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Stroke as a Presenting Feature of COVID-19

International Journal of Clinical Medicine 2020年第12期11卷 743-749页

作者： Asnin Shah Niaz Ahmed Shaikh Khalid Alattar liza mariam thomas Uzma Sabahat Dubai Health Authority Internal Medicine Rashid Hospital Dubai UAE

Objective: To analyze the coronavirus disease-2019 (COVID-19) patients presenting with acute stroke by determining their clinical characteristics, hospitalization course and prognosis. The common and conventional stroke risk factors in these patients were assessed with the aim of determining the role and contribution of the COVID-19 infection to stroke pathogenesis. Methods: Retrospective observational study involving 24 patients from a single tertiary care center over a time period of three months. Risk factors such as Age, Hypertension, Diabetes Mellitus, smoking status and underlying cardiac history were analyzed. COVID-19 relevant laboratory and radiological data were documented. Results: 87.5% of patients had ischemic stroke, with 58.3% of total patients being younger than 55 years. An equal incidence of both Diabetes Mellitus and Hypertension (37.5%) was identified. 29.2% were completely asymptomatic for COVID-19, of which 85.7% had no chest X-ray changes on admission. Eight patients (61.5%) developed pneumonia during admission despite an initially normal chest X-ray. Conclusion: Patients without COVID-19 symptoms and with normal chest radiography presenting with stroke does not rule out a possible underlying COVID-19 infection. Such patients may be positive for the virus and may go on to develop pneumonia shortly after suffering from strokes. This could suggest that stroke in COVID-19 patients is a possible initial presenting feature and consequence of the inflammatory state triggered by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. It is imperative to analyze the association of COVID-19 and stroke, and to maintain a high index of suspicion of COVID-19 infection in stroke patients, to enhance early detection and reduce transmission.

关键词： COVID-19 Coronavirus Stroke Hypercoagulable UAE

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Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?

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Neural Regeneration Research 2019年第4期14卷 582-587页

作者： Elisa Piscianz liza Vecchi Brumatti Alberto Tommasini Annalisa Marcuzzi Department of Medicine Surgery and Health Sciences University of Trieste Institute for Maternal and Child Health-IRCCS "Burlo Garofolo"

The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders.

关键词： cholesterol inflammation apoptosis autophagy neurons inherited disease necroptosis neuronal dysfunction

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超高强微钢纤维增韧混凝土的制备及其力学性能研究

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土木工程学报 2009年第6期42卷 1-7页

作者：王冲 liza O'Moore 重庆大学重庆400045 University of Queensland QLD 4072Australia

高脆性是超高强混凝土难以被广泛应用的主要原因之一。为降低脆性,利用长度为6mm与13mm的三种微钢纤维,制备超高强微钢纤维混凝土,研究不同纤维长径比及掺量条件下混凝土的力学性能指标,其中包括ASTMC1018方法测试超高强微纤维混凝土的... 详细信息

高脆性是超高强混凝土难以被广泛应用的主要原因之一。为降低脆性,利用长度为6mm与13mm的三种微钢纤维,制备超高强微钢纤维混凝土,研究不同纤维长径比及掺量条件下混凝土的力学性能指标,其中包括ASTMC1018方法测试超高强微纤维混凝土的抗弯韧性。试验结果显示:随纤维掺量的增加,超高强混凝土能量吸收能力增加明显;与不掺纤维时相比,1.0%体积掺量下三种纤维混凝土的初始裂缝强度、抗折强度和韧性指数均有显著提高,掺量2.0%时初始裂缝强度、抗折强度和韧性指数的增加受到影响;长度为6mm的纤维在2.0%掺量时抗压强度相对较大,而长度为13mm的两种纤维在掺量1.0%时抗压强度较高;掺入3种纤维的混凝土劈拉强度和弹性模量也由于纤维的掺入而有所增加。结果表明,微钢纤维用于增韧超高强混凝土时,宜采用适宜掺量。

关键词：微钢纤维超高强混凝土制备力学性能

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Pneumatosis cystoides intestinalis

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World Journal of Gastroenterology 2011年第44期17卷 4932-4936页

作者： Francesco Azzaroli Laura Turco liza Ceroni Stefania Sartoni Galloni Federica Buonfiglioli Claudio Calvanese Giuseppe Mazzella Department of Clinical Medicine Division of GastroenterologyS.Orsola-Malpighi HospitalUniversity of Bologna Department of Emergency General Surgery and TransplantationS.Orsola-Malpighi HospitalUniversity of Bologna

Pneumatosis cystoides intestinalis(PCI) is a rare condition that may be associated with a variety of *** presenting clinical picture may be very heterogeneous and represent a challenge for the *** the present paper we describe both a common and an uncommon clinical presentation of PCI and review the pertaining *** cases confirm that,apart from asymptomatic cases,the clinical presentation of PCI may be widely different and suggest that a new onset of stipsis might be the presenting *** might be suggested by a simple X-ray of the digestive tract showing a change in the characteristics of the intestinal wall in two-thirds of these ***,one third of the patients do not have a suggestive X-ray and require a computed tomography(CT) scan/nuclear magnetic resonance that may reveal a thickened bowel wall containing gas to confirm the diagnosis and distinguish PCI from intraluminal air or submucosal *** also allows the detection of additional findings that may suggest an underlying,potentially worrisome cause of PCI such as bowel wall thickening,altered contrast mucosal enhancement,dilated bowel,soft tissue stranding,ascites and the presence of portal *** results also point out that clinicians and endoscopists should be aware of the possible presentations of PCI in order to correctly manage the patients affected with this disease and avoid unnecessary *** increasing number of colonoscopies performed for colon cancer screening makes PCI more frequently casually encountered and/or provoked,therefore the possible endoscopic appearances of this disease should be well known by endoscopists.

关键词： Pneumatosis cystoides intestinalis Pneumoperitoneum Treatment Hyperbaric oxygen Endoscopy

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Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup

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World Journal of Methodology 2017年第4期7卷 117-128页

作者： Pupalan Iyngkaran Nagesh S Anavekar Christopher Neil liza thomas David L Hare Department of Medicine Northern Territory Medical School Flinders University Charles Darwin University Campus Department of Cardiology Northern Hospital Northern Health University of Melbourne Cardiology Unit Western Health Department of Medicine Western Precinct University of Melbourne South Western Sydney Clinical School University of New South Wales Westmead Hospital Westmead Clincal School University of Sydney Cardiovascular Research University of Mel-bourne Heart Failure Services Austin Health

The symptom cluster of shortness of breath(SOB) contributes significantly to the outpatient workload of cardiology services. The workup of these patients includes blood chemistry and biomarkers, imaging and functional testing of the heart and lungs. A diagnosis of diastolic heart failure is inferred through the exclusion of systolic abnormalities, a normal pulmonary function test and normal hemoglobin, coupled with diastolic abnormalities on echocardiography. Differentiating confounders such as obesity or deconditioning in a patient with diastolic abnormalities is difficult. While the most recent guidelines provide more avenues for diagnosis, such as incorporating the left atrial size, little emphasis is given to understanding left atrial function, which contributes to at least 25% of diastolic left ventricular filling; additionally, exercise stress testing to elicit symptoms and test the dynamics of diastolic parameters, especially when access to the "gold standard" invasive tests is lacking, presents clinical translational gaps. It is thus important in diastolic heart failure work up to understand left atrial mechanics and the role of exercise testing to build a comprehensive argument for the diagnosis of diastolic heart failure in a patient presenting with SOB.

关键词： Diastolic heart failure Exercise stress test Left atrium Shortness of breath Work-up

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Falling Snow

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小学生时代（大嘴英语） 2023年第12期 26-28页

作者： Anonymous liza Woodruff 不详

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Evolution of liver transplantation in the metabolic dysfunctionassociated steatotic liver disease era: Tracking impact through time

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World Journal of Transplantation 2024年第4期14卷 84-94页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi Estefanía liza Zuly Placido-Damian Javier Diaz-Ferrer Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Medicine Faculty Universidad San Martin de PorresLima 02002Peru Gastroenterology Service Clinica InternacionalLima 02002Peru

Liver transplantation(LT)for metabolic dysfunction-associated steatotic liver disease(MASLD)is increasing globally due to rising rates of obesity and metabolic syndrome,posing significant *** patients typically present with advanced age,higher body mass index(BMI),and metabolic com-orbidities such as diabetes,hypertension,and *** pre-transplant evaluations are crucial for assessing surgical risks and preparing patients for *** patients with higher BMI may experience longer operative times,potentially affecting intraoperative *** the months following LT,MASLD recipients face persistent challenges,including a higher incidence of metabolic syndrome and cardiovascular events compared to non-MASLD ***,survival rates at 1-,3-,and 5-years post-LT do not markedly differ from other etiologies,indicating comparable surgical *** outcomes in MASLD patients undergoing LT demands a multidisciplinary approach from pre-transplant assessment to post-transplant *** must address metabolic comorbidities,manage cardiovascular health,and monitor steatosis recurrence,which can be exacerbated by obesity and *** approach aims to mitigate long-term graft complications and mortality risks,ultimately enhancing transplant success and patient *** research is essential to refine these approaches and meet the evolving challenges posed by MASLD as a leading indication for LT worldwide.

关键词： Liver transplantation Metabolic dysfunction-associated steatotic liver disease Alcohol liver disease Hepatitis C Hepatitis B Hepatocellular carcinoma

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 755-756页

作者： Jaafar Juanarita Mohd Noor Raja Azmi Yaakub Azhany Ahmad Tajudin liza-Sharmini Department of Ophthalmology School of Medical SciencesUniversiti Sains Malaysia

A 24 year-old Malay lady presented with high grade fever,myalgia,generalized rashes,severe headache and was positive for dengue serology *** lowest platelet count was 45×10~9 cells/*** complained of sudden onset of painlessness,profound loss of vision bilaterally 7 days after the onset of *** examination,her right eye best corrected vision was 6/30 and left eye was6/*** anterior segment examination was *** revealed there were multiple retinal haemorrhages found at posterior pole of both fundi and elevation at fovea area with subretinal *** examination revealed normal findings except for residual petechial *** was managed *** vision improved tremendously after 2 *** retinal hemorrhages and foveal elevation showed sign of *** manifestations following dengue fever is ***,bilateral visual loss can occur if both fovea arc involved.

关键词： Dengue fever Maculopathy Foveolitis

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文化沟通或软实力 ——匈牙利孔子学院案例研究

文化沟通或软实力 ——匈牙利孔子学院案例研究

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作者： liza Hajdu 浙江大学

学位级别：硕士

This thesis investigates a much discussed,yet often misunderstood topic:Confucius Institutes(CIs)and their influence on foreign *** more than 500 CIs having opened worldwide during the last decade and a half,the Chinese government's cultural initiative has sparked large debates over the institutes' real *** a number of countries both scholars and politicians have been urging university staff members to close CIs at their university *** reason for the fierce opposition against CIs is that many perceive them as a tool in the hands of the Chinese government to shape foreign audiences' view of the country,and as a part of a soft power initiative that aims at attracting foreigners to Chinese values and political *** the other end of the debate there are a few scholars arguing for a more nuanced understanding of the CI network,suggesting that instead of furthering Chinese soft power advances,CIs serve the cause of building a deeper cultural understanding between China and other *** thesis aims at providing a fresh insight into this *** basis of this dissertation is a primary research which has been carried out to see how current and former Hungarian CI students' perception of China has changed due to them having studied at a *** the research both qualitative and quantitative data was collected,in which participants were asked to reflect on their own CI experiences and to recount how their cultural and non-cultural interest towards China has been transformed during their CI *** the data was collected,and the pre-and post-CI experiences were compared I came to the conclusion that CIs should not be regarded as vehicles of Chinese soft power advancement as their soft power effects are ***,I would suggest to see CIs as peaceful cultural institutions aiming at the enhancement of a deeper cultural understanding between China and other nations of the world.

关键词：硕士学位论文 engage claimed 文化沟通 interested courses political instance university institutions

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Friends

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小学生时代（大嘴英语） 2021年第6期 28-29页

作者： Diana Murray liza Woodruff(图) 不详

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