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Molecular dynamics simulations for the growth of CH_4-CO_2 mixed hydrate

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Journal of Energy Chemistry 2014年第6期23卷 747-754页

作者： lizhi yi Deqing Liang Xuebing Zhou Dongliang Li Key Laboratory of Renewable Energy and Gas Hydrate Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou Center for Gas Hydrate Research Guangzhou Institute of Energy Conversion Chinese Academy of Sciences University of Chinese Academy of Sciences

Molecular dynamics simulations are performed to study the growth mechanism of CH4-CO2 mixed hydrate in xco2 = 75%, xco2 = 50%, and zco2 = 25% systems at T = 250 K, 255 K and 260 K, respectively. Our simulation results show that the growth rate of CH4-CO2 mixed hydrate increases as the CO2 concentration in the initial solution phase increases and the temperature decreases. Via hydrate formation, the composition of CO2 in hydrate phase is higher than that in initial solution phase and the encaging capacity of CO2 in hydrates increases with the decrease in temperature. By analysis of the cage occupancy ratio of CH4 molecules and CO2 molecules in large cages to small cages, we find that CO2 molecules are preferably encaged into the large cages of the hydrate crystal as compared with CH4 molecules. Interestingly, CH4 molecules and CO2 molecules frequently replace with each other in some particular cage sites adjacent to hydrate/solution interface during the crystal growth process. These two species of guest molecules eventually act to stabilize the newly formed hydrates, with CO2 molecules occupying large cages and CH4 molecules occupying small cages in hydrate.

关键词： molecular dynamics simulations methane-carbon dioxide mixed hydrate growth clathrate

Nanoparticle monolayer-based flexible strain gauge with ultrafast dynamic response for acoustic vibration detection

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Nano Research 2015年第9期8卷 2978-2987页

作者： lizhi yi Weihong Jiao Ke Wu Lihua Qian Xunxing Yu Qi Xia Kuanmin Mao Songliu Yuan Shuai Wang yingtao Jiang School of Physics Huazhong University of Science and Technology Wuhan 430074 China School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China Nevada Nanotechnology Center & Department of Electrical and Computer Engineering University of Nevada Las Vegas Nevada 89154-4026 USA

The relatively poor dynamic response of current flexible strain gauges has prevented their wide adoption in portable electronics. In this work, we present a greatly improved flexible strain gauge, where one strip of Au nanoparticle （NP） monolayer assembled on a polyethylene terephthalate film is utilized as the active unit. The proposed flexible gauge is capable of responding to applied stimuli without detectable hysteresis via electron tunneling between adjacent nanoparticles within the Au NP monolayer. Based on experimental quantification of the time and frequency domain dependence of the electrical resistance of the proposed strain gauge, acoustic vibrations in the frequency range of 1 to 20,000 Hz could be reliably detected. In addition to being used to measure musical tone, audible speech, and creature vocalization, as demonstrated in this study, the ultrafast dynamic response of this flexible strain gauge can be used in a wide range of applications, including miniaturized vibratory sensors, safe entrance guard management systems, and ultrasensitive pressure sensors.

关键词： gold nanoparticle,strain gauge,self-assembly electron tunneling

Allelic reprogramming of chromatin states in human early embryos

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National Science Review 2024年第3期11卷 58-71页

作者： Shenli Yuan Lei Gao Wenrong Tao Jianhong Zhan Gang Lu Jingye Zhang Chuanxin Zhang lizhi yi Zhenbo Liu Zhenzhen Hou Min Dai Han Zhao Zi-Jiang Chen Jiang Liu Keliang Wu Center for Reproductive Medicine Shandong University CAS Key Laboratory of Genome Sciences and Information Collaborative Innovation Center of Genetics and Development Beijing Institute of Genomicsand China National Center for BioinformationChinese Academy of Sciences University of Chinese Academy of Sciences CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical Sciences the Chinese University of Hong Kong Key Laboratory of Reproductive Endocrinology of the Ministry of Education Shandong University Center for Reproductive Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

The reprogramming of parental epigenomes in human early embryos remains elusive. To what extent the characteristics of parental epigenomes are conserved between humans and mice is currently unknown. Here,we mapped parental haploid epigenomes using human parthenogenetic and androgenetic embryos. Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse *** allelic patterns of epigenetic states for orthologous regions are not conserved between humans and mice. Nevertheless, it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in humans and mice. In addition, for DNA-methylation-dependent imprinting, we report 19 novel imprinted genes and their associated germline differentially methylated regions. Unlike in mice, H3K27me3-dependent imprinting is not observed in human early ***, allele-specific epigenomic reprogramming is different in humans and mice.

关键词： human embryo epigenetics reprogramming DNA methylation H3K27me3 chromatin accessibility

The Role of DNA Methylation Reprogramming During Sex Determination and Transition in Zebrafish

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 48-63页

作者： Xinxin Wang Xin Ma Gaobo Wei Weirui Ma Zhen Zhang Xuepeng Chen Lei Gao Zhenbo Liu Yue Yuan lizhi yi Jun Wang Toshinobu Tokumoto Junjiu Huang Dahua Chen Jian Zhang Jiang Liu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences/China National Center for BioinformationBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Reproductive Medicine of Guangdong Province the First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Integrated Bioscience Section Graduate School of Science and TechnologyNational University Corporation Shizuoka UniversityShizuoka 422-8529Japan State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Center for Life SciencesSchool of Life SciencesYunnan UniversityKunming 650091China CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

DNA methylation is a prevalent epigenetic modification in vertebrates,and it has been shown to be involved the regulation of gene expression and embryo ***,it remains unclear how DNA methylation regulates sexual development,especially in species without sex *** determine this,we utilized zebrafish to investigate DNA methylation reprogramming during juvenile germ cell development and adult female-to-male sex *** reveal that primordial germ cells(PGCs)undergo significant DNA methylation reprogramming during germ cell development,and the methylome of PGCs is reset to an oocyte/ovary-like pattern at 9 days post fertilization(9 dpf).When DNA methyltransferase(DNMT)activity in juveniles was blocked after 9 dpf,the zebrafish developed into *** also show that Tet3 is involved in PGC ***,we find that DNA methylome reprogramming during adult zebrafish sex transition is similar to the reprogramming during the sex differentiation from 9 dpf PGCs to ***,inhibiting DNMT activity can prevent the female-to-male sex transition,suggesting that methylation reprogramming is required for zebrafish sex *** summary,DNA methylation plays important roles in zebrafish germ cell development and sexual plasticity.

关键词： Germ cell DNA methylation Sex determination Sex transition Sexual plasticity

ASCancer Atlas: a knowledgebase of aberrant alternative splicing in human cancers

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ASCancer Atlas: a knowledgebase of aberrant alternative spli...

Epigenomic landscapes during prefrontal cortex development and aging in rhesus

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Song Wu Mochen Zhang Zheng Gone Guoliang Wang lizhi yi Peiqi Xing Wei Zhao Rujiao Li yiming Bao National Genomics Data Center Beijing Institute of Genomics Chinese Academy of Sciences/China National Center for Bioinformation CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences

Different isoforms of a gene produced by alternative splicing(AS) could play diverse roles in human cancers. Dysregulated alternative splicing performs important function in tumorigenesis and progression. In recent years, a growing number of studies have reported that aberrant alternative splicing is closely related to human cancers. There are many AS-related databases that focus on human cancers. They can be divided into two major categories-one is based on data reanalysis and annotation in TCGA(The Cancer Genome Atlas), such as TCGASpliceSeq, CancerSplicingQTL and ExonSkipDB;and the other is based on data from public resources(e.g., LncAS2 Cancer). No resource,however, is available to collect and integrate tumor-specific splicing variants, which have been experimentally confirmed and frequently reported in multiple publications. Here we present ASCancer Atlas(https://***/ascancer/home), a public knowledgebase of alternative splicing variants in human cancers by curating a large number of literatures and mining data of TCGA. Unlike existing data-oriented databases, ASCancer Atlas dedicates to collecting, integrating and visualizing tumorspecific alternative splicing variants and normalizes their experimentally proven function. ASCancer Atlas currently houses 385 manually curated publications from January 2010 to June 2021, involving77 cancer subtypes, 203 genes and 407 splice variant entries. It covers six alternative splicing events,including exon skipped(ES), alternative 5’ splice site(A5 SS), alternative 3’ splice site(A3 SS),mutually exclusive exons(MEX), intron retained(IR) and complex events. Meanwhile, ASCancer Atlas illustrates related regulatory mechanism, biological function, signaling pathway and potential clinical application of splicing variants. ASCancer Atlas provides a comprehensive overview of splicing dysregulation in human cancers, which attribute to better understand the role of aberrant alternative splicing in human cancers. As more

关键词： Alternative splicing Splicing variants Human cancer Knowledgebase

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National Science Review 2024年第8期11卷 75-97页

作者： Chao Ning Xi Wu Xudong Zhao Zongyang Lu Xuelong Yao Tao Zhou lizhi yi Yaoyu Sun Shuaishuai Wu Zhenbo Liu Xingxu Huang Lei Gao Jiang Liu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of Biophysics Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC) State Key Laboratory of Drug Regulatory Science Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Guangzhou Nvwa Life Technology Co. Ltd Shenzhen Neher Neural Plasticity Laboratory CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

The prefrontal cortex(PFC) is essential for higher-level cognitive *** epigenetic dynamics participates in PFC development and aging is ***,we profiled epigenomic landscapes of rhesus monkey PFCs from prenatal to aging *** dynamics of chromatin states,including higher-order chromatin structure,chromatin interaction and histone modifications are coordinated to regulate stage-specific gene transcription,participating in distinct processes of *** changes of epigenetic signals occur around the birth ***,genes involved in neuronal cell differentiation and layer specification are pre-configured by bivalent *** identified a cis-regulatory module and the transcription factors(TFs) associated with basal radial glia development,which was associated with large brain size in *** TFs include GLI3,CREB5 and ***,the genes associated with the basal radial glia(bRG)-associated cis-element module,such as SRY and SOX9,are enriched in sex ***-associated single nucleotide polymorphisms are more enriched in super enhancers(SEs) than typical enhancers,suggesting that SEs play an important role in neural network wiring.A cis-regulatory element of DBN1 is identified,which is critical for neuronal cell proliferation and synaptic neuron ***,the loss of distal chromatin interaction and H3K27me3 signal are hallmarks of PFC aging,which are associated with abnormal expression of aging-related genes and transposon activation,***,our findings shed light on epigenetic mechanisms underlying primate brain development and aging.

关键词： rhesus macaque prefrontal cortex 3D genomics chromatin immunoprecipitation sequencing development aging

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虚拟仿真技术在电工技术教学中的应用

科教导刊 2016年第6X期 75-76页

作者：易礼智湖南工程职业技术学院湖南长沙410151

随着计算机技术和虚拟仿真技术的发展,虚拟仿真技术在电工技术教学中的应用也越来越广泛,也让电工技术的教学手段和教学模式产生了极为重大的影响。本文首先分析了虚拟仿真技术在电工技术教学中应用的优势,接着提出了虚拟仿真技术在电... 详细信息

随着计算机技术和虚拟仿真技术的发展,虚拟仿真技术在电工技术教学中的应用也越来越广泛,也让电工技术的教学手段和教学模式产生了极为重大的影响。本文首先分析了虚拟仿真技术在电工技术教学中应用的优势,接着提出了虚拟仿真技术在电工技术教学中的应用。

关键词：虚拟仿真技术电工技术 Multisim EWB

CH4-CO2气体水合物分解的分子动力学模拟

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广东化工 2018年第17期45卷 26-28页

作者：易莉芝广东省分布式能源系统重点实验室、化学工程与能源技术学院东莞理工学院广东东莞523808

本文采用分子动力学方法,构建水合物晶体-液态水模型,研究270K下CO_2晶穴占有率θ=87.5%,75%的CH_4-CO_2混合气体水合物的微观分解过程。结果表明,在相同的温度下,相比θ=75%的水合物,θ=87.5%的混合气体水合物更容易分解;混合气体水合... 详细信息

本文采用分子动力学方法,构建水合物晶体-液态水模型,研究270K下CO_2晶穴占有率θ=87.5%,75%的CH_4-CO_2混合气体水合物的微观分解过程。结果表明,在相同的温度下,相比θ=75%的水合物,θ=87.5%的混合气体水合物更容易分解;混合气体水合物的分解是由外及内逐层进行,并且分解过程对大、小晶穴不具选择性。

关键词：混合水合物分解分子动力学模拟

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深度学习在智能小车多目标识别中的应用

现代工业经济和信息化 2022年第5期12卷 24-25,58页

作者：易礼智湖南工程职业技术学院湖南长沙410151

伴随着智能化装置的研发与使用,智能小车的功能不断丰富,但在实际操作过程中缺乏对多重目标进行分类识别,导致智能小车的使用潜力受到限制,以此为出发点,对如何实现智能小车的多目标识别进行分析,结合深度学习的方式将其拓展到智能小车... 详细信息

伴随着智能化装置的研发与使用,智能小车的功能不断丰富,但在实际操作过程中缺乏对多重目标进行分类识别,导致智能小车的使用潜力受到限制,以此为出发点,对如何实现智能小车的多目标识别进行分析,结合深度学习的方式将其拓展到智能小车的实际使用中,能够快速对智能小车指令系统与目标物体进行精确定位,有助于智能小车的未来发展潜力的挖掘,并能够提升使用智能小车行业的市场拓展,对提高生产积极性、减少其他设备的繁琐使用以及走向智能化时代具有重要意义。

关键词：深度学习智能小车多目标识别