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Rab GTPases interactome analysis of dendritic cells reveals anti-microbial functions of the Rab32 complex in bacterial containment

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Rab GTPases interactome analysis of dendritic cells reveals ...

第十届全国免疫学学术大会

作者： Yuanyuan li Yu Wang Yi Yang Xiangyu tang Liyun Zou Li Ma Qingsang Ni lizhang tang Siqi Liu Lin Regina Liting Wang Quanfang Wei Haiying Rang Qijing Li Ying Wan Biomedical Analysis Center Third Military Medical University Department of Immunology Duke University Medical Center

To assume their essential roles in innate immunity,dendritic cells(DCs)orchestrate complex membrane trafficking through an interconnected transportation network linked together by Rab *** a tandem affinity purification strategy and mass spectrometry,we depicted an interactomic landscape of major members of the mammalian Rab GTPase family including 649 high confidence *** comprehensive proteomics analysis provided a global view of intracellular membrane organization and when complemented by various imaging tools,inspired many novel hypotheses on the functions of Rab subnetworks in ***,we investigated dynamic changes to the Rab32 subnetwork in DCs induced by *** infection,and uncovered a novel and essential role of this subnetwork in controlling the intracellular proliferation of Listeria in vitro and in ***,Rab32 formed a persistent complex with two newly identified interacting proteins PHB and PHB2–to encompass bacteria both during early phagosome formation and after Listeria escapes the original containment *** addition,all three proteins are indispensable for the process of phagosome to lysosome ***,the establishment of a functional compartmentalization overview and an organizational framework of intracellular Rab-mediated vesicle trafficking underscore the importance of this work as a resource for future investigations.

关键词： Dendritic cell Membrane transport Rab GTPase Listeria

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川西新场蓬莱镇组上段储层特征

天然气工业 1997年第5期17卷 20-22页

作者：唐立章邓永富吕克正华川石油天然气勘探开发总公司研究院

四川西部新场上侏罗统蓬莱镇组储层物性和孔隙结构与低孔渗的上三叠统—中侏罗统致密砂岩比较，其储集条件明显变好，孔隙度一般为１５％～１８％，平均渗透率３６３×１０－３μｍ２，属致密型向常规型过渡的储层类型。储层砂体厚度... 详细信息

四川西部新场上侏罗统蓬莱镇组储层物性和孔隙结构与低孔渗的上三叠统—中侏罗统致密砂岩比较，其储集条件明显变好，孔隙度一般为１５％～１８％，平均渗透率３６３×１０－３μｍ２，属致密型向常规型过渡的储层类型。储层砂体厚度自西向东有增厚的趋势，储集性也逐渐变好，但总体差异不大；有四种基本孔隙类型，孔隙宽度服从正态分布；从Ⅰ类储集岩到Ⅳ类储集岩，孔隙结构由好变坏、毛细管压力由粗歪度变为细歪度、排驱压力和饱和度中值压力由小变大、孔喉半径依次变小、储渗性依次下降，直至变为非储集岩。储渗性主要受方解石含量和粘土矿物产状的影响。

关键词：盆地早侏罗世储集层特征孔隙结构储集层

Adaptive backstepping control of tracked robot running trajectory based on real-time slip parameter estimation

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International Journal of Agricultural and Biological Engineering 2020年第4期13卷 178-187页

作者： En Lu Zheng Ma Yaoming Li lizhang Xu Zhong tang School of Agricultural Equipment Engineering Jiangsu UniversityZhenjiangJiangsu 212013China World Precise Machinery(China)Co. LtdWorld Industrial ParkPicheng TownDanyangJiangsu 212311China

To ensure the stable driving of tracked robots in a complex farmland environment,an adaptive backstepping control method for tracked robots was proposed based on real-time slip parameter *** to the kinematics analysis method,the kinematic model of the tracked robot was established,and then,its pose error differential equation was further *** this basis,the trajectory tracking controller of the tracked robot was designed based on the backstepping control ***,according to the trajectory tracking error of the tracked robot,the back propagation neural network(BPNN)was used to adaptively adjust the control parameters in the backstepping controller,and the inputs of the BPNN are the trajectory tracking error xe,ye,θ*** that,the soft-switching sliding mode observer(SSMO)was designed to identify the slip parameters during the running of the tracked *** then the parameters were compensated into the adaptive backstepping controller to reduce the trajectory tracking *** simulation results show that the proposed adaptive backstepping control method with SSMO can improve the accuracy of the trajectory tracking control of the tracked ***,the designed SSMO can accurately estimate the slip parameters.

关键词： tracked robot trajectory control adaptive backstepping control neural networks slip parameter sliding mode observer

Modeling of working environment and coverage path planning method of combine harvesters

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International Journal of Agricultural and Biological Engineering 2020年第2期13卷 132-137页

作者： En Lu lizhang Xu Yaoming Li Zhong tang Zheng Ma School of Agricultural Equipment Engineering Jiangsu UniversityZhenjiang 212013China World Precise Machinery(China)Co. LtdWorld Industrial ParkPicheng TownDanyang 212311China

This paper mainly studied the working environment modeling and coverage path planning of combine *** boundaries of the farmland to be harvested were extracted through the farmland satellite imagery and canny *** polygon approximation method was used to fit the extracted boundaries as *** edge offset of the farmland and obstacles was realized based on the principle of straight *** to the structure data of the split points which were obtained through the improved scan line algorithm,the coverage path planning of the combine harvester was ***,the circular arc transition algorithm was used to optimize the harvesting paths to achieve the smooth turning of the combine harvester at the edge of farmland and when encountering *** simulation results show that the proposed the proposed polygon approximation method can accurately depict the boundaries of the farmland to be harvested,and reduce the amount of data to be ***,the designed path planning method can realize the coverage path planning of the combine harvester in irregular and internal obstacle farmland.

关键词： combine harvester environmental modeling path planning farmland turning

Rab蛋白家族的蛋白相互作用组研究揭示树突状细胞Rab32蛋白复合体防御细菌感染机制

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科学新闻 2017年第4期 47-47页

作者： Yuanyuan Li Yu Wang Liyun Zou Xiangyu tang Yi Yang Li Ma Qingzhu Jia Qingshan Ni Siqi Liu lizhang tang Regina Lin Elizabeth Wong Wei Sun Liting Wang Quanfang Wei Haiying Ran Liqun Zhang Hengning Lian Wei Huang Yuzhang Wu 李启靖万瑛杜克大学医学院免疫系中国人民解放军第三军医大学生物医学分析测试中心

文章简介树突状细胞发挥功能依赖胞内广泛存在的Rab蛋白介导的复杂膜转运系统。本研究首先建立一种新的串联亲和纯化策略,通过液质联用解析了树突状细胞Rab蛋白家族的相互作用组。结合应用影像学技术,揭示树突状细胞内膜性结构的全局转... 详细信息

文章简介树突状细胞发挥功能依赖胞内广泛存在的Rab蛋白介导的复杂膜转运系统。本研究首先建立一种新的串联亲和纯化策略,通过液质联用解析了树突状细胞Rab蛋白家族的相互作用组。结合应用影像学技术,揭示树突状细胞内膜性结构的全局转运视图。通过研究李斯特菌感染树突状细胞过程中Rab32

关键词：树突状细胞 Rab32 蛋白相互作用蛋白家族蛋白复合体

切纵流联合收割机纵轴流滚筒长度设计与优化(英文)

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农业工程学报 2014年第23期30卷 28-34页

作者：唐忠李耀明徐立章江苏大学现代农业装备与技术教育部重点实验室镇江212013

为优化设计切纵流联合收割机纵轴流滚筒的长度,该文通过设计脱粒分离长度可变的纵轴流滚筒并进行喂入量为7 kg/s的水稻脱粒分离性能和籽粒分布试验,分析纵轴流滚筒下脱出混合物的分布规律,建立纵轴流滚筒的籽粒分布方程,计算纵轴流滚筒... 详细信息

为优化设计切纵流联合收割机纵轴流滚筒的长度,该文通过设计脱粒分离长度可变的纵轴流滚筒并进行喂入量为7 kg/s的水稻脱粒分离性能和籽粒分布试验,分析纵轴流滚筒下脱出混合物的分布规律,建立纵轴流滚筒的籽粒分布方程,计算纵轴流滚筒长度;通过计算纵轴流滚筒顶盖导流板的最佳导角对纵轴流滚筒长度进行优化,确定纵轴流滚筒长度的最佳值并进行水稻脱粒分离性能试验。结果表明,在水稻喂入量为7 kg/s,纵轴流滚筒顶盖导流角为7.64°时,优化后的纵轴流滚筒长度最佳值为3 159.77 mm,经优化后的纵轴流滚筒脱粒分离的籽粒夹带损失率约为0.29%。该研究为纵轴流联合收割机的纵轴流滚筒设计提供了参考。

关键词：农业机械设计优化联合收割机脱粒分离纵轴流滚筒分布规律

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单切双横流脱粒分离装置参数试验与优化!

农业机械学报 2015年第5期46卷 62-67,92页

作者：李耀明周伟徐立章孙韬唐忠江苏大学现代农业装备与技术教育部重点实验室镇江212013

为解决全喂入式联合收获机收获秆青叶茂难脱高产水稻时脱粒分离损失大且容易出现堵塞的问题,设计了单切双横流脱粒分离装置,在单切双横流脱粒分离装置试验台上,通过对比试验分别对凹板筛栅条轴向间距、顶盖导向板个数和滚筒轴间距进行... 详细信息

为解决全喂入式联合收获机收获秆青叶茂难脱高产水稻时脱粒分离损失大且容易出现堵塞的问题,设计了单切双横流脱粒分离装置,在单切双横流脱粒分离装置试验台上,通过对比试验分别对凹板筛栅条轴向间距、顶盖导向板个数和滚筒轴间距进行了优选,得到优选结构参数为:第Ⅰ切流、第Ⅱ横轴流和第Ⅲ横轴流凹板筛栅条轴向间距分别为10 mm、16 mm和16 mm,第Ⅱ横轴流和第Ⅲ横轴流顶盖导向板的个数都为4个,第Ⅰ切流和第Ⅱ横轴流以及第Ⅱ横轴流和第Ⅲ横轴流滚筒轴间距分别为645 mm和667.5 mm;在得到的优选结构参数下,以喂入量、脱粒间隙和滚筒转速为试验因素进行正交试验,并运用模糊综合评价法和极差分析得出试验范围内切双横流水稻脱粒分离装置的优选工作参数为:喂入量为5 kg/s,第Ⅰ切流、第Ⅱ横轴流和第Ⅲ横轴流脱粒间隙分别为40 mm、35 mm和40 mm,第Ⅰ切流、第Ⅱ横轴流和第Ⅲ横轴流滚筒转速分别为550 r/min、600 r/min和750 r/min。在此参数下,得到单切双横流脱粒分离装置的性能指标为:未脱净率0.05%,夹带损失率0.36%,脱粒总损失率0.41%,第Ⅰ切流、第Ⅱ横轴流和第Ⅲ横轴流脱粒滚筒功耗分别为3.33 k W、21.26 k W和12.58 k W,脱粒滚筒总功耗37.17 k W,脱出物杂余质量分数14.37%。

关键词：联合收获机水稻多滚筒脱粒分离试验优化

风筛式清选装置振动筛上物料运动CFD-DEM数值模拟

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农业机械学报 2012年第2期43卷 79-84页

作者：李洪昌李耀明唐忠徐立章江苏大学现代农业装备与技术教育部重点实验室镇江212013

采用计算流体力学和颗粒离散元耦合的方法模拟风筛式清选装置中物料在筛面上的运动,并将模拟结果和试验结果进行了对比。仿真结果表明:在一定范围内风机出风口风速增加,物料后移速度增加,有助于提高振动筛的处理能力,但也会增加籽粒的损... 详细信息

采用计算流体力学和颗粒离散元耦合的方法模拟风筛式清选装置中物料在筛面上的运动,并将模拟结果和试验结果进行了对比。仿真结果表明:在一定范围内风机出风口风速增加,物料后移速度增加,有助于提高振动筛的处理能力,但也会增加籽粒的损失;风速增加使籽粒在筛下分布后移,在15分区后籽粒数量很少。通过试验验证表明,利用CFD-DEM耦合对风筛式清选装置进行数值模拟是可行的。

关键词：风筛式清选装置振动筛计算流体力学离散元法数值模拟

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深圳市淋病报告发病率男女差异分析

英国医学杂志中文版 2016年第11期19卷 639-644页

作者： Mingzhou Xiong Lina Lan Tiejian Feng Guanglu Zhao Feng Wang Fuchang Hong Xiaobing Wu Chunlai Zhang lizhang Wen Aizhong Liu John McCulloch Best Weiming tang STD Prevention and Control Department Shenzhen Center for Chronic Disease Control Shenzhen Guangdong China Department of Epidemiology and Health Statistics Public Health School of Central South University Changsha Hunan China. STD Prevention and Control Department Shenzhen Center for Chronic Disease Control Shenzhen Guangdong China. Department of Epidemiology and Health Statistics Public Health School of Central South University Changsha Hunan China. UCSF School of Medicine San Francisco California USA. Project-China University of North Carolina Guangzhou Guangdong China Department of STI Control Guangdong Provincial Center for Skin Diseases and STIs control Guangzhou Guangdong China.

摘要目的通过评估中国淋病临床诊断和上报的过程，分析淋病报告发病率和真实发病率的差异。研究地点来自深圳市34家医院的26个皮肤性病科、34个妇产科和28个泌尿科门诊是研究的调查点。研究对象研究共纳入2754名研究对象，2534名完成了... 详细信息

摘要目的通过评估中国淋病临床诊断和上报的过程，分析淋病报告发病率和真实发病率的差异。研究地点来自深圳市34家医院的26个皮肤性病科、34个妇产科和28个泌尿科门诊是研究的调查点。研究对象研究共纳入2754名研究对象，2534名完成了问卷调查且提供了生殖道分泌物拭子。

关键词：淋病男女差异分析治疗方法临床分析