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Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries

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Nano Research 2023年第2期16卷 2938-2948页

作者： Xiaoru Sun Huitong Ruan Qidong Liu Silu Cao Qi Jing Yaru Xu Lize Xiong Wenguo Cui Cheng Li Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai 200434China

Neuroinflammation,commonly associated with various central nervous system(CNS)diseases such as postoperative cognitive dysfunction(POCD),is primarily mediated by the disruption of biological signals in microglia.However,the effective treatment of CNS diseases remains an ongoing challenge as biological signals show limited microglia-targeting effect.In this study,taking advantage of the highly expressed lipoprotein receptor-related protein-1(LRP1)on the microglia,a nanobiosignal delivery system modified by LRP1 high-affinity peptide ligand RAP12(RAP:receptor-associated protein)was constructed to specifically regulate neuroinflammation via targeting microglia.The uptake of the RAP12 modified-nanobiosignaler by microglia increased significantly,indicating its microglia-targeting ability.Both in vitro/vivo studies proved that the“nanobiosignaler”significantly reduced the secretion of pro-inflammatory cytokines,induced specific M2(anti-inflammatory type)microglia differentiation,and remarkably alleviated cognitive function impairment in the mice model when compared with unmodified groups.It was indicated that the“nanobiosignaler”could target microglia to deliver the biological signal and inhibit the excessive activation of microglia.Overall,the cell-targeted biological signal transmission system inspired by“nanobiosignaler”has broad application prospects in the future.

关键词： biosignal nanoparticles microglia neuroinflammation targeted delivery

Acupuncture for postoperative pain and recovery

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Acupuncture for postoperative pain and recovery

2017中国中西医结合麻醉学会[CSIA]年会暨第四届...

作者： Lize Xiong Xijing Hospital Xi’an

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新年献词:创新推动麻醉学科高质量发展

中华麻醉学杂志 2024年第1期44卷 1-2页

作者：熊利泽同济大学附属上海市第四人民医院、同济大学医学院脑功能与人工智能转化研究所上海200434

日月开新元,天地又一春。在这辞旧迎新的美好时刻,谨此代表《中华麻醉学杂志》编委会及编辑部,对长期以来热忱支持和关心本刊发展与建设的各位编审专家,向广大的作者、读者及企业一如既往的大力支持,致以诚挚的谢意!并预祝大家龙年大吉... 详细信息

日月开新元,天地又一春。在这辞旧迎新的美好时刻,谨此代表《中华麻醉学杂志》编委会及编辑部,对长期以来热忱支持和关心本刊发展与建设的各位编审专家,向广大的作者、读者及企业一如既往的大力支持,致以诚挚的谢意!并预祝大家龙年大吉、顺遂安康!

关键词：新年献词麻醉学科发展与建设创新推动《中华麻醉学杂志》编审编委会

新年献辞:新型冠状病毒肺炎疫情后麻醉学科的发展

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中华麻醉学杂志 2022年第1期42卷 1-2页

作者：熊利泽同济大学附属上海市第四人民医院同济大学医学院脑功能与人工智能转化研究所上海200434

2021年新型冠状病毒肺炎(以下简称新冠肺炎)疫情继续肆虐全球,据Worldometer网站实时统计数据,截至2022年1月1日(北京时间06:30),全球累计确诊新冠肺炎288228816例,累计死亡达5451594例。这场疫情给人们生命安全、身体健康、社会生活和... 详细信息

2021年新型冠状病毒肺炎(以下简称新冠肺炎)疫情继续肆虐全球,据Worldometer网站实时统计数据,截至2022年1月1日(北京时间06:30),全球累计确诊新冠肺炎288228816例,累计死亡达5451594例。这场疫情给人们生命安全、身体健康、社会生活和经济造成了巨大的损失和影响。

关键词：统计数据新年献辞肺炎麻醉学科疫情生命安全

Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C

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Neuroscience Bulletin 2019年第2期35卷 336-346页

作者： Zongping Fang Yun Feng Yuheng Li Jiao Deng Huang Nie Qianzhi Yang Shiquan Wang Hailong Dong Lize Xiong Department of Anesthesiology and Perioperative Medicine Xijing HospitalThe Fourth Military Medical University Department of Gastroenterology The First Affiliated Hospi-tal of Xi'an Jiaotong University

We have previously reported that Cystatin C(CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen(HBO) preconditioning; however,the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. As a marker of autophagy inhibition, p62 was downregulated by HBO preconditioning and this was blocked by CysC knockdown. Besides, the beneficial effects of preserving lysosomal membrane integrity and enhancing autolysosome formation induced by HBO preconditioning were abolished in CysC-/-rats.Furthermore, we demonstrated that exogenous CysC reduced the neurological deficits and infarct volume after brain ischemic injury, while 3-methyladenine partially reversed this neuroprotection. In the present study, we showed that CysC is biochemically and morphologically essential for promoting autophagic flux, and highlighted the translational potential of HBO preconditioning and CysC for stroke treatment.

关键词： Stroke Ischemia/reperfusion HBO preconditioning Cystatin C Autophagy Autophagic flux

3D-bioprinted cholangiocarcinoma-on-a-chip model for evaluating drug responses

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Bio-Design and Manufacturing 2023年第4期6卷 373-389页

作者： Qiong Liu Luis SMille Cesar Villalobos Ingrid Anaya Matthias Vostatek Sili Yi Wanlu Li Junlong Liao Huanghui Wu Yongteng Song Lize Xiong Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai 200434China Department of Bioengineering Stanford UniversityPalo AltoCA 94305USA Biotechnological Engineering Program Monterrey Institute of Technology and Higher Education64849 MonterreyNuevo LeónMexico Molecular Biotechnology University of Applied Sciences Campus Vienna1100 ViennaAustria Rapid Manufacturing Engineering Center School of Mechatronical Engineering and AutomationShanghai UniversityShanghai 200444China

Cholangiocarcinoma(CCA)is characterized by heterogeneous mutations and a refractory nature.Thus,the development of a model for effective drug screening is urgently needed.As the established therapeutic testing models for CCA are often ineffective,we fabricated an enabling three-dimensional(3D)-bioprinted CCA-on-a-chip model that to a good extent resembled the multicellular microenvironment and the anatomical microstructure of the hepato-vascular-biliary system to perform high-content antitumor drug screening.Specifically,cholangiocytes,hepatocytes,and vascular endotheliocytes were employed for 3D bioprinting of the models,allowing for a high degree of spatial and tube-like microstructural control.Interestingly,it was possible to observe CCA cells attached to the surfaces of the gelatin methacryloyl(GelMA)hydrogelembedded microchannels and overgrown in a thickening manner,generating bile duct stenosis,which was expected to be analogous to the in vivo configuration.Over 4000 differentially expressed genes were detected in the CCA cells in our 3D coculture model compared to the traditional two-dimensional(2D)monoculture.Further screening revealed that the CCA cells grown in the 3D traditional model were more sensitive to the antitumoral prodrug than those in the 2D monoculture due to drug biotransformation by the neighboring functional hepatocytes.This study provides proof-of-concept validation of our bioprinted CCA-on-a-chip as a promising drug screening model for CCA treatment and paves the way for potential personalized medicine strategies for CCA patients in the future.

关键词： Tumor-on-a-chip Biliary tumor 3D bioprinting Tumor microenvironment Drug screening

Retina-Inspired Organic Heterojunction-Based Optoelectronic Synapses for Artificial Visual Systems

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Research 2021年第1期2021卷 442-451页

作者： Junyao Zhang Yang Lu Shilei Dai Ruizhi Wang Dandan Hao Shiqi Zhang Lize Xiong Jia Huang Interdisciplinary Materials Research Center School of Materials Science and EngineeringShanghai Institute of Intelligent Science and TechnologyTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China

For the realization of retina-inspired neuromorphic visual systems which simulate basic functions of human visual systems,optoelectronic synapses capable of combining perceiving,processing,and memorizing in a single device have attracted immense interests.Here,optoelectronic synaptic transistors based on tris(2-phenylpyridine)iridium(Ir(ppy)_(3))and poly(3,3-didodecylquarterthiophene)(PQT-12)heterojunction structure are presented.The organic heterojunction serves as a basis for distinctive synaptic characteristics under different wavelengths of light.Furthermore,synaptic transistor arrays are fabricated to demonstrate their optical perception efficiency and color recognition capability under multiple illuminating conditions.The wavelength-tunability of synaptic behaviors further enables the mimicry of mood-modulated visual learning and memorizing processes of humans.More significantly,the computational dynamics of neurons of synaptic outputs including associated learning and optical logic functions can be successfully demonstrated on the presented devices.This work may locate the stage for future studies on optoelectronic synaptic devices toward the implementation of artificial visual systems.

关键词： Visual artificial optoelectronic

年终盘点:2022年《NEJM》发表麻醉学领域相关研究亮点精粹

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中华麻醉学杂志 2023年第1期43卷 5-12页

作者：雷翀熊利泽空军军医大学西京医院麻醉与围术期医学科西安710032 同济大学医学院附属上海市第四人民医院同济大学医学院脑功能与人工智能转化研究所上海200434

2022年《The New England Journal of Medicine》(NEJM)杂志出版52期,共发表研究型论著210篇。随着大多数国家和地区疫情趋于稳定,新型冠状病毒感染相关研究较前两年有所减少。除此之外本年度杂志继续沿袭一贯传统,对肿瘤新疗法和治疗进... 详细信息

2022年《The New England Journal of Medicine》(NEJM)杂志出版52期,共发表研究型论著210篇。随着大多数国家和地区疫情趋于稳定,新型冠状病毒感染相关研究较前两年有所减少。除此之外本年度杂志继续沿袭一贯传统,对肿瘤新疗法和治疗进展,传染性疾病的流行、防治与新疫苗的研发,慢性疾病的治疗进展、流行状况调查、对健康状况的影响等方面给予了较高关注。针对围术期领域,本年度相关论文主要集中于重症患者的液体治疗、机械通气患者的管理、患者围术期管理、不同治疗方案对患者远期转归的影响等。本文精选其中7个主题14篇相关的亮点研究,以飨读者。

关键词：麻醉学液体治疗机械通气患者围术期管理重症患者冠状病毒感染传染性疾病亮点

Spectrum-dependent photonic synapses based on 2D imine polymers for power-efficient neuromorphic computing

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InfoMat 2021年第8期3卷 904-916页

作者： Junyao Zhang Qianqian Shi Ruizhi Wang Xuan Zhang Li Li Jianhua Zhang Li Tian Lize Xiong Jia Huang Interdisciplinary Materials Research Center School of Materials Science and EngineeringShanghai Institute of Intelligent Science and TechnologyTongji UniversityShanghaiPeople's Republic of China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital Affiliated to Tongji UniversityShanghaiPeople's Republic of China Key Laboratory of Advanced Display and System Application Ministry of EducationShanghai UniversityShanghaiPeople's Republic of China

2D polymers(2DPs)have attracted increasing interests in sensors,catalysis,and gas storage applications.Furthermore,2DPs with unique band structure and tunable photophysical properties also have immense potential for application in photonic neuromorphic computing.Here,photonic synaptic transistors based on 2DPs as the light-tunable charge-trapping medium are developed for the first time.The resulted organic transistors can successfully emulate common synaptic functions,including excitatory postsynaptic current,pair-pulse facilitation,the transition of short-term memory to long-term memory,and dynamic filtering.Benefitting from the high photosensitivity of the 2DP,the devices can be operated under a low operating voltage of0.1 V,and achieve an ultralow energy consumption of~0.29 pJ per event.In addition,the heterostructure formed between the 2DP and organic semiconductor enables spectrum-dependent synaptic responses,which facilitates the simulation of visual learning and memory processes in distinct emotional states.The underlying mechanism of spectrum-dependent synaptic-like behaviors is systematically validated with in situ atomic force microscopy based electrical techniques.The spectrum-enabled tunability of synaptic behaviors further promotes the realization of optical logic functions and associative learning.This work inspires the new application of 2DPs in photonic synapses for future neuromorphic computing.

关键词： 2D polymers neuromorphic computing photonic synapses synaptic functions