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Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma

Chinese Neurosurgical Journal 2022年第2期8卷 111-119页

作者： liyun zhong Pei Yang Chuanbao Zhang Zheng Wang Tao Jiang Baoshi Chen Xia Shan Xiaoguang Qiu Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases 119 South 4th Ring Road WestBeijing 100070China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical University119 South 4th Ring Road WestBeijing 100070China

Background:Adjuvant temozolomide(TMZ)chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma(HGG).However,the influence of long-term TMZ chemotherapy on serum ions concentration is unclear.Methods:One hundred and thirty-eight patients with HGG were included.Their blood samples were collected for blood biochemistry and routine test.The alteration in serum ions concentration,total protein,albumin,globin,and blood cells counts were used to identify the impact of long-term TMZ chemotherapy.Results:Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles,we identified that serum potassium concentration had a downward trend after TMZ administration(1st vs.6th,p<0.001;1st vs.12th,p<0.001).Additionally,the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles(r=−0.649,p=0.023).The hematological adverse events mainly centered on grade 1 to 2.Conclusion:Long-term administration of TMZ may lead to serum ions disturbance.Besides the myelosuppression,we should pay attention to the alteration in serum ions concentration,and give patients proper symptomatic treatment when necessary.

关键词： High-grade glioma(HGG) Temozolomide(TMZ) Chemotherapy Toxicity

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肠道微生物疗法干预孤独症谱系障碍的研究进展

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中国医药导报 2024年第3期21卷 68-71页

作者：钟佳何丽云赵宁侠陕西中医药大学陕西咸阳712046 陕西中医药大学第一临床医学院陕西咸阳712046 西安中医脑病医院陕西西安710032

孤独症谱系障碍(ASD)是一种复杂的神经发育疾病,发病率逐年上升。除了语言、行为和社交受损症状外,大部分患儿伴有不同程度的胃肠道症状。目前,ASD病理机制不明,随着对肠道菌群的深入研究,发现ASD患儿的症状与肠道微生物密切相关。因此... 详细信息

孤独症谱系障碍(ASD)是一种复杂的神经发育疾病,发病率逐年上升。除了语言、行为和社交受损症状外,大部分患儿伴有不同程度的胃肠道症状。目前,ASD病理机制不明,随着对肠道菌群的深入研究,发现ASD患儿的症状与肠道微生物密切相关。因此,调节肠道菌群成为防治ASD的热点之一。本文就肠道微生态对ASD的影响,通过肠道微生物(益生菌、益生元、粪便微生物移植)干预对“脑肠轴”的机制和作用进行综述,旨在为ASD的发病机制和临床治疗提供新理论基础、新思路。

关键词：孤独症谱系障碍肠道微生物益生菌益生元粪便微生物移植

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Human Machine Interface with Wearable Electronics Using Biodegradable Triboelectric Films for Calligraphy Practice and Correction

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Nano-Micro Letters 2022年第12期14卷 630-644页

作者： Shen Shen Jia Yi zhongda Sun Zihao Guo Tianyiyi He liyun Ma Huimin Li Jiajia Fu Chengkuo Lee zhong Lin Wang Jiangsu Engineering Technology Research Center for Functional Textiles Jiangnan UniversityNo.1800 Lihu AvenueWuxiP.R.China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083P.R.China China National Textile and Apparel Council Key Laboratory of Natural Dyes Soochow UniversitySuzhou 215123People’s Republic of China School of Material Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

Letter handwriting,especially stroke correction,is of great importance for recording languages and expressing and exchanging ideas for individual behavior and the public.In this study,a biodegradable and conductive carboxymethyl chitosan-silk fibroin(CSF)film is prepared to design wearable triboelectric nanogenerator(denoted as CSF-TENG),which outputs of V_(oc)≈165 V,I_(sc)≈1.4μA,and Q_(sc)≈72 mW cm^(−2).Further,in vitro biodegradation of CSF film is performed through trypsin and lysozyme.The results show that trypsin and lysozyme have stable and favorable biodegradation properties,removing 63.1%of CSF film after degrading for 11 days.Further,the CSF-TENG-based human-machine interface(HMI)is designed to promptly track writing steps and access the accuracy of letters,resulting in a straightforward communication media of human and machine.The CSF-TENG-based HMI can automatically recognize and correct three representative letters(F,H,and K),which is benefited by HMI system for data processing and analysis.The CSF-TENG-based HMI can make decisions for the next stroke,highlighting the stroke in advance by replacing it with red,which can be a candidate for calligraphy practice and correction.Finally,various demonstrations are done in real-time to achieve virtual and real-world controls including writing,vehicle movements,and healthcare.

关键词： Letter handwriting Triboelectric nanogenerator Biodegradable Human-machine interface Calligraphy practice

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Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai,2018–2021

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Virologica Sinica 2023年第5期38卷 671-679页

作者： Lijuan Lu Yuanyun Ao Ran Jia Huaqing zhong Pengcheng Liu Menghua Xu liyun Su Lingfeng Cao Jin Xu Department of Clinical Laboratory Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201100China Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai201100China

Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in children.In this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to 2021.The overall detection rate of NoV was 11.9%(181/1545),with annual detection rates of 9.4%(36/381),13.6%(29/213),5.8%(13/226)and 14.2%(103/725),respectively.Of note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9%,65/594)(P=0.023)and 2021(14.2%,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GI group(1.1%,2/181),GII group(98.3%,178/181)and GIX group(0.6%,1/181)according to the VP1 gene.The most common NoV VP1 genotype was GII.4 Sydney_2012(63.5%,115/181),followed by GII.3(19.9%,36/181)and GII.2(9.4%,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GII.P16(44.8%,78/174),followed by GII.P31(25.9%,45/174)and GII.P12(21.3%,37/174).Among the 174 cases,GII.4 Sydney_2012[P16](36.8%,64/174)was the dominant genotype,followed by GII.4 Sydney_2012[P31](25.3%,44/174),GII.3[P12](20.1%,35/174)and GII.2[P16](8.0%,14/174).In particular,the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31]in 2018-2019 to GII.4 Sydney_2012[P16]in 2020-2021.This is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in Shanghai.These data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.

关键词： Norovirus(NoV) Acute gastroenteritis Children Genotype Recombination

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青少年癫痫患者学业障碍影响因素的质性研究

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中国实用神经疾病杂志 2024年第2期27卷 225-229页

作者：李京连陆朋玮李倩仲丽芸首都医科大学附属北京天坛医院北京100050

目的了解青少年癫痫患者学业障碍的影响因素,为提升青少年癫痫患者教育质量提供参考。方法采用现象学研究方法,选取2022-10—2023-01于首都医科大学附属北京天坛医院癫痫中心住院的10例青少年癫痫患者进行半结构式访谈,使用Colaizzi内... 详细信息

目的了解青少年癫痫患者学业障碍的影响因素,为提升青少年癫痫患者教育质量提供参考。方法采用现象学研究方法,选取2022-10—2023-01于首都医科大学附属北京天坛医院癫痫中心住院的10例青少年癫痫患者进行半结构式访谈,使用Colaizzi内容分析法提炼主题。结果根据访谈结果将青少年癫痫患者学业障碍因素分为三个类别,即个人归因、刺激归因、环境归因。个人因素主要包括内在病耻感、疾病造成的学业中断、担忧疾病发作、疾病对认知功能的影响、疾病造成的生理不适等。刺激因素主要包括教师及同伴群体,环境归因主要涉及家庭支持不足,学校重视度不够。结论医疗结构、学校、家庭均应重视青少年癫痫患者学业情况,针对性地给予科学、有效的干预,以为青少年癫痫患者提供更好的受教育环境,提升青少年教育质量。

关键词：青少年癫痫学业障碍影响因素访谈

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Tailoring the surface structure of iron compounds to optimize the selectivity of 3-nitrostyrene hydrogenation reaction over Pt catalyst

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Chinese Chemical Letters 2022年第6期33卷 2911-2914页

作者： Ying Zhang Tongtong Gao Chengshan Dai liyun Zhang Yiming Niu Junnan Chen zhong-Wen Liu Bingsen Zhang School of Petrochemical Engineering Liaoning Shihua UniversityFushun 113001China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi’an 710119China School of Materials Science and Engineering University of Science and Technology ofChinaShenyang 110016China Department of Chemical Engineering Qufu Normal UniversityQufu 273165China

Selective hydrogenation of substituted nitroarenes is an important reaction to obtain amines.Supported metal catalysts are wildly used in this reaction because the surface structure of supports can tune the properties of the supported metal nanoparticles(NPs)and promote the selectivity to amines.Herein,Pt NPs were immobilized on Fe OOH,Fe_(3)O_(4)andα-Fe_2O_(3)nanorods to synthesize a series of iron compounds supported Pt catalysts by liquid phase reduction method.Chemoselective hydrogenation of 3-nitrostyrene to 3-aminostyrene was used as probe reaction to evaluate the performance of the catalysts.The results show that Pt/Fe OOH exhibits the highest selectivity and activity.Fe OOH support with pores and-OH groups can tune the electronic structure of Pt NPs.The positive charge of Pt NPs supported on Fe OOH is key factor for improving the catalytic performance.

关键词： Pt Electronic structure Surface structure Iron compounds Selective hydrogenation 3-Nitrostyrene

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基于Siebens领域管理模式的延续性护理在帕金森病脑深部电刺激术后患者中的应用

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中华现代护理杂志 2024年第8期30卷 1084-1089页

作者：富晶夏小童刘德峰袁巧玲刘嘉欣仲丽芸首都医科大学附属北京天坛医院神经外科北京100070

目的探讨以Siebens领域管理模式为基础的延续性护理对帕金森病脑深部电刺激术后患者的影响。方法采用便利抽样法,选取2021年1月—2022年6月北京天坛医院功能神经外科接受脑深部电刺激术手术的169例帕金森病患者为研究对象。采用随机数... 详细信息

目的探讨以Siebens领域管理模式为基础的延续性护理对帕金森病脑深部电刺激术后患者的影响。方法采用便利抽样法,选取2021年1月—2022年6月北京天坛医院功能神经外科接受脑深部电刺激术手术的169例帕金森病患者为研究对象。采用随机数字表法分为对照组84例,观察组85例,对照组使用常规延续护理,观察组在对照组基础上采取基于Siebens领域管理模式的延续性护理。比较两组患者出院6个月的日常生活能力量表、Morisky服药依从性、生活质量量表、帕金森病睡眠障碍量表和非预期程控率。结果出院6个月后,两组患者日常生活能力得分、生活质量评分和睡眠质量得分均较干预前提高(P<0.05);观察组患者服药依从性较干预前提高(P<0.05)。观察组患者的日常生活能力得分、服药依从性、生活质量评分和睡眠质量得分均高于对照组(P<0.05)。在出院后6个月内,观察组的非预期程控率低于对照组(P<0.05)。结论在脑深部电刺激治疗帕金森患者的治疗以及出院康复过程中,采取以Siebens领域管理模式为基础的延续性护理模式,有助于保证患者的用药依从性,改善术后睡眠质量和生活质量,降低患者的非预期程控次数,具有一定的临床应用价值。

关键词：帕金森病延续性护理生活质量 Siebens领域管理模式脑深部电刺激

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Two Successful Livebirths from Both Hemiuteruses After Laparoscopic Cervical Cerclage in a Uterus Didelphys Patient with Cervical Insufficiency

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Maternal-Fetal Medicine 2022年第2期4卷 155-158页

作者： Limei Zhang Xue zhong Yuqing Chen Tianyu Peng liyun Yu Jian Cai Shuzhong Yao Zilian Wang Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China.

Uterus didelphys occurs in~0.4%of females and is found in~11%-20%of all uterus defects.It is a risk factor for cervical insufficiency,consequently contributing to late miscarriage or preterm birth.Thus far,only two prior cases of uterus didelphys accompanied by cervical insufficiency treated through laparoscopic cervical cerclage have been reported;however,livebirth only occurred in one hemiuterus.Herein,we report a case of uterus didelphys in a patient diagnosed with cervical insufficiency.Following the placement of a modified laparoscopic cervical cerclage,the patient had two successful livebirths through both hemiuteruses,respectively,with longer gestation age(ie,>36 weeks).The aim of this case report was to provide useful information for clinical practitioners to make better decisions on the management of cervical insufficiency in patients with uterus didelphys,and identify obstetric complications that clinicians should pay attention to during pregnancy.

关键词： Urogenital abnormalities Uterus didelphys Cervical insufficiency Laparoscopic cervical cerclage Obstetric outcomes

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The holographic reconstructing algorithm and its error analysis about phase-shifting phase measurement

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Frontiers of Electrical and Electronic Engineering in China 2007年第3期2卷 293-297页

作者： LU Xiaoxu zhong liyun ZHANG Yimo School of Information and Optoelectronic Science and Engineering South China Normal UniversityGuangzhou 510631China College of Life Science and Technology Jinan UniversityGuangzhou 510632China School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China

Phase-shifting measurement and its error estimation method were studied according to the holographic principle.A function of synchronous superposition of object complex amplitude reconstructed from N-step phase-shifting through one integral period(N-step phase-shifting function for short)was proposed.In N-step phase-shifting measurement,the interferograms are seen as a series of in-line holo-grams and the reference beam is an ideal parallel-plane wave.So the N-step phase-shifting function can be obtained by multiplying the interferogram by the original reference wave.In ideal conditions,the proposed method is a kind of synchro-nous superposition algorithm in which the complex ampli-tude is separated,measured and superposed.When error exists in measurement,the result of the N-step phase-shifting function is the optimal expected value of the least-squares fitting method.In the above method,the N+1-step phase-shifting function can be obtained from the N-step phase-shifting function.It shows that the N-step phase-shifting function can be separated into two parts:the ideal N-step phase-shifting function and its errors.The phase-shifting errors in N-steps phase-shifting phase measurement can be treated the same as the relative errors of amplitude and intensity under the understanding of the N+1-step phase-shifting function.The difficulties of the error estimation in phase-shifting phase measurement were restricted by this error esti-mation method.Meanwhile,the maximum error estimation method of phase-shifting phase measurement and its formula were proposed.

关键词： optical measurement information optics phase-shifting phase measurement N-step phase-shifting function N+1-step phase-shifting algorithm error

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High-Efficiency Wastewater Purification System Based on Coupled Photoelectric–Catalytic Action Provided by Triboelectric Nanogenerator

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Nano-Micro Letters 2021年第12期13卷 95-108页

作者： Shen Shen Jiajia Fu Jia Yi liyun Ma Feifan Sheng Chengyu Li Tingting Wang Chuan Ning Hongbo Wang Kai Dong zhong Lin Wang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China Jiangsu Engineering Technology Research Centre for Functional Textiles Jiangnan UniversityNo.1800 Lihu AvenueWuxiPeople’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Material Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

It is of great importance to explore a creative route to improve the degradation e ciency of organic pollutants in wastewater.Herein,we construct a unique hybrid system by combining self-powered triboelectric nanogenerator(TENG)with carbon dots-TiO_(2)sheets doped three-dimensional graphene oxide photocatalyst(3 DGA@CDs-TNs),which can significantly enhance the degradation e ciency of brilliant green(BG)and direct blue 5 B(DB)owing to the powerful interaction of TENG and 3 DGA@CDs-TNs photocatalyst.The power output of TENG can be applied for wastewater purification directly,which exhibits a selfpowered electrocatalytic technology.Furthermore,the results also verify that TENG can replace conventional electric catalyst to remove pollutants e ectively from wastewater without any consumption.Subsequently,the unstable fragments and the plausible removal pathways of the two pollutants are proposed.Our work sheds light on the development of e cient and sustainable TENG/photocatalyst system,opening up new opportunities and possibilities for comprehensive utilization of random energy.

关键词： Triboelectric nanogenerators Self-powered 3DGA@CDs-TNs photocatalyst Hybrid system Wastewater purification

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