowned for their abundant production of secondary metabolites,which exhibit notable pharmacological activities and great potential for drug *** biosynthesis of secondary metabolites is highly intricate and influenced by various intrinsic and extrinsic factors,resulting in substantial species diversity and content ***,precise regulation of secondary metabolite synthesis is of utmost *** recent years,genome sequencing has emerged as a valuable tool for investigating the synthesis and regulation of secondary metabolites in medicinal plants,facilitated by the widespread use of high-throughput sequencing *** review highlights the latest advancements in genome sequencing within this field and presents several strategies for studying secondary ***,the article elucidates how genome sequencing can unravel the pathways for secondary metabolite synthesis in medicinal plants,offering insights into the functions and regulatory mechanisms of participating *** analyses of plant genomes allow identification of shared pathways of metabolite synthesis among species,thereby providing novel avenues for obtaining cost-effective biosynthetic *** examining individual genomic variations,genes or gene clusters associated with the synthesis of specific compounds can be discovered,indicating potential targets and directions for drug development and the exploration of alternative compound ***,the advent of gene-editing technology has enabled the precise modifications of medicinal plant *** of specific secondary metabolite synthesis pathways becomes thus feasible,enabling the precise editing of target genes to regulate secondary metabolite production within *** findings serve as valuable references and lessons for future drug development endeavors,conservation of rare resources,and the exploration of new resources.

关键词： Biosynthetic pathways Gene editing Genome sequencing Medicinal plants Secondary metabolites

Investigation of Electrical Parameters of Fresh Water and Produced Mixed Injection in High-Salinity Reservoirs

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Fluid Dynamics & Materials Processing 2023年第10期19卷 2695-2706页

作者： Jun Li Guofeng Cheng Hongwei Xiao Xiang Li lizhi wang Hui Xu Yu wang Nannan Liu Shangping Chen Xing Shi PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China Changqing Oilfield No.5 Oil Production Plant PetroChinaXi’an710000China Exploration and Development Research Institute of Daqing Oilfield Co. Ltd.Daqing163712China Key Laboratory of Shallow Geothermal Energy Ministry of Natural Resources of the People’s Republic of ChinaBeijing100195China Jiangsu Key Laboratory of Oil-Gas Storage and Transportation Technology School of Petroleum and Natural Gas EngineeringChangzhou UniversityChangzhou213164China Sinopec International Petroleum Exploration and Production Corporation Beijing100029China

Assuming a reservoir with a typical salt-lake background in the Qaidam Basin as a testbed,in this study the var-iation law of the rock electrical parameters has been determined through water displacement experiments with different *** made evident by the results,the saturation index increases with the degree of water *** the salinity of the injected water is lower than 80000 ppm,the resistivity of the rock sampleﬁrst decreases,then it remains almost constant in an intermediate stage,andﬁnally it grows,thereby giving rise to a‘U’proﬁle *** the salinity decreases,the water saturation corresponding to the inﬂection point of the resistivity becomes lower,thereby leading to a wider‘U’type range and a higher terminal *** dif-ferent samples,higher initial resistivity of the sample in the oil-bearing state,and higher resistivity after low-sali-nity water washing are obtained when a thicker lithology is considered.

关键词： High salinity reservoir mixed injection saturation index resistivity electrical parameters